LLPS-Mum-4583
Cyb5r3

▼ OVERVIEW

Status: Reviewed
Protein Name: NADH-cytochrome b5 reductase 3
Gene Name: Cyb5r3, Dia1
Ensembl Gene: ENSMUSG00000018042.18
Ensembl Protein: ENSMUSP00000125636.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613
NucleolusPredicted from orthologsN/A(View)

▼ FUNCTION

Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKLFQRSTPA  ITLENPDIKY  PLRLIDKEVI  SPDTRRFRFA  LPSPQHILGL  PIGQHIYLST  60
61    RIDGNLVIRP  YTPVSSDDDK  GFVDLVVKVY  FKDTHPKFPA  GGKMSQYLEN  MKIGDTIEFR  120
121   GPNGLLVYQG  KGKFAIRADK  KSNPVVRTVK  SVGMIAGGTG  ITPMLQVIRA  VLKDPNDHTV  180
181   CYLLFANQSE  KDILLRPELE  ELRNEHSARF  KLWYTVDKAP  DGEHGKPLVE  QEAAHAVLVA  240
241   CSWLWRNQTS  EGKCPQPTAR  EQQSQGGDPR  PCFLVSHTAP  GWQRSPLISL  GLAHFGAGLG  300
301   AVLRVGWLLL  CSW  313
Nucleotide CDS Sequence (FASTA)
1     ATGGGGGCCC  AGCTGAGCAC  GTTGAGCCAC  GTGGTGCTCT  CGCCCGTCTG  GTTCATCTAC  60
61    AGTCTCTTCA  TGAAGCTGTT  TCAGCGCTCC  ACACCGGCCA  TCACCCTCGA  GAACCCCGAC  120
121   ATCAAGTACC  CTCTGAGGCT  CATCGACAAG  GAGGTCATCA  GTCCTGACAC  TCGGCGCTTC  180
181   CGATTTGCCC  TCCCTTCACC  CCAGCACATC  CTGGGCCTTC  CTATTGGCCA  ACACATCTAC  240
241   CTCTCGACTA  GGATCGATGG  CAACTTGGTC  ATTCGGCCCT  ACACCCCTGT  GTCGAGCGAT  300
301   GATGACAAGG  GCTTTGTGGA  CTTGGTGGTC  AAGGTTTACT  TCAAGGACAC  CCATCCCAAG  360
361   TTTCCAGCTG  GAGGGAAAAT  GTCTCAGTAC  CTGGAAAACA  TGAAGATTGG  AGACACCATT  420
421   GAATTCCGGG  GTCCCAATGG  GCTACTGGTC  TACCAGGGCA  AAGGGAAGTT  TGCCATCCGT  480
481   GCAGACAAGA  AGTCCAACCC  CGTTGTCAGG  ACGGTGAAGT  CTGTAGGCAT  GATTGCAGGA  540
541   GGGACAGGCA  TCACCCCAAT  GCTGCAGGTG  ATCCGAGCCG  TCCTGAAGGA  CCCAAACGAC  600
601   CACACCGTGT  GCTATCTGCT  CTTTGCCAAC  CAGTCCGAGA  AAGATATCCT  GTTGCGGCCT  660
661   GAGCTGGAGG  AACTGAGGAA  CGAACATTCT  GCTCGCTTCA  AGCTCTGGTA  CACAGTGGAC  720
721   AAAGCCCCTG  ATGCCTGGGA  CTATAGCCAG  GGCTTCGTGA  ATGAGGAGAT  GATCAGGGAC  780
781   CACCTTCCAA  CTCCTGGGGA  GGAGCCGCTG  ATACTGATGT  GTGGACCCCC  ACCAATGATC  840
841   CAGTTTGCCT  GTTTGCCAAA  CCTGGAGCGT  GTGGGCCATC  CCAAGGAGCG  ATGCTTCACC  900
901   TTCTGA  906

▼ KEYWORD

ID
Family
Acetylation
Alternative promoter usage
Cholesterol biosynthesis
Cholesterol metabolism
Complete proteome
Cytoplasm
Direct protein sequencing
Endoplasmic reticulum
FAD
Flavoprotein
Lipid biosynthesis
Lipid metabolism
Lipoprotein
Membrane
Mitochondrion
Mitochondrion outer membrane
Myristate
NAD
Oxidoreductase
Phosphoprotein
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Lipid droplet
Cellular Component
Mitochondrial inner membrane
Cellular Component
Mitochondrial outer membrane
Molecular Function
ADP binding
Molecular Function
AMP binding
Molecular Function
Cytochrome-b5 reductase activity, acting on NAD(P)H
Molecular Function
FAD binding
Molecular Function
Flavin adenine dinucleotide binding
Molecular Function
NAD binding
Biological Process
Cholesterol biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-3599Rattus norvegicus93.562e-144 416
LLPS-Dio-4276Dipodomys ordii93.263e-120 350
LLPS-Nol-4120Nomascus leucogenys90.52e-136 395
LLPS-Poa-4223Pongo abelii90.137e-137 397
LLPS-Loa-2763Loxodonta africana89.644e-139 401
LLPS-Ova-1568Ovis aries89.279e-139 402
LLPS-Ict-1910Ictidomys tridecemlineatus88.842e-138 400
LLPS-Chs-3237Chlorocebus sabaeus88.565e-117 348
LLPS-Fec-4122Felis catus88.462e-135 395
LLPS-Tut-0345Tursiops truncatus88.412e-136 396
LLPS-Mup-0109Mustela putorius furo88.413e-136 395
LLPS-Urm-1266Ursus maritimus87.981e-135 398
LLPS-Eqc-0731Equus caballus87.984e-137 398
LLPS-Caf-4470Canis familiaris87.987e-136 395
LLPS-Orc-3118Oryctolagus cuniculus87.862e-118 348
LLPS-Aim-1031Ailuropoda melanoleuca87.558e-136 394
LLPS-Pat-4377Pan troglodytes87.122e-136 397
LLPS-Pap-1876Pan paniscus87.122e-136 397
LLPS-Cas-2244Carlito syrichta87.128e-136 395
LLPS-Fud-3608Fukomys damarensis87.124e-137 397
LLPS-Bot-4331Bos taurus86.891e-115 345
LLPS-Rhb-2975Rhinopithecus bieti86.73e-135 394
LLPS-Aon-2021Aotus nancymaae86.72e-136 395
LLPS-Man-4152Macaca nemestrina86.278e-135 393
LLPS-Cea-3630Cercocebus atys86.271e-134 392
LLPS-Paa-2120Papio anubis86.278e-135 393
LLPS-Mal-3653Mandrillus leucophaeus86.278e-135 393
LLPS-Hos-2059Homo sapiens85.845e-136 396
LLPS-Maf-2219Macaca fascicularis85.843e-134 392
LLPS-Gog-4339Gorilla gorilla85.842e-135 395
LLPS-Mam-3154Macaca mulatta85.412e-134 392
LLPS-Sus-4233Sus scrofa85.414e-132 385
LLPS-Mea-3921Mesocricetus auratus85.256e-154 442
LLPS-Otg-2872Otolemur garnettii84.559e-135 392
LLPS-Cap-4561Cavia porcellus84.123e-132 385
LLPS-Sah-2247Sarcophilus harrisii80.699e-126 369
LLPS-Caj-3894Callithrix jacchus79.151e-116 345
LLPS-Scf-3582Scleropages formosus76.065e-114 339
LLPS-Anc-3189Anolis carolinensis75.977e-119 351
LLPS-Pof-3413Poecilia formosa74.432e-112 335
LLPS-Dar-2089Danio rerio74.362e-118 350
LLPS-Pes-2169Pelodiscus sinensis73.394e-115 342
LLPS-Gaa-1582Gasterosteus aculeatus72.441e-108 325
LLPS-Anp-2196Anas platyrhynchos71.121e-109 328
LLPS-Fia-3309Ficedula albicollis70.822e-110 330
LLPS-Asm-0548Astyanax mexicanus70.822e-111 332
LLPS-Tag-0175Taeniopygia guttata70.764e-110 329
LLPS-Gaga-0964Gallus gallus70.692e-108 327
LLPS-Xim-3671Xiphophorus maculatus70.564e-112 334
LLPS-Meg-3224Meleagris gallopavo70.514e-107 322
LLPS-Lac-1778Latimeria chalumnae70.451e-103 313
LLPS-Tar-3371Takifugu rubripes70.136e-111 333
LLPS-Xet-0208Xenopus tropicalis69.332e-112 335
LLPS-Ten-3185Tetraodon nigroviridis69.265e-110 328
LLPS-Orn-1189Oreochromis niloticus69.21e-110 330
LLPS-Icp-3539Ictalurus punctatus67.932e-108 324
LLPS-Scm-3090Scophthalmus maximus67.514e-107 323
LLPS-Cii-1482Ciona intestinalis63.161e-84 264
LLPS-Drm-0791Drosophila melanogaster62.561e-81 257
LLPS-Cae-1938Caenorhabditis elegans62.54e-82 257
LLPS-Mod-3941Monodelphis domestica61.734e-92 283
LLPS-Php-0099Physcomitrella patens54.861e-59 209
LLPS-Phv-1005Phaseolus vulgaris50.963e-59 208
LLPS-Brr-0913Brassica rapa50.478e-58 204
LLPS-Brn-2911Brassica napus50.474e-59 204
LLPS-Mua-0978Musa acuminata50.253e-55 199
LLPS-Pot-2279Populus trichocarpa49.512e-54 195
LLPS-Tra-1407Triticum aestivum49.071e-56 201
LLPS-Gor-0699Gossypium raimondii49.021e-52 190
LLPS-Mae-1525Manihot esculenta48.768e-56 192
LLPS-Osl-1112Ostreococcus lucimarinus48.532e-48 168
LLPS-Glm-2370Glycine max48.536e-56 199
LLPS-Chc-0303Chondrus crispus48.446e-56 199
LLPS-Met-0346Medicago truncatula48.293e-52 189
LLPS-Bro-2732Brassica oleracea48.112e-56 201
LLPS-Sob-2553Sorghum bicolor47.965e-55 197
LLPS-Via-2439Vigna angularis47.83e-53 191
LLPS-Cus-1925Cucumis sativus47.762e-52 189
LLPS-Amt-1870Amborella trichopoda47.621e-52 190
LLPS-Sei-0428Setaria italica47.518e-55 196
LLPS-Vir-1091Vigna radiata47.329e-53 190
LLPS-Ors-2008Oryza sativa47.228e-54 193
LLPS-Orm-0649Oryza meridionalis47.221e-53 194
LLPS-Org-0550Oryza glaberrima47.225e-54 194
LLPS-Orgl-1127Oryza glumaepatula47.227e-54 194
LLPS-Art-2553Arabidopsis thaliana47.172e-55 197
LLPS-Arl-0918Arabidopsis lyrata47.172e-55 197
LLPS-Hea-1011Helianthus annuus47.064e-53 191
LLPS-Orbr-0613Oryza brachyantha46.93e-57 202
LLPS-Ori-2234Oryza indica46.34e-55 197
LLPS-Orb-1173Oryza barthii46.32e-55 198
LLPS-Asni-1212Aspergillus niger46.272e-44 160
LLPS-Sem-0424Selaginella moellendorffii45.891e-55 198
LLPS-Orp-1578Oryza punctata45.838e-55 196
LLPS-Dac-1893Daucus carota45.415e-52 188
LLPS-Abg-1521Absidia glauca45.238e-42 152
LLPS-Brd-2324Brachypodium distachyon44.021e-50 184
LLPS-Chr-0042Chlamydomonas reinhardtii43.484e-40 147
LLPS-Fus-1087Fusarium solani42.726e-38 145
LLPS-Gas-0713Galdieria sulphuraria42.52e-39 147
LLPS-Aso-1386Aspergillus oryzae42.114e-36 136
LLPS-Asf-0163Aspergillus flavus42.115e-36 137
LLPS-Trv-0142Trichoderma virens41.447e-40 150
LLPS-Asn-1511Aspergillus nidulans41.283e-36 138
LLPS-Miv-1500Microbotryum violaceum41.182e-36 144
LLPS-Nef-0664Neosartorya fischeri40.891e-40 153
LLPS-Ast-1427Aspergillus terreus40.832e-35 138
LLPS-Fuv-1252Fusarium verticillioides40.725e-39 148
LLPS-Hov-1896Hordeum vulgare40.653e-30 121
LLPS-Mao-1088Magnaporthe oryzae40.27e-30 122
LLPS-Viv-0819Vitis vinifera40.183e-39 145
LLPS-Asfu-0271Aspergillus fumigatus40.09e-40 150
LLPS-Lep-0825Leersia perrieri39.94e-41 150
LLPS-Tru-0852Triticum urartu39.811e-36 142
LLPS-Beb-0790Beauveria bassiana39.451e-29 120
LLPS-Sac-0876Saccharomyces cerevisiae39.116e-31 123
LLPS-Trr-0856Trichoderma reesei38.993e-33 129
LLPS-Cogr-1387Colletotrichum graminicola38.54e-30 121
LLPS-Sol-2005Solanum lycopersicum38.465e-37 139
LLPS-Sot-1934Solanum tuberosum38.465e-38 142
LLPS-Prp-1912Prunus persica38.425e-35 134
LLPS-Coo-1569Colletotrichum orbiculare38.072e-31 125
LLPS-Tum-1479Tuber melanosporum38.052e-33 130
LLPS-Phn-1295Phaeosphaeria nodorum37.981e-32 127
LLPS-Nia-2439Nicotiana attenuata37.52e-36 137
LLPS-Thc-0575Theobroma cacao37.56e-36 136
LLPS-Kop-1158Komagataella pastoris37.212e-27 114
LLPS-Coc-1384Corchorus capsularis36.611e-34 133
LLPS-Zyt-0703Zymoseptoria tritici36.451e-30 123
LLPS-Dos-0942Dothistroma septosporum36.167e-29 118
LLPS-Asg-1269Ashbya gossypii36.066e-24 103
LLPS-Zem-1100Zea mays34.36e-34 131