LLPS-Mum-a248
Icam5

▼ OVERVIEW

Status: Reviewed
Protein Name: Intercellular adhesion molecule 5
Gene Name: Icam5, Icam3, Tlcn
Ensembl Gene: ENSMUSG00000032174.5
Ensembl Protein: ENSMUSP00000019616.4
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPGPSPGLRR  ALLGLWAALG  LGILGISAVA  LEPFWADLQP  RVALVERGGS  LWLNCSTNCP  60
61    RPERGGLETS  LRRNGTQRGL  RWLARQLVDI  REPETQPVCF  FRCARRTLQA  RGLIRTFQRP  120
121   DRVELVPLPS  WQPVGENFTL  SCRVPGAGPR  ASLTLTLLRG  GQELIRRSFV  GEPPRARGAM  180
181   LTARVLARRE  DHRVNFSCLA  ELDLRPHGLG  LFANSSAPRQ  LRTFAMPPHS  PSLIAPRVLE  240
241   VDSERPVTCT  LDGLFPAPEA  GVYLSLGDQR  LNPNVTLDGD  SLVATATATA  SAEQEGTKQL  300
301   MCVVTLGGES  RETQENLTVY  SFPTPLLTLS  EPEAPEGKMV  TISCWAGARA  LVTLEGIPAA  360
361   VPGQPAELQL  NVTKNDDKRG  FFCDAALDVD  GETLRKNQSS  ELRVLYAPRL  DDLDCPRSWT  420
421   WPEGPEQTLH  CEARGNPEPS  VHCARPEGGA  VLALGLLGPV  TRALAGTYRC  TAVNGQGQAV  480
481   KDVTLTVEYA  PALDSVGCPE  HITWLEGTEA  SLSCVAHGVP  PPSVSCVRSG  KEEVMEGPLR  540
541   VAREHAGTYR  CEAINARGSA  AKNVAVTVEY  GPSFEELGCP  SNWTWVEGSG  KLFSCEVDGK  600
601   PEPRVECVGS  EGASEGIVLP  LVSSNSGPRN  SMTPGNLSPG  IYLCNATNRH  GSTVKTVVVS  660
661   AESPPQMDES  SCPSHQTWLE  GAEATALACS  ARGRPSPRVH  CSREGAARLE  RLQVSREDAG  720
721   TYRCVATNAH  GTDSRTVTVG  VEYRPVVAEL  AASPPSVRPG  GNFTLTCRAE  AWPPAQISWR  780
781   APPGALNLGL  SSNNSTLSVA  GAMGSHGGEY  ECAATNAHGR  HARRITVRVA  GPWLWVAVGG  840
841   AAGGAALLAA  GAGLAFYVQS  TACKKGEYNV  QEAESSGEAV  CLNGAGGTPG  AEGGAETPGT  900
901   AESPADGEVF  AIQLTSS  917
Nucleotide CDS Sequence (FASTA)
1     ATGCCGGGGC  CTTCGCCAGG  GCTGCGCCGA  GCGCTCCTCG  GCCTCTGGGC  TGCCCTGGGC  60
61    CTGGGGATCC  TAGGCATCTC  AGCGGTCGCG  CTAGAACCTT  TCTGGGCGGA  CCTTCAGCCC  120
121   CGCGTGGCGC  TCGTGGAGCG  CGGGGGCTCG  CTGTGGCTCA  ACTGCAGCAC  TAACTGTCCG  180
181   CGGCCGGAGC  GCGGTGGCCT  GGAGACCTCG  CTACGCCGAA  ACGGGACCCA  GAGGGGTCTG  240
241   CGCTGGCTGG  CTCGGCAGCT  GGTGGACATC  CGAGAGCCTG  AGACCCAGCC  GGTCTGCTTC  300
301   TTCCGCTGCG  CGCGCCGCAC  ACTCCAAGCG  CGTGGACTCA  TCCGAACTTT  CCAGCGACCG  360
361   GATCGGGTAG  AGCTGGTGCC  GCTCCCTTCT  TGGCAGCCAG  TGGGCGAGAA  CTTCACCTTG  420
421   AGCTGCAGGG  TCCCGGGAGC  AGGACCCCGA  GCGAGCCTCA  CATTGACCCT  GCTGCGGGGC  480
481   GGCCAGGAGC  TGATTCGCCG  CAGTTTCGTA  GGCGAGCCAC  CCCGAGCGCG  GGGTGCGATG  540
541   CTCACCGCCA  GGGTCCTGGC  ACGCAGGGAG  GACCACAGGG  TCAATTTCTC  ATGCCTCGCC  600
601   GAGCTTGACC  TGCGGCCACA  CGGCTTGGGA  CTGTTTGCAA  ATAGCTCGGC  CCCCAGACAG  660
661   CTCCGTACCT  TTGCCATGCC  TCCACATTCC  CCGAGTCTTA  TTGCTCCCCG  AGTCTTAGAA  720
721   GTGGACTCAG  AAAGGCCGGT  GACTTGCACG  TTGGATGGAC  TGTTTCCTGC  CCCAGAAGCC  780
781   GGGGTTTACC  TCTCTCTGGG  AGATCAGAGG  CTCAATCCTA  ATGTGACCCT  CGATGGGGAC  840
841   AGCCTTGTGG  CCACTGCCAC  AGCTACAGCA  AGCGCAGAAC  AGGAAGGCAC  CAAACAGCTG  900
901   ATGTGCGTCG  TGACCCTCGG  GGGCGAAAGC  AGGGAGACCC  AGGAAAACCT  GACTGTTTAC  960
961   AGCTTCCCGA  CTCCTCTTCT  GACTTTGAGT  GAGCCAGAAG  CCCCCGAGGG  AAAAATGGTG  1020
1021  ACCATAAGCT  GCTGGGCAGG  GGCTCGAGCC  CTTGTCACCC  TGGAGGGAAT  TCCAGCTGCG  1080
1081  GTCCCGGGGC  AGCCCGCTGA  GCTCCAGTTA  AATGTTACAA  AGAACGATGA  CAAGCGGGGC  1140
1141  TTCTTCTGCG  ACGCCGCCCT  CGATGTGGAC  GGGGAAACTC  TAAGAAAAAA  CCAGAGCTCT  1200
1201  GAGCTTCGTG  TCCTGTATGC  ACCTCGCCTG  GATGACTTGG  ATTGTCCCAG  AAGCTGGACG  1260
1261  TGGCCAGAGG  GTCCAGAGCA  GACCCTCCAC  TGCGAGGCCC  GCGGAAACCC  TGAGCCCTCG  1320
1321  GTGCACTGTG  CAAGGCCTGA  GGGCGGGGCG  GTGCTAGCGC  TGGGCCTATT  GGGTCCAGTG  1380
1381  ACCCGTGCCC  TCGCAGGCAC  TTACCGATGC  ACAGCAGTCA  ATGGGCAAGG  CCAGGCGGTC  1440
1441  AAAGATGTGA  CCCTGACCGT  GGAATATGCC  CCAGCGCTGG  ACAGTGTAGG  CTGCCCAGAA  1500
1501  CATATTACTT  GGCTGGAGGG  AACGGAGGCA  TCGCTTAGCT  GTGTGGCACA  CGGGGTCCCA  1560
1561  CCACCTAGCG  TGAGTTGTGT  GCGCTCTGGA  AAGGAGGAAG  TCATGGAAGG  GCCTCTGCGC  1620
1621  GTGGCCCGGG  AGCACGCCGG  CACTTACCGA  TGCGAAGCCA  TCAACGCCAG  AGGATCAGCG  1680
1681  GCCAAAAATG  TGGCCGTCAC  GGTGGAATAT  GGTCCCAGTT  TTGAGGAGTT  GGGCTGCCCC  1740
1741  AGCAACTGGA  CGTGGGTAGA  GGGATCTGGA  AAGCTGTTTT  CCTGTGAAGT  TGATGGGAAG  1800
1801  CCAGAACCAC  GTGTGGAGTG  CGTAGGCTCG  GAGGGTGCAA  GCGAAGGGAT  AGTGTTGCCC  1860
1861  TTGGTGTCCT  CAAACTCTGG  TCCTAGAAAC  TCTATGACCC  CTGGTAACCT  GTCACCGGGC  1920
1921  ATTTACCTCT  GCAACGCCAC  CAACCGGCAC  GGCTCCACAG  TCAAAACAGT  CGTCGTGAGC  1980
1981  GCGGAGTCGC  CGCCACAGAT  GGATGAATCC  AGTTGCCCGA  GTCACCAGAC  CTGGCTGGAA  2040
2041  GGAGCTGAGG  CTACCGCGCT  GGCCTGCAGT  GCCAGGGGCC  GCCCCTCTCC  ACGGGTGCAT  2100
2101  TGCTCCAGGG  AGGGTGCCGC  CAGGCTGGAG  AGGCTACAGG  TGTCCCGAGA  GGATGCGGGG  2160
2161  ACCTACCGCT  GTGTGGCCAC  CAATGCGCAT  GGCACGGATT  CACGGACGGT  CACTGTGGGT  2220
2221  GTGGAATACC  GGCCTGTGGT  GGCTGAGCTG  GCAGCCTCGC  CCCCAAGCGT  GCGGCCGGGC  2280
2281  GGTAACTTCA  CTCTGACCTG  CCGCGCAGAG  GCTTGGCCTC  CAGCCCAGAT  CAGCTGGCGC  2340
2341  GCGCCCCCGG  GGGCTCTCAA  CCTCGGCCTC  TCCAGCAACA  ATAGCACTCT  GAGCGTGGCG  2400
2401  GGAGCCATGG  GCAGCCATGG  CGGCGAGTAT  GAGTGTGCAG  CGACCAATGC  GCATGGGCGC  2460
2461  CACGCACGGC  GCATCACAGT  GCGCGTGGCC  GGTCCATGGC  TGTGGGTCGC  TGTGGGCGGT  2520
2521  GCGGCAGGGG  GCGCGGCGCT  GCTGGCCGCT  GGGGCCGGCC  TGGCCTTCTA  CGTGCAATCC  2580
2581  ACCGCTTGCA  AGAAGGGCGA  GTACAACGTC  CAGGAGGCTG  AGAGCTCAGG  CGAGGCCGTG  2640
2641  TGTCTCAATG  GCGCGGGCGG  GACACCGGGT  GCAGAAGGCG  GAGCAGAGAC  CCCAGGCACT  2700
2701  GCAGAGTCAC  CTGCAGATGG  CGAGGTTTTC  GCTATCCAGC  TGACATCTTC  CTGA  2754

▼ KEYWORD

ID
Family
Cell adhesion
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Integral component of plasma membrane
Cellular Component
Plasma membrane
Molecular Function
Integrin binding
Biological Process
Cell adhesion
Biological Process
Cell-cell adhesion
Biological Process
Phagocytosis

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a247Rattus norvegicus97.820.01798
LLPS-Mea-a227Mesocricetus auratus93.130.01643
LLPS-Ict-a246Ictidomys tridecemlineatus86.230.01521
LLPS-Pap-a243Pan paniscus85.650.01420
LLPS-Eqc-a249Equus caballus85.480.01477
LLPS-Tut-a145Tursiops truncatus85.20.01101
LLPS-Caf-a245Canis familiaris85.140.01446
LLPS-Ova-a243Ovis aries85.080.0948
LLPS-Sus-a249Sus scrofa84.920.01418
LLPS-Mal-a243Mandrillus leucophaeus83.990.01357
LLPS-Pat-a242Pan troglodytes83.980.01431
LLPS-Hos-a250Homo sapiens83.980.01434
LLPS-Gog-a241Gorilla gorilla83.980.01432
LLPS-Fec-a245Felis catus83.970.01437
LLPS-Bot-a251Bos taurus83.950.01420
LLPS-Mup-a250Mustela putorius furo83.410.01482
LLPS-Aim-a241Ailuropoda melanoleuca83.230.01424
LLPS-Otg-a247Otolemur garnettii83.210.01422
LLPS-Caj-a243Callithrix jacchus82.680.01414
LLPS-Rhb-a239Rhinopithecus bieti81.920.01388
LLPS-Urm-a227Ursus maritimus81.830.01187
LLPS-Paa-a245Papio anubis81.660.01382
LLPS-Man-a244Macaca nemestrina81.660.01382
LLPS-Cea-a246Cercocebus atys81.550.01380
LLPS-Mam-a244Macaca mulatta81.470.01403
LLPS-Cap-a244Cavia porcellus81.110.01394
LLPS-Aon-a249Aotus nancymaae81.10.01387
LLPS-Chs-a245Chlorocebus sabaeus80.980.01196
LLPS-Myl-a235Myotis lucifugus80.690.01395
LLPS-Dio-a240Dipodomys ordii79.350.0717
LLPS-Orc-a236Oryctolagus cuniculus75.830.0863
LLPS-Loa-a243Loxodonta africana64.810.0905
LLPS-Sah-a236Sarcophilus harrisii64.060.0573
LLPS-Poa-a244Pongo abelii62.610.0567
LLPS-Fud-a242Fukomys damarensis62.190.0714
LLPS-Ere-a059Erinaceus europaeus54.552e-91300
LLPS-Nol-a246Nomascus leucogenys52.743e-166506
LLPS-Cas-a226Carlito syrichta51.696e-75257