LLPS-Mum-a1033
Ndufa6

▼ OVERVIEW

Status: Reviewed
Protein Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Complex I-B14; CI-B14; NADH-ubiquinone oxidoreductase B14 subunit
Gene Name: Ndufa6
Ensembl Gene: ENSMUSG00000022450.6
Ensembl Protein: ENSMUSP00000155547.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client
PDB: 6G72 (A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V, W, X, Y, Z, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAAATGLRQ  AAAAAASTSV  KPIFSRDLNE  AKRRVRELYR  AWYREVPNTV  HLMQLDITVK  60
61    QGRDKVREMF  MKNAHVTDPR  VVDLLVIKGK  MELQETIKVW  KQRTHVMRFF  HETETPRPKD  120
121   FLSKFYMGHD  P  131
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGCCG  CGGCCACCGG  CCTGCGCCAA  GCTGCTGCTG  CGGCAGCCAG  TACCTCGGTG  60
61    AAGCCCATTT  TCAGTCGCGA  CCTGAACGAG  GCCAAGCGGA  GGGTGCGCGA  GCTCTACCGC  120
121   GCTTGGTATC  GGGAGGTGCC  GAACACCGTG  CACTTAATGC  AGCTGGATAT  CACGGTGAAA  180
181   CAAGGACGGG  ATAAAGTCCG  AGAAATGTTC  ATGAAGAATG  CCCATGTCAC  AGACCCCAGA  240
241   GTGGTTGATC  TGCTGGTCAT  TAAGGGAAAG  ATGGAGCTCC  AGGAAACCAT  CAAAGTATGG  300
301   AAGCAGCGGA  CACACGTTAT  GCGGTTTTTC  CATGAAACAG  AAACACCAAG  GCCAAAGGAT  360
361   TTCTTATCTA  AGTTCTATAT  GGGCCATGAC  CCATGA  396

▼ KEYWORD

ID
Family
3D-structure
Complete proteome
Direct protein sequencing
Electron transport
Membrane
Mitochondrion
Mitochondrion inner membrane
Reference proteome
Respiratory chain
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrial membrane
Cellular Component
Mitochondrial respiratory chain complex I
Cellular Component
Mitochondrion
Biological Process
Mitochondrial respiratory chain complex I assembly
Biological Process
Oxidation-reduction process
Biological Process
Response to oxidative stress

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mam-a1014Macaca mulatta95.713e-43145
LLPS-Ran-a1023Rattus norvegicus95.421e-87260
LLPS-Myl-a951Myotis lucifugus93.861e-74227
LLPS-Orc-a953Oryctolagus cuniculus93.021e-76232
LLPS-Caf-a1009Canis familiaris92.862e-73224
LLPS-Loa-a998Loxodonta africana92.682e-50163
LLPS-Ict-a1013Ictidomys tridecemlineatus92.195e-82245
LLPS-Otg-a1012Otolemur garnettii91.414e-82246
LLPS-Urm-a916Ursus maritimus91.412e-81244
LLPS-Aim-a980Ailuropoda melanoleuca91.411e-80242
LLPS-Ova-a990Ovis aries91.411e-81245
LLPS-Bot-a1028Bos taurus91.413e-82247
LLPS-Dio-a986Dipodomys ordii90.843e-78236
LLPS-Fec-a1026Felis catus90.622e-80241
LLPS-Gaga-a920Gallus gallus90.092e-70216
LLPS-Mal-a1006Mandrillus leucophaeus89.843e-79239
LLPS-Cea-a1026Cercocebus atys89.843e-79239
LLPS-Ere-a261Erinaceus europaeus89.849e-81242
LLPS-Mup-a989Mustela putorius furo89.844e-79239
LLPS-Maf-a1025Macaca fascicularis89.848e-79238
LLPS-Man-a1031Macaca nemestrina89.848e-79238
LLPS-Paa-a1030Papio anubis89.843e-79239
LLPS-Rhb-a1017Rhinopithecus bieti89.848e-80240
LLPS-Fud-a984Fukomys damarensis89.847e-80240
LLPS-Tut-a536Tursiops truncatus89.065e-79238
LLPS-Sus-a1029Sus scrofa89.061e-79239
LLPS-Chs-a1021Chlorocebus sabaeus89.068e-79238
LLPS-Cap-a1022Cavia porcellus89.066e-79238
LLPS-Eqc-a1028Equus caballus88.552e-81244
LLPS-Nol-a1000Nomascus leucogenys88.283e-78237
LLPS-Pat-a1034Pan troglodytes87.51e-77235
LLPS-Hos-a1048Homo sapiens87.51e-77235
LLPS-Caj-a1018Callithrix jacchus87.52e-77234
LLPS-Cas-a877Carlito syrichta87.52e-78237
LLPS-Pap-a1002Pan paniscus87.51e-77235
LLPS-Gog-a1019Gorilla gorilla86.724e-77233
LLPS-Poa-a1003Pongo abelii86.725e-77234
LLPS-Ora-a844Ornithorhynchus anatinus86.721e-76232
LLPS-Xet-a874Xenopus tropicalis86.616e-69212
LLPS-Mod-a982Monodelphis domestica86.268e-78234
LLPS-Tag-a880Taeniopygia guttata85.953e-74226
LLPS-Fia-a899Ficedula albicollis85.122e-73224
LLPS-Anp-a811Anas platyrhynchos82.932e-46153
LLPS-Orn-a882Oreochromis niloticus82.889e-64199
LLPS-Sah-a923Sarcophilus harrisii82.581e-75229
LLPS-Xim-a893Xiphophorus maculatus82.146e-64200
LLPS-Gaa-a862Gasterosteus aculeatus81.254e-63197
LLPS-Pof-a884Poecilia formosa81.255e-63197
LLPS-Anc-a924Anolis carolinensis81.21e-74226
LLPS-Lac-a889Latimeria chalumnae80.928e-73222
LLPS-Orl-a876Oryzias latipes80.364e-62195
LLPS-Asm-a884Astyanax mexicanus79.343e-70215
LLPS-Scm-a851Scophthalmus maximus78.818e-66204
LLPS-Scf-a862Scleropages formosus78.638e-71217
LLPS-Dar-a892Danio rerio74.621e-65204
LLPS-Ten-a842Tetraodon nigroviridis74.052e-66206
LLPS-Tar-a845Takifugu rubripes73.286e-66205
LLPS-Aon-a1033Aotus nancymaae72.819e-52167
LLPS-Leo-a881Lepisosteus oculatus62.022e-48160
LLPS-Cii-a247Ciona intestinalis55.365e-1367.0
LLPS-Drm-a245Drosophila melanogaster50.439e-38132