LLPS-Mum-4845
Cep68
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Centrosomal protein of 68 kDa |
| Gene Name: | Cep68 |
| Ensembl Gene: | ENSMUSG00000044066.14 |
| Ensembl Protein: | ENSMUSP00000054943.7 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000050611.13 | ENSMUSP00000054943.7 |
| Ensembl | ENSMUST00000109596.7 | ENSMUSP00000105225.1 |
| Ensembl | ENSMUST00000162811.1 | ENSMUSP00000125113.1 |
| UniProt | Q8C0D9, CEP68_MOUSE, Q3US49, Q5SW85, Q8R2V0 | |
| GeneBank | BC027174, AK140820, AK031622, AL606522 | BAE24488.1, BAC27484.1, AAH27174.1 |
| RefSeq | NM_172260.3 | NP_758464.2 |
| Entrez | 216543 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MALSEDEAEA EVSVNTKVPS CGRWNSGKLL PSGLEPDQPL HLGVEGGPLW RAEADPGCIS 60 61 GVFLSRVHTA SKEPVADRSK PPLRGPLPSA SVGTGEVLHS MGSQMEEDRL PASQDLLPAL 120 121 QVFGTITVCS GQEADSEDFQ ATLDPSQVLG LSQQPHTSGL PLPPQWKSTV SPGAPQLSSR 180 181 SISASSVGSS LQDHQEKAGP QRASFANVSS PELTVPQAAH SVVGAGPPLQ GSAQPLTSGS 240 241 DATGLGKRHL SFQAEYWACA LPNSLPPSPN RHSALWDPNK EYEDLLDYTY PLRPGPQLPK 300 301 QPESHVLTEP VLQDSGVDLD SLSVSPASTL KSPTNVSHNC SSAEVPTLPF SGARESCLKR 360 361 WPLGIFQKQG GTSLSSWNQL ASTPRAPGTE DASWENREAA LRGTAEDCLP IGEDLRMGSP 420 421 QLKTKEKEPP FPRQKRGRQH VSCPACVTPG WPSEEEVGSD EEYLALPTRL TQVSSLVSYS 480 481 GARPSFVNLH TGAAEEHSSL QVSDSDKPAS PTLDSSHRKH PSGTSFQGPV GQNPCFRHSI 540 541 QPQDSRGKSS LMSNQTLGVS SKPLKTQPAS KAMTDRRLFS ELVAGETLPR TTDEQEKASL 600 601 VQCVQTFCCR LEELICWLYN VTDVADLSAP PRTSLTGLKS SLQLYRQFKK DVDEHQSLTE 660 661 SVLEKGEILL QCLLDNTPVL KDVLERIAKQ SGELESRADH LYDSILASLD MLAGCTLIPD 720 721 NRPTAAEHPH EGL 733 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCCTGA GTGAAGATGA GGCTGAGGCA GAAGTGTCTG TCAACACAAA GGTCCCATCC 60 61 TGTGGCAGGT GGAACTCTGG GAAGCTGCTG CCCTCAGGGC TTGAACCAGA TCAGCCCCTA 120 121 CATCTGGGTG TTGAGGGGGG GCCACTGTGG AGGGCTGAAG CTGACCCTGG CTGCATCTCG 180 181 GGAGTTTTCT TGTCACGGGT CCATACTGCC AGCAAAGAAC CAGTAGCAGA TAGGTCTAAG 240 241 CCTCCCCTCA GAGGCCCGCT TCCTTCTGCC AGTGTGGGCA CTGGAGAGGT TTTACACTCT 300 301 ATGGGCAGCC AAATGGAGGA AGACAGGCTT CCTGCCTCCC AGGACCTACT TCCAGCTCTT 360 361 CAAGTCTTTG GAACTATAAC TGTTTGCTCA GGACAGGAGG CTGACAGTGA AGACTTCCAG 420 421 GCTACGCTTG ATCCATCTCA GGTGTTGGGC CTCAGCCAGC AACCACACAC CTCAGGTCTC 480 481 CCTCTCCCGC CACAGTGGAA GTCCACGGTG AGCCCAGGTG CTCCTCAGCT TTCTAGCAGA 540 541 AGCATCTCTG CCTCCTCGGT GGGCAGCAGT CTTCAGGATC ACCAAGAGAA GGCAGGACCT 600 601 CAGAGGGCCT CTTTTGCCAA TGTCTCCTCT CCCGAGTTGA CTGTACCCCA GGCAGCCCAC 660 661 TCTGTGGTGG GGGCAGGGCC TCCGCTCCAG GGGTCAGCAC AGCCTCTGAC CTCTGGCAGT 720 721 GATGCTACAG GCCTGGGTAA GAGACACCTC TCCTTTCAGG CAGAATACTG GGCCTGTGCG 780 781 CTGCCAAATT CTCTGCCTCC TTCCCCTAAC CGCCACTCCG CACTCTGGGA CCCAAATAAA 840 841 GAGTATGAAG ATCTGCTTGA CTACACTTAC CCACTGAGGC CTGGGCCTCA GCTCCCAAAG 900 901 CAACCTGAAA GTCATGTCCT GACTGAGCCT GTTCTGCAGG ACTCAGGTGT AGATCTGGAC 960 961 AGTTTGTCTG TCTCCCCAGC AAGTACTCTA AAGTCACCCA CTAATGTCTC CCACAATTGC 1020 1021 TCATCAGCAG AAGTGCCTAC TCTGCCATTT TCTGGAGCCA GAGAGTCATG TCTTAAGCGC 1080 1081 TGGCCCTTGG GAATATTCCA GAAACAGGGT GGCACAAGCT TGTCATCCTG GAACCAGCTT 1140 1141 GCATCAACCC CTAGAGCCCC AGGCACTGAA GATGCTTCTT GGGAGAACAG AGAGGCAGCC 1200 1201 CTGAGGGGCA CAGCGGAGGA CTGCCTCCCT ATAGGTGAGG ACCTCCGAAT GGGCTCTCCC 1260 1261 CAGCTGAAGA CGAAGGAGAA AGAGCCACCC TTTCCCAGAC AGAAGAGAGG CAGGCAGCAT 1320 1321 GTTAGCTGCC CGGCCTGTGT GACGCCTGGA TGGCCATCAG AAGAGGAGGT GGGAAGTGAT 1380 1381 GAGGAGTACC TTGCTCTGCC CACCAGGCTG ACTCAGGTCT CTAGTTTGGT GTCCTACTCA 1440 1441 GGTGCCAGGC CCTCCTTTGT GAACCTACAC ACTGGGGCTG CTGAGGAACA CAGTTCACTA 1500 1501 CAAGTCTCAG ACAGTGACAA GCCAGCCTCC CCCACATTGG ACTCCAGCCA CAGGAAGCAT 1560 1561 CCTTCTGGAA CTTCCTTTCA AGGGCCTGTG GGCCAGAACC CCTGCTTCAG GCATTCTATC 1620 1621 CAGCCCCAGG ACTCTAGAGG CAAAAGTAGT CTGATGAGTA ACCAGACCCT CGGGGTCTCT 1680 1681 TCAAAACCAC TGAAAACTCA GCCCGCCTCA AAAGCCATGA CGGACAGGCG GCTGTTCTCC 1740 1741 GAGCTAGTAG CTGGAGAGAC ACTTCCCAGG ACGACAGATG AGCAGGAGAA AGCTTCTCTA 1800 1801 GTGCAGTGTG TGCAGACATT TTGCTGTCGG CTGGAAGAGC TGATCTGCTG GTTGTATAAT 1860 1861 GTCACAGATG TTGCTGACCT CAGTGCTCCA CCCAGGACCA GCCTTACAGG TCTCAAGTCT 1920 1921 TCTCTGCAGC TTTACAGGCA ATTTAAGAAA GATGTAGACG AACATCAGTC CCTGACAGAG 1980 1981 AGCGTCTTGG AGAAGGGAGA GATTCTTCTT CAGTGCCTGT TGGATAACAC CCCAGTTTTA 2040 2041 AAGGATGTCC TTGAGAGGAT TGCAAAGCAG TCTGGTGAGC TGGAGAGCCG TGCAGATCAT 2100 2101 CTTTATGACT CTATCTTAGC CTCTTTGGAC ATGTTGGCTG GCTGCACCCT CATCCCTGAC 2160 2161 AACAGGCCAA CAGCAGCAGA ACACCCACAT GAAGGGCTTT AA 2202 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell junction | |
Cellular Component | Centrosome | |
Cellular Component | Cytosol | |
Cellular Component | Microtubule organizing center | |
Cellular Component | Nucleus | |
Molecular Function | Protein domain specific binding | |
Molecular Function | Protein kinase binding | |
Biological Process | Centriole-centriole cohesion | |
Biological Process | Centrosome cycle | |
Biological Process | Protein localization to organelle |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-0127 | Rattus norvegicus | 81.52 | 0.0 | 1137 |
| LLPS-Nol-2098 | Nomascus leucogenys | 80.0 | 8e-58 | 212 |
| LLPS-Orn-3811 | Oreochromis niloticus | 76.74 | 1e-16 | 87.8 |
| LLPS-Xim-0058 | Xiphophorus maculatus | 75.0 | 3e-15 | 83.6 |
| LLPS-Pof-4084 | Poecilia formosa | 75.0 | 2e-15 | 84.3 |
| LLPS-Mea-0101 | Mesocricetus auratus | 72.16 | 0.0 | 934 |
| LLPS-Meg-1941 | Meleagris gallopavo | 71.7 | 8e-17 | 88.2 |
| LLPS-Tag-0980 | Taeniopygia guttata | 69.81 | 1e-17 | 86.3 |
| LLPS-Anp-0219 | Anas platyrhynchos | 69.23 | 1e-15 | 84.0 |
| LLPS-Icp-2937 | Ictalurus punctatus | 68.18 | 9e-14 | 79.0 |
| LLPS-Pes-3141 | Pelodiscus sinensis | 67.44 | 3e-19 | 96.7 |
| LLPS-Leo-3327 | Lepisosteus oculatus | 67.31 | 7e-15 | 82.8 |
| LLPS-Dar-0082 | Danio rerio | 66.67 | 4e-15 | 83.6 |
| LLPS-Gaga-3987 | Gallus gallus | 66.67 | 5e-17 | 89.7 |
| LLPS-Man-4596 | Macaca nemestrina | 63.11 | 0.0 | 680 |
| LLPS-Lac-4019 | Latimeria chalumnae | 62.75 | 3e-13 | 77.0 |
| LLPS-Dio-3396 | Dipodomys ordii | 62.2 | 0.0 | 742 |
| LLPS-Gaa-1197 | Gasterosteus aculeatus | 61.9 | 4e-16 | 83.6 |
| LLPS-Maf-4391 | Macaca fascicularis | 60.79 | 0.0 | 702 |
| LLPS-Mam-2099 | Macaca mulatta | 60.79 | 0.0 | 703 |
| LLPS-Mal-0252 | Mandrillus leucophaeus | 60.66 | 0.0 | 701 |
| LLPS-Ict-1977 | Ictidomys tridecemlineatus | 60.63 | 0.0 | 744 |
| LLPS-Pap-2237 | Pan paniscus | 60.61 | 0.0 | 705 |
| LLPS-Chs-3246 | Chlorocebus sabaeus | 60.53 | 0.0 | 710 |
| LLPS-Paa-4293 | Papio anubis | 60.53 | 0.0 | 699 |
| LLPS-Gog-3144 | Gorilla gorilla | 60.47 | 0.0 | 696 |
| LLPS-Orl-0226 | Oryzias latipes | 60.47 | 3e-10 | 67.8 |
| LLPS-Cea-1137 | Cercocebus atys | 60.39 | 0.0 | 697 |
| LLPS-Hos-1378 | Homo sapiens | 60.34 | 0.0 | 696 |
| LLPS-Pat-2922 | Pan troglodytes | 60.34 | 0.0 | 701 |
| LLPS-Poa-2380 | Pongo abelii | 60.26 | 0.0 | 688 |
| LLPS-Loa-3643 | Loxodonta africana | 59.97 | 0.0 | 587 |
| LLPS-Eqc-2319 | Equus caballus | 59.76 | 0.0 | 703 |
| LLPS-Rhb-3886 | Rhinopithecus bieti | 59.74 | 0.0 | 690 |
| LLPS-Aim-4024 | Ailuropoda melanoleuca | 58.82 | 0.0 | 671 |
| LLPS-Aon-0698 | Aotus nancymaae | 58.78 | 0.0 | 686 |
| LLPS-Caj-3274 | Callithrix jacchus | 58.65 | 0.0 | 678 |
| LLPS-Cas-2429 | Carlito syrichta | 58.3 | 0.0 | 671 |
| LLPS-Fec-3575 | Felis catus | 58.08 | 0.0 | 694 |
| LLPS-Tut-1970 | Tursiops truncatus | 57.43 | 0.0 | 672 |
| LLPS-Myl-4226 | Myotis lucifugus | 57.2 | 0.0 | 659 |
| LLPS-Mup-1501 | Mustela putorius furo | 56.82 | 0.0 | 647 |
| LLPS-Fud-4048 | Fukomys damarensis | 56.78 | 0.0 | 686 |
| LLPS-Orc-1655 | Oryctolagus cuniculus | 56.69 | 0.0 | 630 |
| LLPS-Cap-1476 | Cavia porcellus | 56.64 | 0.0 | 639 |
| LLPS-Sus-2652 | Sus scrofa | 56.61 | 0.0 | 643 |
| LLPS-Otg-4159 | Otolemur garnettii | 55.26 | 7e-179 | 534 |
| LLPS-Bot-3562 | Bos taurus | 55.2 | 0.0 | 641 |
| LLPS-Urm-3727 | Ursus maritimus | 55.09 | 5e-176 | 527 |
| LLPS-Fia-0092 | Ficedula albicollis | 55.07 | 9e-16 | 84.0 |
| LLPS-Xet-3515 | Xenopus tropicalis | 54.05 | 4e-15 | 83.2 |
| LLPS-Ere-1045 | Erinaceus europaeus | 53.04 | 0.0 | 596 |
| LLPS-Caf-3052 | Canis familiaris | 52.44 | 0.0 | 585 |
| LLPS-Asm-1322 | Astyanax mexicanus | 45.0 | 5e-16 | 86.7 |
| LLPS-Mod-1557 | Monodelphis domestica | 41.29 | 8e-82 | 274 |
| LLPS-Tar-0995 | Takifugu rubripes | 41.0 | 1e-12 | 75.5 |
| LLPS-Sah-1849 | Sarcophilus harrisii | 38.27 | 2e-117 | 377 |
| LLPS-Ora-3393 | Ornithorhynchus anatinus | 33.05 | 3e-11 | 71.6 |
| LLPS-Anc-2425 | Anolis carolinensis | 32.12 | 1e-51 | 191 |
| LLPS-Scf-0493 | Scleropages formosus | 31.53 | 2e-10 | 69.3 |
| LLPS-Ova-3173 | Ovis aries | 28.57 | 2e-10 | 68.6 |
| LLPS-Scm-2846 | Scophthalmus maximus | 26.71 | 4e-07 | 58.2 |