LLPS-Mum-a1120
Gabbr1

▼ OVERVIEW

Status: Reviewed
Protein Name: Gamma-aminobutyric acid type B receptor subunit 1
Gene Name: Gabbr1
Ensembl Gene: ENSMUSG00000024462.17
Ensembl Protein: ENSMUSP00000025338.9
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:10773016, PubMed:10075644). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10773016, PubMed:10075644). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (By similarity). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLLLLLVPLF  LRPLGAGGAQ  TPNVTSEGCQ  IIHPPWEGGI  RYRGLTRDQV  KAINFLPVDY  60
61    EIEYVCRGER  EVVGPKVRKC  LANGSWTDMD  TPSRCVRICS  KSYLTLENGK  VFLTGGDLPA  120
121   LDGARVDFRC  DPDFHLVGSS  RSICSQGQWS  TPKPHCQVNR  TPHSERRAVY  IGALFPMSGG  180
181   WPGGQACQPA  VEMALEDVNS  RRDILPDYEL  KLIHHDSKCD  PGQATKYLYE  LLYNDPIKII  240
241   LMPGCSSVST  LVAEAARMWN  LIVLSYGSSS  PALSNRQRFP  TFFRTHPSAT  LHNPTRVKLF  300
301   EKWGWKKIAT  IQQTTEVFTS  TLDDLEERVK  EAGIEITFRQ  SFFSDPAVPV  KNLKRQDARI  360
361   IVGLFYETEA  RKVFCEVYKE  RLFGKKYVWF  LIGWYADNWF  KTYDPSINCT  VEEMTEAVEG  420
421   HITTEIVMLN  PANTRSISNM  TSQEFVEKLT  KRLKRHPEET  GGFQEAPLAY  DAIWALALAL  480
481   NKTSGGGGRS  GVRLEDFNYN  NQTITDQIYR  AMNSSSFEGV  SGHVVFDASG  SRMAWTLIEQ  540
541   LQGGSYKKIG  YYDSTKDDLS  WSKTDKWIGG  SPPADQTLVI  KTFRFLSQKL  FISVSVLSSL  600
601   GIVLAVVCLS  FNIYNSHVRY  IQNSQPNLNN  LTAVGCSLAL  AAVFPLGLDG  YHIGRSQFPF  660
661   VCQARLWLLG  LGFSLGYGSM  FTKIWWVHTV  FTKKEEKKEW  RKTLEPWKLY  ATVGLLVGMD  720
721   ILTLAIWQIV  DPLHRTIETF  AKEEPKEDID  VSILPQLEHC  SSKKMNTWLG  IFYGYKGLLL  780
781   LLGIFLAYET  KSVSTEKIND  HRAVGMAIYN  VAVLCLITAP  VTMILSSQQD  AAFAFASLAI  840
841   VFSSYITLVV  LFVPKMRRLI  TRGEWQSEAQ  DTMKTGSSTN  NNEEEKSRLL  EKENRELEKI  900
901   IAEKEERVSE  LRHQLQSRQQ  IRSRRHPPTP  PDPSGGLPRG  PSEPPDRLSC  DGSRVHLLYK  960
Nucleotide CDS Sequence (FASTA)
1     ATGCTGCTGC  TGCTGCTGGT  GCCTCTCTTC  CTCCGCCCCC  TGGGCGCTGG  CGGGGCTCAG  60
61    ACCCCCAACG  TCACCTCGGA  AGGTTGCCAG  ATTATACATC  CGCCCTGGGA  AGGTGGCATC  120
121   AGGTACCGTG  GCTTGACTCG  CGACCAGGTG  AAGGCCATCA  ATTTCCTGCC  TGTGGACTAT  180
181   GAGATTGAAT  ATGTGTGCCG  GGGCGAACGC  GAGGTGGTGG  GGCCCAAGGT  GCGCAAGTGC  240
241   CTGGCCAACG  GCTCCTGGAC  GGATATGGAC  ACACCCAGTC  GCTGTGTCCG  AATCTGCTCC  300
301   AAGTCTTATT  TGACCCTGGA  AAATGGGAAG  GTTTTCCTGA  CGGGTGGGGA  CCTCCCAGCT  360
361   CTGGATGGAG  CCCGGGTGGA  TTTCCGATGT  GACCCCGACT  TCCATCTGGT  GGGCAGCTCC  420
421   CGGAGCATCT  GTAGTCAGGG  CCAGTGGAGC  ACCCCCAAGC  CCCACTGCCA  GGTGAATCGA  480
481   ACGCCACACT  CAGAACGGCG  TGCAGTATAC  ATCGGGGCGC  TGTTTCCCAT  GAGCGGGGGC  540
541   TGGCCGGGGG  GCCAGGCCTG  CCAGCCTGCG  GTGGAGATGG  CGCTGGAGGA  CGTTAACAGC  600
601   CGCAGAGACA  TCCTGCCGGA  CTACGAGCTC  AAGCTTATCC  ACCACGACAG  CAAGTGCGAC  660
661   CCAGGGCAAG  CCACCAAGTA  CTTGTATGAA  CTACTCTACA  ACGACCCCAT  CAAGATCATC  720
721   CTCATGCCCG  GCTGCAGCTC  TGTGTCCACA  CTGGTAGCCG  AGGCTGCCCG  GATGTGGAAC  780
781   CTTATTGTGC  TCTCATATGG  CTCCAGCTCA  CCAGCCTTGT  CAAACCGACA  GCGGTTTCCA  840
841   ACGTTCTTTC  GGACACATCC  ATCCGCCACA  CTCCACAATC  CCACCCGGGT  GAAACTCTTC  900
901   GAAAAGTGGG  GCTGGAAGAA  GATTGCCACC  ATCCAGCAGA  CTACCGAGGT  CTTCACCTCA  960
961   ACACTGGATG  ACCTGGAGGA  GCGAGTGAAA  GAGGCTGGGA  TTGAGATCAC  TTTTCGACAG  1020
1021  AGTTTCTTCT  CAGATCCAGC  TGTGCCTGTT  AAAAACCTGA  AGCGTCAAGA  TGCTCGAATC  1080
1081  ATCGTGGGAC  TTTTCTATGA  GACCGAAGCC  CGGAAAGTTT  TTTGTGAGGT  CTATAAGGAA  1140
1141  CGGCTCTTTG  GGAAGAAGTA  TGTCTGGTTT  CTCATCGGGT  GGTATGCTGA  CAACTGGTTC  1200
1201  AAAACCTATG  ACCCGTCAAT  CAATTGTACA  GTAGAAGAGA  TGACTGAGGC  GGTGGAGGGC  1260
1261  CATATCACCA  CGGAGATTGT  CATGCTGAAC  CCTGCCAACA  CCCGAAGCAT  TTCCAACATG  1320
1321  ACATCACAGG  AATTTGTGGA  GAAACTAACC  AAGCGGCTGA  AAAGACACCC  TGAGGAGACT  1380
1381  GGAGGCTTCC  AGGAGGCACC  ACTGGCCTAT  GATGCTATCT  GGGCCTTGGC  TTTGGCCTTG  1440
1441  AACAAGACCT  CTGGAGGAGG  TGGCCGTTCA  GGAGTGCGCC  TGGAGGACTT  TAACTACAAC  1500
1501  AACCAGACCA  TTACAGACCA  AATCTACCGG  GCCATGAACT  CCTCCTCCTT  TGAGGGTGTT  1560
1561  TCTGGCCACG  TGGTCTTTGA  TGCCAGCGGC  TCCCGGATGG  CATGGACGCT  TATCGAGCAG  1620
1621  CTACAGGGCG  GCAGCTACAA  GAAGATCGGC  TACTACGACA  GCACCAAGGA  TGATCTTTCC  1680
1681  TGGTCCAAAA  CAGACAAGTG  GATCGGAGGG  TCTCCCCCAG  CCGACCAGAC  CTTGGTCATC  1740
1741  AAGACATTCC  GTTTCCTGTC  ACAGAAACTC  TTTATCTCCG  TCTCAGTTCT  CTCCAGCCTG  1800
1801  GGCATTGTTC  TTGCTGTTGT  CTGTCTGTCC  TTTAACATCT  ACAACTCCCA  CGTTCGTTAT  1860
1861  ATCCAGAACT  CCCAGCCCAA  CCTGAACAAT  CTGACTGCTG  TGGGCTGCTC  ACTGGCACTA  1920
1921  GCTGCTGTCT  TCCCCCTTGG  GCTGGATGGT  TACCACATAG  GGAGAAGCCA  GTTCCCATTT  1980
1981  GTCTGCCAGG  CCCGCCTTTG  GCTCTTGGGC  TTAGGCTTTA  GTCTGGGCTA  TGGCTCTATG  2040
2041  TTCACCAAGA  TCTGGTGGGT  CCACACAGTC  TTCACAAAGA  AGGAGGAGAA  GAAGGAATGG  2100
2101  AGGAAGACCC  TAGAGCCTTG  GAAACTGTAC  GCCACTGTAG  GCCTGCTGGT  GGGCATGGAT  2160
2161  ATCCTGACTC  TTGCCATCTG  GCAGATTGTG  GACCCCTTGC  ACCGAACCAT  TGAGACTTTT  2220
2221  GCCAAGGAGG  AACCAAAGGA  AGACATTGAT  GTCTCCATTC  TGCCCCAGCT  GGAGCACTGC  2280
2281  AGCTCCAAGA  AGATGAATAC  ATGGCTCGGC  ATTTTCTATG  GTTACAAAGG  GCTGCTGCTG  2340
2341  CTGCTGGGAA  TCTTTCTTGC  TTATGAGACC  AAAAGTGTGT  CCACTGAAAA  GATCAATGAC  2400
2401  CACAGGGCCG  TGGGCATGGC  TATCTACAAT  GTTGCGGTCC  TGTGTCTCAT  TACCGCTCCT  2460
2461  GTCACCATGA  TCCTTTCCAG  CCAGCAGGAC  GCAGCCTTCG  CCTTTGCCTC  TCTGGCCATT  2520
2521  GTGTTCTCTT  CCTACATTAC  TCTGGTTGTG  CTCTTTGTGC  CTAAGATGCG  CAGGTTGATC  2580
2581  ACTCGAGGTG  AATGGCAGTC  TGAAGCACAG  GACACAATGA  AAACAGGATC  ATCCACCAAC  2640
2641  AACAATGAGG  AAGAGAAGTC  CCGACTGTTG  GAGAAGGAAA  ACCGTGAATT  GGAAAAGATC  2700
2701  ATCGCCGAGA  AAGAGGAGCG  TGTCTCTGAA  CTGCGCCATC  AGCTCCAGTC  TCGGCAGCAG  2760
2761  ATCCGCTCCC  GGCGCCACCC  CCCAACACCC  CCAGACCCCT  CTGGGGGCCT  TCCCAGGGGA  2820
2821  CCCTCAGAGC  CCCCTGACCG  GCTTAGCTGT  GATGGGAGTC  GAGTACATTT  GCTTTACAAG  2880
2881  TGA  2883

▼ KEYWORD

ID
Family
Alternative splicing
Cell junction
Cell membrane
Cell projection
Coiled coil
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Repeat
Signal
Sushi
Synapse
Transducer
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axolemma
Cellular Component
Cell junction
Cellular Component
Cytoplasm
Cellular Component
Dendritic shaft
Cellular Component
Dendritic spine
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Extracellular space
Cellular Component
G protein-coupled receptor dimeric complex
Cellular Component
G protein-coupled receptor heterodimeric complex
Cellular Component
GABA receptor complex
Cellular Component
GABA-ergic synapse
Cellular Component
Glutamatergic synapse
Cellular Component
Integral component of plasma membrane
Cellular Component
Integral component of postsynaptic membrane
Cellular Component
Integral component of presynaptic membrane
Cellular Component
Intracellular membrane-bounded organelle
Cellular Component
Membrane
Cellular Component
Membrane raft
Cellular Component
Mitochondrial membrane
Cellular Component
Neuron projection
Cellular Component
Neuronal cell body
Cellular Component
Postsynaptic membrane
Cellular Component
Presynapse
Cellular Component
Presynaptic membrane
Cellular Component
Schaffer collateral - CA1 synapse
Cellular Component
Synaptic membrane
Cellular Component
Synaptic vesicle
Molecular Function
Extracellular matrix protein binding
Molecular Function
G protein-coupled GABA receptor activity
Molecular Function
G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
Molecular Function
Protein heterodimerization activity
Molecular Function
Transcription factor binding
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process
Gamma-aminobutyric acid signaling pathway
Biological Process
Negative regulation of adenylate cyclase activity
Biological Process
Negative regulation of cell population proliferation
Biological Process
Negative regulation of dopamine secretion
Biological Process
Negative regulation of epinephrine secretion
Biological Process
Negative regulation of gamma-aminobutyric acid secretion
Biological Process
Negative regulation of synaptic transmission
Biological Process
Osteoblast differentiation
Biological Process
Positive regulation of glutamate secretion
Biological Process
Positive regulation of growth hormone secretion
Biological Process
Regulation of glutamate secretion

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mal-a1089Mandrillus leucophaeus99.250.01932
LLPS-Urm-a976Ursus maritimus98.980.01397
LLPS-Cea-a1114Cercocebus atys98.960.01980
LLPS-Cas-a991Carlito syrichta98.960.01978
LLPS-Sus-a1113Sus scrofa98.960.01979
LLPS-Bot-a1113Bos taurus98.960.01979
LLPS-Poa-a1084Pongo abelii98.850.01054
LLPS-Chs-a1100Chlorocebus sabaeus98.850.01978
LLPS-Maf-a1106Macaca fascicularis98.850.01978
LLPS-Man-a1117Macaca nemestrina98.850.01977
LLPS-Mam-a1093Macaca mulatta98.850.01977
LLPS-Hos-a1136Homo sapiens98.750.01977
LLPS-Gog-a1100Gorilla gorilla98.750.01977
LLPS-Otg-a1093Otolemur garnettii98.640.01968
LLPS-Rhb-a1100Rhinopithecus bieti98.640.01971
LLPS-Nol-a1077Nomascus leucogenys98.580.0574
LLPS-Dio-a1068Dipodomys ordii98.540.01972
LLPS-Tut-a572Tursiops truncatus98.50.01897
LLPS-Eqc-a1115Equus caballus98.270.01649
LLPS-Orc-a1022Oryctolagus cuniculus98.120.01964
LLPS-Loa-a1076Loxodonta africana97.970.01904
LLPS-Mup-a1066Mustela putorius furo97.940.01784
LLPS-Fec-a1110Felis catus97.920.01769
LLPS-Cap-a1103Cavia porcellus97.780.01640
LLPS-Fud-a1054Fukomys damarensis97.350.01901
LLPS-Caj-a1105Callithrix jacchus97.230.01966
LLPS-Pat-a1123Pan troglodytes96.90.01939
LLPS-Pap-a1077Pan paniscus96.90.01939
LLPS-Aon-a1117Aotus nancymaae96.540.01962
LLPS-Mea-a1061Mesocricetus auratus95.830.01942
LLPS-Ran-a1109Rattus norvegicus95.560.01949
LLPS-Ict-a1093Ictidomys tridecemlineatus95.550.01945
LLPS-Paa-a1113Papio anubis94.380.01824
LLPS-Caf-a1088Canis familiaris94.00.01726
LLPS-Sah-a990Sarcophilus harrisii90.420.01734
LLPS-Mod-a1059Monodelphis domestica84.770.01445
LLPS-Orl-a943Oryzias latipes79.530.01233
LLPS-Ten-a913Tetraodon nigroviridis79.10.01060
LLPS-Anc-a994Anolis carolinensis78.810.01529
LLPS-Xim-a964Xiphophorus maculatus75.80.01256
LLPS-Scm-a918Scophthalmus maximus73.250.01394
LLPS-Ora-a910Ornithorhynchus anatinus73.120.0723
LLPS-Scf-a927Scleropages formosus72.760.01423
LLPS-Icp-a961Ictalurus punctatus72.440.01306
LLPS-Dar-a958Danio rerio72.050.01411
LLPS-Asm-a953Astyanax mexicanus71.640.01421
LLPS-Pof-a952Poecilia formosa71.340.01389
LLPS-Xet-a935Xenopus tropicalis71.330.01383
LLPS-Gaa-a930Gasterosteus aculeatus70.670.01403
LLPS-Orn-a950Oreochromis niloticus70.040.01407
LLPS-Tar-a915Takifugu rubripes68.010.01273
LLPS-Drm-a220Drosophila melanogaster50.130.0801