LLPS-Mum-4891
Sae1
▼ OVERVIEW
Status: | Unreviewed |
Protein Name: | SUMO-activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A |
Gene Name: | Sae1, Aos1, Sua1, Ubl1a1, Uble1a |
Ensembl Gene: | ENSMUSG00000052833.9 |
Ensembl Protein: | ENSMUSP00000147771.1 |
Organism: | Mus musculus |
Taxa ID: | 10090 |
LLPS Type: | Others |
▼ Classification
Condensates:
Condensate | Evidence | Orthologs |
---|---|---|
Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity). |
▼ CROSS REFERENCE
Database | Nucleotide ID | Protein ID |
---|---|---|
Ensembl | ENSMUST00000211741.1 | ENSMUSP00000147771.1 |
Ensembl | ENSMUST00000094815.4 | ENSMUSP00000092409.3 |
Ensembl | ENSMUST00000210999.1 | ENSMUSP00000147409.1 |
UniProt | Q9R1T2, SAE1_MOUSE, Q3TRG9, Q3TWJ0, Q9CSW9 | |
GeneBank | BC068164, AK090012, AK010313, AB024303, AK162789, AK159672, AK087556, AK154139, AK011783 | BAC41044.1, AAH68164.1, BAE37060.1, BAB26845.1, BAC39925.1, BAB27838.1, BAE32401.1, BAA82876.1, BAE35276.1 |
RefSeq | NM_001285891.1, NM_001285892.1, NM_019748.3 | NP_001272820.1, NP_001272821.1, NP_062722.1 |
Entrez | 56459 |
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 MVEKEEAGGG GGGGISEEEA AQYDRQIRLW GLEAQKRLRA SRVLIVGMKG LGAEIAKNLI 60 61 LAGVKGLTML DHEQVSPEDP GAQFLIQTGS VGRNRAEASL ERAQNLNPMV DVKVDTEDVE 120 121 KKPESFFTKF DAVCLTCCSR DVIIKVDQIC HRNSIKFFTG DVFGYHGYTF ANLGEHEFVE 180 181 EKTKVAKVSQ GVEDGPEAKR AKLDSSETTM VKKKVLFCPV KEALEVDWSG EKAKAALKRT 240 241 APDYFLLQVL LKFRTDKGRD PTSESYKEDA ELLLQIRNDV FDSLGISPDL LPDDFVRYCF 300 301 SEMAPVCAVV GGILAQEIVK ALSQRDPPHN NFFFFDGMKG SGIVECLGPQ 350 |
Nucleotide CDS Sequence (FASTA) |
1 ATGGTAGAGA AGGAGGAGGC TGGCGGCGGC GGCGGCGGTG GCATCAGCGA GGAGGAGGCA 60 61 GCGCAGTATG ACCGACAGAT CCGCCTGTGG GGACTGGAGG CCCAGAAGCG GCTTCGAGCT 120 121 TCCCGGGTGC TGATTGTTGG CATGAAAGGA CTTGGAGCTG AAATTGCCAA GAATCTTATC 180 181 CTGGCAGGAG TCAAAGGGCT CACCATGCTG GACCACGAAC AGGTATCTCC AGAAGACCCT 240 241 GGAGCTCAGT TCTTGATTCA GACTGGGTCT GTGGGCCGCA ATAGGGCCGA GGCCTCTTTG 300 301 GAACGAGCCC AGAATCTCAA TCCCATGGTG GATGTAAAGG TGGACACTGA GGATGTAGAG 360 361 AAGAAGCCAG AGTCCTTCTT CACGAAGTTT GATGCGGTGT GCCTGACTTG CTGCTCCAGA 420 421 GATGTCATCA TTAAAGTCGA CCAGATCTGT CACAGAAACA GCATTAAGTT CTTCACAGGA 480 481 GATGTCTTTG GGTACCATGG GTACACCTTT GCGAATCTTG GAGAGCATGA ATTTGTAGAA 540 541 GAGAAAACCA AAGTTGCCAA AGTAAGCCAA GGAGTGGAAG ATGGACCTGA GGCCAAGAGA 600 601 GCAAAGCTTG ATTCATCAGA GACAACCATG GTCAAAAAGA AAGTGCTTTT TTGCCCTGTA 660 661 AAAGAGGCGC TAGAAGTGGA CTGGAGTGGA GAGAAAGCCA AGGCTGCCCT GAAGCGTACT 720 721 GCCCCCGACT ACTTTCTGCT GCAAGTGCTG CTGAAATTCC GCACAGATAA AGGGAGAGAT 780 781 CCGACTTCTG AGAGCTACAA GGAGGATGCG GAGCTGCTGC TGCAGATACG GAATGACGTG 840 841 TTTGACTCCC TGGGCATCAG TCCTGACCTG CTTCCCGATG ACTTTGTCAG GTACTGCTTC 900 901 TCTGAGATGG CCCCAGTATG TGCTGTGGTT GGAGGGATCT TGGCACAGGA AATTGTGAAG 960 961 GCCCTGTCTC AAAGGGACCC TCCTCACAAC AACTTCTTCT TCTTCGACGG CATGAAGGGG 1020 1021 AGTGGAATTG TGGAGTGCCT TGGTCCCCAG TGA 1053 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | SUMO activating enzyme complex | |
Molecular Function | ATP-dependent protein binding | |
Molecular Function | Protein C-terminus binding | |
Molecular Function | Protein heterodimerization activity | |
Molecular Function | Small protein activating enzyme binding | |
Molecular Function | SUMO activating enzyme activity | |
Biological Process | Protein modification by small protein conjugation | |
Biological Process | Protein sumoylation |
▼ ANNOTATION
Mutation | ||||
CGAP |
Physicochemical | ||||
Compute pI/Mw | AAindex |
Function | ||||
CGDB | PIRSF | CellMarker |
Localization | ||||
COMPARTMENTS |
Expression | ||||
ArrayExpress | GXD | TISSUES |
Element | ||||
miRWalk | RAID | microRNA.org |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Ran-2271 | Rattus norvegicus | 96.05 | 0.0 | 624 |
LLPS-Ict-4151 | Ictidomys tridecemlineatus | 93.31 | 0.0 | 612 |
LLPS-Mea-1078 | Mesocricetus auratus | 93.31 | 0.0 | 613 |
LLPS-Caj-4539 | Callithrix jacchus | 93.31 | 0.0 | 614 |
LLPS-Poa-0575 | Pongo abelii | 93.01 | 0.0 | 613 |
LLPS-Pat-3864 | Pan troglodytes | 93.01 | 0.0 | 613 |
LLPS-Hos-1074 | Homo sapiens | 93.01 | 0.0 | 613 |
LLPS-Maf-4361 | Macaca fascicularis | 93.01 | 0.0 | 613 |
LLPS-Gog-2779 | Gorilla gorilla | 93.01 | 0.0 | 613 |
LLPS-Mam-3873 | Macaca mulatta | 92.74 | 0.0 | 559 |
LLPS-Mal-3842 | Mandrillus leucophaeus | 92.74 | 0.0 | 559 |
LLPS-Chs-4550 | Chlorocebus sabaeus | 92.45 | 1e-179 | 508 |
LLPS-Rhb-1712 | Rhinopithecus bieti | 92.4 | 0.0 | 609 |
LLPS-Fec-4405 | Felis catus | 92.1 | 0.0 | 606 |
LLPS-Loa-1731 | Loxodonta africana | 91.79 | 0.0 | 606 |
LLPS-Aim-3854 | Ailuropoda melanoleuca | 91.79 | 0.0 | 603 |
LLPS-Sus-4505 | Sus scrofa | 91.79 | 0.0 | 608 |
LLPS-Tut-0226 | Tursiops truncatus | 91.49 | 0.0 | 607 |
LLPS-Ova-4038 | Ovis aries | 91.49 | 0.0 | 605 |
LLPS-Mup-1909 | Mustela putorius furo | 91.49 | 0.0 | 600 |
LLPS-Fud-1557 | Fukomys damarensis | 91.49 | 0.0 | 606 |
LLPS-Aon-1388 | Aotus nancymaae | 91.46 | 0.0 | 592 |
LLPS-Urm-1980 | Ursus maritimus | 91.32 | 0.0 | 563 |
LLPS-Cap-3005 | Cavia porcellus | 90.75 | 0.0 | 602 |
LLPS-Caf-0596 | Canis familiaris | 90.58 | 0.0 | 601 |
LLPS-Dio-2429 | Dipodomys ordii | 89.89 | 9e-174 | 493 |
LLPS-Cea-3702 | Cercocebus atys | 89.36 | 0.0 | 583 |
LLPS-Myl-4403 | Myotis lucifugus | 89.17 | 0.0 | 560 |
LLPS-Eqc-0861 | Equus caballus | 88.24 | 1e-57 | 199 |
LLPS-Otg-2814 | Otolemur garnettii | 85.2 | 0.0 | 553 |
LLPS-Bot-4586 | Bos taurus | 84.55 | 0.0 | 591 |
LLPS-Nol-0448 | Nomascus leucogenys | 84.19 | 0.0 | 540 |
LLPS-Mod-3155 | Monodelphis domestica | 83.94 | 0.0 | 563 |
LLPS-Orc-2073 | Oryctolagus cuniculus | 83.83 | 0.0 | 541 |
LLPS-Paa-2854 | Papio anubis | 83.59 | 0.0 | 533 |
LLPS-Pap-0742 | Pan paniscus | 83.28 | 0.0 | 533 |
LLPS-Man-4178 | Macaca nemestrina | 82.77 | 3e-180 | 510 |
LLPS-Sah-3179 | Sarcophilus harrisii | 81.9 | 0.0 | 521 |
LLPS-Ora-3496 | Ornithorhynchus anatinus | 81.52 | 6e-179 | 506 |
LLPS-Cas-2257 | Carlito syrichta | 80.75 | 2e-105 | 316 |
LLPS-Anc-3773 | Anolis carolinensis | 77.44 | 0.0 | 519 |
LLPS-Lac-2019 | Latimeria chalumnae | 76.9 | 0.0 | 517 |
LLPS-Tag-0101 | Taeniopygia guttata | 74.14 | 2e-60 | 196 |
LLPS-Xet-3831 | Xenopus tropicalis | 74.1 | 8e-180 | 509 |
LLPS-Gaga-0949 | Gallus gallus | 72.88 | 6e-149 | 434 |
LLPS-Scf-0039 | Scleropages formosus | 70.15 | 8e-160 | 459 |
LLPS-Dar-3931 | Danio rerio | 69.54 | 3e-157 | 452 |
LLPS-Orn-4043 | Oreochromis niloticus | 69.0 | 6e-145 | 421 |
LLPS-Xim-4014 | Xiphophorus maculatus | 68.79 | 4e-158 | 454 |
LLPS-Orl-0727 | Oryzias latipes | 68.48 | 2e-149 | 432 |
LLPS-Icp-3169 | Ictalurus punctatus | 67.67 | 8e-140 | 409 |
LLPS-Pof-1561 | Poecilia formosa | 67.58 | 3e-156 | 450 |
LLPS-Asm-1116 | Astyanax mexicanus | 67.29 | 3e-103 | 310 |
LLPS-Scm-3972 | Scophthalmus maximus | 66.67 | 2e-147 | 427 |
LLPS-Gaa-3008 | Gasterosteus aculeatus | 65.76 | 2e-147 | 427 |
LLPS-Tar-3523 | Takifugu rubripes | 63.53 | 6e-142 | 413 |
LLPS-Leo-1149 | Lepisosteus oculatus | 63.13 | 3e-149 | 432 |
LLPS-Ten-3176 | Tetraodon nigroviridis | 58.66 | 2e-129 | 381 |
LLPS-Cii-0562 | Ciona intestinalis | 44.68 | 9e-94 | 290 |
LLPS-Art-1327 | Arabidopsis thaliana | 41.56 | 3e-21 | 99.8 |
LLPS-Hea-1208 | Helianthus annuus | 41.56 | 3e-21 | 99.8 |
LLPS-Sot-0399 | Solanum tuberosum | 40.91 | 2e-21 | 100 |
LLPS-Arl-2849 | Arabidopsis lyrata | 40.91 | 4e-21 | 99.4 |
LLPS-Nia-1304 | Nicotiana attenuata | 40.26 | 3e-21 | 99.4 |
LLPS-Fus-0348 | Fusarium solani | 39.22 | 2e-21 | 99.8 |
LLPS-Fuv-0224 | Fusarium verticillioides | 39.22 | 6e-22 | 101 |
LLPS-Drm-2220 | Drosophila melanogaster | 39.02 | 2e-63 | 211 |
LLPS-Nec-0241 | Neurospora crassa | 38.96 | 1e-22 | 103 |
LLPS-Nef-0413 | Neosartorya fischeri | 38.95 | 9e-25 | 110 |
LLPS-Asc-0582 | Aspergillus clavatus | 38.37 | 1e-24 | 110 |
LLPS-Lem-0266 | Leptosphaeria maculans | 38.31 | 6e-24 | 108 |
LLPS-Brn-1911 | Brassica napus | 38.31 | 5e-21 | 99.0 |
LLPS-Tra-2595 | Triticum aestivum | 37.66 | 2e-21 | 100 |
LLPS-Phv-0647 | Phaseolus vulgaris | 36.65 | 3e-23 | 99.8 |
LLPS-Dos-0564 | Dothistroma septosporum | 36.36 | 6e-23 | 105 |
LLPS-Phn-1135 | Phaeosphaeria nodorum | 36.36 | 2e-23 | 106 |
LLPS-Zyt-1268 | Zymoseptoria tritici | 36.36 | 4e-22 | 102 |
LLPS-Tum-1518 | Tuber melanosporum | 35.82 | 2e-53 | 187 |
LLPS-Pytr-0661 | Pyrenophora triticirepentis | 35.26 | 4e-23 | 105 |
LLPS-Pug-0598 | Puccinia graminis | 35.12 | 2e-52 | 184 |
LLPS-Gag-1048 | Gaeumannomyces graminis | 35.03 | 4e-47 | 171 |
LLPS-Mae-1807 | Manihot esculenta | 34.78 | 3e-06 | 53.1 |
LLPS-Php-1783 | Physcomitrella patens | 34.72 | 3e-49 | 174 |
LLPS-Pyt-1272 | Pyrenophora teres | 34.1 | 3e-22 | 103 |
LLPS-Cogr-0594 | Colletotrichum graminicola | 33.91 | 9e-42 | 157 |
LLPS-Beb-1596 | Beauveria bassiana | 33.9 | 7e-42 | 158 |
LLPS-Asg-0791 | Ashbya gossypii | 33.84 | 4e-42 | 156 |
LLPS-Glm-1763 | Glycine max | 33.7 | 1e-06 | 54.7 |
LLPS-Asni-1559 | Aspergillus niger | 33.63 | 3e-49 | 176 |
LLPS-Coo-1278 | Colletotrichum orbiculare | 33.62 | 3e-42 | 159 |
LLPS-Trv-1585 | Trichoderma virens | 33.53 | 8e-45 | 163 |
LLPS-Mao-0994 | Magnaporthe oryzae | 33.52 | 1e-42 | 159 |
LLPS-Zem-2242 | Zea mays | 33.33 | 1e-48 | 172 |
LLPS-Cog-1384 | Colletotrichum gloeosporioides | 33.33 | 7e-40 | 152 |
LLPS-Miv-0927 | Microbotryum violaceum | 33.33 | 1e-49 | 175 |
LLPS-Sob-0355 | Sorghum bicolor | 33.33 | 3e-48 | 171 |
LLPS-Aso-1491 | Aspergillus oryzae | 33.04 | 2e-48 | 173 |
LLPS-Asf-0729 | Aspergillus flavus | 33.04 | 2e-48 | 173 |
LLPS-Gor-1176 | Gossypium raimondii | 32.93 | 2e-48 | 172 |
LLPS-Fuo-1334 | Fusarium oxysporum | 32.66 | 1e-42 | 160 |
LLPS-Trr-1046 | Trichoderma reesei | 32.66 | 3e-42 | 156 |
LLPS-Brr-2129 | Brassica rapa | 32.63 | 8e-44 | 159 |
LLPS-Coc-0562 | Corchorus capsularis | 32.61 | 3e-06 | 53.1 |
LLPS-Vir-1478 | Vigna radiata | 32.61 | 2e-06 | 53.9 |
LLPS-Dac-0856 | Daucus carota | 32.61 | 2e-06 | 54.3 |
LLPS-Via-0871 | Vigna angularis | 32.53 | 3e-39 | 147 |
LLPS-Sei-1848 | Setaria italica | 32.44 | 7e-48 | 171 |
LLPS-Sac-1150 | Saccharomyces cerevisiae | 32.43 | 4e-43 | 158 |
LLPS-Ved-1386 | Verticillium dahliae | 32.37 | 2e-39 | 151 |
LLPS-Pot-0970 | Populus trichocarpa | 32.33 | 6e-47 | 168 |
LLPS-Thc-1911 | Theobroma cacao | 32.33 | 2e-44 | 163 |
LLPS-Blg-1018 | Blumeria graminis | 32.16 | 1e-44 | 164 |
LLPS-Orp-0624 | Oryza punctata | 32.14 | 5e-48 | 171 |
LLPS-Orni-1987 | Oryza nivara | 32.14 | 7e-48 | 171 |
LLPS-Met-2590 | Medicago truncatula | 32.13 | 2e-41 | 154 |
LLPS-Bro-2349 | Brassica oleracea | 32.02 | 6e-42 | 154 |
LLPS-Amt-0595 | Amborella trichopoda | 32.02 | 1e-40 | 150 |
LLPS-Scs-0595 | Sclerotinia sclerotiorum | 32.01 | 1e-44 | 162 |
LLPS-Asfu-1625 | Aspergillus fumigatus | 31.95 | 8e-40 | 150 |
LLPS-Orr-0362 | Oryza rufipogon | 31.85 | 6e-47 | 168 |
LLPS-Orm-0995 | Oryza meridionalis | 31.85 | 6e-47 | 168 |
LLPS-Orgl-2012 | Oryza glumaepatula | 31.85 | 5e-46 | 166 |
LLPS-Hov-0108 | Hordeum vulgare | 31.85 | 1e-45 | 166 |
LLPS-Orb-1795 | Oryza barthii | 31.85 | 3e-46 | 166 |
LLPS-Ori-2224 | Oryza indica | 31.85 | 6e-47 | 168 |
LLPS-Ors-0484 | Oryza sativa | 31.55 | 3e-46 | 166 |
LLPS-Brd-1278 | Brachypodium distachyon | 31.55 | 2e-45 | 164 |
LLPS-Sol-2416 | Solanum lycopersicum | 31.42 | 7e-44 | 161 |
LLPS-Tru-0610 | Triticum urartu | 31.29 | 4e-45 | 164 |
LLPS-Orbr-1770 | Oryza brachyantha | 31.25 | 3e-43 | 158 |
LLPS-Asn-1570 | Aspergillus nidulans | 30.97 | 4e-38 | 145 |
LLPS-Cae-1751 | Caenorhabditis elegans | 30.86 | 1e-38 | 146 |
LLPS-Viv-0545 | Vitis vinifera | 30.82 | 4e-43 | 157 |
LLPS-Lep-0853 | Leersia perrieri | 30.23 | 5e-41 | 152 |
LLPS-Cus-1908 | Cucumis sativus | 30.06 | 6e-43 | 157 |
LLPS-Chc-0359 | Chondrus crispus | 29.97 | 1e-30 | 123 |
LLPS-Scj-1268 | Schizosaccharomyces japonicus | 29.69 | 1e-37 | 142 |
LLPS-Scc-0361 | Schizosaccharomyces cryophilus | 29.66 | 3e-36 | 139 |
LLPS-Sem-2235 | Selaginella moellendorffii | 29.62 | 6e-34 | 133 |
LLPS-Mua-1784 | Musa acuminata | 29.52 | 1e-40 | 150 |
LLPS-Prp-2345 | Prunus persica | 29.31 | 4e-41 | 152 |
LLPS-Kop-1152 | Komagataella pastoris | 29.28 | 9e-30 | 121 |
LLPS-Scp-1225 | Schizosaccharomyces pombe | 29.14 | 2e-24 | 105 |
LLPS-Yal-0188 | Yarrowia lipolytica | 29.1 | 2e-34 | 134 |
LLPS-Crn-0456 | Cryptococcus neoformans | 29.1 | 8e-34 | 133 |
LLPS-Mel-1104 | Melampsora laricipopulina | 28.46 | 7e-26 | 114 |
LLPS-Abg-1718 | Absidia glauca | 28.31 | 2e-23 | 106 |
LLPS-Ast-0251 | Aspergillus terreus | 27.81 | 2e-23 | 106 |
LLPS-Cis-0304 | Ciona savignyi | 27.74 | 2e-23 | 106 |
LLPS-Usm-0733 | Ustilago maydis | 25.72 | 1e-23 | 107 |
LLPS-Put-0902 | Puccinia triticina | 25.6 | 2e-22 | 103 |
LLPS-Spr-0673 | Sporisorium reilianum | 24.59 | 8e-23 | 102 |