LLPS-Mum-4891
Sae1

▼ OVERVIEW


Status: Unreviewed
Protein Name: SUMO-activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A
Gene Name: Sae1, Aos1, Sua1, Ubl1a1, Uble1a
Ensembl Gene: ENSMUSG00000052833.9
Ensembl Protein: ENSMUSP00000147771.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION


The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity).

▼ SEQUENCE


Protein Sequence (FASTA)
1     MVEKEEAGGG  GGGGISEEEA  AQYDRQIRLW  GLEAQKRLRA  SRVLIVGMKG  LGAEIAKNLI  60
61    LAGVKGLTML  DHEQVSPEDP  GAQFLIQTGS  VGRNRAEASL  ERAQNLNPMV  DVKVDTEDVE  120
121   KKPESFFTKF  DAVCLTCCSR  DVIIKVDQIC  HRNSIKFFTG  DVFGYHGYTF  ANLGEHEFVE  180
181   EKTKVAKVSQ  GVEDGPEAKR  AKLDSSETTM  VKKKVLFCPV  KEALEVDWSG  EKAKAALKRT  240
241   APDYFLLQVL  LKFRTDKGRD  PTSESYKEDA  ELLLQIRNDV  FDSLGISPDL  LPDDFVRYCF  300
301   SEMAPVCAVV  GGILAQEIVK  ALSQRDPPHN  NFFFFDGMKG  SGIVECLGPQ  350
Nucleotide CDS Sequence (FASTA)
1     ATGGTAGAGA  AGGAGGAGGC  TGGCGGCGGC  GGCGGCGGTG  GCATCAGCGA  GGAGGAGGCA  60
61    GCGCAGTATG  ACCGACAGAT  CCGCCTGTGG  GGACTGGAGG  CCCAGAAGCG  GCTTCGAGCT  120
121   TCCCGGGTGC  TGATTGTTGG  CATGAAAGGA  CTTGGAGCTG  AAATTGCCAA  GAATCTTATC  180
181   CTGGCAGGAG  TCAAAGGGCT  CACCATGCTG  GACCACGAAC  AGGTATCTCC  AGAAGACCCT  240
241   GGAGCTCAGT  TCTTGATTCA  GACTGGGTCT  GTGGGCCGCA  ATAGGGCCGA  GGCCTCTTTG  300
301   GAACGAGCCC  AGAATCTCAA  TCCCATGGTG  GATGTAAAGG  TGGACACTGA  GGATGTAGAG  360
361   AAGAAGCCAG  AGTCCTTCTT  CACGAAGTTT  GATGCGGTGT  GCCTGACTTG  CTGCTCCAGA  420
421   GATGTCATCA  TTAAAGTCGA  CCAGATCTGT  CACAGAAACA  GCATTAAGTT  CTTCACAGGA  480
481   GATGTCTTTG  GGTACCATGG  GTACACCTTT  GCGAATCTTG  GAGAGCATGA  ATTTGTAGAA  540
541   GAGAAAACCA  AAGTTGCCAA  AGTAAGCCAA  GGAGTGGAAG  ATGGACCTGA  GGCCAAGAGA  600
601   GCAAAGCTTG  ATTCATCAGA  GACAACCATG  GTCAAAAAGA  AAGTGCTTTT  TTGCCCTGTA  660
661   AAAGAGGCGC  TAGAAGTGGA  CTGGAGTGGA  GAGAAAGCCA  AGGCTGCCCT  GAAGCGTACT  720
721   GCCCCCGACT  ACTTTCTGCT  GCAAGTGCTG  CTGAAATTCC  GCACAGATAA  AGGGAGAGAT  780
781   CCGACTTCTG  AGAGCTACAA  GGAGGATGCG  GAGCTGCTGC  TGCAGATACG  GAATGACGTG  840
841   TTTGACTCCC  TGGGCATCAG  TCCTGACCTG  CTTCCCGATG  ACTTTGTCAG  GTACTGCTTC  900
901   TCTGAGATGG  CCCCAGTATG  TGCTGTGGTT  GGAGGGATCT  TGGCACAGGA  AATTGTGAAG  960
961   GCCCTGTCTC  AAAGGGACCC  TCCTCACAAC  AACTTCTTCT  TCTTCGACGG  CATGAAGGGG  1020
1021  AGTGGAATTG  TGGAGTGCCT  TGGTCCCCAG  TGA  1053

▼ KEYWORD


ID
Family
Acetylation
Alternative splicing
Complete proteome
Ligase
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation pathway

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
SUMO activating enzyme complex
Molecular Function
ATP-dependent protein binding
Molecular Function
Protein C-terminus binding
Molecular Function
Protein heterodimerization activity
Molecular Function
Small protein activating enzyme binding
Molecular Function
SUMO activating enzyme activity
Biological Process
Protein modification by small protein conjugation
Biological Process
Protein sumoylation

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-2271Rattus norvegicus96.050.0 624
LLPS-Ict-4151Ictidomys tridecemlineatus93.310.0 612
LLPS-Mea-1078Mesocricetus auratus93.310.0 613
LLPS-Caj-4539Callithrix jacchus93.310.0 614
LLPS-Poa-0575Pongo abelii93.010.0 613
LLPS-Pat-3864Pan troglodytes93.010.0 613
LLPS-Hos-1074Homo sapiens93.010.0 613
LLPS-Maf-4361Macaca fascicularis93.010.0 613
LLPS-Gog-2779Gorilla gorilla93.010.0 613
LLPS-Mam-3873Macaca mulatta92.740.0 559
LLPS-Mal-3842Mandrillus leucophaeus92.740.0 559
LLPS-Chs-4550Chlorocebus sabaeus92.451e-179 508
LLPS-Rhb-1712Rhinopithecus bieti92.40.0 609
LLPS-Fec-4405Felis catus92.10.0 606
LLPS-Loa-1731Loxodonta africana91.790.0 606
LLPS-Aim-3854Ailuropoda melanoleuca91.790.0 603
LLPS-Sus-4505Sus scrofa91.790.0 608
LLPS-Tut-0226Tursiops truncatus91.490.0 607
LLPS-Ova-4038Ovis aries91.490.0 605
LLPS-Mup-1909Mustela putorius furo91.490.0 600
LLPS-Fud-1557Fukomys damarensis91.490.0 606
LLPS-Aon-1388Aotus nancymaae91.460.0 592
LLPS-Urm-1980Ursus maritimus91.320.0 563
LLPS-Cap-3005Cavia porcellus90.750.0 602
LLPS-Caf-0596Canis familiaris90.580.0 601
LLPS-Dio-2429Dipodomys ordii89.899e-174 493
LLPS-Cea-3702Cercocebus atys89.360.0 583
LLPS-Myl-4403Myotis lucifugus89.170.0 560
LLPS-Eqc-0861Equus caballus88.241e-57 199
LLPS-Otg-2814Otolemur garnettii85.20.0 553
LLPS-Bot-4586Bos taurus84.550.0 591
LLPS-Nol-0448Nomascus leucogenys84.190.0 540
LLPS-Mod-3155Monodelphis domestica83.940.0 563
LLPS-Orc-2073Oryctolagus cuniculus83.830.0 541
LLPS-Paa-2854Papio anubis83.590.0 533
LLPS-Pap-0742Pan paniscus83.280.0 533
LLPS-Man-4178Macaca nemestrina82.773e-180 510
LLPS-Sah-3179Sarcophilus harrisii81.90.0 521
LLPS-Ora-3496Ornithorhynchus anatinus81.526e-179 506
LLPS-Cas-2257Carlito syrichta80.752e-105 316
LLPS-Anc-3773Anolis carolinensis77.440.0 519
LLPS-Lac-2019Latimeria chalumnae76.90.0 517
LLPS-Tag-0101Taeniopygia guttata74.142e-60 196
LLPS-Xet-3831Xenopus tropicalis74.18e-180 509
LLPS-Gaga-0949Gallus gallus72.886e-149 434
LLPS-Scf-0039Scleropages formosus70.158e-160 459
LLPS-Dar-3931Danio rerio69.543e-157 452
LLPS-Orn-4043Oreochromis niloticus69.06e-145 421
LLPS-Xim-4014Xiphophorus maculatus68.794e-158 454
LLPS-Orl-0727Oryzias latipes68.482e-149 432
LLPS-Icp-3169Ictalurus punctatus67.678e-140 409
LLPS-Pof-1561Poecilia formosa67.583e-156 450
LLPS-Asm-1116Astyanax mexicanus67.293e-103 310
LLPS-Scm-3972Scophthalmus maximus66.672e-147 427
LLPS-Gaa-3008Gasterosteus aculeatus65.762e-147 427
LLPS-Tar-3523Takifugu rubripes63.536e-142 413
LLPS-Leo-1149Lepisosteus oculatus63.133e-149 432
LLPS-Ten-3176Tetraodon nigroviridis58.662e-129 381
LLPS-Cii-0562Ciona intestinalis44.689e-94 290
LLPS-Art-1327Arabidopsis thaliana41.563e-2199.8
LLPS-Hea-1208Helianthus annuus41.563e-2199.8
LLPS-Sot-0399Solanum tuberosum40.912e-21 100
LLPS-Arl-2849Arabidopsis lyrata40.914e-2199.4
LLPS-Nia-1304Nicotiana attenuata40.263e-2199.4
LLPS-Fus-0348Fusarium solani39.222e-2199.8
LLPS-Fuv-0224Fusarium verticillioides39.226e-22 101
LLPS-Drm-2220Drosophila melanogaster39.022e-63 211
LLPS-Nec-0241Neurospora crassa38.961e-22 103
LLPS-Nef-0413Neosartorya fischeri38.959e-25 110
LLPS-Asc-0582Aspergillus clavatus38.371e-24 110
LLPS-Lem-0266Leptosphaeria maculans38.316e-24 108
LLPS-Brn-1911Brassica napus38.315e-2199.0
LLPS-Tra-2595Triticum aestivum37.662e-21 100
LLPS-Phv-0647Phaseolus vulgaris36.653e-2399.8
LLPS-Dos-0564Dothistroma septosporum36.366e-23 105
LLPS-Phn-1135Phaeosphaeria nodorum36.362e-23 106
LLPS-Zyt-1268Zymoseptoria tritici36.364e-22 102
LLPS-Tum-1518Tuber melanosporum35.822e-53 187
LLPS-Pytr-0661Pyrenophora triticirepentis35.264e-23 105
LLPS-Pug-0598Puccinia graminis35.122e-52 184
LLPS-Gag-1048Gaeumannomyces graminis35.034e-47 171
LLPS-Mae-1807Manihot esculenta34.783e-0653.1
LLPS-Php-1783Physcomitrella patens34.723e-49 174
LLPS-Pyt-1272Pyrenophora teres34.13e-22 103
LLPS-Cogr-0594Colletotrichum graminicola33.919e-42 157
LLPS-Beb-1596Beauveria bassiana33.97e-42 158
LLPS-Asg-0791Ashbya gossypii33.844e-42 156
LLPS-Glm-1763Glycine max33.71e-0654.7
LLPS-Asni-1559Aspergillus niger33.633e-49 176
LLPS-Coo-1278Colletotrichum orbiculare33.623e-42 159
LLPS-Trv-1585Trichoderma virens33.538e-45 163
LLPS-Mao-0994Magnaporthe oryzae33.521e-42 159
LLPS-Zem-2242Zea mays33.331e-48 172
LLPS-Cog-1384Colletotrichum gloeosporioides33.337e-40 152
LLPS-Miv-0927Microbotryum violaceum33.331e-49 175
LLPS-Sob-0355Sorghum bicolor33.333e-48 171
LLPS-Aso-1491Aspergillus oryzae33.042e-48 173
LLPS-Asf-0729Aspergillus flavus33.042e-48 173
LLPS-Gor-1176Gossypium raimondii32.932e-48 172
LLPS-Fuo-1334Fusarium oxysporum32.661e-42 160
LLPS-Trr-1046Trichoderma reesei32.663e-42 156
LLPS-Brr-2129Brassica rapa32.638e-44 159
LLPS-Coc-0562Corchorus capsularis32.613e-0653.1
LLPS-Vir-1478Vigna radiata32.612e-0653.9
LLPS-Dac-0856Daucus carota32.612e-0654.3
LLPS-Via-0871Vigna angularis32.533e-39 147
LLPS-Sei-1848Setaria italica32.447e-48 171
LLPS-Sac-1150Saccharomyces cerevisiae32.434e-43 158
LLPS-Ved-1386Verticillium dahliae32.372e-39 151
LLPS-Pot-0970Populus trichocarpa32.336e-47 168
LLPS-Thc-1911Theobroma cacao32.332e-44 163
LLPS-Blg-1018Blumeria graminis32.161e-44 164
LLPS-Orp-0624Oryza punctata32.145e-48 171
LLPS-Orni-1987Oryza nivara32.147e-48 171
LLPS-Met-2590Medicago truncatula32.132e-41 154
LLPS-Bro-2349Brassica oleracea32.026e-42 154
LLPS-Amt-0595Amborella trichopoda32.021e-40 150
LLPS-Scs-0595Sclerotinia sclerotiorum32.011e-44 162
LLPS-Asfu-1625Aspergillus fumigatus31.958e-40 150
LLPS-Orr-0362Oryza rufipogon31.856e-47 168
LLPS-Orm-0995Oryza meridionalis31.856e-47 168
LLPS-Orgl-2012Oryza glumaepatula31.855e-46 166
LLPS-Hov-0108Hordeum vulgare31.851e-45 166
LLPS-Orb-1795Oryza barthii31.853e-46 166
LLPS-Ori-2224Oryza indica31.856e-47 168
LLPS-Ors-0484Oryza sativa31.553e-46 166
LLPS-Brd-1278Brachypodium distachyon31.552e-45 164
LLPS-Sol-2416Solanum lycopersicum31.427e-44 161
LLPS-Tru-0610Triticum urartu31.294e-45 164
LLPS-Orbr-1770Oryza brachyantha31.253e-43 158
LLPS-Asn-1570Aspergillus nidulans30.974e-38 145
LLPS-Cae-1751Caenorhabditis elegans30.861e-38 146
LLPS-Viv-0545Vitis vinifera30.824e-43 157
LLPS-Lep-0853Leersia perrieri30.235e-41 152
LLPS-Cus-1908Cucumis sativus30.066e-43 157
LLPS-Chc-0359Chondrus crispus29.971e-30 123
LLPS-Scj-1268Schizosaccharomyces japonicus29.691e-37 142
LLPS-Scc-0361Schizosaccharomyces cryophilus29.663e-36 139
LLPS-Sem-2235Selaginella moellendorffii29.626e-34 133
LLPS-Mua-1784Musa acuminata29.521e-40 150
LLPS-Prp-2345Prunus persica29.314e-41 152
LLPS-Kop-1152Komagataella pastoris29.289e-30 121
LLPS-Scp-1225Schizosaccharomyces pombe29.142e-24 105
LLPS-Yal-0188Yarrowia lipolytica29.12e-34 134
LLPS-Crn-0456Cryptococcus neoformans29.18e-34 133
LLPS-Mel-1104Melampsora laricipopulina28.467e-26 114
LLPS-Abg-1718Absidia glauca28.312e-23 106
LLPS-Ast-0251Aspergillus terreus27.812e-23 106
LLPS-Cis-0304Ciona savignyi27.742e-23 106
LLPS-Usm-0733Ustilago maydis25.721e-23 107
LLPS-Put-0902Puccinia triticina25.62e-22 103
LLPS-Spr-0673Sporisorium reilianum24.598e-23 102