LLPS-Mum-a087
Coasy
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000107308.3 | ENSMUSP00000102929.3 |
| Ensembl | ENSMUST00000001806.9 | ENSMUSP00000001806.3 |
| UniProt | Q9DBL7, COASY_MOUSE, A2BFA8, Q3TVZ2, Q8K3Y4 | |
| GeneBank | AK166894, AK159912, AF521095, AK004878, AK159405, BC020046, BX255926 | BAE39099.1, AAH20046.1, AAM77669.1, BAB23636.2, BAE35475.1, BAE35057.1 |
| RefSeq | NM_001305982.1, XM_006534257.2, XM_017314771.1 | NP_001292911.1, XP_006534320.1, XP_017170260.1 |
| Entrez | 71743 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAVFRSGLLV LTTPLATLAA RLPPILTSAS RLVNHTLYVH LQPGMNLGGP AQPQASPVQA 60 61 TFEVLDFITH LYTGADLHRH LDVRILLTNI QTKSTFLPVL SSVQNLAHPP EVVLTDFQTL 120 121 DGSQYNPVKQ QLERYATSCY SCSPQLASVL LYPDYGTGEL PLEPPNALLP STIRPASPVA 180 181 RSPRQPVRGY HRGAVGGTFD RLHNAHKVLL SVACVLAQEQ LVVGVADKDL LKSKLLPELL 240 241 QPYAERVEHL TEFLVDIKPS LTFELVPLLD PYGPAGSDPT LEFLVVSEET YRGGMAVNRF 300 301 RLENGKEELA LYQIQLLKDQ SHNENEEDKV SSSSFRQRIL GNLLQPPNER PELPSGLYVL 360 361 GLTGISGSGK SSVAQRLKNL GAYIIDSDHL GHRAYAPGGP AYQPVVEAFG TDILHKDGTI 420 421 NRKVLGSRVF GNKKQMKILT DIVWPVIAKL AREEMDVAVA KGKTLCVIDA AMLLEAGWQS 480 481 MVHEVWTVVI PETEAVRRIV ERDGLSEAAA QSRLQSQMSG QQLVEQSNVV LSTLWESHVT 540 541 QSQVEKAWNL LQKRLPKAYQ TRN 563 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCGTGT TCCGCTCAGG CCTCCTGGTG CTGACAACGC CGCTGGCCAC CCTGGCCGCA 60 61 CGCCTGCCTC CCATCCTGAC CTCGGCGTCC CGCCTGGTGA ATCACACCCT CTATGTGCAC 120 121 CTGCAGCCGG GCATGAACCT GGGGGGACCC GCTCAGCCTC AGGCCAGCCC TGTGCAGGCC 180 181 ACATTTGAGG TTCTGGATTT CATCACGCAC CTCTACACTG GTGCCGACCT GCACAGGCAC 240 241 CTGGACGTCA GAATTCTACT GACCAATATC CAAACCAAGA GCACCTTTCT CCCTGTGCTG 300 301 TCCTCAGTCC AGAATCTGGC CCACCCTCCA GAAGTGGTTC TGACGGACTT CCAGACCCTG 360 361 GACGGGAGCC AGTACAACCC TGTTAAACAA CAGCTAGAGC GTTATGCCAC CAGTTGTTAC 420 421 AGCTGTTCTC CACAGCTGGC TTCTGTGTTG CTGTATCCGG ATTATGGAAC TGGAGAGCTG 480 481 CCTTTGGAGC CCCCGAATGC CCTCTTACCC TCTACTATAA GGCCGGCTTC CCCGGTTGCC 540 541 AGATCTCCAA GGCAGCCTGT GCGTGGCTAC CACCGTGGGG CCGTGGGTGG CACTTTTGAC 600 601 CGCTTGCACA ATGCCCACAA AGTGTTGCTC AGTGTTGCAT GTGTACTGGC CCAGGAGCAG 660 661 CTTGTGGTGG GAGTAGCTGA CAAAGATCTG TTGAAGAGCA AGTTGCTCCC CGAGCTGCTC 720 721 CAGCCGTATG CAGAGCGCGT GGAGCATCTG ACTGAGTTCC TGGTGGACAT CAAGCCCTCC 780 781 CTGACCTTTG AACTCGTCCC CCTGCTGGAT CCCTATGGGC CTGCTGGGTC CGACCCCACC 840 841 TTGGAGTTCC TGGTGGTCAG CGAGGAGACC TACCGTGGGG GGATGGCTGT CAACCGCTTC 900 901 CGCCTTGAGA ATGGCAAAGA AGAACTTGCT TTGTACCAGA TACAACTGCT GAAGGACCAG 960 961 AGTCACAATG AAAATGAGGA GGACAAGGTC AGCTCCTCCA GCTTTCGCCA GCGAATCCTG 1020 1021 GGAAACCTGC TTCAGCCTCC AAATGAGAGG CCGGAGCTCC CGTCAGGTCT CTATGTGCTC 1080 1081 GGGCTCACAG GCATCAGTGG CTCTGGGAAA AGCTCGGTAG CTCAGCGGCT GAAGAACTTG 1140 1141 GGAGCATACA TCATCGACAG CGACCATCTG GGCCATCGGG CCTATGCTCC TGGGGGTCCT 1200 1201 GCCTACCAGC CTGTGGTGGA GGCCTTTGGA ACAGATATTC TCCATAAAGA TGGCACCATC 1260 1261 AATAGGAAGG TCCTGGGCAG CCGGGTGTTT GGGAACAAGA AGCAGATGAA GATCCTCACA 1320 1321 GATATTGTGT GGCCAGTTAT CGCAAAGCTG GCCCGGGAGG AGATGGATGT GGCTGTGGCT 1380 1381 AAGGGAAAAA CTCTGTGTGT AATCGATGCT GCTATGCTGC TTGAAGCTGG CTGGCAGAGT 1440 1441 ATGGTACACG AGGTGTGGAC CGTCGTCATC CCTGAGACTG AGGCTGTTCG ACGCATTGTT 1500 1501 GAGAGGGATG GACTAAGTGA GGCAGCCGCT CAGAGCCGGC TGCAGAGCCA GATGAGCGGC 1560 1561 CAGCAGCTGG TAGAGCAGAG CAACGTGGTT CTGAGCACCT TGTGGGAGTC ACATGTCACA 1620 1621 CAGAGCCAGG TGGAAAAGGC GTGGAATCTT CTACAGAAGC GCCTCCCTAA GGCTTACCAG 1680 1681 ACCAGGAACT GA 1692 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Mitochondrial matrix | |
Cellular Component | Nucleoplasm | |
Molecular Function | ATP binding | |
Molecular Function | Dephospho-CoA kinase activity | |
Molecular Function | Pantetheine-phosphate adenylyltransferase activity | |
Biological Process | Coenzyme A biosynthetic process |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-a087 | Rattus norvegicus | 95.38 | 0.0 | 1103 |
| LLPS-Mea-a080 | Mesocricetus auratus | 92.54 | 0.0 | 1073 |
| LLPS-Caf-a084 | Canis familiaris | 89.61 | 0.0 | 1025 |
| LLPS-Eqc-a089 | Equus caballus | 89.07 | 0.0 | 1021 |
| LLPS-Orc-a083 | Oryctolagus cuniculus | 88.77 | 0.0 | 1016 |
| LLPS-Urm-a079 | Ursus maritimus | 88.37 | 0.0 | 1014 |
| LLPS-Aim-a083 | Ailuropoda melanoleuca | 88.19 | 0.0 | 1005 |
| LLPS-Poa-a083 | Pongo abelii | 88.06 | 0.0 | 1019 |
| LLPS-Sus-a087 | Sus scrofa | 87.63 | 0.0 | 1003 |
| LLPS-Pat-a083 | Pan troglodytes | 87.52 | 0.0 | 1013 |
| LLPS-Cea-a087 | Cercocebus atys | 87.52 | 0.0 | 1016 |
| LLPS-Gog-a085 | Gorilla gorilla | 87.52 | 0.0 | 1011 |
| LLPS-Maf-a085 | Macaca fascicularis | 87.52 | 0.0 | 1016 |
| LLPS-Pap-a081 | Pan paniscus | 87.52 | 0.0 | 1013 |
| LLPS-Mam-a084 | Macaca mulatta | 87.52 | 0.0 | 1016 |
| LLPS-Caj-a083 | Callithrix jacchus | 87.41 | 0.0 | 1014 |
| LLPS-Mal-a085 | Mandrillus leucophaeus | 87.34 | 0.0 | 1014 |
| LLPS-Hos-a084 | Homo sapiens | 87.34 | 0.0 | 1007 |
| LLPS-Man-a085 | Macaca nemestrina | 87.34 | 0.0 | 1016 |
| LLPS-Paa-a084 | Papio anubis | 87.34 | 0.0 | 1013 |
| LLPS-Fec-a087 | Felis catus | 87.23 | 0.0 | 995 |
| LLPS-Ict-a086 | Ictidomys tridecemlineatus | 87.23 | 0.0 | 1011 |
| LLPS-Aon-a086 | Aotus nancymaae | 87.23 | 0.0 | 1009 |
| LLPS-Cas-a078 | Carlito syrichta | 87.0 | 0.0 | 934 |
| LLPS-Chs-a084 | Chlorocebus sabaeus | 86.99 | 0.0 | 1008 |
| LLPS-Otg-a085 | Otolemur garnettii | 86.45 | 0.0 | 998 |
| LLPS-Bot-a088 | Bos taurus | 86.4 | 0.0 | 965 |
| LLPS-Tut-a045 | Tursiops truncatus | 85.97 | 0.0 | 997 |
| LLPS-Ova-a087 | Ovis aries | 85.48 | 0.0 | 979 |
| LLPS-Dio-a082 | Dipodomys ordii | 85.28 | 0.0 | 970 |
| LLPS-Rhb-a085 | Rhinopithecus bieti | 84.97 | 0.0 | 992 |
| LLPS-Nol-a087 | Nomascus leucogenys | 84.85 | 0.0 | 965 |
| LLPS-Myl-a084 | Myotis lucifugus | 84.77 | 0.0 | 962 |
| LLPS-Loa-a084 | Loxodonta africana | 83.87 | 0.0 | 966 |
| LLPS-Cap-a086 | Cavia porcellus | 81.49 | 0.0 | 925 |
| LLPS-Sah-a083 | Sarcophilus harrisii | 71.61 | 0.0 | 816 |
| LLPS-Tag-a080 | Taeniopygia guttata | 67.24 | 2e-107 | 331 |
| LLPS-Ora-a075 | Ornithorhynchus anatinus | 66.67 | 1e-28 | 116 |
| LLPS-Anp-a079 | Anas platyrhynchos | 63.22 | 9e-29 | 116 |
| LLPS-Pes-a077 | Pelodiscus sinensis | 60.21 | 0.0 | 588 |
| LLPS-Xet-a073 | Xenopus tropicalis | 59.28 | 0.0 | 669 |
| LLPS-Anc-a081 | Anolis carolinensis | 58.71 | 0.0 | 620 |
| LLPS-Fia-a080 | Ficedula albicollis | 58.29 | 6e-166 | 487 |
| LLPS-Meg-a075 | Meleagris gallopavo | 57.2 | 5e-86 | 275 |
| LLPS-Lac-a078 | Latimeria chalumnae | 55.76 | 0.0 | 601 |
| LLPS-Scf-a070 | Scleropages formosus | 53.56 | 0.0 | 540 |
| LLPS-Tar-a073 | Takifugu rubripes | 52.32 | 0.0 | 530 |
| LLPS-Ten-a073 | Tetraodon nigroviridis | 51.77 | 2e-177 | 522 |
| LLPS-Icp-a078 | Ictalurus punctatus | 51.53 | 9e-179 | 525 |
| LLPS-Pof-a076 | Poecilia formosa | 51.42 | 2e-175 | 517 |
| LLPS-Asm-a073 | Astyanax mexicanus | 51.37 | 3e-154 | 461 |
| LLPS-Xim-a075 | Xiphophorus maculatus | 51.33 | 3e-175 | 516 |
| LLPS-Gaga-a080 | Gallus gallus | 51.19 | 1e-160 | 478 |
| LLPS-Orl-a078 | Oryzias latipes | 50.99 | 9e-180 | 528 |
| LLPS-Scm-a070 | Scophthalmus maximus | 50.89 | 5e-176 | 518 |
| LLPS-Orn-a076 | Oreochromis niloticus | 50.71 | 0.0 | 547 |
| LLPS-Leo-a070 | Lepisosteus oculatus | 50.61 | 2e-119 | 367 |
| LLPS-Gaa-a943 | Gasterosteus aculeatus | 50.53 | 1e-168 | 500 |
| LLPS-Dar-a073 | Danio rerio | 50.0 | 3e-178 | 524 |