LLPS-Mum-4931
Fam98a

▼ OVERVIEW

Status: Unreviewed
Protein Name: Protein FAM98A
Gene Name: Fam98a
Ensembl Gene: ENSMUSG00000002017.10
Ensembl Protein: ENSMUSP00000108126.3
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Positively stimulates PRMT1-induced protein arginine methylation (By similarity). Involved in skeletal homeostasis (PubMed:27777970). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MECDLMETDI  LESLEDLGYK  GPLLDDGALL  QAVSAGAASP  EFTKLCAWLV  SELRVLCKLE  60
61    ENVQATNSPS  EAEEFQLEVS  GLLGEMNCPY  PSLTSGDVTK  RLLVEKNCLL  LLTYLISELE  120
121   AARMLCVNAP  PKKAQEGGGS  EVFQELKGIC  IALGMSKPPA  NITMFQFFSG  IEKKLKETLA  180
181   KVPPNHVGKP  LLKKPMGPAH  WEKIEAINQA  IANEYEVRRK  LLIKRLDVTV  QSFGWSDRAK  240
241   SQTDKLAKVY  QPKRSLLSPK  GKVSVAHLLA  ARQDLSKILR  TSSGSIREKT  ACAINKVLMG  300
301   RVPDRGGRPN  EIEPPPPEMP  PWQKRQDGPQ  QQAGGRGGGR  GGYEHSSYGG  RGGHEQGGRG  360
361   GRGSYDHGGR  GGGRGNKHQG  GWTDGGSGSG  GGYQDGAYRD  SGFQPGGYHG  GHSGGYQAGG  420
421   YGGFQTSSYT  GSGYQGGGYQ  QDNRYQDGGH  HGERGSGRGG  RGGRGGRGGR  GSQGGGWGGR  480
481   GSQTYHQGGQ  FEQHFQHGGY  QYSHSGFGQG  RHYTS  515
Nucleotide CDS Sequence (FASTA)
1     ATGGAGTGTG  ACCTCATGGA  GACTGACATC  TTGGAGTCGT  TGGAAGATCT  AGGTTACAAG  60
61    GGCCCATTGT  TGGACGATGG  TGCACTGTTG  CAGGCAGTCT  CCGCTGGAGC  CGCTTCCCCG  120
121   GAGTTTACCA  AACTCTGCGC  TTGGCTGGTG  TCTGAATTAA  GAGTCCTTTG  TAAACTAGAA  180
181   GAAAATGTGC  AGGCAACTAA  CAGTCCAAGC  GAAGCTGAAG  AGTTCCAGCT  TGAGGTGAGT  240
241   GGGCTACTTG  GGGAGATGAA  CTGCCCGTAT  CCTTCTCTGA  CATCCGGGGA  TGTAACCAAG  300
301   CGCCTTCTTG  TTGAGAAGAA  CTGCCTCCTT  TTGCTCACAT  ACCTCATCTC  AGAACTAGAA  360
361   GCTGCCAGAA  TGCTCTGTGT  GAATGCTCCT  CCAAAAAAAG  CTCAAGAAGG  AGGCGGTAGT  420
421   GAGGTCTTTC  AAGAGTTGAA  AGGCATATGT  ATTGCTCTAG  GAATGTCCAA  ACCTCCAGCC  480
481   AATATAACTA  TGTTCCAATT  CTTCAGCGGG  ATTGAGAAAA  AATTAAAGGA  AACATTAGCA  540
541   AAAGTTCCGC  CTAATCATGT  GGGAAAGCCG  TTACTGAAGA  AGCCGATGGG  ACCAGCCCAC  600
601   TGGGAAAAGA  TAGAAGCCAT  TAACCAAGCC  ATAGCCAATG  AATATGAAGT  CCGGAGGAAG  660
661   CTGCTAATCA  AACGCTTGGA  TGTCACCGTC  CAGTCCTTTG  GCTGGTCTGA  CAGAGCTAAG  720
721   AGTCAGACAG  ACAAACTAGC  TAAGGTTTAC  CAGCCGAAGC  GCTCACTCTT  GTCGCCTAAA  780
781   GGTAAGGTCT  CTGTTGCTCA  CCTTCTGGCC  GCCAGACAAG  ACTTGTCAAA  GATTTTAAGG  840
841   ACAAGCAGTG  GGTCCATAAG  AGAAAAGACT  GCCTGTGCCA  TTAATAAGGT  GCTGATGGGC  900
901   AGGGTGCCTG  ACAGAGGCGG  CAGACCTAAT  GAAATTGAAC  CTCCACCCCC  AGAGATGCCA  960
961   CCGTGGCAGA  AAAGACAAGA  TGGCCCCCAG  CAGCAAGCAG  GAGGCCGAGG  CGGAGGGAGA  1020
1021  GGTGGTTATG  AACATTCCTC  ATACGGAGGA  CGAGGAGGTC  ATGAACAAGG  AGGGAGAGGT  1080
1081  GGACGTGGTA  GCTATGACCA  CGGTGGCCGA  GGGGGAGGAA  GAGGAAATAA  ACATCAAGGA  1140
1141  GGCTGGACAG  ATGGAGGGAG  TGGAAGTGGA  GGTGGTTATC  AGGACGGTGC  TTATCGAGAT  1200
1201  TCGGGCTTCC  AGCCTGGTGG  CTATCATGGT  GGCCACAGTG  GTGGCTACCA  AGCTGGTGGC  1260
1261  TATGGTGGTT  TCCAGACATC  TTCATATACA  GGAAGTGGCT  ACCAGGGCGG  TGGATACCAG  1320
1321  CAAGACAATA  GATACCAAGA  TGGTGGGCAC  CATGGTGAAC  GAGGCAGTGG  TCGTGGGGGA  1380
1381  AGAGGTGGTC  GAGGGGGTCG  GGGAGGACGT  GGAAGCCAGG  GAGGAGGCTG  GGGAGGAAGA  1440
1441  GGGAGCCAGA  CTTATCATCA  AGGGGGCCAG  TTTGAACAGC  ACTTCCAACA  TGGAGGCTAT  1500
1501  CAGTATAGTC  ATTCTGGATT  TGGACAAGGA  AGACATTATA  CTAGTTGA  1548

▼ KEYWORD

ID
Family
Complete proteome
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
TRNA-splicing ligase complex
Molecular Function
Protein methyltransferase activity
Biological Process
Lysosome localization
Biological Process
Positive regulation of cell population proliferation
Biological Process
Positive regulation of gene expression
Biological Process
Positive regulation of ruffle assembly
Biological Process
Protein methylation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-4292Rattus norvegicus97.60.0 612
LLPS-Ict-0039Ictidomys tridecemlineatus97.30.0 611
LLPS-Orc-3397Oryctolagus cuniculus97.30.0 610
LLPS-Ere-0493Erinaceus europaeus96.910.0 591
LLPS-Otg-3672Otolemur garnettii96.862e-91 290
LLPS-Mea-2381Mesocricetus auratus96.70.0 607
LLPS-Caf-3974Canis familiaris96.410.0 602
LLPS-Eqc-2651Equus caballus96.40.0 607
LLPS-Nol-1038Nomascus leucogenys96.40.0 606
LLPS-Hos-0961Homo sapiens96.40.0 605
LLPS-Aon-1583Aotus nancymaae96.40.0 606
LLPS-Caj-3933Callithrix jacchus96.40.0 606
LLPS-Fud-3373Fukomys damarensis96.40.0 607
LLPS-Gog-2052Gorilla gorilla96.40.0 606
LLPS-Mam-4527Macaca mulatta96.10.0 605
LLPS-Cap-3864Cavia porcellus96.10.0 603
LLPS-Man-3488Macaca nemestrina96.10.0 605
LLPS-Pat-4911Pan troglodytes96.10.0 604
LLPS-Urm-2635Ursus maritimus96.10.0 603
LLPS-Pap-4232Pan paniscus96.10.0 604
LLPS-Rhb-2211Rhinopithecus bieti96.10.0 605
LLPS-Mup-3419Mustela putorius furo96.10.0 604
LLPS-Aim-0720Ailuropoda melanoleuca96.10.0 603
LLPS-Mal-3706Mandrillus leucophaeus96.10.0 605
LLPS-Paa-4573Papio anubis96.10.0 605
LLPS-Cea-1001Cercocebus atys96.10.0 605
LLPS-Chs-0182Chlorocebus sabaeus96.10.0 605
LLPS-Maf-4143Macaca fascicularis96.10.0 605
LLPS-Loa-3595Loxodonta africana95.80.0 601
LLPS-Fec-4688Felis catus95.80.0 602
LLPS-Sus-3838Sus scrofa95.80.0 602
LLPS-Bot-3619Bos taurus95.20.0 598
LLPS-Ova-0882Ovis aries95.20.0 598
LLPS-Myl-1662Myotis lucifugus95.20.0 600
LLPS-Tut-2038Tursiops truncatus94.880.0 589
LLPS-Ora-3237Ornithorhynchus anatinus94.352e-145 432
LLPS-Cas-1750Carlito syrichta93.580.0 568
LLPS-Sah-2535Sarcophilus harrisii92.790.0 588
LLPS-Mod-2705Monodelphis domestica92.490.0 586
LLPS-Poa-3312Pongo abelii92.470.0 590
LLPS-Pes-0181Pelodiscus sinensis90.990.0 574
LLPS-Fia-0813Ficedula albicollis90.770.0 555
LLPS-Tag-3024Taeniopygia guttata90.150.0 549
LLPS-Anp-1456Anas platyrhynchos89.090.0 533
LLPS-Anc-2385Anolis carolinensis88.890.0 561
LLPS-Dio-3377Dipodomys ordii85.291e-170 499
LLPS-Xet-3549Xenopus tropicalis82.373e-175 511
LLPS-Leo-3601Lepisosteus oculatus80.125e-173 506
LLPS-Asm-1265Astyanax mexicanus79.577e-165 486
LLPS-Dar-1194Danio rerio78.867e-163 480
LLPS-Scm-2204Scophthalmus maximus76.921e-157 466
LLPS-Pof-3755Poecilia formosa76.623e-160 473
LLPS-Orn-2578Oreochromis niloticus76.472e-76 245
LLPS-Gaa-0727Gasterosteus aculeatus76.073e-151 449
LLPS-Xim-2031Xiphophorus maculatus76.01e-158 468
LLPS-Scf-3449Scleropages formosus75.347e-146 429
LLPS-Orl-2369Oryzias latipes75.086e-159 468
LLPS-Tar-3367Takifugu rubripes75.02e-158 467
LLPS-Ten-0161Tetraodon nigroviridis73.549e-154 453
LLPS-Lac-2526Latimeria chalumnae57.764e-108 334
LLPS-Gaga-1647Gallus gallus55.146e-101 318
LLPS-Meg-1633Meleagris gallopavo54.695e-97 306
LLPS-Cis-1806Ciona savignyi52.65e-36 138
LLPS-Icp-1729Ictalurus punctatus47.526e-71 238
LLPS-Cii-2235Ciona intestinalis42.153e-55 197