LLPS-Mum-4997
Cdc16

▼ OVERVIEW


Status: Unreviewed
Protein Name: Cell division cycle protein 16 homolog; Anaphase-promoting complex subunit 6; APC6; Cyclosome subunit 6
Gene Name: Cdc16, Anapc6
Ensembl Gene: ENSMUSG00000038416.15
Ensembl Protein: ENSMUSP00000047950.8
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION


Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).

▼ SEQUENCE


Protein Sequence (FASTA)
1     MNLEPLRKRV  RQYLDQQQYQ  SALFWADKVA  SLSHEEPQDV  YWLAQCLYLT  AQYHRAAHAL  60
61    RSRKLDKLYE  ACRYLAARCH  YAAKEHQQAL  DILDMEEPIN  RRLFEKYLKD  DNGSRDPSSD  120
121   WEMSQSSIKS  SICLLRGKIY  DALDNRTLAT  YSYKEALKLD  VYCFEAFDLL  TSHHMLTAQE  180
181   EKELLDSLPL  NKLCAEEQEL  LRFVFENKLK  KYNKPSETVI  PESVDGLQEN  LDVVVSLAER  240
241   HYYNCDFKMC  YKLTSTVMEK  DPFHANCLPV  HIGTLVELNK  ANELFYLSHK  LVDLYPSNPV  300
301   SWFAVGCYYL  MVGHKNEHAR  RYLSKATTLE  KTYGPAWIAY  GHSFAVESEH  DQAMAAYFTA  360
361   AQLMKGCHLP  MLYIGLEYGL  TNNSKLAERF  FGQALSIAPE  DPFVIHEVGV  VAFQNGEWKT  420
421   AEKWFLDALE  KIKAIGNEVT  VDKWEPLLNN  LGHVCRKLKK  YAEALDYHRQ  ALVLIPQNAS  480
481   TYSAIGYIHS  LMGNFENAVD  YFHTALGLRR  DDTFSVTMLG  HCIEMYIGDS  EAYIGADIKD  540
541   KLKCYDFDVH  TMKTLKNIIS  PPWDFRDFEV  EKQNTEEAGL  APLQNSTKAP  ESRPNLEETF  600
601   EIEMNESDMM  LETSMSDHST  620
Nucleotide CDS Sequence (FASTA)
1     ATGAACCTGG  AGCCGCTGCG  CAAACGCGTC  CGGCAGTACC  TGGACCAGCA  ACAGTATCAA  60
61    AGTGCTCTGT  TTTGGGCAGA  CAAGGTAGCT  TCACTCTCTC  ATGAGGAGCC  CCAGGATGTT  120
121   TATTGGTTGG  CTCAGTGCCT  TTACCTCACA  GCGCAGTACC  ACCGAGCAGC  CCATGCGCTC  180
181   CGGTCACGCA  AGCTGGACAA  ATTGTATGAA  GCTTGCCGAT  ACCTTGCAGC  TAGATGCCAC  240
241   TATGCTGCAA  AAGAGCACCA  GCAGGCTCTG  GACATCCTTG  ACATGGAGGA  GCCAATTAAC  300
301   AGAAGGCTCT  TTGAGAAATA  CCTGAAGGAT  GACAATGGCT  CGAGAGACCC  TTCCAGTGAC  360
361   TGGGAGATGT  CACAGTCTTC  CATAAAGAGC  TCGATTTGTC  TCCTGAGAGG  GAAGATCTAT  420
421   GATGCTTTAG  ATAATCGCAC  CCTGGCTACC  TACAGTTACA  AAGAGGCTCT  GAAACTGGAT  480
481   GTCTACTGCT  TTGAAGCCTT  TGACCTTTTG  ACATCACACC  ACATGCTGAC  AGCACAGGAA  540
541   GAAAAAGAAC  TTCTGGACTC  CCTGCCTCTT  AACAAGCTCT  GTGCTGAAGA  ACAAGAGTTG  600
601   CTGCGATTTG  TATTTGAGAA  CAAATTAAAG  AAGTATAATA  AGCCCAGTGA  AACGGTCATT  660
661   CCCGAGTCAG  TGGACGGCTT  GCAGGAGAAT  CTGGACGTGG  TAGTGTCTTT  AGCTGAGAGA  720
721   CACTATTACA  ACTGTGATTT  TAAGATGTGC  TACAAGCTTA  CTTCTACAGT  GATGGAGAAA  780
781   GATCCTTTCC  ATGCAAACTG  TTTACCTGTG  CACATAGGAA  CTCTTGTGGA  GCTGAATAAA  840
841   GCGAATGAAC  TTTTCTATCT  TTCTCACAAA  CTGGTGGATT  TATATCCGAG  TAATCCTGTG  900
901   TCTTGGTTTG  CGGTGGGATG  TTACTATCTC  ATGGTTGGTC  ATAAAAATGA  GCATGCCAGA  960
961   AGATATCTCA  GCAAAGCTAC  CACGTTGGAG  AAGACCTACG  GTCCTGCCTG  GATAGCCTAC  1020
1021  GGGCATTCCT  TCGCTGTGGA  GAGTGAGCAC  GACCAAGCAA  TGGCTGCTTA  CTTCACAGCA  1080
1081  GCACAGCTGA  TGAAGGGGTG  TCACTTGCCA  ATGCTATATA  TTGGATTAGA  ATATGGTCTG  1140
1141  ACCAATAACT  CGAAACTGGC  TGAGCGGTTC  TTTGGCCAAG  CTCTGAGCAT  CGCCCCAGAA  1200
1201  GACCCATTTG  TCATCCATGA  GGTTGGAGTG  GTTGCCTTTC  AGAATGGAGA  ATGGAAAACA  1260
1261  GCAGAAAAAT  GGTTTCTCGA  TGCTTTGGAA  AAAATTAAAG  CAATTGGAAA  TGAGGTCACA  1320
1321  GTTGACAAAT  GGGAACCTTT  GTTGAACAAC  TTGGGGCATG  TCTGCAGAAA  ACTTAAGAAA  1380
1381  TATGCTGAGG  CTTTGGATTA  CCACAGGCAG  GCACTGGTGC  TAATCCCTCA  GAACGCATCC  1440
1441  ACCTACTCTG  CTATAGGGTA  CATCCACAGT  CTGATGGGCA  ACTTTGAAAA  CGCTGTGGAC  1500
1501  TATTTCCACA  CAGCTCTTGG  TCTCAGGCGA  GACGACACAT  TTTCTGTTAC  AATGCTTGGT  1560
1561  CACTGCATTG  AAATGTACAT  CGGGGATTCG  GAAGCTTATA  TCGGAGCAGA  CATTAAAGAC  1620
1621  AAATTAAAGT  GCTATGACTT  CGATGTGCAT  ACAATGAAAA  CACTAAAAAA  CATCATTTCG  1680
1681  CCTCCATGGG  ATTTCAGGGA  CTTTGAAGTA  GAAAAGCAGA  ACACAGAGGA  AGCGGGACTT  1740
1741  GCACCTCTGC  AAAACTCCAC  TAAAGCTCCA  GAGTCCAGAC  CTAACTTGGA  AGAGACTTTT  1800
1801  GAAATTGAAA  TGAACGAAAG  TGACATGATG  CTAGAGACGT  CTATGTCAGA  CCACAGCACA  1860
1861  TAG  1863

▼ KEYWORD


ID
Family
Cell cycle
Cell division
Complete proteome
Mitosis
Phosphoprotein
Reference proteome
Repeat
TPR repeat
Ubl conjugation pathway

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Anaphase-promoting complex
Cellular Component
Centrosome
Cellular Component
Cytoplasm
Cellular Component
Nucleus
Cellular Component
Spindle microtubule
Biological Process
Cell cycle
Biological Process
Cell division
Biological Process
Protein K11-linked ubiquitination

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-1703Rattus norvegicus98.390.01280
LLPS-Mea-4359Mesocricetus auratus96.940.01263
LLPS-Dio-2233Dipodomys ordii96.450.01259
LLPS-Sus-0846Sus scrofa95.970.01253
LLPS-Bot-3036Bos taurus95.810.01249
LLPS-Chs-0985Chlorocebus sabaeus95.810.01251
LLPS-Caj-2786Callithrix jacchus95.810.01246
LLPS-Rhb-0757Rhinopithecus bieti95.810.01251
LLPS-Fud-2767Fukomys damarensis95.70.01216
LLPS-Gog-4457Gorilla gorilla95.650.01251
LLPS-Cap-2911Cavia porcellus95.650.01244
LLPS-Mam-1146Macaca mulatta95.480.01246
LLPS-Eqc-0014Equus caballus95.480.01249
LLPS-Man-4018Macaca nemestrina95.480.01246
LLPS-Hos-0417Homo sapiens95.480.01248
LLPS-Pap-0534Pan paniscus95.480.01248
LLPS-Pat-2767Pan troglodytes95.480.01248
LLPS-Otg-0711Otolemur garnettii95.480.01114
LLPS-Mup-1685Mustela putorius furo95.360.01217
LLPS-Tut-0942Tursiops truncatus95.320.01243
LLPS-Paa-2645Papio anubis95.320.01241
LLPS-Mal-3678Mandrillus leucophaeus95.210.01213
LLPS-Myl-1551Myotis lucifugus95.160.01241
LLPS-Caf-1827Canis familiaris95.160.01245
LLPS-Fec-4432Felis catus95.160.01246
LLPS-Maf-3457Macaca fascicularis95.060.01053
LLPS-Ova-0192Ovis aries94.520.01232
LLPS-Ict-0389Ictidomys tridecemlineatus94.490.01219
LLPS-Urm-3489Ursus maritimus94.310.01222
LLPS-Aim-4010Ailuropoda melanoleuca94.130.01220
LLPS-Cas-3311Carlito syrichta93.850.01215
LLPS-Loa-3558Loxodonta africana93.750.01228
LLPS-Nol-4254Nomascus leucogenys93.090.01205
LLPS-Sah-3334Sarcophilus harrisii92.780.01218
LLPS-Mod-0456Monodelphis domestica92.780.01218
LLPS-Anp-1191Anas platyrhynchos91.170.01134
LLPS-Tag-2269Taeniopygia guttata91.030.01197
LLPS-Gaga-3406Gallus gallus90.870.01192
LLPS-Fia-3798Ficedula albicollis90.850.01191
LLPS-Pes-2387Pelodiscus sinensis90.850.01196
LLPS-Meg-0995Meleagris gallopavo90.80.01165
LLPS-Ora-1605Ornithorhynchus anatinus89.780.0 599
LLPS-Cea-2689Cercocebus atys88.710.01133
LLPS-Orc-3547Oryctolagus cuniculus88.420.01131
LLPS-Poa-3794Pongo abelii88.390.01134
LLPS-Xet-2792Xenopus tropicalis87.190.0 685
LLPS-Anc-0219Anolis carolinensis84.00.01087
LLPS-Lac-1453Latimeria chalumnae80.730.0 897
LLPS-Asm-2410Astyanax mexicanus79.330.01011
LLPS-Icp-3481Ictalurus punctatus79.230.01022
LLPS-Dar-3341Danio rerio79.230.01016
LLPS-Orn-1007Oreochromis niloticus79.10.01010
LLPS-Scf-3053Scleropages formosus78.850.0 961
LLPS-Orl-0772Oryzias latipes78.490.01004
LLPS-Tar-3741Takifugu rubripes78.330.01002
LLPS-Aon-4273Aotus nancymaae78.330.0 818
LLPS-Xim-1574Xiphophorus maculatus78.30.0 994
LLPS-Pof-2224Poecilia formosa78.120.0 991
LLPS-Gaa-3251Gasterosteus aculeatus77.370.0 987
LLPS-Scm-3754Scophthalmus maximus77.350.0 987
LLPS-Leo-2432Lepisosteus oculatus74.090.0 966
LLPS-Cii-1734Ciona intestinalis59.691e-171 501
LLPS-Drm-1436Drosophila melanogaster50.01e-102 334
LLPS-Tru-0676Triticum urartu44.173e-89 290
LLPS-Orgl-0657Oryza glumaepatula42.42e-114 366
LLPS-Orb-2326Oryza barthii42.48e-115 366
LLPS-Orni-1388Oryza nivara42.43e-114 366
LLPS-Orr-1752Oryza rufipogon42.42e-114 366
LLPS-Orm-1749Oryza meridionalis42.48e-114 365
LLPS-Org-0405Oryza glaberrima42.42e-116 366
LLPS-Ors-0372Oryza sativa42.43e-116 365
LLPS-Brd-0171Brachypodium distachyon42.353e-113 363
LLPS-Php-1861Physcomitrella patens42.31e-131 405
LLPS-Orbr-0185Oryza brachyantha42.223e-111 352
LLPS-Sei-1729Setaria italica42.214e-120 380
LLPS-Orp-1844Oryza punctata42.213e-112 366
LLPS-Ori-2318Oryza indica42.199e-104 348
LLPS-Arl-1721Arabidopsis lyrata42.181e-122 381
LLPS-Brn-1408Brassica napus42.065e-126 390
LLPS-Brr-1997Brassica rapa42.065e-126 390
LLPS-Art-2421Arabidopsis thaliana42.04e-119 372
LLPS-Tra-0549Triticum aestivum41.922e-126 392
LLPS-Bro-1756Brassica oleracea41.871e-123 385
LLPS-Hov-0298Hordeum vulgare41.762e-121 380
LLPS-Sem-1624Selaginella moellendorffii41.639e-129 397
LLPS-Gor-2570Gossypium raimondii41.391e-120 376
LLPS-Thc-0250Theobroma cacao41.377e-119 371
LLPS-Zem-1115Zea mays41.232e-118 372
LLPS-Amt-2248Amborella trichopoda41.231e-122 381
LLPS-Sol-0620Solanum lycopersicum41.041e-117 368
LLPS-Nia-2618Nicotiana attenuata41.045e-117 367
LLPS-Pot-1009Populus trichocarpa40.964e-117 367
LLPS-Via-2072Vigna angularis40.933e-116 364
LLPS-Phv-0027Phaseolus vulgaris40.934e-117 366
LLPS-Glm-1462Glycine max40.752e-114 360
LLPS-Cus-0515Cucumis sativus40.671e-113 358
LLPS-Sob-1845Sorghum bicolor40.494e-114 360
LLPS-Mae-2621Manihot esculenta40.441e-116 365
LLPS-Chr-1139Chlamydomonas reinhardtii40.194e-57 211
LLPS-Viv-0042Vitis vinifera40.182e-116 365
LLPS-Met-1307Medicago truncatula40.115e-117 366
LLPS-Hea-2524Helianthus annuus40.114e-116 364
LLPS-Coc-0611Corchorus capsularis39.961e-118 370
LLPS-Lep-0752Leersia perrieri39.212e-96 322
LLPS-Prp-1735Prunus persica39.12e-110 350
LLPS-Mua-1265Musa acuminata38.323e-110 348
LLPS-Scj-0179Schizosaccharomyces japonicus37.021e-102 333
LLPS-Scc-1159Schizosaccharomyces cryophilus36.424e-101 328
LLPS-Asg-0192Ashbya gossypii35.881e-89 299
LLPS-Scs-1017Sclerotinia sclerotiorum35.661e-40 155
LLPS-Scp-1142Schizosaccharomyces pombe35.261e-92 306
LLPS-Dac-1144Daucus carota34.716e-82 273
LLPS-Yal-1408Yarrowia lipolytica34.317e-95 314
LLPS-Beb-0816Beauveria bassiana34.152e-74 253
LLPS-Pytr-1550Pyrenophora triticirepentis34.112e-91 302
LLPS-Pyt-0841Pyrenophora teres33.752e-88 294
LLPS-Phn-0704Phaeosphaeria nodorum33.631e-88 295
LLPS-Fuv-0097Fusarium verticillioides33.594e-67 234
LLPS-Pug-0382Puccinia graminis33.581e-64 231
LLPS-Tum-0858Tuber melanosporum33.462e-87 291
LLPS-Osl-1006Ostreococcus lucimarinus33.41e-85 286
LLPS-Put-0005Puccinia triticina32.931e-56 207
LLPS-Trr-1453Trichoderma reesei32.772e-89 296
LLPS-Blg-1090Blumeria graminis32.679e-86 286
LLPS-Vir-1762Vigna radiata32.562e-70 245
LLPS-Fus-0616Fusarium solani32.536e-89 295
LLPS-Sac-1277Saccharomyces cerevisiae32.483e-85 290
LLPS-Miv-0500Microbotryum violaceum32.472e-75 263
LLPS-Fuo-0956Fusarium oxysporum32.411e-89 296
LLPS-Trv-1414Trichoderma virens32.352e-87 291
LLPS-Nec-0574Neurospora crassa32.262e-89 297
LLPS-Asfu-1110Aspergillus fumigatus31.748e-70 244
LLPS-Asni-0548Aspergillus niger31.728e-70 245
LLPS-Nef-0741Neosartorya fischeri31.541e-66 238
LLPS-Asn-1453Aspergillus nidulans31.388e-69 244
LLPS-Crn-1169Cryptococcus neoformans31.372e-71 253
LLPS-Cog-1357Colletotrichum gloeosporioides31.344e-79 269
LLPS-Lem-1512Leptosphaeria maculans31.284e-83 280
LLPS-Coo-1299Colletotrichum orbiculare31.251e-80 273
LLPS-Cogr-1629Colletotrichum graminicola31.252e-79 270
LLPS-Ved-0743Verticillium dahliae31.094e-88 293
LLPS-Spr-1485Sporisorium reilianum31.052e-58 216
LLPS-Usm-1086Ustilago maydis31.051e-57 214
LLPS-Gag-0554Gaeumannomyces graminis30.823e-82 278
LLPS-Kop-0951Komagataella pastoris30.771e-81 276
LLPS-Dos-1165Dothistroma septosporum30.761e-76 262
LLPS-Mao-1145Magnaporthe oryzae30.581e-82 280
LLPS-Abg-0712Absidia glauca30.181e-69 246
LLPS-Asc-0138Aspergillus clavatus29.918e-71 249
LLPS-Aso-1447Aspergillus oryzae29.367e-63 227
LLPS-Ast-0765Aspergillus terreus29.276e-63 227
LLPS-Cae-1524Caenorhabditis elegans29.033e-43 169
LLPS-Mel-0402Melampsora laricipopulina28.571e-70 250
LLPS-Zyt-0933Zymoseptoria tritici28.523e-69 243
LLPS-Asf-0330Aspergillus flavus28.16e-57 210
LLPS-Gas-0961Galdieria sulphuraria26.652e-44 171
LLPS-Cym-0905Cyanidioschyzon merolae26.227e-29 126
LLPS-Cis-1846Ciona savignyi25.272e-1171.6
LLPS-Ten-2407Tetraodon nigroviridis25.04e-1168.9