LLPS-Mum-4986
Amdhd2

▼ OVERVIEW

Status: Unreviewed
Protein Name: N-acetylglucosamine-6-phosphate deacetylase
Gene Name: Amdhd2
Ensembl Gene: ENSMUSG00000036820.12
Ensembl Protein: ENSMUSP00000036141.5
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MRSGQCAAGA  PVLQFTNCRI  LRGGTLLRED  LWVRGGRILD  PEKLFFEERR  VADEQRDCGG  60
61    RILAPGFIDV  QINGGFGVDF  SKATEDVGSG  VALVARRLLS  HGVTSFCPTL  VTSPPEVYHK  120
121   AHSSSYKCAR  SSWALPGRPC  SCEPCPHAPS  PPLCFPHAAG  STGKVLPQIP  VKSGGPHGAG  180
181   VLGVHLEGPF  ISREKRGAHP  EAYLRSFEAN  AFHDVLATYG  PLDNVCIVTL  APELDRSHEV  240
241   IQALTAQGIR  VSLGHSVADL  RAAEVAVQSG  ATFITHLFNA  MLPFHHRDPG  IVGLLTSDQL  300
301   PPGHCIFYGM  IADGIHTNPA  ALRIAHRAHP  QGLVLVTDAV  PALGLGNGRH  TLGQQEVEVD  360
361   GLIAYIAGTK  TLGGSIAPMD  VCVRHFLQAT  GCSVESALEA  ASLHPAQMLG  LEKTKGSLDF  420
421   GADADFVVLD  DTLHVQATYI  SGELVWQAEE  AGP  453
Nucleotide CDS Sequence (FASTA)
1     ATGCGTAGCG  GGCAGTGCGC  AGCGGGGGCC  CCGGTGCTCC  AGTTCACCAA  CTGCCGCATC  60
61    CTGCGTGGCG  GCACGCTCCT  CAGGGAGGAT  CTGTGGGTGC  GCGGGGGCCG  AATCCTGGAC  120
121   CCAGAAAAGC  TGTTTTTTGA  GGAGAGGCGT  GTGGCTGATG  AGCAGCGGGA  CTGCGGAGGC  180
181   CGCATCCTGG  CGCCTGGCTT  TATCGATGTG  CAGATCAACG  GTGGATTTGG  TGTTGACTTC  240
241   TCCAAGGCTA  CGGAGGACGT  GGGTTCGGGG  GTCGCCCTAG  TGGCCCGGAG  GCTCCTGTCC  300
301   CACGGTGTCA  CCTCCTTCTG  TCCCACCCTG  GTCACCTCCC  CACCAGAGGT  TTATCACAAG  360
361   GTCCTTCCTC  AGATCCCTGT  GAAGAGTGGA  GGTCCCCATG  GGGCAGGGGT  CCTCGGGGTG  420
421   CACTTGGAGG  GCCCATTCAT  CAGCCGGGAA  AAGCGGGGTG  CACACCCCGA  GGCCTACCTC  480
481   CGCTCCTTTG  AAGCCAATGC  TTTTCATGAT  GTGTTGGCCA  CATATGGGCC  CCTGGACAAC  540
541   GTCTGCATTG  TGACACTTGC  CCCTGAACTA  GACCGGAGCC  ATGAAGTGAT  CCAGGCACTG  600
601   ACAGCCCAAG  GCATCCGTGT  GTCTCTAGGG  CACTCAGTGG  CCGACCTGCG  GGCTGCAGAA  660
661   GTGGCAGTGC  AGAGTGGGGC  CACCTTCATC  ACTCACCTCT  TCAATGCCAT  GTTGCCTTTC  720
721   CACCACCGTG  ACCCAGGCAT  AGTAGGGCTT  CTGACCAGTG  ACCAGCTGCC  CCCAGGCCAC  780
781   TGCATCTTCT  ATGGGATGAT  TGCTGATGGC  ATACACACCA  ACCCTGCAGC  TCTGCGCATT  840
841   GCTCACCGGG  CCCATCCCCA  GGGGCTGGTG  CTGGTCACTG  ATGCTGTCCC  TGCCCTGGGC  900
901   TTGGGCAATG  GCCGCCATAC  ACTGGGACAG  CAGGAGGTGG  AGGTAGATGG  GCTAATAGCG  960
961   TACATTGCAG  GCACCAAGAC  ACTGGGTGGC  AGCATAGCCC  CCATGGATGT  GTGCGTCCGG  1020
1021  CATTTCCTGC  AGGCTACAGG  CTGTAGTGTG  GAGTCGGCCC  TGGAAGCTGC  CTCCCTCCAC  1080
1081  CCTGCCCAGA  TGCTGGGGCT  GGAGAAGACC  AAGGGGAGCC  TGGACTTTGG  TGCTGATGCA  1140
1141  GACTTTGTGG  TGCTCGACGA  CACTCTCCAT  GTCCAGGCCA  CTTACATCTC  TGGTGAATTG  1200
1201  GTGTGGCAGG  CAGAGGAAGC  TGGGCCGTGA  1230

▼ KEYWORD

ID
Family
Carbohydrate metabolism
Complete proteome
Hydrolase
Metal-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
Metal ion binding
Molecular Function
N-acetylgalactosamine-6-phosphate deacetylase activity
Molecular Function
N-acetylglucosamine-6-phosphate deacetylase activity
Biological Process
Carbohydrate metabolic process
Biological Process
N-acetylglucosamine catabolic process
Biological Process
N-acetylneuraminate catabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-4731Rattus norvegicus88.50.0 786
LLPS-Mea-1257Mesocricetus auratus85.430.0 751
LLPS-Fec-1066Felis catus82.930.0 726
LLPS-Ict-2755Ictidomys tridecemlineatus82.930.0 729
LLPS-Eqc-2542Equus caballus82.930.0 728
LLPS-Nol-4380Nomascus leucogenys82.510.0 682
LLPS-Orc-3606Oryctolagus cuniculus82.470.0 717
LLPS-Man-3135Macaca nemestrina82.260.0 727
LLPS-Mam-0969Macaca mulatta82.260.0 727
LLPS-Chs-1946Chlorocebus sabaeus82.260.0 727
LLPS-Caf-3793Canis familiaris82.040.0 719
LLPS-Aon-3490Aotus nancymaae82.030.0 679
LLPS-Mup-1655Mustela putorius furo81.820.0 715
LLPS-Mal-2981Mandrillus leucophaeus81.730.0 686
LLPS-Myl-3865Myotis lucifugus81.680.0 699
LLPS-Cap-0018Cavia porcellus81.460.0 719
LLPS-Dio-3033Dipodomys ordii81.440.0 687
LLPS-Otg-3847Otolemur garnettii80.80.0 676
LLPS-Bot-0080Bos taurus80.650.0 664
LLPS-Loa-4321Loxodonta africana80.180.0 706
LLPS-Aim-3972Ailuropoda melanoleuca79.960.0 684
LLPS-Rhb-1175Rhinopithecus bieti78.430.0 685
LLPS-Sus-3647Sus scrofa77.470.0 700
LLPS-Tut-0464Tursiops truncatus77.20.0 689
LLPS-Ova-0888Ovis aries77.190.0 654
LLPS-Cea-4100Cercocebus atys77.120.0 692
LLPS-Caj-0091Callithrix jacchus77.080.0 705
LLPS-Paa-1722Papio anubis77.080.0 706
LLPS-Pat-4021Pan troglodytes76.840.0 693
LLPS-Gog-1667Gorilla gorilla76.840.0 692
LLPS-Poa-3213Pongo abelii76.670.0 701
LLPS-Hos-3875Homo sapiens76.630.0 692
LLPS-Pap-0994Pan paniscus76.510.0 652
LLPS-Maf-2070Macaca fascicularis76.410.0 692
LLPS-Sah-3589Sarcophilus harrisii71.430.0 605
LLPS-Ora-3214Ornithorhynchus anatinus70.954e-141 413
LLPS-Leo-1168Lepisosteus oculatus69.22e-101 314
LLPS-Anc-2540Anolis carolinensis68.53e-177 509
LLPS-Anp-1031Anas platyrhynchos66.20.0 559
LLPS-Gaga-2057Gallus gallus65.710.0 580
LLPS-Fia-3348Ficedula albicollis64.820.0 586
LLPS-Tag-2257Taeniopygia guttata64.820.0 586
LLPS-Scf-2569Scleropages formosus64.430.0 548
LLPS-Xet-3551Xenopus tropicalis64.210.0 580
LLPS-Pof-0345Poecilia formosa63.920.0 567
LLPS-Xim-2744Xiphophorus maculatus63.920.0 566
LLPS-Mod-0042Monodelphis domestica63.790.0 595
LLPS-Pes-2521Pelodiscus sinensis63.38e-73 234
LLPS-Orn-3497Oreochromis niloticus63.080.0 577
LLPS-Lac-2767Latimeria chalumnae62.670.0 563
LLPS-Orl-2010Oryzias latipes62.420.0 558
LLPS-Ten-0340Tetraodon nigroviridis60.981e-172 498
LLPS-Dar-0304Danio rerio60.630.0 556
LLPS-Tar-2529Takifugu rubripes59.431e-177 511
LLPS-Gaa-2851Gasterosteus aculeatus58.446e-171 493
LLPS-Icp-2378Ictalurus punctatus57.561e-170 493
LLPS-Scm-2719Scophthalmus maximus55.232e-159 463
LLPS-Cii-1475Ciona intestinalis53.532e-156 456
LLPS-Drm-0270Drosophila melanogaster51.894e-149 439
LLPS-Cae-0545Caenorhabditis elegans47.182e-136 405
LLPS-Abg-1497Absidia glauca41.453e-105 327
LLPS-Pyt-0768Pyrenophora teres40.733e-86 278
LLPS-Pytr-1052Pyrenophora triticirepentis40.696e-86 276
LLPS-Lem-1360Leptosphaeria maculans40.694e-88 283
LLPS-Asc-0457Aspergillus clavatus40.59e-85 273
LLPS-Phn-0472Phaeosphaeria nodorum40.193e-88 282
LLPS-Asf-1388Aspergillus flavus40.047e-91 289
LLPS-Aso-0750Aspergillus oryzae40.047e-91 289
LLPS-Asni-1391Aspergillus niger38.983e-87 280
LLPS-Trr-0584Trichoderma reesei38.812e-82 267
LLPS-Asfu-0429Aspergillus fumigatus38.741e-87 281
LLPS-Fuo-0980Fusarium oxysporum38.552e-43 160
LLPS-Nef-0912Neosartorya fischeri38.532e-85 275
LLPS-Fus-0618Fusarium solani38.064e-81 264
LLPS-Asn-1174Aspergillus nidulans38.032e-85 275
LLPS-Ast-1119Aspergillus terreus37.963e-79 259
LLPS-Mao-0682Magnaporthe oryzae37.911e-86 279
LLPS-Cogr-1043Colletotrichum graminicola37.647e-83 269
LLPS-Ved-1329Verticillium dahliae37.56e-86 276
LLPS-Trv-0913Trichoderma virens37.443e-78 256
LLPS-Fuv-0541Fusarium verticillioides37.021e-80 263
LLPS-Beb-1080Beauveria bassiana36.91e-78 258
LLPS-Coo-0275Colletotrichum orbiculare36.322e-78 257
LLPS-Gag-0660Gaeumannomyces graminis36.018e-77 253
LLPS-Map-0772Magnaporthe poae35.796e-78 256
LLPS-Spr-0954Sporisorium reilianum35.524e-71 238
LLPS-Usm-1395Ustilago maydis35.292e-69 234
LLPS-Dos-0496Dothistroma septosporum35.03e-64 219
LLPS-Cog-1418Colletotrichum gloeosporioides34.572e-70 235
LLPS-Nec-0838Neurospora crassa34.521e-51 188
LLPS-Crn-1566Cryptococcus neoformans34.512e-57 201
LLPS-Yal-1520Yarrowia lipolytica33.793e-69 232