LLPS-Mum-a007
Camkk1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Calcium/calmodulin-dependent protein kinase kinase 1
Gene Name: Camkk1, Camkk
Ensembl Gene: ENSMUSG00000020785.17
Ensembl Protein: ENSMUSP00000123441.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MESGPAVCCQ  DPRAELVDRV  AAINVAHLEE  ADEGPEPARN  GVDPPPRARA  ASVIPGSASR  60
61    PTPVRPSLSA  RKFSLQERPA  GSCLGAQVGP  YSTGPASHIS  PRSWRRPTIE  SHRVAISDTE  120
121   DCVQLNQYKL  QSEIGKGAYG  VVRLAYNESE  DRHYAMKVLS  KKKLLKQYGF  PRRPPPRGSQ  180
181   ATQGGPAKQL  LPLERVYQEI  AILKKLDHVN  VVKLIEVLDD  PAEDNLYLVF  DLLRKGPVME  240
241   VPCDKPFPEE  QARLYLRDII  LGLEYLHCQK  IVHRDIKPSN  LLLGDDGHVK  IADFGVSNQF  300
301   EGNDAQLSST  AGTPAFMAPE  AISDSGQSFS  GKALDVWATG  VTLYCFVYGK  CPFIDDYILT  360
361   LHRKIKNEAV  VFPEEPEVSE  DLKDLILRML  DKNPETRIGV  SDIKLHPWVT  KHGEEPLPSE  420
421   EEHCSVVEVT  EEEVKNSVRL  IPSWTTVILV  KSMLRKRSFG  NPFEPQARRE  ERSMSAPGSL  480
481   LMKEGCGEGC  KSPELPGVQE  DEAAS  505
Nucleotide CDS Sequence (FASTA)
1     ATGGAGAGTG  GCCCAGCCGT  CTGCTGCCAA  GACCCTCGTG  CAGAGCTGGT  GGATCGGGTG  60
61    GCGGCCATCA  ATGTGGCCCA  CTTGGAAGAA  GCAGATGAGG  GTCCAGAGCC  TGCCAGGAAT  120
121   GGTGTGGATC  CTCCACCCCG  GGCCAGAGCT  GCCTCCGTGA  TCCCTGGCAG  TGCTTCAAGA  180
181   CCCACTCCAG  TGCGCCCCAG  CCTCTCGGCT  AGAAAGTTCT  CCCTGCAGGA  ACGACCAGCT  240
241   GGAAGCTGTC  TGGGGGCTCA  AGTTGGGCCT  TACTCTACAG  GACCTGCCAG  TCACATCTCT  300
301   CCTCGGTCCT  GGCGGAGACC  CACCATCGAG  TCCCACCGTG  TGGCCATCTC  AGACACAGAG  360
361   GACTGTGTGC  AACTGAACCA  GTACAAGCTG  CAGAGTGAGA  TTGGCAAGGG  TGCCTATGGT  420
421   GTGGTGAGGC  TGGCCTACAA  CGAAAGTGAA  GACAGACACT  ATGCAATGAA  AGTTCTTTCC  480
481   AAAAAGAAGT  TACTGAAGCA  GTATGGCTTT  CCTCGCCGTC  CTCCCCCCAG  AGGGTCCCAA  540
541   GCTACCCAGG  GAGGGCCAGC  CAAACAGCTG  CTGCCCCTGG  AGCGTGTGTA  TCAGGAGATT  600
601   GCCATTCTAA  AGAAGCTGGA  CCACGTGAAT  GTAGTCAAAT  TGATCGAGGT  CCTGGATGAT  660
661   CCCGCTGAAG  ACAACCTCTA  TTTGGTGTTC  GACCTCCTGA  GAAAAGGGCC  AGTCATGGAA  720
721   GTGCCCTGCG  ACAAGCCCTT  CCCAGAGGAG  CAAGCTCGCC  TCTACCTCCG  GGACATCATC  780
781   CTGGGCCTCG  AGTACTTGCA  CTGCCAGAAG  ATTGTCCACA  GGGACATCAA  GCCATCTAAC  840
841   CTACTCCTTG  GGGACGACGG  GCATGTGAAG  ATCGCCGACT  TTGGTGTCAG  TAACCAGTTT  900
901   GAGGGGAATG  ATGCTCAGCT  GTCCAGTACG  GCAGGGACCC  CGGCATTCAT  GGCCCCGGAG  960
961   GCCATTTCTG  ATTCCGGCCA  GAGCTTCAGT  GGGAAGGCCT  TGGATGTATG  GGCCACTGGG  1020
1021  GTCACGCTAT  ATTGCTTTGT  CTATGGGAAG  TGCCCGTTCA  TTGATGACTA  CATCCTGACC  1080
1081  CTGCACCGTA  AGATCAAGAA  TGAGGCCGTG  GTGTTCCCTG  AGGAGCCAGA  GGTCAGCGAG  1140
1141  GACCTCAAAG  ACCTGATCCT  GAGGATGCTA  GACAAGAATC  CTGAGACAAG  AATTGGGGTG  1200
1201  TCAGATATCA  AGTTACACCC  TTGGGTGACC  AAGCATGGAG  AGGAGCCCCT  CCCTTCAGAG  1260
1261  GAGGAGCACT  GCAGTGTGGT  GGAGGTGACC  GAGGAAGAGG  TGAAGAACTC  AGTCAGGCTC  1320
1321  ATCCCCAGCT  GGACCACTGT  GATCCTGGTC  AAGTCTATGC  TGAGAAAGCG  TTCCTTTGGA  1380
1381  AACCCATTCG  AGCCCCAAGC  ACGCAGGGAA  GAAAGATCCA  TGTCTGCACC  AGGAAGCTTA  1440
1441  CTGATGAAAG  AAGGATGCGG  AGAAGGGTGC  AAAAGCCCAG  AGCTTCCCGG  AGTCCAGGAG  1500
1501  GATGAGGCTG  CGTCCTGA  1518

▼ KEYWORD

ID
Family
ATP-binding
Calmodulin-binding
Complete proteome
Cytoplasm
Direct protein sequencing
Kinase
Methylation
Nucleotide-binding
Nucleus
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Nucleoplasm
Molecular Function
ATP binding
Molecular Function
Calmodulin binding
Molecular Function
Calmodulin-dependent protein kinase activity
Molecular Function
Protein serine/threonine kinase activity
Biological Process
Activation of protein kinase activity
Biological Process
Intracellular signal transduction
Biological Process
Positive regulation of protein kinase activity

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ova-a010Ovis aries95.950.0684
LLPS-Ran-a007Rattus norvegicus95.640.0931
LLPS-Ict-a007Ictidomys tridecemlineatus94.060.0948
LLPS-Fec-a008Felis catus93.860.0928
LLPS-Fud-a007Fukomys damarensis93.660.0936
LLPS-Pat-a005Pan troglodytes93.470.0924
LLPS-Cea-a005Cercocebus atys93.470.0924
LLPS-Hos-a006Homo sapiens93.470.0925
LLPS-Aon-a007Aotus nancymaae93.470.0936
LLPS-Chs-a008Chlorocebus sabaeus93.470.0927
LLPS-Maf-a006Macaca fascicularis93.470.0926
LLPS-Mam-a006Macaca mulatta93.470.0925
LLPS-Mal-a005Mandrillus leucophaeus93.270.0924
LLPS-Gog-a005Gorilla gorilla93.270.0923
LLPS-Pap-a005Pan paniscus93.270.0923
LLPS-Paa-a006Papio anubis93.270.0923
LLPS-Sus-a007Sus scrofa92.870.0924
LLPS-Eqc-a009Equus caballus92.870.0942
LLPS-Caf-a007Canis familiaris92.670.0915
LLPS-Orc-a007Oryctolagus cuniculus92.670.0920
LLPS-Cap-a006Cavia porcellus92.670.0922
LLPS-Mup-a007Mustela putorius furo92.480.0915
LLPS-Myl-a009Myotis lucifugus92.480.0917
LLPS-Caj-a006Callithrix jacchus92.390.0815
LLPS-Urm-a008Ursus maritimus91.880.0900
LLPS-Bot-a009Bos taurus91.880.0927
LLPS-Loa-a008Loxodonta africana91.090.0901
LLPS-Poa-a007Pongo abelii86.90.0905
LLPS-Tut-a003Tursiops truncatus86.520.0895
LLPS-Man-a005Macaca nemestrina86.150.0864
LLPS-Nol-a007Nomascus leucogenys86.140.0834
LLPS-Cas-a004Carlito syrichta86.070.0880
LLPS-Dio-a007Dipodomys ordii82.640.0778
LLPS-Anc-a006Anolis carolinensis81.866e-123369
LLPS-Tag-a007Taeniopygia guttata74.890.0638
LLPS-Mod-a004Monodelphis domestica72.840.0667
LLPS-Pes-a006Pelodiscus sinensis72.370.0708
LLPS-Anp-a006Anas platyrhynchos72.040.0671
LLPS-Leo-a004Lepisosteus oculatus71.940.0674
LLPS-Gaa-a007Gasterosteus aculeatus71.110.0635
LLPS-Fia-a008Ficedula albicollis70.840.0684
LLPS-Gaga-a005Gallus gallus70.420.0669
LLPS-Meg-a005Meleagris gallopavo70.230.0659
LLPS-Icp-a008Ictalurus punctatus69.70.0623
LLPS-Orn-a007Oreochromis niloticus69.560.0629
LLPS-Lac-a006Latimeria chalumnae69.180.0681
LLPS-Orl-a007Oryzias latipes68.950.0624
LLPS-Xet-a005Xenopus tropicalis68.930.0639
LLPS-Xim-a006Xiphophorus maculatus68.780.0624
LLPS-Sah-a008Sarcophilus harrisii68.060.0622
LLPS-Pof-a008Poecilia formosa67.530.0619
LLPS-Scf-a006Scleropages formosus67.320.0652
LLPS-Ten-a006Tetraodon nigroviridis66.190.0613
LLPS-Dar-a009Danio rerio64.570.0614
LLPS-Scm-a008Scophthalmus maximus64.430.0622
LLPS-Tar-a006Takifugu rubripes61.410.0555
LLPS-Cii-a003Ciona intestinalis58.444e-123372
LLPS-Cae-a002Caenorhabditis elegans54.882e-139422
LLPS-Cis-a003Ciona savignyi53.682e-134405