LLPS-Mum-a176
Cep170b
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Centrosomal protein of 170 kDa protein B; Centrosomal protein 170B; Cep170B |
| Gene Name: | Cep170b, Kiaa0284 |
| Ensembl Gene: | ENSMUSG00000072825.11 |
| Ensembl Protein: | ENSMUSP00000152451.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
▼ FUNCTION
| Plays a role in microtubule organization. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000222711.1 | ENSMUSP00000152451.1 |
| Ensembl | ENSMUST00000220942.1 | ENSMUSP00000152673.1 |
| Ensembl | ENSMUST00000220627.1 | ENSMUSP00000152143.1 |
| Ensembl | ENSMUST00000101018.10 | ENSMUSP00000098580.3 |
| Ensembl | ENSMUST00000092279.6 | ENSMUSP00000089930.6 |
| Ensembl | ENSMUST00000179041.7 | ENSMUSP00000137331.1 |
| UniProt | Q80U49, C170B_MOUSE, Q3UH33, Q3UHG1, Q80UM2 | |
| GeneBank | AK147612, BC050077, AK122236, AK147410 | BAE28024.1, BAE27896.1, AAH50077.1, BAC65518.1 |
| RefSeq | NM_001024602.3, XM_006515766.3 | NP_001019773.2, XP_006515829.1 |
| Entrez | 217882 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSVTSWFLVS SSGTRHRLPR ELIFVGRDEC ELMLQSRSVD KQHAVINYDQ DRDEHWVKDL 60 61 GSLNGTFVND VRIPDQKYIT LKLNDVIRFG YDSNMYVLER VQHRVPEEAL KHEKYTSQLQ 120 121 VSVKVSAPKR GDALPDHTPY CESSQPRPEK GDRRHGAEAV AYRTPLYGQP SWWGEDDSGA 180 181 PSEDRHQEEP YSERPKDLAQ QNGELDSCRA PAEPPDYSFR REPSYFEIPT KETPQPPRLP 240 241 EVPTQEVPTK DQEAGVGGTA PVVQSHASFT IEFDDCSPGK VKIKDHITKF SLRQRRAPSK 300 301 ETTPVETVSA ETKVADWLVQ NDPSLLRRDG PGDDRHSTKS DLPVHTRTLK GHKHEDGTQS 360 361 DSEDPLAKTA SVSGASAEAS GEQVRLQRQI KRDPQELLHN QQAFVIEFFD GDTPRKKRSQ 420 421 SFTHTPPADP KADKRRGPGT SDRDRPGVSV RATGSSSGPQ RASSLKREKT EERLGNTSPV 480 481 PRASTRSFGS VGRRSRLAQD FMAQCMRDSS PATRPAPEKT PPVLPAPLTP RGASPVTPST 540 541 TPPPPTDPQL TKARKQEEDD SLSDAGTYTI ETEAQDQEVE EARRMIDQVF GVFESPELSR 600 601 VSSATFRPVI RGDKDESSDG GMAQRMALLQ EFASRAPGMA PQMEQQSLLV PGSPGGQKWV 660 661 SRWASLADSY SDAGLPEDGP GRRTGEPEGP LPVRTRRLLP QLPSGRADSP AGLEAARRNG 720 721 PGPPELGSEP ANCLIGQEDL DPDSLSDASG SDGGRGPEPG TERQEDLAWV RGRRSPRAPG 780 781 ELVPTSFFIG DQNGEATFPK KSFVGPGEVD GPGRVVQTSP SARDGLYVSS NGRMVIQLRS 840 841 GRSPEPDPAP PKETLTFARQ ESFTKEPTSG PPAPGKLPHI SSHPLLQDLA AARASRLDFH 900 901 AQDTHLILKE TETALAALEA RLRSKSADEC DGGSTPRPPE DSLSGDSDVD TASTISLLSG 960 961 KNGPSPTTPQ TPGPQKESPL SPPTVPDPGG ATPGSARERM SERQHRPTPA DLGPGDTSRR 1020 1021 AAMRRGHGSR GSLDWPEEER GSGLAHLPSS NHETPEATLA GRQGPRRKPA APPPSPAARE 1080 1081 EQSRSSATAQ KVQQALTRSN SLSTPRPTRA SRLRRARLGD ASDTEAVDGE RGTAANPEPA 1140 1141 NRAAPEQAKK LTRLDILAMP RKRAGSFTGP SDSETAPART GFSGRSAELY STSRKPTIAE 1200 1201 ARAAAKKAAA TAANTGPRQP FSRARPGSAR YSSNTRRRQQ GSDYTSTSEE EYGSHHSSPK 1260 1261 HTRSHASTAT QTPRGSSSTR ARSQGPRDTD DDEEEPDPYG FIVQTAEIAE IARLSQTLVK 1320 1321 DVAILAREIH DVAGDGDSLG SPGPTRSPSL GNVPNTPAST ISAREELVQR IPEASLNFQK 1380 1381 VPPGSMNSHN LDQNMNDSRD DALTNKTRPR NREEVIFDNL MLNPVSQLSH AIRENTEHLA 1440 1441 EKMKVLFQNT GRAWEDLEAR INSENEVPIL KTSNKEISSI LKELRRVQKQ LEVINAIVDP 1500 1501 SLNLDLLMGN RAPSGSGQPG LGKARPAAQS STSPASVDTL LPALPLRSFP QRANCGPPGL 1560 1561 PEPAFLPDAE RFLI 1574 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGCGTCA CATCTTGGTT CCTGGTGAGC AGCAGTGGCA CCCGCCACCG GCTCCCGCGT 60 61 GAACTCATCT TCGTGGGGCG TGATGAATGT GAGCTCATGT TGCAGTCCCG TAGTGTGGAC 120 121 AAGCAGCATG CCGTCATCAA CTACGACCAG GACCGTGATG AGCACTGGGT GAAGGACCTG 180 181 GGCAGTCTCA ATGGGACATT TGTGAATGAT GTGCGCATCC CAGACCAGAA GTACATCACA 240 241 CTGAAGCTCA ATGACGTCAT CCGCTTTGGC TATGATTCCA ACATGTACGT GTTAGAGCGT 300 301 GTGCAGCACC GTGTTCCCGA GGAGGCGCTC AAGCACGAGA AGTACACCAG CCAGCTGCAG 360 361 GTGAGCGTCA AGGTCTCTGC GCCCAAGAGG GGTGATGCAC TGCCCGACCA CACACCCTAC 420 421 TGCGAGTCCT CACAGCCTAG ACCAGAGAAA GGTGACCGAA GACATGGAGC AGAGGCGGTC 480 481 GCTTACCGCA CACCCCTGTA TGGGCAGCCC TCCTGGTGGG GTGAGGATGA CAGTGGGGCA 540 541 CCATCTGAAG ACCGGCACCA GGAGGAGCCC TACTCAGAGC GTCCCAAGGA CCTGGCACAG 600 601 CAAAATGGTG AGCTGGACAG CTGCCGTGCT CCCGCCGAGC CACCAGACTA CTCGTTCAGA 660 661 CGTGAGCCCA GCTACTTTGA GATCCCCACG AAGGAAACCC CGCAGCCTCC AAGGCTCCCT 720 721 GAGGTGCCTA CCCAGGAAGT GCCCACAAAA GACCAGGAGG CAGGTGTTGG TGGGACTGCC 780 781 CCTGCCCGTA CTGGCTTCTC CGGTCGCAGT GCTGAGCTCT ACAGCACCAG CCGTAAGCCC 840 841 ACGATAGCTG AGGCCCGTGC TGCTGCCAAG AAGGCTGCTG CTACTGCAGC CAACACTGGC 900 901 CCCCGCCAGC CCTTCAGCAG GGCTCGCCCG GGCAGTGCCA GATATTCTTC CAACACGAGG 960 961 CGTCGGCAGC AGGGTTCGGA TTACACGTCC ACCTCCGAGG AGGAGTATGG GTCCCACCAC 1020 1021 AGCTCCCCTA AACACACACG CTCCCATGCC TCAACAGCCA CACAGACCCC AAGGGGCAGC 1080 1081 AGCTCTACCC GGGCTCGCTC CCAGGGCCCC CGAGACACAG ATGATGACGA GGAAGAGCCT 1140 1141 GACCCCTACG GCTTCATCGT GCAGACAGCA GAGATCGCAG AGATTGCTAG GCTAAGCCAG 1200 1201 ACACTAGTGA AGGATGTGGC CATCCTGGCC AGGGAGATCC ATGATGTGGC TGGAGACGGG 1260 1261 GACTCACTGG GCTCCCCAGG CCCCACTCGC AGCCCATCTC TCGGGAATGT GCCCAACACC 1320 1321 CCTGCCTCAA CCATCTCAGC CCGGGAAGAG CTGGTACAGC GTATACCAGA GGCCAGCCTG 1380 1381 AACTTCCAGA AAGTGCCGCC TGGCTCTATG AACTCTCACA ACTTGGACCA GAACATGAAT 1440 1441 GACAGCCGAG ACGATGCTCT GACCAACAAG ACGAGGCCTC GGAACCGTGA GGAGGTGATC 1500 1501 TTTGATAATC TGATGCTAAA CCCGGTGTCC CAGCTGTCAC ATGCCATTCG TGAAAACACG 1560 1561 GAGCATCTTG CTGAGAAGAT GAAGGTCCTC TTCCAGAATA CAGGCCGGGC CTGGGAGGAC 1620 1621 TTAGAGGCCA GAATCAACTC TGAGAATGAA GTACCCATCC TGAAGACATC CAACAAGGAA 1680 1681 ATCAGCTCCA TCCTGAAGGA ACTTCGACGC GTACAGAAGC AGTTAGAAGT CATCAATGCC 1740 1741 ATCGTGGACC CCAGCTTGAA CCTCGACCTA CTGATGGGAA ACAGGGCTCC TTCAGGGTCT 1800 1801 GGCCAGCCAG GACTTGGGAA AGCCCGGCCA GCAGCTCAGA GCTCAACTTC ACCTGCCTCG 1860 1861 GTGGATACCT TGCTGCCAGC CCTGCCTCTC AGGAGCTTCC CACAGCGGGC CAACTGCGGG 1920 1921 CCCCCCGGCC TCCCGGAGCC TGCCTTCCTT CCTGATGCTG AGAGGTTTCT GATCTAA 1977 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Microtubule |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-a175 | Rattus norvegicus | 94.92 | 0.0 | 2858 |
| LLPS-Mea-a162 | Mesocricetus auratus | 91.82 | 0.0 | 2760 |
| LLPS-Ora-a1069 | Ornithorhynchus anatinus | 90.99 | 8e-66 | 228 |
| LLPS-Ova-a1185 | Ovis aries | 84.5 | 5e-62 | 217 |
| LLPS-Pat-a172 | Pan troglodytes | 82.57 | 0.0 | 942 |
| LLPS-Ict-a174 | Ictidomys tridecemlineatus | 82.13 | 0.0 | 2427 |
| LLPS-Hos-a176 | Homo sapiens | 80.63 | 0.0 | 2358 |
| LLPS-Dio-a171 | Dipodomys ordii | 80.52 | 0.0 | 2291 |
| LLPS-Chs-a176 | Chlorocebus sabaeus | 80.43 | 0.0 | 2362 |
| LLPS-Eqc-a179 | Equus caballus | 80.01 | 0.0 | 2117 |
| LLPS-Pap-a172 | Pan paniscus | 79.99 | 0.0 | 2354 |
| LLPS-Maf-a176 | Macaca fascicularis | 79.86 | 0.0 | 2216 |
| LLPS-Gog-a173 | Gorilla gorilla | 79.86 | 0.0 | 2214 |
| LLPS-Man-a174 | Macaca nemestrina | 79.75 | 0.0 | 2211 |
| LLPS-Mal-a172 | Mandrillus leucophaeus | 79.72 | 0.0 | 2214 |
| LLPS-Rhb-a173 | Rhinopithecus bieti | 79.62 | 0.0 | 746 |
| LLPS-Caj-a172 | Callithrix jacchus | 79.33 | 0.0 | 2297 |
| LLPS-Aon-a177 | Aotus nancymaae | 79.29 | 0.0 | 2311 |
| LLPS-Mam-a174 | Macaca mulatta | 78.54 | 0.0 | 2284 |
| LLPS-Sus-a176 | Sus scrofa | 78.35 | 0.0 | 2176 |
| LLPS-Cea-a177 | Cercocebus atys | 78.29 | 0.0 | 2277 |
| LLPS-Otg-a176 | Otolemur garnettii | 78.02 | 0.0 | 2259 |
| LLPS-Paa-a176 | Papio anubis | 77.95 | 0.0 | 2336 |
| LLPS-Fud-a171 | Fukomys damarensis | 77.75 | 0.0 | 2246 |
| LLPS-Cap-a177 | Cavia porcellus | 76.45 | 0.0 | 2219 |
| LLPS-Caf-a173 | Canis familiaris | 76.36 | 0.0 | 2138 |
| LLPS-Bot-a179 | Bos taurus | 76.16 | 0.0 | 2177 |
| LLPS-Aim-a169 | Ailuropoda melanoleuca | 75.92 | 0.0 | 2146 |
| LLPS-Poa-a173 | Pongo abelii | 74.62 | 0.0 | 1342 |
| LLPS-Mup-a176 | Mustela putorius furo | 74.2 | 0.0 | 2137 |
| LLPS-Fec-a175 | Felis catus | 73.74 | 0.0 | 2053 |
| LLPS-Nol-a180 | Nomascus leucogenys | 72.85 | 0.0 | 2050 |
| LLPS-Loa-a171 | Loxodonta africana | 66.45 | 0.0 | 1729 |
| LLPS-Mod-a167 | Monodelphis domestica | 62.88 | 0.0 | 1769 |
| LLPS-Sah-a167 | Sarcophilus harrisii | 61.57 | 0.0 | 1620 |
| LLPS-Tag-a158 | Taeniopygia guttata | 56.12 | 0.0 | 1533 |
| LLPS-Anp-a158 | Anas platyrhynchos | 55.9 | 0.0 | 1613 |
| LLPS-Fia-a161 | Ficedula albicollis | 55.3 | 0.0 | 1565 |
| LLPS-Anc-a166 | Anolis carolinensis | 54.74 | 0.0 | 1429 |
| LLPS-Meg-a150 | Meleagris gallopavo | 54.26 | 0.0 | 1526 |
| LLPS-Gaga-a163 | Gallus gallus | 53.1 | 0.0 | 1408 |
| LLPS-Pes-a157 | Pelodiscus sinensis | 51.92 | 0.0 | 1044 |