LLPS-Mum-a337
Acap2

▼ OVERVIEW

Status: Reviewed
Protein Name: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; Centaurin-beta-2; Cnt-b2
Gene Name: Acap2, Centb2, Kiaa0041
Ensembl Gene: ENSMUSG00000049076.11
Ensembl Protein: ENSMUSP00000156077.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKMTVDFEEC  LKDSPRFRAA  LEEVEGDVAE  LELKLDKLVK  LCIAMIDTGK  AFCVANKQFM  60
61    NGIRDLAQYS  SNDAVVETSL  TKFSDSLQEM  INFHTILFDQ  TQRSIKAQLQ  NFVKEDLRKF  120
121   KDAKKQFEKV  SEEKENALVK  NAQVQRNKQH  EVEEAANILT  ATRKCFRHIA  LDYVLQINVL  180
181   QSKRRSEILK  SMLSFMYAHL  AFFHQGYDLF  SELGPYMKDL  GAQLDRLVVD  AAKEKREMEQ  240
241   KHSTIQQKDF  SSDDSKLEYN  VDAANGIVME  GYLFKRASNA  FKTWNRRWFS  IQNNQLVYQK  300
301   KFKDSPTVVV  EDLRLCTVKH  CEDIERRFCF  EVVSPTKSCM  LQADSEKLRQ  AWIKAVQTSI  360
361   ATAYREKGDE  SEKLDKKSSP  STGSLDSGNE  SKEKLLKGES  ALQRVQCIPG  NTSCCDCGLA  420
421   DPRWASINLG  ITLCIECSGI  HRSLGVHFSK  VRSLTLDTWE  PELLKLMCEL  GNDVINRVYE  480
481   AKLEKMGVKK  PQPGQRQEKE  AYIRAKYVER  KFVDKYSALL  SPSEQEKRII  SKSCEDQRLS  540
541   HARASVHTPV  AAVTSDEARR  ESLFCPDELD  SLFSYFDTSS  KLRSIKSNDS  GIQQCSEDGR  600
601   ESLPSTVSAN  SLYEPEGERQ  ESSVFLDSKH  LNPGLQLYRA  SYEKNLPKMA  EALAHGADVN  660
661   WANSDENQAT  PLIQAVLGGS  LVTCEFLLQN  GANVNQRDVQ  GRGPLHHATV  LGHTGQVCLF  720
721   LKRGANQHAT  DEEGKDPLSI  AVEAANADIV  TLLRLARMNE  EMRESEGLYG  QPGDETYQDI  780
781   FRDFSQMASN  NPEKLNRFQQ  DSQKF  805
Nucleotide CDS Sequence (FASTA)
1     ATGAAGATGA  CGGTGGATTT  CGAGGAGTGT  CTGAAGGACT  CGCCCCGCTT  CAGGGCTGCT  60
61    TTGGAAGAGG  TAGAAGGAGA  TGTGGCTGAG  CTGGAACTAA  AACTCGACAA  GCTTGTGAAA  120
121   CTGTGTATCG  CGATGATTGA  CACTGGCAAA  GCCTTTTGTG  TTGCAAATAA  ACAGTTCATG  180
181   AATGGGATCC  GAGACCTGGC  CCAGTATTCT  AGCAATGATG  CTGTGGTTGA  GACAAGTTTG  240
241   ACCAAGTTTT  CTGACAGTCT  TCAGGAAATG  ATCAATTTCC  ACACAATTCT  GTTTGACCAA  300
301   ACCCAGAGAT  CAATTAAGGC  CCAGCTTCAG  AACTTTGTCA  AAGAAGATCT  TAGAAAATTC  360
361   AAAGATGCCA  AGAAACAATT  TGAAAAAGTC  AGTGAAGAAA  AGGAAAACGC  ACTAGTAAAA  420
421   AATGCCCAAG  TTCAAAGAAA  CAAACAGCAC  GAGGTTGAAG  AGGCTGCAAA  CATTCTCACG  480
481   GCCACGCGGA  AATGCTTCCG  GCACATAGCG  CTTGACTACG  TCCTGCAGAT  CAATGTGCTT  540
541   CAGTCAAAAC  GGAGATCGGA  AATCCTGAAA  TCAATGCTGT  CCTTCATGTA  CGCACATCTG  600
601   GCCTTCTTCC  ATCAAGGGTA  TGACCTGTTC  AGTGAGCTTG  GGCCCTACAT  GAAAGATCTT  660
661   GGAGCACAGT  TGGATCGACT  GGTTGTAGAT  GCAGCAAAGG  AGAAAAGAGA  GATGGAGCAA  720
721   AAACACTCTA  CGATCCAGCA  GAAGGATTTC  TCCAGTGACG  ATTCCAAGCT  AGAGTATAAT  780
781   GTAGACGCTG  CAAATGGCAT  TGTCATGGAA  GGGTATCTGT  TCAAACGAGC  CAGCAACGCC  840
841   TTCAAAACGT  GGAACAGACG  CTGGTTCTCC  ATACAGAACA  ATCAGTTGGT  TTACCAGAAA  900
901   AAGTTTAAGG  ACAGCCCCAC  TGTGGTGGTG  GAAGACCTCA  GGCTCTGCAC  AGTGAAGCAT  960
961   TGCGAAGACA  TCGAGCGGCG  GTTCTGCTTT  GAGGTCGTCT  CTCCAACAAA  AAGTTGTATG  1020
1021  CTCCAGGCAG  ATTCTGAAAA  GCTTCGCCAG  GCCTGGATTA  AGGCTGTTCA  GACCAGTATT  1080
1081  GCAACTGCTT  ATAGAGAGAA  GGGCGATGAA  TCAGAGAAAT  TGGATAAGAA  GTCGTCCCCA  1140
1141  TCAACCGGAA  GCCTAGATTC  TGGAAATGAA  TCAAAAGAGA  AGTTATTGAA  AGGAGAAAGT  1200
1201  GCTCTGCAGC  GTGTGCAGTG  TATCCCTGGC  AACACCAGCT  GCTGTGACTG  TGGTCTGGCA  1260
1261  GACCCACGGT  GGGCCAGCAT  CAACCTGGGC  ATTACCTTGT  GCATTGAGTG  CTCTGGGATT  1320
1321  CATCGGAGCC  TTGGGGTTCA  TTTTTCGAAA  GTAAGATCTT  TAACTTTAGA  CACTTGGGAG  1380
1381  CCAGAGCTCT  TAAAGCTTAT  GTGTGAATTG  GGAAATGATG  TTATAAATCG  AGTTTATGAA  1440
1441  GCTAAACTGG  AAAAAATGGG  TGTAAAGAAA  CCACAGCCAG  GACAAAGACA  GGAGAAGGAG  1500
1501  GCATATATCA  GAGCGAAATA  TGTGGAAAGG  AAATTTGTGG  ATAAGTACTC  TGCATTGCTG  1560
1561  TCTCCGTCTG  AGCAGGAAAA  AAGGATCATC  TCTAAGAGCT  GCGAGGACCA  GAGGCTGAGC  1620
1621  CATGCCAGAG  CATCTGTCCA  CACCCCAGTC  AAAAGTAATG  ACAGCGGGAT  CCAGCAATGC  1680
1681  TCTGAGGATG  GACGAGAATC  TCTACCTTCC  ACGGTGTCAG  CCAATAGCTT  ATATGAGCCT  1740
1741  GAAGGAGAAA  GGCAAGAGTC  TTCTGTGTTT  CTTGACTCTA  AACATCTTAA  TCCAGGACTT  1800
1801  CAGCTTTATA  GGGCTTCGTA  CGAAAAAAAC  CTTCCCAAGA  TGGCTGAGGC  TTTGGCTCAC  1860
1861  GGTGCAGATG  TGAACTGGGC  TAATTCAGAT  GAAAACCAAG  CAACACCACT  CATCCAGGCT  1920
1921  GTATTAGGGG  GCTCTTTGGT  GACATGTGAG  TTCCTGTTGC  AGAATGGTGC  TAATGTGAAC  1980
1981  CAAAGAGATG  TCCAAGGCCG  GGGACCACTG  CACCATGCCA  CCGTCTTAGG  ACACACAGGG  2040
2041  CAGGTGTGCT  TATTCCTCAA  GCGAGGTGCC  AATCAACATG  CCACTGACGA  GGAGGGGAAG  2100
2101  GACCCTCTGA  GTATCGCCGT  GGAAGCAGCC  AACGCTGACA  TAGTAACCCT  GTTACGCTTA  2160
2161  GCAAGAATGA  ATGAGGAAAT  GCGGGAATCA  GAAGGACTTT  ATGGACAGCC  AGGTGATGAA  2220
2221  ACTTACCAGG  ATATTTTTCG  TGATTTTTCT  CAAATGGCAT  CCAATAATCC  AGAGAAACTC  2280
2281  AATCGTTTCC  AGCAAGATTC  ACAGAAGTTC  TGA  2313

▼ KEYWORD

ID
Family
Alternative splicing
ANK repeat
Coiled coil
Complete proteome
Endosome
GTPase activation
Membrane
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endosome membrane
Cellular Component
Ruffle
Molecular Function
GTPase activator activity
Molecular Function
Metal ion binding
Molecular Function
Phosphatidylinositol-3,5-bisphosphate binding
Molecular Function
Rab GTPase binding
Biological Process
Actin filament-based process
Biological Process
Cellular response to nerve growth factor stimulus
Biological Process
Endocytic recycling

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a334Rattus norvegicus98.640.01658
LLPS-Aon-a337Aotus nancymaae96.020.01607
LLPS-Caj-a330Callithrix jacchus95.90.01604
LLPS-Mam-a329Macaca mulatta95.530.01599
LLPS-Nol-a327Nomascus leucogenys95.430.01563
LLPS-Chs-a329Chlorocebus sabaeus95.330.01610
LLPS-Paa-a332Papio anubis95.20.01609
LLPS-Sus-a335Sus scrofa95.010.01540
LLPS-Cea-a333Cercocebus atys94.740.01605
LLPS-Pap-a328Pan paniscus94.740.01605
LLPS-Maf-a333Macaca fascicularis93.930.01597
LLPS-Man-a332Macaca nemestrina93.930.01597
LLPS-Fec-a333Felis catus93.810.01588
LLPS-Dio-a325Dipodomys ordii92.30.01533
LLPS-Eqc-a339Equus caballus92.210.01524
LLPS-Aim-a322Ailuropoda melanoleuca92.170.01531
LLPS-Cap-a331Cavia porcellus92.170.01534
LLPS-Mea-a308Mesocricetus auratus92.110.01472
LLPS-Pat-a329Pan troglodytes92.050.01532
LLPS-Hos-a337Homo sapiens92.050.01532
LLPS-Otg-a335Otolemur garnettii91.780.01521
LLPS-Myl-a317Myotis lucifugus91.250.01482
LLPS-Rhb-a325Rhinopithecus bieti91.180.01509
LLPS-Urm-a305Ursus maritimus91.150.01484
LLPS-Mup-a330Mustela putorius furo91.010.01517
LLPS-Orc-a320Oryctolagus cuniculus91.010.01521
LLPS-Fud-a326Fukomys damarensis90.980.01483
LLPS-Poa-a329Pongo abelii90.680.01500
LLPS-Mal-a323Mandrillus leucophaeus90.640.01494
LLPS-Ova-a326Ovis aries90.190.01486
LLPS-Loa-a325Loxodonta africana89.610.01467
LLPS-Mod-a317Monodelphis domestica88.690.01444
LLPS-Caf-a332Canis familiaris88.50.01471
LLPS-Bot-a337Bos taurus88.270.01031
LLPS-Gaga-a297Gallus gallus87.230.01479
LLPS-Sah-a310Sarcophilus harrisii86.340.01267
LLPS-Gog-a328Gorilla gorilla86.230.01412
LLPS-Ora-a286Ornithorhynchus anatinus86.040.01395
LLPS-Anp-a278Anas platyrhynchos84.430.01372
LLPS-Meg-a276Meleagris gallopavo84.30.01372
LLPS-Pes-a294Pelodiscus sinensis82.850.01291
LLPS-Fia-a288Ficedula albicollis82.540.01358
LLPS-Leo-a295Lepisosteus oculatus75.60.01291
LLPS-Orn-a295Oreochromis niloticus74.250.01247
LLPS-Pof-a297Poecilia formosa74.230.01264
LLPS-Ten-a284Tetraodon nigroviridis72.950.01191
LLPS-Gaa-a286Gasterosteus aculeatus72.680.01174
LLPS-Xim-a301Xiphophorus maculatus72.60.01256
LLPS-Dar-a296Danio rerio71.870.01195
LLPS-Orl-a291Oryzias latipes71.690.01248
LLPS-Scm-a280Scophthalmus maximus71.610.01224
LLPS-Xet-a294Xenopus tropicalis71.430.01114
LLPS-Scf-a1055Scleropages formosus71.430.01102
LLPS-Icp-a297Ictalurus punctatus69.330.01121
LLPS-Lac-a299Latimeria chalumnae63.120.0952
LLPS-Asm-a1086Astyanax mexicanus62.790.0994
LLPS-Tar-a285Takifugu rubripes62.750.0948
LLPS-Cas-a1057Carlito syrichta58.70.0814
LLPS-Tag-a1054Taeniopygia guttata55.870.0735
LLPS-Anc-a310Anolis carolinensis54.710.0680
LLPS-Ict-a1181Ictidomys tridecemlineatus50.810.0705