LLPS-Mum-a1067
Shisa6

▼ OVERVIEW

Status: Reviewed
Protein Name: Protein shisa-6; Cystine-knot AMPAR modulating protein of 52 kDa; CKAMP52; Shisa family member 6
Gene Name: Shisa6, Gm879
Ensembl Gene: ENSMUSG00000053930.13
Ensembl Protein: ENSMUSP00000071025.6
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (PubMed:26931375). May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway (PubMed:28196692).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MALRRLLLPP  LLLSLLLSLA  SLHLPPGADA  ARGRSGNRTL  NAGAVGGRRA  GGALARGGRE  60
61    LNSTARASGV  PEAGSRRGQS  AAAAAAAAAA  ASATVTYETC  WGYYDVSGQY  DKEFECNNSE  120
121   SGYLYCCGTC  YYRFCCKKRH  EKLDQRQCTN  YQSPVWVQTP  STKVVSPGPE  NKYDPEKDKT  180
181   NFTVYITCGV  IAFVIVAGVF  AKVSYDKAHR  PPREMNIHRA  LADILRQQGP  IPIAHCERET  240
241   ISAIDTSPKE  NTPVRSTSKN  HYTPVRTAKQ  TPGDRQYNHP  ILSSATQTPT  HEKPRMNNIL  300
301   TSATEPYDLS  FSRSYQNLAH  LPPSYESAVK  TNPSKYSSLK  RLTDKEADEY  YMRRRHLPDL  360
361   AARGTLPLNV  IQMSQQKPLP  RERPRRPIRA  MSQDRVLSPR  RGLPDEFGMP  YDRILSDEQL  420
421   LSTERLHSQD  PLLSPERTAF  PEQSLSRAIS  HTDVFVSTPV  LDRYRMTKMH  SHPSASNNSY  480
481   ATLGQSQTAA  KRHAFASRRH  NTVEQLHYIP  GHHTCYTASK  TEVTV  525
Nucleotide CDS Sequence (FASTA)
1     ATGGCGCTGC  GCCGCCTCCT  GCTGCCGCCT  CTGCTGCTGT  CGCTGCTGCT  GTCGCTCGCG  60
61    TCCCTGCACC  TGCCGCCCGG  CGCAGACGCC  GCCCGCGGCC  GCTCCGGGAA  CCGGACCCTG  120
121   AACGCGGGAG  CCGTCGGAGG  TCGGCGTGCT  GGGGGCGCCC  TGGCCCGAGG  CGGCCGCGAA  180
181   CTAAACAGCA  CCGCCCGAGC  GTCCGGCGTC  CCGGAGGCGG  GCAGCCGGCG  GGGACAGTCC  240
241   GCAGCAGCGG  CAGCGGCGGC  GGCGGCGGCG  GCCAGCGCGA  CTGTTACTTA  CGAGACGTGC  300
301   TGGGGCTACT  ACGACGTGAG  CGGCCAGTAC  GACAAGGAGT  TCGAGTGCAA  CAACAGCGAG  360
361   AGCGGCTACC  TGTACTGCTG  CGGCACCTGC  TACTATCGCT  TCTGCTGCAA  GAAGCGCCAC  420
421   GAGAAGCTGG  ACCAGCGCCA  GTGCACCAAC  TACCAAAGCC  CCGTATGGGT  GCAGACGCCC  480
481   AGCACCAAGG  TAGTGTCGCC  GGGGCCCGAG  AACAAGTACG  ACCCGGAGAA  GGACAAGACC  540
541   AACTTCACCG  TCTACATCAC  TTGCGGGGTG  ATCGCCTTCG  TCATCGTGGC  GGGCGTCTTC  600
601   GCCAAGGTCT  CCTATGACAA  GGCCCACCGC  CCTCCGCGAG  AGATGAACAT  CCACAGGGCT  660
661   CTGGCTGACA  TTCTAAGACA  ACAGGGACCA  ATCCCCATAG  CACACTGTGA  AAGAGAAACC  720
721   ATCTCGGCCA  TCGATACCTC  TCCCAAAGAG  AACACGCCGG  TCCGATCAAC  CTCCAAAAAC  780
781   CACTACACCC  CTGTGCGCAC  AGCCAAGCAG  ACTCCAGGTG  ATCGTCAGTA  TAATCATCCG  840
841   ATCTTAAGCA  GCGCTACCCA  GACCCCTACA  CATGAGAAGC  CACGGATGAA  TAACATTCTG  900
901   ACGTCGGCCA  CGGAACCCTA  TGACCTCTCC  TTCTCACGCT  CTTACCAGAA  CTTAGCCCAC  960
961   TTGCCTCCAT  CATATGAATC  TGCAGTGAAA  ACCAATCCAA  GCAAGTACTC  GTCTCTGAAG  1020
1021  AGGCTAACGG  ACAAGGAAGC  TGATGAGTAT  TACATGAGAA  GGAGGCACCT  GCCAGACCTT  1080
1081  GCAGCCCGTG  GTACCCTCCC  CCTCAATGTC  ATCCAGATGT  CTCAACAGAA  GCCACTTCCT  1140
1141  CGAGAACGGC  CACGCAGGCC  CATCAGGGCC  ATGTCCCAGG  ACAGGGTCTT  GTCTCCACGT  1200
1201  CGGGGATTGC  CAGATGAATT  CGGCATGCCC  TATGACCGCA  TCTTGTCTGA  TGAACAGCTG  1260
1261  CTCTCCACAG  AGCGCCTGCA  CTCCCAGGAC  CCGTTGCTGT  CCCCAGAGAG  GACAGCCTTC  1320
1321  CCGGAGCAGT  CGCTGTCGCG  GGCCATCTCG  CATACGGACG  TCTTTGTGTC  CACGCCAGTG  1380
1381  CTGGACCGCT  ACCGCATGAC  CAAGATGCAC  TCCCATCCCA  GTGCCTCCAA  TAACTCCTAT  1440
1441  GCCACCCTGG  GCCAGAGCCA  GACAGCAGCC  AAGCGCCACG  CCTTTGCCTC  TCGCAGACAC  1500
1501  AACACGGTGG  AGCAGTTACA  CTATATCCCA  GGCCATCACA  CCTGCTACAC  AGCCAGCAAG  1560
1561  ACTGAAGTGA  CCGTGTGA  1578

▼ KEYWORD

ID
Family
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Glycoprotein
Membrane
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Wnt signaling pathway

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
AMPA glutamate receptor complex
Cellular Component
Asymmetric, glutamatergic, excitatory synapse
Cellular Component
Cell junction
Cellular Component
Dendritic spine membrane
Cellular Component
Glutamatergic synapse
Cellular Component
Integral component of postsynaptic density membrane
Cellular Component
Postsynaptic density
Cellular Component
Postsynaptic membrane
Cellular Component
Synapse
Molecular Function
Ionotropic glutamate receptor binding
Molecular Function
PDZ domain binding
Biological Process
Excitatory chemical synaptic transmission
Biological Process
Negative regulation of canonical Wnt signaling pathway
Biological Process
Postsynaptic neurotransmitter receptor diffusion trapping
Biological Process
Regulation of AMPA glutamate receptor clustering
Biological Process
Regulation of AMPA receptor activity
Biological Process
Regulation of postsynaptic neurotransmitter receptor activity
Biological Process
Regulation of short-term neuronal synaptic plasticity
Biological Process
Spermatogenesis
Biological Process
Wnt signaling pathway

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cap-a1055Cavia porcellus98.814e-178513
LLPS-Ran-a1058Rattus norvegicus97.90.01060
LLPS-Mea-a1010Mesocricetus auratus97.90.01068
LLPS-Dio-a1020Dipodomys ordii97.60.0933
LLPS-Ict-a1044Ictidomys tridecemlineatus96.650.0907
LLPS-Aon-a1066Aotus nancymaae96.625e-162472
LLPS-Mal-a1040Mandrillus leucophaeus96.036e-160467
LLPS-Man-a1064Macaca nemestrina96.034e-159465
LLPS-Otg-a1043Otolemur garnettii94.141e-158462
LLPS-Bot-a1061Bos taurus91.85e-154450
LLPS-Maf-a1056Macaca fascicularis90.830.0878
LLPS-Poa-a1035Pongo abelii90.430.0553
LLPS-Cea-a1061Cercocebus atys89.330.0915
LLPS-Pat-a1069Pan troglodytes88.950.0918
LLPS-Paa-a1063Papio anubis88.950.0912
LLPS-Hos-a1083Homo sapiens88.760.0917
LLPS-Eqc-a1063Equus caballus88.580.0917
LLPS-Fec-a1059Felis catus88.340.0889
LLPS-Caj-a1053Callithrix jacchus87.850.0895
LLPS-Meg-a840Meleagris gallopavo86.158e-136402
LLPS-Fia-a928Ficedula albicollis86.111e-127380
LLPS-Gaga-a949Gallus gallus85.969e-138407
LLPS-Sus-a1062Sus scrofa85.710.0585
LLPS-Caf-a1042Canis familiaris85.640.0595
LLPS-Mup-a1018Mustela putorius furo84.541e-175506
LLPS-Anc-a953Anolis carolinensis82.253e-133395
LLPS-Lac-a914Latimeria chalumnae80.55e-132392
LLPS-Sah-a949Sarcophilus harrisii74.852e-78251
LLPS-Ora-a872Ornithorhynchus anatinus72.551e-63213
LLPS-Pes-a900Pelodiscus sinensis72.494e-168490
LLPS-Anp-a835Anas platyrhynchos70.343e-64214
LLPS-Asm-a912Astyanax mexicanus60.746e-177518
LLPS-Xet-a902Xenopus tropicalis58.766e-101314
LLPS-Tar-a872Takifugu rubripes57.722e-166490
LLPS-Orn-a910Oreochromis niloticus55.013e-160476
LLPS-Ten-a871Tetraodon nigroviridis54.931e-165488
LLPS-Gaa-a887Gasterosteus aculeatus54.021e-169499
LLPS-Dar-a920Danio rerio53.593e-65221
LLPS-Pof-a911Poecilia formosa53.144e-152455
LLPS-Scf-a1063Scleropages formosus52.053e-70233