LLPS-Mum-4508
Nagk

▼ OVERVIEW

Status: Unreviewed
Protein Name: N-acetyl-D-glucosamine kinase
Gene Name: Nagk, Gnk
Ensembl Gene: ENSMUSG00000034744.13
Ensembl Protein: ENSMUSP00000042026.7
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear specklePredicted from orthologs(View)

▼ FUNCTION

Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Also has ManNAc kinase activity.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MTRGGARVGG  SEVTARVEVA  TADQRWQRGG  TRSKVLLLSE  DGQILAEADG  LSTNHWLIGT  60
61    DQCVERINEM  VDRAKQKAGV  DPLVPLRSLG  LSLSGGEQED  AVRLLIEELR  HRFPNLSENY  120
121   LITTDAAGSI  ATATPDGGIV  LISGTGSNCR  LINPDGSESG  CGGWGHMMGD  EGSAYWIAHQ  180
181   AVKIVFDSID  NLEAAPHDIG  HVKQAMFDYF  QVPDRLGILT  HLYRDFDKCK  FAGFCQKIAE  240
241   GAHQGDPLSR  YIFRKAGEML  GRHVVAVLPE  IDPVLFQGEL  GLPILCVGSV  WKSWELLKEG  300
301   FLLALTLGRE  QQAQNSFSSF  TLMKLRHSSA  LGGASLGARH  IGYHLPMDYS  INAIAFYSYT  360
361   F  361
Nucleotide CDS Sequence (FASTA)
1     ATGGCCGCGC  TTTATGGTGG  CGTGGAAGGG  GGAGGCACAC  GGTCCAAAGT  CCTTTTACTT  60
61    TCTGAGGATG  GGCAGATCCT  GGCAGAAGCA  GATGGACTGA  GCACAAACCA  CTGGCTGATT  120
121   GGCACAGACC  AGTGTGTGGA  GAGGATCAAT  GAGATGGTGG  ACAGGGCCAA  ACAGAAGGCT  180
181   GGAGTGGATC  CTCTGGTGCC  CCTTCGAAGC  CTGGGCCTGT  CCCTGAGTGG  TGGGGAGCAG  240
241   GAGGATGCAG  TGAGGCTCCT  GATTGAGGAG  TTGAGGCACC  GCTTTCCCAA  CCTGAGTGAA  300
301   AACTACTTAA  TCACCACGGA  TGCAGCAGGT  TCCATCGCCA  CAGCCACACC  GGACGGTGGG  360
361   ATTGTGCTCA  TCTCTGGAAC  AGGCTCCAAC  TGTAGGCTTA  TCAACCCTGA  TGGCTCCGAG  420
421   AGTGGCTGTG  GAGGCTGGGG  CCACATGATG  GGAGACGAGG  GCTCAGCCTA  CTGGATTGCA  480
481   CACCAAGCTG  TGAAAATTGT  GTTTGATTCC  ATCGACAACC  TGGAGGCAGC  TCCTCATGAT  540
541   ATTGGCCATG  TCAAGCAGGC  CATGTTCGAC  TATTTCCAGG  TGCCAGATCG  GCTTGGAATC  600
601   CTCACCCATT  TGTATAGGGA  CTTTGATAAA  TGCAAGTTTG  CTGGATTTTG  CCAGAAAATT  660
661   GCAGAAGGTG  CACATCAGGG  AGACCCTCTT  TCCAGGTACA  TCTTCAGGAA  GGCTGGAGAG  720
721   ATGCTGGGCA  GACATGTTGT  GGCAGTATTG  CCAGAGATTG  ACCCGGTTTT  GTTCCAAGGG  780
781   GAGCTTGGCC  TCCCCATTCT  GTGTGTGGGC  TCAGTGTGGA  AGAGCTGGGA  GCTCCTGAAG  840
841   GAAGGCTTTC  TCCTGGCGCT  GACGCTGGGC  CGAGAGCAGC  AGGCACAGAA  CTCCTTCTCC  900
901   AGCTTCACCC  TGATGAAGTT  GCGGCATTCT  TCTGCATTGG  GGGGTGCCAG  CCTGGGGGCC  960
961   AGGCACATTG  GATACCACCT  TCCCATGGAC  TACAGTATCA  ATGCCATTGC  CTTCTATTCC  1020
1021  TATACCTTCT  AG  1032

▼ KEYWORD

ID
Family
Acetylation
ATP-binding
Complete proteome
Kinase
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
ATP binding
Molecular Function
N-acetylglucosamine kinase activity
Molecular Function
N-acylmannosamine kinase activity
Biological Process
N-acetylglucosamine metabolic process
Biological Process
N-acetylneuraminate catabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-1382Rattus norvegicus95.50.0 637
LLPS-Orc-3525Oryctolagus cuniculus93.990.0 630
LLPS-Sus-4688Sus scrofa93.437e-135 396
LLPS-Cas-3675Carlito syrichta92.790.0 625
LLPS-Gog-1668Gorilla gorilla92.490.0 621
LLPS-Nol-3480Nomascus leucogenys92.490.0 620
LLPS-Pap-2986Pan paniscus92.490.0 620
LLPS-Pat-4193Pan troglodytes92.490.0 620
LLPS-Ict-3252Ictidomys tridecemlineatus92.220.0 622
LLPS-Myl-2550Myotis lucifugus92.190.0 619
LLPS-Aon-1207Aotus nancymaae92.190.0 624
LLPS-Caj-1093Callithrix jacchus92.190.0 625
LLPS-Poa-1917Pongo abelii92.190.0 618
LLPS-Hos-0268Homo sapiens91.890.0 617
LLPS-Rhb-3576Rhinopithecus bieti91.890.0 619
LLPS-Paa-4605Papio anubis91.590.0 618
LLPS-Maf-2500Macaca fascicularis91.590.0 617
LLPS-Cea-0942Cercocebus atys91.590.0 617
LLPS-Man-1622Macaca nemestrina91.590.0 618
LLPS-Bot-3893Bos taurus91.290.0 614
LLPS-Mal-3429Mandrillus leucophaeus91.290.0 615
LLPS-Ova-0571Ovis aries91.290.0 615
LLPS-Chs-0502Chlorocebus sabaeus90.990.0 614
LLPS-Loa-4602Loxodonta africana90.990.0 613
LLPS-Caf-3476Canis familiaris90.731e-94 290
LLPS-Aim-3778Ailuropoda melanoleuca90.690.0 611
LLPS-Mea-2620Mesocricetus auratus90.390.0 617
LLPS-Eqc-2723Equus caballus90.383e-156 450
LLPS-Otg-1305Otolemur garnettii89.790.0 600
LLPS-Mam-4370Macaca mulatta89.290.0 600
LLPS-Dio-0130Dipodomys ordii89.20.0 630
LLPS-Fec-3841Felis catus88.890.0 604
LLPS-Urm-2756Ursus maritimus88.581e-129 384
LLPS-Cap-4110Cavia porcellus87.090.0 587
LLPS-Mup-4517Mustela putorius furo86.490.0 584
LLPS-Fud-1655Fukomys damarensis83.10.0 592
LLPS-Anc-2742Anolis carolinensis72.135e-126 369
LLPS-Gaga-0971Gallus gallus65.521e-28 122
LLPS-Xet-3665Xenopus tropicalis65.171e-154 446
LLPS-Scm-2295Scophthalmus maximus62.573e-143 417
LLPS-Orn-1627Oreochromis niloticus62.281e-142 416
LLPS-Orl-2733Oryzias latipes61.981e-143 418
LLPS-Mod-2960Monodelphis domestica61.384e-147 427
LLPS-Pes-1624Pelodiscus sinensis61.191e-129 382
LLPS-Lac-3649Latimeria chalumnae61.179e-109 327
LLPS-Scf-0008Scleropages formosus60.963e-141 414
LLPS-Xim-0825Xiphophorus maculatus60.679e-138 403
LLPS-Asm-3132Astyanax mexicanus60.662e-141 412
LLPS-Icp-3020Ictalurus punctatus60.571e-135 397
LLPS-Tar-3147Takifugu rubripes60.485e-137 401
LLPS-Dar-3468Danio rerio60.362e-143 417
LLPS-Pof-0973Poecilia formosa59.232e-138 405
LLPS-Gaa-3058Gasterosteus aculeatus58.982e-136 400
LLPS-Ten-2032Tetraodon nigroviridis58.816e-128 378
LLPS-Leo-3505Lepisosteus oculatus51.326e-71 228
LLPS-Cii-1965Ciona intestinalis46.274e-95 294
LLPS-Cis-0416Ciona savignyi45.77e-62 204
LLPS-Ora-2452Ornithorhynchus anatinus45.54e-48 170
LLPS-Drm-1797Drosophila melanogaster45.057e-90 281
LLPS-Cae-0670Caenorhabditis elegans32.83e-40 154
LLPS-Nia-1349Nicotiana attenuata30.371e-0757.4
LLPS-Arl-2304Arabidopsis lyrata29.596e-0961.2
LLPS-Art-3020Arabidopsis thaliana29.086e-0961.2
LLPS-Brn-3392Brassica napus28.125e-0755.1
LLPS-Bro-1733Brassica oleracea28.061e-0756.6
LLPS-Sot-0840Solanum tuberosum27.991e-0860.1
LLPS-Vir-1360Vigna radiata27.862e-0859.3
LLPS-Sol-2090Solanum lycopersicum27.27e-0960.8
LLPS-Phv-0589Phaseolus vulgaris27.21e-0963.2
LLPS-Lep-0402Leersia perrieri27.112e-0757.0
LLPS-Mae-1732Manihot esculenta27.081e-1066.2
LLPS-Mua-1260Musa acuminata26.861e-1478.6
LLPS-Via-1269Vigna angularis26.822e-0859.3
LLPS-Prp-1822Prunus persica26.571e-0860.5
LLPS-Viv-2099Vitis vinifera26.533e-0962.0
LLPS-Dac-0746Daucus carota26.446e-1373.2
LLPS-Brr-1396Brassica rapa26.443e-0858.9
LLPS-Orp-1648Oryza punctata26.054e-1064.7
LLPS-Met-0164Medicago truncatula25.959e-0857.4
LLPS-Glm-2148Glycine max25.951e-0860.5
LLPS-Coc-1890Corchorus capsularis25.873e-1271.2
LLPS-Tra-2805Triticum aestivum25.866e-1064.3
LLPS-Brd-1994Brachypodium distachyon25.869e-1063.5
LLPS-Orbr-0164Oryza brachyantha25.868e-1063.9
LLPS-Zem-1798Zea mays25.791e-0963.2
LLPS-Hea-1674Helianthus annuus25.763e-0858.9
LLPS-Orgl-1093Oryza glumaepatula25.671e-0963.2
LLPS-Orb-1389Oryza barthii25.671e-0963.2
LLPS-Ori-0333Oryza indica25.671e-0963.2
LLPS-Orni-2108Oryza nivara25.671e-0963.2
LLPS-Orr-2308Oryza rufipogon25.671e-0963.2
LLPS-Orm-1489Oryza meridionalis25.671e-0963.2
LLPS-Org-0611Oryza glaberrima25.671e-0963.2
LLPS-Ors-0888Oryza sativa25.671e-0963.2
LLPS-Pot-1853Populus trichocarpa25.678e-1063.5
LLPS-Amt-2280Amborella trichopoda25.676e-0960.8
LLPS-Cus-0111Cucumis sativus25.653e-1168.2
LLPS-Tru-0460Triticum urartu25.489e-1063.5
LLPS-Sei-1300Setaria italica25.41e-0860.5
LLPS-Sem-0304Selaginella moellendorffii25.311e-0551.2
LLPS-Gor-0635Gossypium raimondii24.921e-0860.1
LLPS-Thc-2253Theobroma cacao24.769e-0754.3
LLPS-Sob-2009Sorghum bicolor24.529e-1063.5
LLPS-Hov-1714Hordeum vulgare24.142e-0962.8