LLPS-Mum-4797
Slc10a2
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Ileal sodium/bile acid cotransporter; Apical sodium-dependent bile acid transporter; ASBT; Ileal Na(+)/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; IBAT; ISBT; Na(+)-dependent ileal bile acid transporter; Sodium/taurocholate cotransporting polypeptide, ileal; Solute carrier family 10 member 2 |
| Gene Name: | Slc10a2, Ntcp2 |
| Ensembl Gene: | ENSMUSG00000023073.2 |
| Ensembl Protein: | ENSMUSP00000023835.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000023835.2 | ENSMUSP00000023835.1 |
| UniProt | P70172, NTCP2_MOUSE, Q8VI83, Q925U7 | |
| GeneBank | AF266728, AF266724, AB078635, AB002693, AF266726, AF266725, AY529655, D87059, AF266727, AF271073 | BAB84081.1, BAA19606.1, AAK55514.1, BAA13237.1, AAS20611.1 |
| RefSeq | NM_011388.3 | NP_035518.1 |
| Entrez | 20494 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MDNSSVCPPN ATVCEGDSCV VPESNFNAIL NTVMSTVLTI LLAMVMFSMG CNVEVHKFLG 60 61 HIKRPWGIFV GFLCQFGIMP LTGFILSVAS GILPVQAVVV LIMGCCPGGT GSNILAYWID 120 121 GDMDLSVSMT TCSTLLALGM MPLCLFVYTK MWVDSGTIVI PYDSIGISLV ALVIPVSFGM 180 181 FVNHKWPQKA KIILKIGSIT GVILIVLIAV IGGILYQSAW IIEPKLWIIG TIFPIAGYSL 240 241 GFFLARLAGQ PWYRCRTVAL ETGMQNTQLC STIVQLSFSP EDLNLVFTFP LIYTVFQLVF 300 301 AAVILGIYVT YRKCYGKNDA EFLEKTDNEM DSRPSFDETN KGFQPDEK 348 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGATAACT CCTCTGTCTG TCCCCCAAAT GCAACTGTCT GCGAAGGCGA TTCCTGCGTA 60 61 GTACCTGAGA GCAACTTCAA TGCAATTCTC AATACAGTGA TGAGCACTGT GCTCACCATC 120 121 CTCTTAGCCA TGGTGATGTT TTCTATGGGG TGCAATGTGG AAGTCCACAA GTTCCTAGGA 180 181 CATATAAAGA GACCATGGGG TATCTTCGTG GGCTTCCTCT GTCAGTTTGG AATCATGCCT 240 241 CTCACAGGCT TTATCCTGTC TGTGGCCTCT GGCATCCTTC CTGTACAGGC TGTAGTGGTG 300 301 CTAATTATGG GTTGCTGCCC TGGAGGAACT GGCTCCAATA TCCTGGCCTA TTGGATAGAT 360 361 GGCGACATGG ACCTCAGTGT TAGCATGACC ACTTGCTCCA CACTGCTTGC CCTTGGAATG 420 421 ATGCCTCTTT GCCTCTTCGT CTACACCAAG ATGTGGGTTG ACTCGGGAAC GATTGTGATT 480 481 CCCTATGATA GCATTGGTAT TTCTCTGGTT GCTCTTGTTA TTCCTGTTTC CTTTGGAATG 540 541 TTTGTAAATC ACAAATGGCC ACAAAAAGCG AAGATTATAC TTAAAATTGG ATCCATCACA 600 601 GGTGTAATTC TCATTGTGCT CATAGCTGTG ATTGGAGGAA TACTGTACCA AAGTGCCTGG 660 661 ATCATTGAAC CCAAACTGTG GATTATAGGA ACAATATTCC CTATAGCTGG CTACAGCCTG 720 721 GGTTTCTTCC TGGCTAGACT AGCTGGTCAA CCCTGGTACA GGTGCCGAAC AGTAGCCTTG 780 781 GAAACTGGAA TGCAGAACAC TCAGCTGTGC TCCACCATTG TACAGCTCTC CTTCTCCCCC 840 841 GAGGATCTCA ACCTGGTGTT CACCTTCCCA CTCATCTATA CTGTTTTCCA GCTCGTCTTT 900 901 GCAGCAGTAA TATTAGGAAT TTATGTCACA TACAGGAAAT GTTATGGAAA AAATGATGCT 960 961 GAGTTTCTAG AGAAAACAGA CAATGAAATG GACTCCAGGC CATCATTTGA TGAGACAAAC 1020 1021 AAGGGATTTC AACCAGATGA GAAGTAG 1047 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Apical plasma membrane | |
Cellular Component | Integral component of membrane | |
Cellular Component | Microvillus | |
Cellular Component | Nucleus | |
Cellular Component | Proteasome complex | |
Molecular Function | Bile acid:sodium symporter activity | |
Biological Process | Bile acid and bile salt transport | |
Biological Process | Response to bacterium |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-4591 | Rattus norvegicus | 89.68 | 0.0 | 604 |
| LLPS-Mea-0882 | Mesocricetus auratus | 86.49 | 0.0 | 609 |
| LLPS-Caf-3666 | Canis familiaris | 82.62 | 4e-176 | 498 |
| LLPS-Orc-4348 | Oryctolagus cuniculus | 82.42 | 0.0 | 572 |
| LLPS-Ict-4612 | Ictidomys tridecemlineatus | 82.18 | 0.0 | 580 |
| LLPS-Eqc-0231 | Equus caballus | 81.61 | 0.0 | 556 |
| LLPS-Dio-1924 | Dipodomys ordii | 81.32 | 0.0 | 567 |
| LLPS-Bot-4820 | Bos taurus | 80.95 | 0.0 | 538 |
| LLPS-Nol-3378 | Nomascus leucogenys | 80.75 | 0.0 | 556 |
| LLPS-Sus-4533 | Sus scrofa | 80.75 | 2e-175 | 499 |
| LLPS-Myl-0024 | Myotis lucifugus | 80.75 | 0.0 | 560 |
| LLPS-Ova-1314 | Ovis aries | 80.55 | 0.0 | 518 |
| LLPS-Hos-3904 | Homo sapiens | 80.46 | 0.0 | 553 |
| LLPS-Pat-0019 | Pan troglodytes | 80.46 | 0.0 | 552 |
| LLPS-Pap-1063 | Pan paniscus | 80.46 | 0.0 | 553 |
| LLPS-Poa-4312 | Pongo abelii | 80.17 | 0.0 | 553 |
| LLPS-Gog-4512 | Gorilla gorilla | 80.17 | 0.0 | 551 |
| LLPS-Paa-3419 | Papio anubis | 80.17 | 0.0 | 554 |
| LLPS-Mal-2275 | Mandrillus leucophaeus | 80.17 | 0.0 | 554 |
| LLPS-Fec-3114 | Felis catus | 79.89 | 0.0 | 548 |
| LLPS-Cea-3956 | Cercocebus atys | 79.89 | 0.0 | 553 |
| LLPS-Chs-2589 | Chlorocebus sabaeus | 79.6 | 0.0 | 551 |
| LLPS-Aon-1029 | Aotus nancymaae | 79.31 | 0.0 | 550 |
| LLPS-Mup-0785 | Mustela putorius furo | 79.31 | 0.0 | 548 |
| LLPS-Mam-2021 | Macaca mulatta | 79.02 | 0.0 | 546 |
| LLPS-Man-4694 | Macaca nemestrina | 78.74 | 0.0 | 546 |
| LLPS-Otg-1563 | Otolemur garnettii | 78.45 | 0.0 | 526 |
| LLPS-Rhb-0747 | Rhinopithecus bieti | 78.45 | 0.0 | 539 |
| LLPS-Maf-3808 | Macaca fascicularis | 78.45 | 0.0 | 548 |
| LLPS-Cas-3856 | Carlito syrichta | 78.22 | 0.0 | 534 |
| LLPS-Aim-4284 | Ailuropoda melanoleuca | 77.87 | 0.0 | 543 |
| LLPS-Caj-3561 | Callithrix jacchus | 77.3 | 0.0 | 537 |
| LLPS-Fud-1341 | Fukomys damarensis | 77.01 | 0.0 | 540 |
| LLPS-Tut-2429 | Tursiops truncatus | 76.72 | 0.0 | 538 |
| LLPS-Cap-3576 | Cavia porcellus | 75.72 | 0.0 | 540 |
| LLPS-Gaga-3361 | Gallus gallus | 72.49 | 1e-167 | 480 |
| LLPS-Ora-1707 | Ornithorhynchus anatinus | 71.1 | 4e-174 | 495 |
| LLPS-Xet-3217 | Xenopus tropicalis | 70.47 | 9e-163 | 467 |
| LLPS-Anc-0354 | Anolis carolinensis | 69.54 | 1e-165 | 475 |
| LLPS-Sah-1797 | Sarcophilus harrisii | 69.28 | 7e-167 | 477 |
| LLPS-Asm-3608 | Astyanax mexicanus | 63.32 | 4e-151 | 437 |
| LLPS-Orn-0054 | Oreochromis niloticus | 60.56 | 4e-148 | 430 |
| LLPS-Lac-3896 | Latimeria chalumnae | 40.0 | 2e-62 | 209 |
| LLPS-Cii-0265 | Ciona intestinalis | 39.93 | 1e-46 | 166 |
| LLPS-Mae-2688 | Manihot esculenta | 38.32 | 2e-15 | 80.5 |
| LLPS-Coc-1819 | Corchorus capsularis | 36.08 | 2e-11 | 68.9 |
| LLPS-Thc-1017 | Theobroma cacao | 34.81 | 2e-16 | 84.0 |
| LLPS-Nia-1972 | Nicotiana attenuata | 33.13 | 3e-18 | 89.0 |
| LLPS-Sol-0370 | Solanum lycopersicum | 33.13 | 2e-18 | 89.4 |
| LLPS-Sot-0093 | Solanum tuberosum | 33.13 | 2e-18 | 89.4 |
| LLPS-Amt-2329 | Amborella trichopoda | 31.23 | 4e-20 | 94.4 |
| LLPS-Cym-1038 | Cyanidioschyzon merolae | 30.3 | 6e-11 | 67.4 |
| LLPS-Prp-0932 | Prunus persica | 30.08 | 4e-21 | 97.1 |
| LLPS-Viv-1379 | Vitis vinifera | 30.04 | 5e-20 | 94.0 |
| LLPS-Cus-0892 | Cucumis sativus | 29.8 | 8e-18 | 87.8 |
| LLPS-Chc-0924 | Chondrus crispus | 29.56 | 2e-12 | 72.0 |
| LLPS-Met-0345 | Medicago truncatula | 29.41 | 3e-20 | 94.4 |
| LLPS-Brd-2103 | Brachypodium distachyon | 29.37 | 8e-21 | 96.3 |
| LLPS-Sob-1732 | Sorghum bicolor | 29.32 | 1e-19 | 93.2 |
| LLPS-Art-0260 | Arabidopsis thaliana | 29.25 | 5e-20 | 94.0 |
| LLPS-Hea-0787 | Helianthus annuus | 29.25 | 2e-20 | 95.1 |
| LLPS-Brn-0511 | Brassica napus | 29.25 | 4e-20 | 94.0 |
| LLPS-Sem-1435 | Selaginella moellendorffii | 29.18 | 9e-21 | 95.9 |
| LLPS-Dac-2269 | Daucus carota | 29.13 | 4e-20 | 94.4 |
| LLPS-Bro-1235 | Brassica oleracea | 28.97 | 4e-19 | 91.3 |
| LLPS-Phv-2144 | Phaseolus vulgaris | 28.85 | 4e-16 | 82.8 |
| LLPS-Brr-0861 | Brassica rapa | 28.85 | 3e-19 | 92.0 |
| LLPS-Pot-1883 | Populus trichocarpa | 28.85 | 9e-21 | 96.3 |
| LLPS-Vir-1745 | Vigna radiata | 28.85 | 2e-16 | 84.0 |
| LLPS-Arl-2096 | Arabidopsis lyrata | 28.85 | 2e-19 | 92.4 |
| LLPS-Via-1505 | Vigna angularis | 28.85 | 2e-16 | 84.0 |
| LLPS-Orp-1609 | Oryza punctata | 28.57 | 9e-21 | 96.3 |
| LLPS-Tra-1303 | Triticum aestivum | 28.57 | 1e-19 | 92.8 |
| LLPS-Lep-1239 | Leersia perrieri | 28.57 | 4e-21 | 97.1 |
| LLPS-Glm-2612 | Glycine max | 28.4 | 2e-18 | 89.4 |
| LLPS-Orbr-1135 | Oryza brachyantha | 28.34 | 7e-21 | 96.3 |
| LLPS-Ors-1009 | Oryza sativa | 28.34 | 5e-21 | 97.1 |
| LLPS-Org-1722 | Oryza glaberrima | 28.34 | 5e-21 | 97.1 |
| LLPS-Orm-0948 | Oryza meridionalis | 28.34 | 5e-21 | 96.7 |
| LLPS-Orr-1362 | Oryza rufipogon | 28.34 | 5e-21 | 97.1 |
| LLPS-Orni-1669 | Oryza nivara | 28.34 | 5e-21 | 97.1 |
| LLPS-Orb-0346 | Oryza barthii | 28.34 | 5e-21 | 97.1 |
| LLPS-Ori-1958 | Oryza indica | 28.34 | 5e-21 | 97.1 |
| LLPS-Orgl-1632 | Oryza glumaepatula | 28.34 | 1e-20 | 97.1 |
| LLPS-Php-0855 | Physcomitrella patens | 27.95 | 2e-17 | 86.7 |
| LLPS-Sei-2121 | Setaria italica | 27.83 | 7e-18 | 88.2 |
| LLPS-Mua-0987 | Musa acuminata | 26.33 | 4e-16 | 82.8 |
| LLPS-Tru-0899 | Triticum urartu | 25.71 | 9e-15 | 79.0 |
| LLPS-Gor-1351 | Gossypium raimondii | 25.44 | 9e-17 | 84.7 |
| LLPS-Gas-0590 | Galdieria sulphuraria | 25.08 | 4e-10 | 64.7 |