LLPS-Mum-a067
Lzts1

▼ OVERVIEW

Status: Reviewed
Protein Name: Leucine zipper putative tumor suppressor 1; F37/Esophageal cancer-related gene-coding leucine-zipper motif; Fez1
Gene Name: Lzts1, Fez1
Ensembl Gene: ENSMUSG00000036306.13
Ensembl Protein: ENSMUSP00000039397.3
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGSVSSLISG  HSFHSKHCRA  SQYKLRKSSH  LKKLNRYSDG  LLRFGFSQDS  GRGKSSSKMG  60
61    KSEDFFYIKV  SQKARGSHRP  DYTALSSGDI  GGQTGVDFDP  ATPPKLMPFS  NQLEMSSDKG  120
121   AVRPTAFKPV  LPRSGAILHS  SPESTSHQLH  PMPPDKPKEQ  ELKPGLCSGA  LSDSGRNSMS  180
181   SLPTHSTTSS  YQLDPLVTPV  GPTSRFGGSA  HNITQGIILQ  DSNMMSLKAL  SFSDGGSKLA  240
241   HPGKADKGAS  CVRSPLSTDE  CTIQELEQKL  LQRETALQKL  QRSFDEKEFA  SGQTFEERPR  300
301   RTRDELECLE  PKSKLKPPSQ  KSQRTQQVLQ  LQVLQLQQEK  RQLRQELESL  MKEQDLLETK  360
361   LRSYEREKTN  FAPALEETQW  EVCQKSGEIS  LLKQQLKESQ  LEVNTKASEI  LSLKAQLKDT  420
421   RGKLDGMELK  TQDLESALRT  KGLELEVCEN  ELQRKKNEAE  LLREKVNLLE  QELMELRAQA  480
481   ALHPAPLGPP  GVGLTFSEDI  PALQRELDRL  RAELKEERQG  HDQMSSGFQH  ERLVWKEEKE  540
541   KVIQYQRQLQ  QSYLAMYQRN  QRLEKALQQL  ARGDGPGEPF  EIDLEGADIP  YEDIIATEI  599
Nucleotide CDS Sequence (FASTA)
1     ATGGGCAGTG  TGAGCAGCCT  TATCTCAGGC  CACAGTTTCC  ACAGCAAGCA  CTGCCGTGCT  60
61    TCACAGTACA  AGCTGCGCAA  GTCCTCCCAC  CTCAAGAAGC  TCAATCGATA  CTCAGATGGG  120
121   CTGCTGAGGT  TTGGCTTCTC  CCAGGACTCA  GGCCGTGGAA  AGTCAAGTTC  CAAAATGGGA  180
181   AAAAGCGAAG  ACTTCTTCTA  CATCAAAGTC  AGCCAGAAGG  CCCGAGGCTC  CCATCGCCCA  240
241   GACTACACAG  CCCTGTCCAG  TGGGGACATA  GGGGGTCAGA  CCGGAGTAGA  TTTTGATCCA  300
301   GCCACCCCAC  CAAAGCTCAT  GCCCTTCTCC  AATCAACTGG  AAATGAGTTC  AGACAAGGGG  360
361   GCAGTAAGGC  CCACTGCCTT  CAAGCCTGTG  CTGCCACGGT  CAGGAGCCAT  CCTCCACTCT  420
421   TCACCTGAGA  GTACCAGCCA  CCAACTTCAT  CCCATGCCTC  CAGATAAGCC  CAAGGAGCAG  480
481   GAGCTGAAGC  CAGGCCTGTG  CTCCGGGGCA  CTGTCTGACT  CAGGCCGGAA  CTCCATGTCT  540
541   AGCCTGCCCA  CGCATAGCAC  CACCAGCAGC  TACCAGCTGG  ATCCTCTGGT  CACCCCCGTG  600
601   GGGCCTACCA  GCCGTTTTGG  GGGTTCAGCT  CACAACATCA  CACAAGGCAT  CATCCTTCAG  660
661   GACAGTAATA  TGATGAGCCT  GAAGGCTCTG  TCGTTCTCTG  ATGGCGGCAG  CAAGCTGGCT  720
721   CACCCAGGCA  AGGCAGATAA  GGGCGCCTCC  TGTGTGCGTT  CCCCACTCTC  CACGGATGAG  780
781   TGCACCATCC  AGGAGCTGGA  GCAGAAGCTG  CTGCAGAGGG  AGACTGCACT  ACAGAAGCTA  840
841   CAGCGCAGTT  TCGATGAGAA  GGAGTTTGCC  TCTGGCCAAA  CCTTTGAGGA  GCGGCCACGG  900
901   CGGACTAGAG  ACGAACTGGA  GTGCCTGGAG  CCTAAGAGCA  AGCTGAAGCC  ACCCTCACAG  960
961   AAGAGCCAGC  GCACACAGCA  GGTGCTCCAG  CTGCAGGTGT  TGCAGTTGCA  GCAGGAGAAA  1020
1021  CGGCAGCTAA  GGCAGGAGCT  AGAGAGCCTA  ATGAAGGAGC  AGGACCTGCT  GGAGACCAAG  1080
1081  CTGAGGTCCT  ACGAGCGGGA  GAAAACCAAC  TTCGCCCCTG  CACTGGAGGA  GACCCAATGG  1140
1141  GAGGTGTGCC  AGAAGTCAGG  TGAGATCTCT  CTTTTGAAGC  AACAGCTCAA  AGAGTCCCAA  1200
1201  TTAGAGGTGA  ACACTAAGGC  CAGCGAGATC  CTCAGTCTGA  AGGCACAGCT  GAAGGATACC  1260
1261  CGGGGCAAGC  TGGATGGAAT  GGAGCTGAAG  ACACAGGACT  TGGAGAGTGC  CCTGCGCACC  1320
1321  AAAGGGCTGG  AGCTGGAGGT  CTGTGAGAAC  GAACTGCAGC  GCAAGAAGAA  TGAGGCAGAA  1380
1381  CTGCTGAGAG  AGAAGGTGAA  CCTTCTAGAA  CAGGAGTTGA  TGGAGCTACG  GGCCCAGGCT  1440
1441  GCTCTGCATC  CGGCACCCCT  GGGGCCTCCA  GGGGTTGGGC  TCACTTTCTC  AGAGGACATC  1500
1501  CCTGCTCTGC  AGCGGGAGCT  GGATCGGCTG  CGGGCCGAGC  TGAAGGAGGA  GAGGCAAGGC  1560
1561  CATGACCAGA  TGTCCTCGGG  ATTCCAGCAT  GAGCGGTTGG  TGTGGAAAGA  AGAGAAGGAG  1620
1621  AAAGTGATCC  AGTACCAAAG  GCAGCTGCAG  CAGAGCTACT  TGGCCATGTA  CCAGCGCAAC  1680
1681  CAGCGTCTAG  AGAAGGCCCT  GCAGCAGCTG  GCCCGTGGGG  ATGGTCCAGG  GGAACCCTTT  1740
1741  GAAATTGACC  TGGAGGGAGC  TGACATCCCC  TACGAGGACA  TCATAGCCAC  TGAGATCTGA  1800

▼ KEYWORD

ID
Family
Cell cycle
Cell junction
Cell membrane
Cell projection
Coiled coil
Complete proteome
Cytoplasm
Lipoprotein
Membrane
Myristate
Postsynaptic cell membrane
Reference proteome
Synapse
Tumor suppressor

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Apical plasma membrane
Cellular Component
Cell body
Cellular Component
Cell junction
Cellular Component
Cytoplasm
Cellular Component
Dendritic shaft
Cellular Component
Dendritic spine
Cellular Component
Neuron projection
Cellular Component
Postsynaptic density
Cellular Component
Postsynaptic membrane
Cellular Component
Synapse
Molecular Function
Microtubule binding
Biological Process
Mitotic cell cycle phase transition
Biological Process
Negative regulation of macroautophagy
Biological Process
Regulation of dendrite morphogenesis
Biological Process
Regulation of synaptic plasticity

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a068Rattus norvegicus96.670.01178
LLPS-Mea-a063Mesocricetus auratus94.340.01100
LLPS-Dio-a064Dipodomys ordii91.230.01064
LLPS-Ict-a066Ictidomys tridecemlineatus89.620.01030
LLPS-Chs-a066Chlorocebus sabaeus89.520.01048
LLPS-Pap-a063Pan paniscus89.520.01050
LLPS-Rhb-a065Rhinopithecus bieti89.520.01048
LLPS-Pat-a064Pan troglodytes89.350.01048
LLPS-Mal-a065Mandrillus leucophaeus89.350.01045
LLPS-Hos-a065Homo sapiens89.350.01049
LLPS-Gog-a065Gorilla gorilla89.350.01048
LLPS-Paa-a065Papio anubis89.350.01045
LLPS-Man-a066Macaca nemestrina89.350.01045
LLPS-Maf-a065Macaca fascicularis89.180.01042
LLPS-Caj-a064Callithrix jacchus89.180.01041
LLPS-Mam-a065Macaca mulatta89.180.01042
LLPS-Caf-a064Canis familiaris89.090.01021
LLPS-Cea-a067Cercocebus atys89.020.01040
LLPS-Aon-a067Aotus nancymaae89.020.01037
LLPS-Aim-a064Ailuropoda melanoleuca88.610.01019
LLPS-Cap-a066Cavia porcellus88.610.01000
LLPS-Sus-a067Sus scrofa88.060.01022
LLPS-Fec-a068Felis catus87.950.01013
LLPS-Mup-a066Mustela putorius furo87.790.01011
LLPS-Nol-a067Nomascus leucogenys87.350.01016
LLPS-Myl-a064Myotis lucifugus87.290.01023
LLPS-Bot-a069Bos taurus86.90.01006
LLPS-Loa-a065Loxodonta africana86.860.0999
LLPS-Otg-a065Otolemur garnettii86.480.0989
LLPS-Eqc-a069Equus caballus86.330.0993
LLPS-Fud-a066Fukomys damarensis86.330.01002
LLPS-Poa-a064Pongo abelii81.90.0902
LLPS-Orc-a064Oryctolagus cuniculus81.640.0939
LLPS-Mod-a062Monodelphis domestica79.070.0883
LLPS-Ora-a057Ornithorhynchus anatinus77.320.0880
LLPS-Anp-a057Anas platyrhynchos72.080.0855
LLPS-Gaga-a061Gallus gallus72.010.0816
LLPS-Meg-a054Meleagris gallopavo71.520.0812
LLPS-Fia-a061Ficedula albicollis70.360.0810
LLPS-Tag-a060Taeniopygia guttata69.572e-141422
LLPS-Anc-a061Anolis carolinensis66.940.0785
LLPS-Lac-a059Latimeria chalumnae58.223e-175516
LLPS-Leo-a052Lepisosteus oculatus50.07e-172512