LLPS-Mum-a020
Gas7

▼ OVERVIEW

Status: Reviewed
Protein Name: Growth arrest-specific protein 7
Gene Name: Gas7
Ensembl Gene: ENSMUSG00000033066.15
Ensembl Protein: ENSMUSP00000038420.5
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKPGMVPPPP  GEESQTVILP  PGWHSYLSPQ  GRRYYVNTTT  NETTWERPSS  SPGISASPGP  60
61    HRSSLPTTVN  GYHASGTPAH  PPETAHMSLR  KSTGDSQNLG  SSSPGRKQSK  ENTITINCVT  120
121   FPHPDTMPEQ  QLLKPTEWSY  CDYFWADKKD  PQGNGTVAGF  ELLLQKQLKG  KQMQKEMSEF  180
181   IRERIKIEEE  YAKNLAKLSQ  NSLAAQEEGS  LGEAWAQVKK  SLADEAEVHL  KFSAKLHSEV  240
241   EKPLMNFREN  FKKDMKKCDH  HIADLRKQLA  SRYASVEKAR  KALTERQKDL  EMKTQQLEIK  300
301   LSNKTEEDIK  KARRKSTQAG  DDLMRCVDLY  NQAQSKWFEE  MVTTTLELER  LEVERVEMIR  360
361   QHLCQYTQLR  HETDMFNQST  VEPVDQLLRK  VDPAKDRELW  VREHKTGNIR  PVDMEI  416
Nucleotide CDS Sequence (FASTA)
1     ATGGTCCCCC  CTCCGCCAGG  AGAGGAGAGC  CAGACGGTCA  TCCTTCCACC  CGGCTGGCAC  60
61    AGCTACTTGT  CTCCTCAGGG  CCGCCGTTAC  TATGTCAACA  CGACTACCAA  TGAGACCACC  120
121   TGGGAACGTC  CCAGCAGTTC  TCCTGGGATT  TCAGCCAGCC  CTGGCCCTCA  CAGGAGCTCT  180
181   TTGCCTACAA  CAGTGAATGG  ATACCACGCA  TCAGGGACCC  CGGCGCACCC  TCCAGAGACT  240
241   GCCCACATGA  GTCTCCGAAA  ATCCACCGGT  GATTCCCAGA  ACCTGGGATC  CTCATCGCCA  300
301   GGCAGGAAAC  AGAGCAAGGA  AAACACCATC  ACCATCAACT  GTGTGACATT  CCCTCACCCG  360
361   GACACGATGC  CTGAGCAACA  GCTGCTCAAG  CCCACCGAGT  GGAGCTACTG  TGACTACTTT  420
421   TGGGCGGACA  AGAAGGACCC  ACAAGGCAAT  GGCACGGTGG  CTGGCTTTGA  ACTGCTGCTG  480
481   CAGAAGCAAC  TGAAAGGCAA  GCAGATGCAG  AAGGAGATGT  CCGAGTTCAT  CCGGGAAAGG  540
541   ATAAAGATTG  AAGAAGAATA  TGCAAAGAAC  CTGGCTAAGC  TCTCTCAGAA  CTCCTTGGCT  600
601   GCCCAGGAGG  AAGGCTCCTT  GGGAGAGGCA  TGGGCCCAAG  TAAAGAAGAG  CCTGGCAGAT  660
661   GAGGCTGAAG  TTCATCTCAA  GTTCTCTGCC  AAGCTCCACA  GCGAGGTGGA  GAAACCCCTG  720
721   ATGAACTTCA  GAGAGAACTT  CAAGAAAGAC  ATGAAAAAGT  GCGACCACCA  CATCGCTGAC  780
781   CTCCGTAAGC  AGCTGGCAAG  CCGCTATGCC  TCAGTGGAGA  AGGCCCGCAA  AGCCCTCACA  840
841   GAGCGGCAGA  AAGACCTGGA  GATGAAGACC  CAGCAGCTGG  AGATCAAGTT  GAGCAACAAG  900
901   ACCGAGGAGG  ACATCAAGAA  GGCACGGAGG  AAGTCCACTC  AGGCCGGAGA  TGACCTCATG  960
961   CGCTGTGTGG  ACCTCTACAA  CCAGGCCCAG  TCCAAGTGGT  TTGAAGAGAT  GGTGACGACC  1020
1021  ACACTGGAAC  TGGAGCGGCT  GGAGGTGGAG  AGGGTGGAAA  TGATCCGACA  ACATCTGTGC  1080
1081  CAGTACACAC  AGCTGCGGCA  CGAGACGGAC  ATGTTCAACC  AAAGCACAGT  CGAGCCTGTG  1140
1141  GACCAACTGC  TGCGAAAAGT  GGACCCAGCC  AAAGACAGAG  AGCTATGGGT  CAGAGAGCAC  1200
1201  AAAACAGGCA  ACATCCGCCC  AGTGGACATG  GAGATCTAG  1239

▼ KEYWORD

ID
Family
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Neurogenesis
Phosphoprotein
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Actin filament
Cellular Component
Cytoplasm
Cellular Component
Cytoskeleton
Cellular Component
Plasma membrane
Cellular Component
Ruffle
Molecular Function
Actin filament binding
Molecular Function
Cytoskeletal protein binding
Biological Process
Actin filament bundle assembly
Biological Process
Actin filament polymerization
Biological Process
Neuron differentiation
Biological Process
Neuron projection morphogenesis
Biological Process
Regulation of cell shape

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mea-a018Mesocricetus auratus99.280.0861
LLPS-Ran-a020Rattus norvegicus98.80.0855
LLPS-Cap-a019Cavia porcellus98.550.0858
LLPS-Fud-a020Fukomys damarensis98.310.0856
LLPS-Ict-a020Ictidomys tridecemlineatus98.080.0855
LLPS-Aim-a019Ailuropoda melanoleuca97.70.0622
LLPS-Pat-1402Pan troglodytes97.590.0844
LLPS-Hos-4325Homo sapiens97.590.0844
LLPS-Gog-1402Gorilla gorilla97.590.0847
LLPS-Pap-1367Pan paniscus97.590.0844
LLPS-Nol-1817Nomascus leucogenys97.590.0844
LLPS-Caf-0110Canis familiaris97.570.0844
LLPS-Chs-1533Chlorocebus sabaeus97.360.0849
LLPS-Mal-2823Mandrillus leucophaeus97.350.0847
LLPS-Poa-3800Pongo abelii97.350.0843
LLPS-Paa-1365Papio anubis97.350.0844
LLPS-Otg-1509Otolemur garnettii97.330.0843
LLPS-Orc-3429Oryctolagus cuniculus97.120.0849
LLPS-Rhb-2939Rhinopithecus bieti97.110.0842
LLPS-Caj-1497Callithrix jacchus96.870.0840
LLPS-Aon-2910Aotus nancymaae96.870.0843
LLPS-Maf-3961Macaca fascicularis96.870.0838
LLPS-Man-1883Macaca nemestrina96.870.0838
LLPS-Bot-a022Bos taurus96.870.0839
LLPS-Cea-a018Cercocebus atys96.840.0770
LLPS-Ova-a022Ovis aries96.390.0837
LLPS-Sus-a020Sus scrofa95.90.0835
LLPS-Mup-a020Mustela putorius furo95.835e-43154
LLPS-Myl-1218Myotis lucifugus95.670.0825
LLPS-Fec-a021Felis catus95.420.0807
LLPS-Loa-2031Loxodonta africana94.940.0804
LLPS-Eqc-a022Equus caballus92.090.0657
LLPS-Mod-a017Monodelphis domestica91.50.0784
LLPS-Mam-a019Macaca mulatta89.340.0757
LLPS-Lac-a017Latimeria chalumnae87.923e-119354
LLPS-Asm-a017Astyanax mexicanus86.821e-72232
LLPS-Sah-1220Sarcophilus harrisii86.650.0734
LLPS-Gaga-a017Gallus gallus83.860.0724
LLPS-Tag-a018Taeniopygia guttata83.370.0718
LLPS-Fia-a021Ficedula albicollis82.890.0721
LLPS-Anc-3963Anolis carolinensis82.450.0712
LLPS-Tar-a017Takifugu rubripes82.350.0547
LLPS-Pes-a018Pelodiscus sinensis82.00.0675
LLPS-Dar-a020Danio rerio81.480.0541
LLPS-Anp-2085Anas platyrhynchos80.910.0699
LLPS-Leo-a015Lepisosteus oculatus80.480.0692
LLPS-Scm-0015Scophthalmus maximus79.70.0656
LLPS-Orn-4087Oreochromis niloticus79.250.0655
LLPS-Urm-a020Ursus maritimus78.180.0640
LLPS-Scf-2570Scleropages formosus77.590.0669
LLPS-Xim-3504Xiphophorus maculatus77.190.0643
LLPS-Pof-1788Poecilia formosa76.940.0640
LLPS-Gaa-0265Gasterosteus aculeatus76.190.0638
LLPS-Ten-a017Tetraodon nigroviridis75.940.0628
LLPS-Orl-a018Oryzias latipes75.190.0612
LLPS-Icp-3674Ictalurus punctatus73.460.0617
LLPS-Dio-a020Dipodomys ordii71.780.0538