LLPS-Mum-a160
Glg1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Golgi apparatus protein 1; E-selectin ligand 1; ESL-1; Selel; Golgi sialoglycoprotein MG-160 |
| Gene Name: | Glg1, Esl1, Mg160, Selel |
| Ensembl Gene: | ENSMUSG00000003316.14 |
| Ensembl Protein: | ENSMUSP00000131355.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
▼ FUNCTION
| Binds fibroblast growth factor (By similarity). Binds E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000169020.7 | ENSMUSP00000131355.1 |
| Ensembl | ENSMUST00000164283.7 | ENSMUSP00000131659.1 |
| Ensembl | ENSMUST00000168741.7 | ENSMUSP00000130327.1 |
| Ensembl | ENSMUST00000003404.8 | ENSMUSP00000003404.8 |
| UniProt | Q61543, GSLG1_MOUSE, Q9QZ40 | |
| GeneBank | Y12462, BC021306, X84037 | CAA58855.1, AAH21306.1, CAA73066.1 |
| RefSeq | NM_009149.2 | NP_033175.1 |
| Entrez | 20340 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAVCGRVRGM FRLSAALPLL LLAAAGAQNG HGQGQGPGTN FGPFPGQGGG GSPAGQQPPQ 60 61 QPQLSQQQQQ PPPQQQQQQQ QQSLFAAGGL PARRGGAGPG GTGGGWKLAE EESCREDVTR 120 121 VCPKHTWSNN LAVLECLQDV REPENEISSD CNHLLWNYKL NLTTDPKFES VAREVCKSTI 180 181 SEIKECAEEP VGKGYMVSCL VDHRGNITEY QCHQYITKMT AIIFSDYRLI CGFMDDCKND 240 241 INLLKCGSIR LGEKDAHSQG EVVSCLEKGL VKEAEEKEPK IQVSELCKKA ILRVAELSSD 300 301 DFHLDRHLYF ACRDDRERFC ENTQAGEGRV YKCLFNHKFE ESMSEKCREA LTTRQKLIAQ 360 361 DYKVSYSLAK SCKSDLKKYR CNVENLPRSR EARLSYLLMC LESAVHRGRQ VSSECQGEML 420 421 DYRRMLMEDF SLSPEIILSC RGEIEHHCSG LHRKGRTLHC LMKVVRGEKG NLGMNCQQAL 480 481 QTLIQETDPG ADYRIDRALN EACESVIQTA CKHIRSGDPM ILSCLMEHLY TEKMVEDCEH 540 541 RLLELQYFIS RDWKLDPVLY RKCQGDASRL CHTHGWNETS ELMPPGAVFS CLYRHAYRTE 600 601 EQGRRLSREC RAEVQRILHQ RAMDVKLDPA LQDKCLIDLG KWCSEKTETG QELECLQDHL 660 661 DDLAVECRDI VGNLTELESE DIQIEALLMR ACEPIIQNFC HDVADNQIDS GDLMECLIQN 720 721 KHQKDMNEKC AIGVTHFQLV QMKDFRFSYK FKMACKEDVL KLCPNIKKKV DVVICLSTTV 780 781 RNDTLQEAKE HRVSLKCRKQ LRVEELEMTE DIRLEPDLYE ACKSDIKNYC STVQYGNAQI 840 841 IECLKENKKQ LSTRCHQKVF KLQETEMMDP ELDYTLMRVC KQMIKRFCPE ADSKTMLQCL 900 901 KQNKNSELMD PKCKQMITKR QITQNTDYRL NPVLRKACKA DIPKFCHGIL TKAKDDSELE 960 961 GQVISCLKLR YADQRLSSDC EDQIRIIIQE SALDYRLDPQ LQLHCSDEIA NLCAEEAAAQ 1020 1021 EQTGQVEECL KVNLLKIKTE LCKKEVLNML KESKADIFVD PVLHTACALD IKHHCAAITP 1080 1081 GRGRQMSCLM EALEDKRVRL QPECKKRLND RIEMWSYAAK VAPADGFSDL AMQVMTSPSK 1140 1141 NYILSVISGS ICILFLIGLM CGRITKRVTR ELKDR 1175 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGTGT GTGGACGTGT ACGGGGGATG TTCCGCTTGT CGGCGGCGTT GCCGCTGCTG 60 61 CTGCTCGCGG CAGCAGGGGC CCAGAATGGT CACGGTCAGG GCCAGGGTCC GGGGACCAAC 120 121 TTTGGGCCCT TCCCAGGGCA AGGTGGAGGC GGCAGCCCGG CCGGCCAACA GCCGCCTCAG 180 181 CAGCCTCAGT TATCGCAGCA GCAGCAGCAG CCGCCGCCTC AGCAGCAGCA GCAGCAACAG 240 241 CAGCAGTCGC TTTTCGCGGC GGGCGGGCTC CCGGCCCGGC GGGGCGGAGC GGGGCCCGGT 300 301 GGGACTGGCG GAGGCTGGAA GCTGGCGGAG GAAGAGTCCT GCCGGGAGGA CGTGACCCGT 360 361 GTGTGCCCCA AACACACCTG GAGCAACAAC CTGGCGGTGC TCGAGTGCCT GCAGGACGTG 420 421 AGGGAGTTGT TGTGGAATTA CAAGCTGAAC CTGACTACTG ATCCCAAATT TGAATCTGTG 480 481 GCCAGGGAGG TTTGCAAGTC AACTATTTCC GAGATTAAAG AATGTGCGGA AGAACCAGTT 540 541 GGAAAAGGTT ACATGGTTTC CTGCTTGGTG GATCATCGAG GCAACATCAC TGAGTATCAG 600 601 TGTCATCAAT ACATTACCAA GATGACGGCC ATCATTTTCA GTGATTATCG CTTGATCTGC 660 661 GGCTTCATGG ATGACTGCAA AAATGATATC AACCTCTTGA AATGTGGCAG CATTCGTCTT 720 721 GGGGAAAAGG ATGCACATTC ACAAGGTGAG GTGGTATCAT GTTTGGAAAA AGGCCTGGTA 780 781 AAAGAGGCAG AAGAAAAAGA GCCGAAGATT CAAGTCTCAG AACTCTGCAA GAAAGCCATT 840 841 CTTAGGGTGG CTGAGCTGTC CTCGGATGAC TTTCATTTAG ACCGGCATTT GTATTTTGCT 900 901 TGCCGAGATG ATCGGGAGCG CTTTTGCGAG AATACACAAG CTGGTGAAGG AAGAGTGTAT 960 961 AAATGCCTAT TTAACCATAA GTTTGAAGAA TCCATGAGTG AAAAGTGTAG AGAAGCACTA 1020 1021 ACTACACGCC AGAAGCTCAT TGCCCAGGAT TATAAAGTCA GTTACTCATT AGCCAAATCC 1080 1081 TGTAAGAGTG ACTTGAAAAA ATACCGGTGC AATGTGGAAA ACCTTCCTCG GTCCCGGGAA 1140 1141 GCCAGGCTCT CCTACCTTCT GATGTGCCTG GAGTCAGCAG TGCACAGAGG GCGGCAGGTG 1200 1201 AGCAGTGAGT GCCAAGGTGA GATGCTGGAT TACCGACGCA TGCTGATGGA AGACTTCTCT 1260 1261 CTGAGCCCCG AGATCATCCT GAGCTGTCGA GGGGAGATTG AACACCATTG TTCTGGATTA 1320 1321 CATCGGAAAG GGCGAACCCT CCACTGTCTG ATGAAAGTGG TTCGGGGTGA AAAGGGGAAC 1380 1381 CTTGGAATGA ACTGCCAACA GGCGCTTCAG ACACTGATTC AGGAGACTGA CCCTGGTGCA 1440 1441 GACTACCGCA TTGATCGAGC TTTGAATGAA GCTTGTGAGT CTGTAATACA GACAGCCTGC 1500 1501 AAACACATAC GATCCGGAGA CCCAATGATT CTCTCATGTC TGATGGAGCA TTTATACACA 1560 1561 GAGAAGATGG TGGAAGACTG TGAACACCGG CTCTTAGAGC TACAGTATTT TATCTCTCGG 1620 1621 GATTGGAAGT TGGACCCTGT TTTATACCGA AAATGCCAGG GAGATGCTTC CCGCCTTTGC 1680 1681 CATACCCATG GTTGGAATGA GACCAGTGAA CTTATGCCCC CTGGAGCTGT GTTTTCTTGC 1740 1741 CTATACAGAC ATGCCTACCG CACAGAAGAG CAAGGAAGGA GGCTCTCACG AGAATGTCGA 1800 1801 GCTGAAGTCC AGAGGATCCT GCACCAGCGA GCCATGGATG TTAAGCTGGA TCCTGCCCTC 1860 1861 CAGGACAAGT GCCTCATAGA CCTAGGGAAG TGGTGCAGTG AGAAGACGGA GACTGGGCAG 1920 1921 GAGCTTGAGT GCCTTCAGGA CCATCTCGAT GACTTAGCTG TGGAATGCAG AGACATCGTG 1980 1981 GGCAACCTCA CCGAGTTAGA GTCCGAGGAT ATACAAATAG AAGCTTTGCT GATGAGAGCC 2040 2041 TGTGAGCCTA TCATTCAGAA CTTTTGCCAC GATGTGGCAG ACAACCAGAT CGACTCTGGG 2100 2101 GACCTGATGG AGTGTCTGAT CCAGAACAAG CACCAGAAGG ACATGAACGA GAAGTGTGCC 2160 2161 ATTGGCGTCA CTCACTTCCA GCTGGTACAG ATGAAGGATT TTCGATTCTC TTACAAGTTC 2220 2221 AAAATGGCCT GCAAGGAGGA TGTGTTAAAG CTTTGCCCCA ACATAAAAAA GAAGGTGGAC 2280 2281 GTAGTGATCT GCCTGAGCAC CACTGTGCGC AACGACACTC TGCAGGAGGC CAAGGAGCAC 2340 2341 CGAGTATCAC TCAAGTGCCG CAAGCAGCTT CGTGTGGAAG AGCTGGAGAT GACAGAGGAC 2400 2401 ATCCGTTTGG AACCAGATCT GTATGAAGCC TGCAAGAGTG ACATCAAGAA CTACTGTTCT 2460 2461 ACAGTGCAAT ATGGAAATGC TCAGATTATT GAATGTCTAA AAGAAAACAA GAAGCAGCTG 2520 2521 AGTACCCGTT GCCACCAGAA AGTATTTAAG CTGCAGGAGA CGGAGATGAT GGACCCAGAG 2580 2581 CTAGACTATA CTCTGATGAG AGTCTGCAAG CAGATGATTA AGCGGTTCTG TCCAGAAGCA 2640 2641 GATTCTAAAA CTATGTTGCA GTGTTTAAAA CAAAATAAGA ACAGTGAATT GATGGATCCC 2700 2701 AAATGCAAAC AGATGATAAC CAAGCGCCAG ATCACCCAGA ACACAGATTA CCGCTTAAAC 2760 2761 CCTGTGCTAA GGAAGGCCTG TAAAGCTGAC ATTCCTAAGT TCTGTCATGG CATCCTGACC 2820 2821 AAGGCTAAGG ACGATTCAGA GCTAGAAGGC CAAGTTATCT CATGCCTCAA GCTGAGATAT 2880 2881 GCTGACCAGC GCCTGTCCTC AGACTGTGAG GACCAGATCC GTATCATCAT CCAGGAGTCT 2940 2941 GCTCTGGATT ACCGCCTGGA CCCTCAGCTC CAGCTGCACT GCTCAGATGA GATTGCCAAT 3000 3001 CTATGTGCTG AAGAAGCAGC AGCCCAGGAG CAAACAGGCC AAGTGGAAGA GTGCCTGAAG 3060 3061 GTCAACCTGC TCAAGATCAA GACAGAGCTG TGTAAAAAGG AAGTGTTAAA CATGTTGAAG 3120 3121 GAAAGCAAAG CAGACATCTT TGTGGACCCC GTTCTTCACA CAGCATGTGC CTTGGACATT 3180 3181 AAACACCACT GTGCAGCCAT CACCCCTGGC CGCGGGCGTC AGATGTCCTG CCTGATGGAG 3240 3241 GCCCTGGAAG ATAAGCGAGT GAGATTGCAG CCAGAGTGCA AAAAGCGCCT CAATGACCGG 3300 3301 ATTGAGATGT GGAGTTATGC AGCCAAGGTG GCTCCAGCAG ATGGCTTCTC TGATCTTGCC 3360 3361 ATGCAAGTGA TGACATCTCC CTCAAAGAAC TACATCCTGT CTGTGATCAG CGGGAGCATC 3420 3421 TGCATACTCT TCCTGATTGG CCTGATGTGT GGACGGATCA CCAAGAGAGT GACACGAGAG 3480 3481 CTGAAGGACA G 3491 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Extracellular matrix | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi medial cisterna | |
Cellular Component | Golgi membrane | |
Cellular Component | Integral component of membrane | |
Cellular Component | Intracellular membrane-bounded organelle | |
Cellular Component | Plasma membrane | |
Molecular Function | Fibroblast growth factor binding | |
Biological Process | Bone morphogenesis | |
Biological Process | Negative regulation of protein processing | |
Biological Process | Negative regulation of transforming growth factor beta receptor signaling pathway | |
Biological Process | Regulation of chondrocyte differentiation |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mup-a157 | Mustela putorius furo | 99.27 | 0.0 | 1952 |
| LLPS-Orc-a154 | Oryctolagus cuniculus | 99.16 | 0.0 | 2185 |
| LLPS-Urm-a149 | Ursus maritimus | 98.93 | 0.0 | 2090 |
| LLPS-Chs-a160 | Chlorocebus sabaeus | 98.92 | 0.0 | 2085 |
| LLPS-Pat-a155 | Pan troglodytes | 98.88 | 0.0 | 2185 |
| LLPS-Nol-a162 | Nomascus leucogenys | 98.83 | 0.0 | 2083 |
| LLPS-Hos-a159 | Homo sapiens | 98.79 | 0.0 | 2184 |
| LLPS-Myl-a153 | Myotis lucifugus | 98.64 | 0.0 | 2104 |
| LLPS-Ova-a159 | Ovis aries | 98.64 | 0.0 | 1941 |
| LLPS-Man-a157 | Macaca nemestrina | 97.94 | 0.0 | 2040 |
| LLPS-Ran-a159 | Rattus norvegicus | 97.88 | 0.0 | 2371 |
| LLPS-Cas-a144 | Carlito syrichta | 96.71 | 0.0 | 2053 |
| LLPS-Sus-a159 | Sus scrofa | 96.54 | 0.0 | 2118 |
| LLPS-Fec-a158 | Felis catus | 96.27 | 0.0 | 2326 |
| LLPS-Pap-a155 | Pan paniscus | 96.26 | 0.0 | 2105 |
| LLPS-Gog-a157 | Gorilla gorilla | 96.17 | 0.0 | 2114 |
| LLPS-Caf-a155 | Canis familiaris | 96.12 | 0.0 | 2330 |
| LLPS-Maf-a160 | Macaca fascicularis | 96.11 | 0.0 | 2320 |
| LLPS-Mod-a150 | Monodelphis domestica | 96.07 | 0.0 | 2130 |
| LLPS-Eqc-a162 | Equus caballus | 96.02 | 0.0 | 2198 |
| LLPS-Ict-a156 | Ictidomys tridecemlineatus | 95.98 | 0.0 | 2205 |
| LLPS-Mal-a156 | Mandrillus leucophaeus | 95.87 | 0.0 | 2321 |
| LLPS-Sah-a149 | Sarcophilus harrisii | 95.74 | 0.0 | 2051 |
| LLPS-Tut-a089 | Tursiops truncatus | 95.68 | 0.0 | 2206 |
| LLPS-Loa-a153 | Loxodonta africana | 95.58 | 0.0 | 2300 |
| LLPS-Cea-a160 | Cercocebus atys | 95.55 | 0.0 | 2320 |
| LLPS-Mam-a157 | Macaca mulatta | 95.47 | 0.0 | 2321 |
| LLPS-Mea-a148 | Mesocricetus auratus | 95.15 | 0.0 | 2228 |
| LLPS-Cap-a160 | Cavia porcellus | 95.11 | 0.0 | 2215 |
| LLPS-Fud-a155 | Fukomys damarensis | 95.03 | 0.0 | 2214 |
| LLPS-Fia-a145 | Ficedula albicollis | 94.97 | 0.0 | 2034 |
| LLPS-Anp-a143 | Anas platyrhynchos | 94.97 | 0.0 | 2038 |
| LLPS-Bot-a161 | Bos taurus | 94.85 | 0.0 | 2195 |
| LLPS-Aon-a160 | Aotus nancymaae | 94.79 | 0.0 | 2298 |
| LLPS-Meg-a135 | Meleagris gallopavo | 94.78 | 0.0 | 2034 |
| LLPS-Gaga-a147 | Gallus gallus | 94.39 | 0.0 | 2097 |
| LLPS-Ora-a144 | Ornithorhynchus anatinus | 93.85 | 0.0 | 601 |
| LLPS-Pes-a140 | Pelodiscus sinensis | 93.82 | 0.0 | 2009 |
| LLPS-Rhb-a158 | Rhinopithecus bieti | 93.74 | 0.0 | 2038 |
| LLPS-Anc-a150 | Anolis carolinensis | 92.56 | 0.0 | 2019 |
| LLPS-Otg-a160 | Otolemur garnettii | 92.02 | 0.0 | 2093 |
| LLPS-Tag-a142 | Taeniopygia guttata | 91.9 | 0.0 | 2055 |
| LLPS-Leo-a134 | Lepisosteus oculatus | 86.49 | 0.0 | 1955 |
| LLPS-Poa-a156 | Pongo abelii | 82.6 | 0.0 | 1720 |
| LLPS-Orn-a968 | Oreochromis niloticus | 82.33 | 0.0 | 1872 |
| LLPS-Asm-a135 | Astyanax mexicanus | 81.84 | 0.0 | 1923 |
| LLPS-Lac-a145 | Latimeria chalumnae | 81.73 | 3e-103 | 333 |
| LLPS-Gaa-a138 | Gasterosteus aculeatus | 81.26 | 0.0 | 1866 |
| LLPS-Orl-a136 | Oryzias latipes | 81.23 | 0.0 | 1865 |
| LLPS-Ten-a135 | Tetraodon nigroviridis | 81.12 | 0.0 | 1875 |
| LLPS-Icp-a143 | Ictalurus punctatus | 80.8 | 0.0 | 1868 |
| LLPS-Scm-a129 | Scophthalmus maximus | 80.77 | 0.0 | 1852 |
| LLPS-Xim-a143 | Xiphophorus maculatus | 80.2 | 0.0 | 1867 |
| LLPS-Xet-a140 | Xenopus tropicalis | 80.17 | 0.0 | 1942 |
| LLPS-Dar-a138 | Danio rerio | 80.07 | 0.0 | 1840 |
| LLPS-Dio-a153 | Dipodomys ordii | 79.21 | 0.0 | 1387 |
| LLPS-Pof-a141 | Poecilia formosa | 77.34 | 0.0 | 1883 |
| LLPS-Tar-a134 | Takifugu rubripes | 61.01 | 0.0 | 1368 |