LLPS-Mum-a1062
Trpv2

▼ OVERVIEW

Status: Reviewed
Protein Name: Transient receptor potential cation channel subfamily V member 2
Gene Name: Trpv2, Grc
Ensembl Gene: ENSMUSG00000018507.16
Ensembl Protein: ENSMUSP00000018651.7
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MTSASNPPAF  RLETSDGDEE  GSAEVNKGKN  EPPPMESPFQ  GEDRNFSPQI  KVNLNYRKGL  60
61    GPSQQDPNRF  DRDRLFSVVS  RGVPEELTGL  LEYLRRTSKY  LTDSAYTEGS  TGKTCLMKAV  120
121   LNLQDGVNAC  ILPLLQIDRD  SGNPQPLVNA  QCTDEFYRGH  SALHIAIEKR  SLWCVKLLVE  180
181   NGANVHIRAC  GRFFQKHQGT  CFYFGELPLS  LAACTKQWDV  VTYLLENPHQ  PASLEATDSL  240
241   GNTVLHALVM  IADNSPENSA  LVIHMYDSLL  QMGARLCPTV  QLEDICNHQG  LTPLKLAAKE  300
301   GKIEIFRHIL  QREFSGLYQP  LSRKFTEWCY  GPVRVSLYDL  SSVDSWEKNS  VLEIIAFHCK  360
361   SPHRHRMVVL  EPLNKLLQEK  WDRLIPRFFF  NFACYLVYMI  IFTIVAYHQP  SLEQPAIPSS  420
421   KATFGDSMLL  LGHILILLGG  IYLLLGQLWY  FWRRRLFIWI  SFMDSYFEIL  FLVQALLTVL  480
481   SQVLRFVETE  WYLPLLVSSL  VLGWLNLLYY  TRGFQHTGIY  SVMIQKVILR  DLLRFLLVYL  540
541   VFLFGFAVAL  VSLSREARSP  KAPEDSNTTV  TEKPTLGQEE  EPVPYGGILD  ASLELFKFTI  600
601   GMGELAFQEQ  LRFRGVVLLL  LLAYVLLTYV  LLLNMLIALM  SETVNSVATD  SWSIWKLQKA  660
661   ISVLEMENGY  WWCRRKRHRA  GRLLKVGTKG  DGIPDERWCF  RVEEVNWAAW  EKTLPTLSED  720
721   PSGAGITGYK  KNPTSKPGKN  SASEEDHLPL  QVLQSH  756
Nucleotide CDS Sequence (FASTA)
1     ATGACTTCAG  CCTCCAACCC  CCCAGCTTTT  AGGCTGGAGA  CGTCCGATGG  AGATGAAGAA  60
61    GGCAGTGCTG  AGGTGAACAA  AGGAAAGAAT  GAGCCACCCC  CCATGGAGTC  TCCCTTCCAG  120
121   GGAGAGGACC  GGAACTTCTC  CCCTCAGATT  AAAGTGAATC  TCAACTACCG  AAAGGGACTG  180
181   GGTCCCAGCC  AACAGGACCC  AAATCGGTTT  GACCGTGACC  GACTCTTCAG  TGTGGTCTCC  240
241   CGGGGTGTCC  CCGAGGAGCT  GACTGGACTG  CTAGAGTACC  TGCGCCGGAC  CAGCAAGTAC  300
301   CTCACTGACT  CGGCATACAC  AGAAGGCTCC  ACTGGAAAGA  CGTGCCTGAT  GAAGGCTGTG  360
361   CTGAACCTTC  AGGATGGGGT  CAATGCCTGT  ATCCTGCCGC  TGCTGCAGAT  TGACAGGGAT  420
421   TCCGGCAATC  CTCAGCCCCT  TGTCAATGCC  CAGTGCACCG  ATGAGTTCTA  CCGAGGCCAC  480
481   AGTGCGCTGC  ACATCGCCAT  AGAGAAGAGG  AGCCTGTGGT  GCGTGAAGCT  GCTGGTAGAG  540
541   AATGGAGCGA  ATGTTCACAT  CCGAGCCTGT  GGCCGCTTCT  TCCAAAAGCA  CCAAGGAACT  600
601   TGTTTCTATT  TTGGAGAGCT  ACCTCTTTCT  CTGGCAGCGT  GCACCAAGCA  GTGGGATGTG  660
661   GTGACCTACC  TCCTGGAGAA  CCCACACCAG  CCTGCCAGCC  TGGAGGCCAC  CGACTCCCTG  720
721   GGCAACACAG  TCCTGCATGC  TCTGGTAATG  ATTGCAGACA  ACTCACCTGA  GAACAGTGCG  780
781   CTGGTGATCC  ACATGTATGA  CAGCCTTCTC  CAAATGGGGG  CCCGCCTCTG  CCCCACTGTA  840
841   CAGCTTGAGG  ATATCTGCAA  CCATCAAGGC  CTCACACCCC  TGAAGTTGGC  TGCCAAGGAA  900
901   GGTAAAATTG  AGATCTTCAG  GCACATCCTG  CAGCGGGAGT  TCTCAGGGCT  GTACCAGCCC  960
961   CTTTCCCGAA  AGTTCACCGA  GTGGTGCTAC  GGTCCTGTCC  GAGTGTCACT  GTACGACCTG  1020
1021  TCCTCTGTGG  ACAGTTGGGA  AAAGAACTCG  GTCCTGGAAA  TCATCGCTTT  CCATTGCAAG  1080
1081  AGCCCGCACC  GGCACCGCAT  GGTGGTTTTA  GAGCCACTGA  ACAAGCTTCT  GCAGGAGAAA  1140
1141  TGGGATCGGC  TCATCCCAAG  ATTCTTCTTC  AACTTCGCCT  GTTACTTGGT  CTACATGATC  1200
1201  ATCTTCACCA  TAGTTGCCTA  CCACCAGCCT  TCCCTGGAGC  AGCCAGCCAT  TCCCTCATCA  1260
1261  AAAGCGACTT  TTGGGGACTC  CATGCTGCTG  TTGGGCCACA  TTCTGATCCT  GCTTGGGGGT  1320
1321  ATTTACCTCT  TACTGGGCCA  GCTGTGGTAC  TTTTGGCGGC  GGCGCCTGTT  CATCTGGATC  1380
1381  TCGTTCATGG  ACAGTTACTT  TGAAATCCTC  TTCCTTGTCC  AGGCGCTGCT  CACAGTGCTG  1440
1441  TCCCAGGTGC  TGCGCTTCGT  GGAGACTGAA  TGGTACCTCC  CCCTGTTAGT  GTCATCCCTA  1500
1501  GTGCTGGGCT  GGCTGAACCT  GCTTTATTAT  ACACGTGGCT  TTCAGCACAC  AGGCATCTAC  1560
1561  AGTGTCATGA  TCCAAAAGGT  CATTCTGCGA  GACCTGCTCC  GCTTCCTGCT  GGTCTACCTA  1620
1621  GTCTTCCTTT  TCGGCTTTGC  TGTAGCCCTA  GTAAGCTTGA  GCCGGGAGGC  CCGAAGTCCC  1680
1681  AAAGCCCCTG  AAGATAGCAA  CACCACTGTG  ACGGAAAAGC  CCACGCTGGG  TCAGGAGGAG  1740
1741  GAGCCAGTCC  CATATGGGGG  CATTCTGGAT  GCCTCCCTAG  AGCTGTTCAA  GTTCACCATT  1800
1801  GGTATGGGTG  AGCTGGCTTT  CCAGGAACAG  CTGCGCTTTC  GTGGGGTGGT  GCTGCTGTTG  1860
1861  CTGTTGGCCT  ACGTCCTCCT  CACCTACGTC  CTACTGCTCA  ACATGCTCAT  TGCCCTCATG  1920
1921  AGTGAGACTG  TCAACAGCGT  TGCCACTGAC  AGCTGGAGCA  TCTGGAAGTT  GCAGAAAGCC  1980
1981  ATCTCTGTCT  TGGAGATGGA  GAATGGTTAC  TGGTGGTGCA  GGAGGAAAAG  GCATCGCGCA  2040
2041  GGGAGGCTGC  TGAAAGTTGG  CACCAAAGGG  GATGGTATAC  CTGATGAGCG  CTGGTGCTTC  2100
2101  AGGGTGGAGG  AAGTAAACTG  GGCTGCATGG  GAGAAGACCC  TTCCCACCTT  ATCTGAGGAT  2160
2161  CCATCAGGGG  CAGGCATCAC  TGGTTATAAA  AAGAACCCAA  CCTCTAAACC  TGGGAAGAAC  2220
2221  AGTGCCTCAG  AGGAAGACCA  TCTGCCTCTT  CAGGTCCTCC  AGTCCCACTG  A  2271

▼ KEYWORD

ID
Family
ANK repeat
Calcium
Calcium channel
Calcium transport
Cell membrane
Complete proteome
Cytoplasm
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axon
Cellular Component
Axonal growth cone
Cellular Component
Cell body
Cellular Component
Cell surface
Cellular Component
Cytoplasm
Cellular Component
Endomembrane system
Cellular Component
Growth cone membrane
Cellular Component
Integral component of plasma membrane
Cellular Component
Lamellipodium
Cellular Component
Melanosome
Cellular Component
Plasma membrane
Molecular Function
Calcium channel activity
Molecular Function
Cation channel activity
Molecular Function
Identical protein binding
Molecular Function
Ion channel activity
Biological Process
Negative regulation of cell population proliferation
Biological Process
Positive regulation of axon extension
Biological Process
Positive regulation of calcium ion import
Biological Process
Positive regulation of cold-induced thermogenesis
Biological Process
Response to heat
Biological Process
Response to temperature stimulus

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a1053Rattus norvegicus92.240.01339
LLPS-Mea-a1006Mesocricetus auratus91.220.01348
LLPS-Ict-a1039Ictidomys tridecemlineatus85.750.01230
LLPS-Dio-a1015Dipodomys ordii84.260.01249
LLPS-Orc-a978Oryctolagus cuniculus83.220.01180
LLPS-Eqc-a1058Equus caballus83.030.01211
LLPS-Cas-a896Carlito syrichta82.880.01222
LLPS-Gog-a1048Gorilla gorilla82.830.0873
LLPS-Otg-a1039Otolemur garnettii82.250.01160
LLPS-Fec-a1055Felis catus82.220.01201
LLPS-Caf-a1038Canis familiaris81.720.01191
LLPS-Urm-a939Ursus maritimus81.410.01171
LLPS-Aim-a1004Ailuropoda melanoleuca81.370.01190
LLPS-Pat-a1064Pan troglodytes80.520.01197
LLPS-Maf-a1051Macaca fascicularis80.390.01212
LLPS-Pap-a1030Pan paniscus80.390.01196
LLPS-Aon-a1061Aotus nancymaae80.370.01201
LLPS-Hos-a1078Homo sapiens80.290.01193
LLPS-Paa-a1058Papio anubis80.260.01210
LLPS-Mam-a1041Macaca mulatta80.260.01210
LLPS-Poa-a1030Pongo abelii80.160.01191
LLPS-Mal-a1036Mandrillus leucophaeus80.130.01210
LLPS-Chs-a1048Chlorocebus sabaeus80.130.01208
LLPS-Caj-a1048Callithrix jacchus79.970.01211
LLPS-Loa-a1025Loxodonta africana79.950.01117
LLPS-Mup-a1014Mustela putorius furo79.920.01163
LLPS-Fud-a1009Fukomys damarensis79.840.01174
LLPS-Nol-a1027Nomascus leucogenys79.50.01193
LLPS-Cea-a1056Cercocebus atys78.170.01167
LLPS-Ova-a1015Ovis aries78.110.01120
LLPS-Cap-a1051Cavia porcellus77.450.01120
LLPS-Bot-a1056Bos taurus77.060.01108
LLPS-Myl-a978Myotis lucifugus72.510.0989
LLPS-Man-a1059Macaca nemestrina69.860.01006
LLPS-Mod-a1007Monodelphis domestica67.190.01014
LLPS-Ora-a868Ornithorhynchus anatinus63.710.0922
LLPS-Sah-a945Sarcophilus harrisii61.460.0870
LLPS-Pes-a897Pelodiscus sinensis58.570.0790
LLPS-Anp-a832Anas platyrhynchos57.70.0780
LLPS-Meg-a837Meleagris gallopavo57.520.0799
LLPS-Gaga-a946Gallus gallus55.70.0797
LLPS-Fia-a925Ficedula albicollis55.610.0772
LLPS-Anc-a951Anolis carolinensis51.087e-135415
LLPS-Sus-a1057Sus scrofa50.990.0658
LLPS-Rhb-a1047Rhinopithecus bieti50.680.0659
LLPS-Tag-a907Taeniopygia guttata50.220.0658