LLPS-Mum-a230
Ca2

▼ OVERVIEW

Status: Unreviewed
Protein Name: Carbonic anhydrase 2; Carbonate dehydratase II; Carbonic anhydrase II; CA-II
Gene Name: Ca2, Car2
Ensembl Gene: ENSMUSG00000027562.12
Ensembl Protein: ENSMUSP00000029078.7
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSHHWGYSKH  NGPENWHKDF  PIANGDRQSP  VDIDTATAQH  DPALQPLLIS  YDKAASKSIV  60
61    NNGHSFNVEF  DDSQDNAVLK  GGPLSDSYRL  IQFHFHWGSS  DGQGSEHTVN  KKKYAAELHL  120
121   VHWNTKYGDF  GKAVQQPDGL  AVLGIFLKIG  PASQGLQKVL  EALHSIKTKG  KRAAFANFDP  180
181   CSLLPGNLDY  WTYPGSLTTP  PLLECVTWIV  LREPITVSSE  QMSHFRTLNF  NEEGDAEEAM  240
241   VDNWRPAQPL  KNRKIKASFK  260
Nucleotide CDS Sequence (FASTA)
1     ATGTCCCACC  ACTGGGGATA  CAGCAAGCAC  AACGGACCAG  AGAACTGGCA  CAAGGACTTC  60
61    CCCATTGCCA  ATGGAGACCG  GCAGTCCCCT  GTGGACATTG  ACACAGCAAC  TGCCCAGCAT  120
121   GACCCTGCCC  TACAGCCTCT  GCTCATATCT  TATGATAAAG  CTGCGTCCAA  GAGCATTGTC  180
181   AACAACGGCC  ACTCCTTTAA  CGTTGAGTTT  GATGACTCTC  AGGACAATGC  AGTGCTGAAA  240
241   GGAGGACCCC  TCAGTGACTC  CTACAGATTG  ATCCAGTTTC  ACTTTCACTG  GGGCTCATCT  300
301   GATGGCCAGG  GCTCTGAGCA  CACTGTGAAC  AAAAAAAAAT  ATGCTGCAGA  GCTTCACTTG  360
361   GTTCACTGGA  ACACCAAATA  TGGGGACTTT  GGAAAAGCTG  TGCAGCAACC  GGATGGATTG  420
421   GCTGTTTTGG  GTATTTTTTT  GAAGATTGGA  CCTGCCTCAC  AAGGCCTTCA  GAAAGTCCTT  480
481   GAAGCACTGC  ATTCCATTAA  AACAAAGGGG  AAGCGTGCGG  CCTTTGCTAA  CTTCGATCCT  540
541   TGCTCCCTTC  TTCCTGGAAA  CTTGGACTAC  TGGACATACC  CTGGCTCTCT  GACCACTCCG  600
601   CCTCTGCTGG  AATGTGTGAC  CTGGATCGTG  CTCAGGGAGC  CCATTACTGT  CAGCAGCGAG  660
661   CAGATGTCTC  ATTTCCGTAC  GCTGAACTTC  AATGAGGAGG  GGGATGCTGA  AGAAGCGATG  720
721   GTGGACAACT  GGCGTCCAGC  TCAGCCGCTA  AAGAATAGAA  AGATCAAAGC  GTCCTTTAAG  780
781   TAA  783

▼ KEYWORD

ID
Family
Acetylation
Cell membrane
Complete proteome
Cytoplasm
Direct protein sequencing
Lyase
Membrane
Metal-binding
Phosphoprotein
Reference proteome
Zinc

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Apical part of cell
Cellular Component
Axon
Cellular Component
Basolateral plasma membrane
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Extracellular space
Cellular Component
Microvillus
Cellular Component
Myelin sheath
Cellular Component
Plasma membrane
Molecular Function
Arylesterase activity
Molecular Function
Carbonate dehydratase activity
Molecular Function
Zinc ion binding
Biological Process
Angiotensin-activated signaling pathway
Biological Process
Carbon dioxide transport
Biological Process
Cellular response to fluid shear stress
Biological Process
Kidney development
Biological Process
Morphogenesis of an epithelium
Biological Process
Odontogenesis of dentin-containing tooth
Biological Process
Positive regulation of bone resorption
Biological Process
Positive regulation of cellular pH reduction
Biological Process
Positive regulation of dipeptide transmembrane transport
Biological Process
Positive regulation of osteoclast differentiation
Biological Process
Positive regulation of synaptic transmission, GABAergic
Biological Process
Regulation of anion transport
Biological Process
Regulation of chloride transport
Biological Process
Regulation of intracellular pH
Biological Process
Regulation of pH
Biological Process
Response to estrogen
Biological Process
Response to pH
Biological Process
Response to steroid hormone
Biological Process
Response to zinc ion
Biological Process
Secretion

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a231Rattus norvegicus93.460.0509
LLPS-Mea-a213Mesocricetus auratus87.155e-161457
LLPS-Chs-a230Chlorocebus sabaeus82.313e-159452
LLPS-Cea-a230Cercocebus atys81.926e-159451
LLPS-Fec-a229Felis catus81.922e-158450
LLPS-Man-a228Macaca nemestrina81.546e-158449
LLPS-Mam-a228Macaca mulatta81.546e-158449
LLPS-Maf-a230Macaca fascicularis81.546e-158449
LLPS-Nol-a232Nomascus leucogenys81.542e-157447
LLPS-Gog-a227Gorilla gorilla81.533e-149427
LLPS-Mup-a233Mustela putorius furo81.151e-156446
LLPS-Hos-a233Homo sapiens81.152e-157447
LLPS-Aim-a225Ailuropoda melanoleuca81.151e-156446
LLPS-Poa-a227Pongo abelii81.151e-156446
LLPS-Dio-a226Dipodomys ordii81.153e-156444
LLPS-Paa-a229Papio anubis81.152e-157447
LLPS-Eqc-a233Equus caballus80.634e-132383
LLPS-Caj-a228Callithrix jacchus80.383e-155442
LLPS-Urm-a214Ursus maritimus80.325e-147421
LLPS-Caf-a228Canis familiaris80.04e-155442
LLPS-Ict-a229Ictidomys tridecemlineatus80.06e-155441
LLPS-Rhb-a224Rhinopithecus bieti79.924e-150430
LLPS-Pat-a226Pan troglodytes79.542e-152435
LLPS-Loa-a225Loxodonta africana78.852e-152434
LLPS-Otg-a230Otolemur garnettii78.085e-153436
LLPS-Sus-a231Sus scrofa78.082e-152434
LLPS-Tut-a132Tursiops truncatus78.082e-151432
LLPS-Orc-a222Oryctolagus cuniculus77.993e-152434
LLPS-Pap-a226Pan paniscus76.457e-144414
LLPS-Bot-a233Bos taurus75.492e-145417
LLPS-Aon-a233Aotus nancymaae73.94e-131380
LLPS-Cap-a227Cavia porcellus73.461e-133386
LLPS-Ova-a227Ovis aries71.889e-137395
LLPS-Ere-a050Erinaceus europaeus68.829e-119349
LLPS-Myl-a220Myotis lucifugus66.174e-124363
LLPS-Gaga-a211Gallus gallus65.775e-128373
LLPS-Fia-a206Ficedula albicollis65.04e-127370
LLPS-Tag-a206Taeniopygia guttata65.01e-127372
LLPS-Pes-a206Pelodiscus sinensis64.668e-123359
LLPS-Anc-a215Anolis carolinensis63.988e-122357
LLPS-Tar-a981Takifugu rubripes63.967e-104310
LLPS-Anp-a204Anas platyrhynchos63.573e-120353
LLPS-Gaa-a202Gasterosteus aculeatus63.081e-119352
LLPS-Dar-a206Danio rerio63.082e-120353
LLPS-Orn-a204Oreochromis niloticus63.058e-113335
LLPS-Xim-a459Xiphophorus maculatus63.055e-113335
LLPS-Scf-a431Scleropages formosus62.691e-118349
LLPS-Orl-a443Oryzias latipes61.926e-116342
LLPS-Pof-a455Poecilia formosa61.921e-115341
LLPS-Xet-a205Xenopus tropicalis61.156e-115340
LLPS-Asm-a199Astyanax mexicanus60.776e-116342
LLPS-Scm-a434Scophthalmus maximus60.382e-114338
LLPS-Mod-a219Monodelphis domestica59.535e-112332
LLPS-Mal-a227Mandrillus leucophaeus59.143e-109325
LLPS-Cas-a211Carlito syrichta58.983e-110327
LLPS-Sah-a1057Sarcophilus harrisii58.082e-110328
LLPS-Leo-a454Lepisosteus oculatus57.926e-106317
LLPS-Ten-a431Tetraodon nigroviridis56.982e-100303
LLPS-Ora-a977Ornithorhynchus anatinus56.927e-110328
LLPS-Fud-a1111Fukomys damarensis56.154e-107320
LLPS-Meg-a423Meleagris gallopavo53.824e-100302
LLPS-Lac-a454Latimeria chalumnae53.521e-90277
LLPS-Icp-a454Ictalurus punctatus51.334e-105316