LLPS-Mum-a1081
Dact3
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Dapper homolog 3; Dapper antagonist of catenin 3 |
| Gene Name: | Dact3 |
| Ensembl Gene: | ENSMUSG00000078794.4 |
| Ensembl Protein: | ENSMUSP00000104133.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
▼ FUNCTION
| May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000108493.2 | ENSMUSP00000104133.1 |
| UniProt | Q0PHV7, DACT3_MOUSE | |
| GeneBank | DQ832319 | ABH03019.1 |
| RefSeq | NM_001081655.1 | NP_001075124.1 |
| Entrez | 629378 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MIRAFSFPVS PERGRLRGWL EGSLAGLCEL HWLRERQEYR VQQALRLAQP GMGGAEAEDE 60 61 EDAEEDEDAA AARRAAAALE EQLEALPGLI WDLGQQLGDL SLESGGLDQE SGRSSGFYED 120 121 PSSTGGPDSP PSTFCGDSGF SGSGSYGRLG PSDPRGIYAS ERPKSLGDAS PSAPESVGAR 180 181 VAVPRSFSAP YPTAAAGAET CSSAERRARA GPFLTPSPLH AVALRSPRPS GRVPCGSPDG 240 241 AASRPLDGYI SALLRRRRRR GAGQPRTSPG GADGGARRQN GARPRPPEAS PPPGGARPAR 300 301 EPSTERAWAA AWEAEVPPEP APPAAASPPS SPAEGRLVKA QYIPGAPAAS RGLPGRAARR 360 361 RAPPLTRGRS VEQSPPRERP RAAGRRGRLA EPSGRRGSPR ARKAARSQSE TSLLGRAHAA 420 421 PPPKYPTAER DEPRPPRPRR GPAPTPTVQA CRRWRSTAEI DAPDGRRPRA RVPAPRGPAP 480 481 SPSAPPRRLL YGCAGSDSEC SAVGRPVPLG RRMPSGCAPG GYGESESSAS EGESPAFSSA 540 541 SSDSDGSGGL VWPQQLVAAA GASPSGPGGA AGGGTPAGPA KVFVKIKASH ALKKKILRFR 600 601 SGSLKVMTTV 610 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGATCCGGG CCTTCTCGTT CCCGGTGAGC CCGGAGCGGG GTCGGCTGCG GGGATGGTTG 60 61 GAAGGCAGCC TGGCCGGGCT CTGCGAGTTG CATTGGCTCC GAGAGAGGCA GGAGTACCGC 120 121 GTGCAGCAGG CGCTGCGGCT GGCCCAGCCC GGGATGGGGG GCGCCGAGGC TGAGGACGAG 180 181 GAGGACGCCG AGGAGGACGA GGATGCGGCA GCGGCGCGCA GGGCCGCAGC AGCCCTGGAG 240 241 GAGCAGCTGG AGGCCCTGCC TGGGCTCATC TGGGACCTGG GCCAGCAGCT GGGAGACCTG 300 301 AGTCTGGAGT CTGGTGGCCT GGACCAGGAG AGTGGGCGCA GCTCAGGCTT CTATGAAGAC 360 361 CCCAGTTCTA CTGGAGGCCC AGATTCACCA CCCTCCACCT TCTGCGGGGA CAGTGGCTTC 420 421 TCCGGATCTG GCTCCTATGG ACGCCTGGGT CCCTCGGACC CCCGGGGCAT CTATGCCAGT 480 481 GAGAGACCCA AGTCCTTAGG CGACGCCAGT CCCAGCGCCC CAGAGTCGGT GGGTGCCCGG 540 541 GTTGCAGTGC CTCGATCCTT CTCAGCTCCC TATCCGACGG CAGCAGCCGG AGCTGAGACC 600 601 TGCTCATCCG CGGAACGGCG GGCTCGTGCC GGGCCCTTCC TGACACCTAG CCCACTGCAC 660 661 GCGGTGGCTC TGCGCAGCCC AAGGCCAAGT GGACGCGTAC CGTGCGGCTC GCCGGACGGG 720 721 GCGGCCAGCC GGCCCCTTGA CGGCTACATC TCGGCGCTCC TGCGCAGGCG CCGCCGCCGG 780 781 GGGGCGGGCC AACCGCGCAC AAGTCCCGGG GGCGCGGACG GGGGCGCGCG GCGCCAGAAC 840 841 GGCGCGCGCC CGCGGCCGCC TGAAGCGTCC CCGCCCCCCG GAGGCGCGCG ACCCGCGCGG 900 901 GAACCGTCGA CAGAGCGCGC CTGGGCTGCG GCGTGGGAGG CGGAGGTTCC ACCCGAACCC 960 961 GCGCCTCCGG CCGCCGCGTC GCCGCCCTCC AGTCCGGCAG AGGGCCGCCT CGTGAAGGCA 1020 1021 CAGTACATCC CGGGCGCGCC CGCGGCCTCC AGGGGCCTCC CGGGCCGCGC CGCGCGCCGC 1080 1081 CGGGCTCCGC CGCTTACGCG AGGTCGCAGT GTGGAGCAGT CCCCGCCAAG GGAACGGCCG 1140 1141 CGCGCTGCGG GCCGTCGGGG CCGCCTGGCA GAGCCGTCGG GGCGTCGGGG ATCGCCGAGG 1200 1201 GCGCGCAAAG CGGCGCGCTC GCAGTCTGAG ACCAGTCTAC TGGGCCGCGC GCACGCCGCT 1260 1261 CCGCCACCCA AGTACCCCAC GGCCGAGCGA GACGAACCCC GACCGCCCCG GCCCCGTCGT 1320 1321 GGCCCAGCGC CCACGCCGAC GGTCCAGGCC TGCCGTCGGT GGCGTTCCAC CGCTGAGATC 1380 1381 GACGCACCGG ATGGCCGCCG CCCCCGAGCC CGCGTGCCCG CGCCACGAGG CCCCGCACCC 1440 1441 TCGCCATCTG CGCCCCCGCG CCGGCTGTTG TACGGTTGCG CAGGCAGCGA CTCCGAGTGC 1500 1501 TCAGCGGTAG GGCGGCCGGT GCCGCTCGGC CGTCGGATGC CGTCTGGATG CGCTCCAGGA 1560 1561 GGCTATGGCG AAAGCGAGTC GAGCGCCAGC GAGGGCGAGT CGCCCGCCTT CAGCTCTGCC 1620 1621 TCTAGCGACT CCGACGGCAG CGGAGGCCTC GTGTGGCCGC AGCAACTGGT GGCGGCCGCC 1680 1681 GGGGCCTCGC CGTCGGGGCC CGGGGGTGCT GCTGGTGGAG GGACGCCTGC GGGCCCCGCC 1740 1741 AAGGTCTTCG TGAAGATCAA GGCATCGCAC GCGCTGAAGA AAAAGATCCT TCGTTTTCGG 1800 1801 TCGGGTTCTC TGAAGGTCAT GACGACTGTG TGA 1833 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Molecular Function | Beta-catenin binding | |
Molecular Function | Delta-catenin binding | |
Molecular Function | Identical protein binding | |
Molecular Function | Protein kinase A binding | |
Molecular Function | Protein kinase C binding | |
Biological Process | Negative regulation of canonical Wnt signaling pathway | |
Biological Process | Negative regulation of cell growth | |
Biological Process | Negative regulation of epithelial to mesenchymal transition | |
Biological Process | Negative regulation of Wnt signaling pathway | |
Biological Process | Regulation of Wnt signaling pathway | |
Biological Process | Wnt signaling pathway |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-a1072 | Rattus norvegicus | 99.34 | 0.0 | 1141 |
| LLPS-Pat-a1084 | Pan troglodytes | 97.01 | 2e-105 | 325 |
| LLPS-Mal-a1054 | Mandrillus leucophaeus | 97.01 | 3e-105 | 324 |
| LLPS-Maf-a1069 | Macaca fascicularis | 97.01 | 2e-105 | 325 |
| LLPS-Gog-a1065 | Gorilla gorilla | 97.01 | 2e-105 | 325 |
| LLPS-Nol-a1044 | Nomascus leucogenys | 97.01 | 3e-105 | 325 |
| LLPS-Pap-a1047 | Pan paniscus | 96.41 | 7e-103 | 318 |
| LLPS-Rhb-a1064 | Rhinopithecus bieti | 96.41 | 1e-104 | 323 |
| LLPS-Mea-a1023 | Mesocricetus auratus | 95.98 | 3e-75 | 247 |
| LLPS-Aim-a1017 | Ailuropoda melanoleuca | 92.13 | 3e-56 | 194 |
| LLPS-Dio-a1033 | Dipodomys ordii | 91.76 | 1e-68 | 229 |
| LLPS-Ova-a1031 | Ovis aries | 88.09 | 5e-142 | 426 |
| LLPS-Cap-a1068 | Cavia porcellus | 86.27 | 2e-154 | 463 |
| LLPS-Cea-a1076 | Cercocebus atys | 84.54 | 0.0 | 669 |
| LLPS-Hos-a1097 | Homo sapiens | 84.38 | 0.0 | 670 |
| LLPS-Caj-a1068 | Callithrix jacchus | 84.38 | 0.0 | 666 |
| LLPS-Chs-a1064 | Chlorocebus sabaeus | 83.83 | 0.0 | 663 |
| LLPS-Sus-a1076 | Sus scrofa | 83.6 | 0.0 | 660 |
| LLPS-Paa-a1077 | Papio anubis | 83.6 | 0.0 | 653 |
| LLPS-Eqc-a1077 | Equus caballus | 83.46 | 0.0 | 660 |
| LLPS-Fec-a1073 | Felis catus | 83.28 | 0.0 | 639 |
| LLPS-Ict-a1058 | Ictidomys tridecemlineatus | 81.07 | 1e-47 | 172 |
| LLPS-Poa-a1049 | Pongo abelii | 79.96 | 0.0 | 546 |
| LLPS-Man-a1080 | Macaca nemestrina | 79.44 | 3e-138 | 423 |
| LLPS-Bot-a1075 | Bos taurus | 78.78 | 7e-108 | 340 |
| LLPS-Aon-a1080 | Aotus nancymaae | 78.47 | 0.0 | 586 |
| LLPS-Mam-a1059 | Macaca mulatta | 74.61 | 9e-175 | 519 |
| LLPS-Orn-a923 | Oreochromis niloticus | 73.17 | 2e-08 | 63.9 |
| LLPS-Dar-a1101 | Danio rerio | 69.84 | 7e-11 | 71.6 |
| LLPS-Loa-a1043 | Loxodonta africana | 67.96 | 0.0 | 556 |
| LLPS-Ora-a882 | Ornithorhynchus anatinus | 50.0 | 1e-13 | 74.7 |