LLPS-Mum-4867
Kctd12
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | BTB/POZ domain-containing protein KCTD12; Pfetin; Predominantly fetal expressed T1 domain |
| Gene Name: | Kctd12, Pfet1 |
| Ensembl Gene: | ENSMUSG00000098557.1 |
| Ensembl Protein: | ENSMUSP00000139261.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000184744.1 | ENSMUSP00000139261.1 |
| UniProt | Q6WVG3, KCD12_MOUSE, Q3T9E3 | |
| GeneBank | AK172581, AY267461 | AAP92150.1, BAE43079.1 |
| RefSeq | NM_177715.4 | NP_808383.3 |
| Entrez | 239217 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MALADSTRGL PNGGGGGGGS GSSSSSAEPP LFPDIVELNV GGQVYVTRRC TVVSVPDSLL 60 61 WRMFTQQQPQ ELARDSKGRF FLDRDGFLFR YILDYLRDLQ LVLPDYFPER SRLQREAEYF 120 121 ELPELVRRLG APQQPGPGPP PPHSRRGVHK EGSLGDELLP LGYAEPEPQE GASAGAPSPT 180 181 LELASRSPSG GAAGPLLTPS QSLDGSRRSG YITIGYRGSY TIGRDAQADA KFRRVARITV 240 241 CGKTSLAKEV FGDTLNESRD PDRPPERYTS RYYLKFNFLE QAFDKLSESG FHMVACSSTG 300 301 TCAFASSTDQ SEDKIWTSYT EYVFCRE 327 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCTCTGG CGGACAGCAC CCGAGGATTA CCCAACGGGG GCGGAGGCGG AGGTGGCAGC 60 61 GGCTCGTCGT CGTCCTCGGC GGAGCCGCCG CTCTTCCCGG ACATCGTAGA GCTGAACGTG 120 121 GGAGGGCAGG TGTATGTGAC CCGGCGCTGC ACCGTGGTGT CCGTGCCCGA CTCGCTGCTC 180 181 TGGCGTATGT TCACGCAGCA GCAGCCGCAG GAGCTGGCCC GGGACAGCAA AGGCCGCTTC 240 241 TTTCTGGACC GGGACGGCTT CCTCTTCCGC TACATCCTGG ATTACCTGCG GGACTTGCAG 300 301 CTCGTGCTGC CCGACTACTT CCCGGAGCGC AGCCGGCTGC AGCGCGAGGC CGAGTACTTC 360 361 GAGCTGCCGG AGCTCGTGCG TCGCCTCGGG GCGCCCCAGC AACCCGGTCC GGGGCCACCG 420 421 CCGCCGCACT CGCGCCGCGG GGTGCACAAG GAGGGCTCTC TGGGCGATGA GCTGCTGCCG 480 481 CTGGGCTACG CAGAGCCCGA GCCGCAGGAG GGCGCCTCGG CCGGGGCGCC TTCGCCCACG 540 541 CTGGAGCTGG CTAGCCGCAG CCCGTCCGGG GGCGCGGCGG GGCCCCTGCT CACGCCGTCC 600 601 CAGTCTTTGG ACGGCAGCCG GCGCTCCGGC TACATCACCA TCGGCTACCG CGGCTCCTAC 660 661 ACCATCGGGC GCGACGCTCA GGCGGACGCC AAGTTCCGGC GGGTGGCGCG CATCACCGTG 720 721 TGCGGCAAGA CGTCGCTGGC CAAGGAGGTG TTTGGGGACA CCCTGAATGA GAGCCGGGAC 780 781 CCCGACCGGC CCCCGGAGCG CTACACCTCC CGCTATTACC TCAAGTTCAA CTTCCTAGAG 840 841 CAGGCCTTCG ATAAGCTGTC CGAGTCGGGC TTCCACATGG TGGCGTGCAG CTCCACGGGC 900 901 ACCTGCGCTT TTGCTAGCAG CACCGACCAG AGCGAGGACA AGATCTGGAC CAGCTACACC 960 961 GAGTACGTCT TCTGCAGGGA GTGA 984 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell junction | |
Cellular Component | Postsynaptic membrane | |
Cellular Component | Presynaptic membrane | |
Cellular Component | Receptor complex | |
Molecular Function | Identical protein binding | |
Biological Process | Protein homooligomerization | |
Biological Process | Regulation of G protein-coupled receptor signaling pathway |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pap-1601 | Pan paniscus | 100.0 | 1e-109 | 323 |
| LLPS-Fec-1462 | Felis catus | 99.08 | 0.0 | 566 |
| LLPS-Mup-2295 | Mustela putorius furo | 99.08 | 0.0 | 566 |
| LLPS-Dio-2147 | Dipodomys ordii | 99.08 | 0.0 | 567 |
| LLPS-Ict-0939 | Ictidomys tridecemlineatus | 98.78 | 0.0 | 562 |
| LLPS-Poa-2076 | Pongo abelii | 98.78 | 0.0 | 562 |
| LLPS-Caf-1450 | Canis familiaris | 98.78 | 0.0 | 562 |
| LLPS-Chs-4775 | Chlorocebus sabaeus | 98.78 | 0.0 | 562 |
| LLPS-Mam-4712 | Macaca mulatta | 98.75 | 0.0 | 548 |
| LLPS-Hos-2130 | Homo sapiens | 98.47 | 0.0 | 561 |
| LLPS-Orc-0141 | Oryctolagus cuniculus | 97.84 | 0.0 | 543 |
| LLPS-Mea-2438 | Mesocricetus auratus | 97.57 | 0.0 | 558 |
| LLPS-Otg-1113 | Otolemur garnettii | 97.56 | 0.0 | 560 |
| LLPS-Ere-0958 | Erinaceus europaeus | 97.25 | 0.0 | 550 |
| LLPS-Sus-3014 | Sus scrofa | 97.2 | 0.0 | 545 |
| LLPS-Bot-1138 | Bos taurus | 96.94 | 0.0 | 554 |
| LLPS-Mod-2522 | Monodelphis domestica | 95.38 | 0.0 | 527 |
| LLPS-Cas-3292 | Carlito syrichta | 94.0 | 4e-96 | 288 |
| LLPS-Ova-3634 | Ovis aries | 93.69 | 8e-177 | 500 |
| LLPS-Cap-4420 | Cavia porcellus | 93.58 | 0.0 | 523 |
| LLPS-Loa-3979 | Loxodonta africana | 91.13 | 0.0 | 526 |
| LLPS-Xet-3826 | Xenopus tropicalis | 71.64 | 1e-142 | 413 |
| LLPS-Pes-3814 | Pelodiscus sinensis | 71.56 | 6e-132 | 386 |
| LLPS-Ten-3841 | Tetraodon nigroviridis | 70.71 | 7e-126 | 369 |
| LLPS-Gaga-3289 | Gallus gallus | 70.48 | 2e-128 | 377 |
| LLPS-Xim-1167 | Xiphophorus maculatus | 67.68 | 4e-119 | 351 |
| LLPS-Orl-2780 | Oryzias latipes | 67.24 | 5e-118 | 349 |
| LLPS-Pof-3966 | Poecilia formosa | 66.67 | 2e-119 | 353 |
| LLPS-Leo-3050 | Lepisosteus oculatus | 66.16 | 9e-127 | 372 |
| LLPS-Asm-2809 | Astyanax mexicanus | 66.0 | 1e-113 | 338 |
| LLPS-Tag-3421 | Taeniopygia guttata | 65.54 | 6e-114 | 338 |
| LLPS-Anp-3345 | Anas platyrhynchos | 64.78 | 3e-116 | 345 |
| LLPS-Fia-3579 | Ficedula albicollis | 64.53 | 1e-111 | 333 |
| LLPS-Orn-3282 | Oreochromis niloticus | 64.33 | 4e-122 | 360 |
| LLPS-Tar-0484 | Takifugu rubripes | 64.33 | 2e-124 | 365 |
| LLPS-Gaa-3743 | Gasterosteus aculeatus | 64.22 | 1e-122 | 360 |
| LLPS-Scf-0647 | Scleropages formosus | 64.19 | 4e-111 | 332 |
| LLPS-Dar-3251 | Danio rerio | 63.41 | 9e-118 | 348 |
| LLPS-Anc-2314 | Anolis carolinensis | 63.04 | 1e-113 | 338 |
| LLPS-Lac-3766 | Latimeria chalumnae | 62.92 | 1e-124 | 366 |
| LLPS-Icp-1863 | Ictalurus punctatus | 62.39 | 3e-112 | 334 |
| LLPS-Sah-3810 | Sarcophilus harrisii | 60.47 | 1e-106 | 320 |
| LLPS-Myl-1686 | Myotis lucifugus | 60.14 | 1e-107 | 322 |
| LLPS-Ran-4354 | Rattus norvegicus | 57.77 | 1e-103 | 312 |
| LLPS-Cii-0314 | Ciona intestinalis | 53.78 | 2e-29 | 119 |
| LLPS-Scm-0011 | Scophthalmus maximus | 46.32 | 4e-08 | 57.0 |
| LLPS-Meg-1724 | Meleagris gallopavo | 45.36 | 3e-08 | 57.4 |