LLPS-Mum-4478
Uba2
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | SUMO-activating enzyme subunit 2; Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2 |
| Gene Name: | Uba2, Sae2, Uble1b |
| Ensembl Gene: | ENSMUSG00000052997.15 |
| Ensembl Protein: | ENSMUSP00000135885.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body | Predicted from orthologs | (View) |
▼ FUNCTION
| The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000175991.7 | ENSMUSP00000135885.1 |
| Ensembl | ENSMUST00000102746.10 | ENSMUSP00000099807.4 |
| Ensembl | ENSMUST00000156253.1 | ENSMUSP00000116605.1 |
| Ensembl | ENSMUST00000152037.2 | ENSMUSP00000135078.1 |
| Ensembl | ENSMUST00000134856.8 | ENSMUSP00000135841.1 |
| UniProt | Q9Z1F9, SAE2_MOUSE, Q3TQN3, Q3U819, Q3U9J5, Q8BVX9 | |
| GeneBank | BC054768, AK152415, AK169168, AK151765, AK075938, U35833, AK168673, AK166133, AK146925, AK164826, AK163451 | AAD10338.1, AAH54768.1, BAE27536.1, BAE40523.1, BAE37349.1, BAE31200.1, BAE40947.1, BAC36068.1, BAE38590.1, BAE30671.1, BAE37935.1 |
| RefSeq | NM_016682.2 | NP_057891.1 |
| Entrez | 50995 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MALSRGLPRE LAEAVSGGRV LVVGAGGIGC ELLKNLVLTG FSHIDLIDLD TIDVSNLNRQ 60 61 FLFQKKHVGR SKAQVAKESV LQFHPQANIE AHHDSIMNPD YNVEFFRQFI LVMNALDNRA 120 121 ARNHVNRMCL AADVPLIESG TAGYLGQVTT IKKGVTECYE CHPKPTQRTF PGCTIRNTPS 180 181 EPIHCIVWAK YLFNQLFGEE DADQEVSPDR ADPEAAWEPT EAEARARASN EDGDIKRIST 240 241 KEWAKSTGYD PVKLFTKLFK DDIRYLLTMD KLWRKRKPPV PLDWAEVQSQ GEANADQQNE 300 301 PQLGLKDQQV LDVKSYASLF SKSIETLRVH LAEKGDGAEL IWDKDDPPAM DFVTSAANLR 360 361 MHIFSMNMKS RFDIKSMAGN IIPAIATTNA VIAGLIVLEG LKILSGKIDQ CRTIFLNKQP 420 421 NPRKKLLVPC ALDPPNTNCY VCASKPEVTV RLNVHKVTVL TLQDKIVKEK FAMVAPDVQI 480 481 EDGKGTILIS SEEGETEANN PKKLSDFGIR NGSRLQADDF LQDYTLLINI LHSEDLGKDV 540 541 EFEVVGDSPE KVGPKQAEDA AKSIANGSDD GAQPSTSTAQ EQDDVLIVDS DEEGPSNSTD 600 601 CSGDDKARKR KLEENEAAST KKCRLEQMED PDDVIALD 638 |
| Nucleotide CDS Sequence (FASTA) |
1 Sequence u navailable 20 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleoplasm | |
Cellular Component | SUMO activating enzyme complex | |
Molecular Function | ATP binding | |
Molecular Function | Magnesium ion binding | |
Molecular Function | Protein heterodimerization activity | |
Molecular Function | Small protein activating enzyme binding | |
Molecular Function | SUMO activating enzyme activity | |
Molecular Function | SUMO binding | |
Molecular Function | Transcription factor binding | |
Molecular Function | Transferase activity | |
Molecular Function | Ubiquitin-like protein conjugating enzyme binding | |
Biological Process | Protein modification by small protein conjugation | |
Biological Process | Protein sumoylation |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CellMarker | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-0228 | Rattus norvegicus | 97.48 | 0.0 | 1148 |
| LLPS-Mea-0070 | Mesocricetus auratus | 95.79 | 0.0 | 1129 |
| LLPS-Mam-0614 | Macaca mulatta | 94.38 | 0.0 | 1196 |
| LLPS-Maf-0430 | Macaca fascicularis | 94.38 | 0.0 | 1196 |
| LLPS-Hos-0372 | Homo sapiens | 94.06 | 0.0 | 1197 |
| LLPS-Pat-2824 | Pan troglodytes | 94.06 | 0.0 | 1197 |
| LLPS-Caj-4284 | Callithrix jacchus | 94.06 | 0.0 | 1186 |
| LLPS-Pap-2545 | Pan paniscus | 93.93 | 0.0 | 1011 |
| LLPS-Chs-3791 | Chlorocebus sabaeus | 93.92 | 0.0 | 1193 |
| LLPS-Fec-1450 | Felis catus | 93.91 | 0.0 | 1199 |
| LLPS-Ict-1630 | Ictidomys tridecemlineatus | 93.91 | 0.0 | 1196 |
| LLPS-Poa-0027 | Pongo abelii | 93.75 | 0.0 | 1008 |
| LLPS-Cas-1799 | Carlito syrichta | 93.75 | 0.0 | 1191 |
| LLPS-Mup-3475 | Mustela putorius furo | 93.75 | 0.0 | 1194 |
| LLPS-Orc-3197 | Oryctolagus cuniculus | 93.59 | 0.0 | 1192 |
| LLPS-Caf-2934 | Canis familiaris | 93.59 | 0.0 | 1195 |
| LLPS-Bot-2793 | Bos taurus | 93.59 | 0.0 | 1200 |
| LLPS-Myl-2227 | Myotis lucifugus | 93.45 | 0.0 | 1188 |
| LLPS-Eqc-3338 | Equus caballus | 93.43 | 0.0 | 1103 |
| LLPS-Aim-0595 | Ailuropoda melanoleuca | 93.29 | 0.0 | 1180 |
| LLPS-Otg-3857 | Otolemur garnettii | 93.28 | 0.0 | 1191 |
| LLPS-Cap-2409 | Cavia porcellus | 93.28 | 0.0 | 1190 |
| LLPS-Ova-0721 | Ovis aries | 93.11 | 0.0 | 1105 |
| LLPS-Man-1756 | Macaca nemestrina | 92.79 | 0.0 | 1168 |
| LLPS-Aon-1546 | Aotus nancymaae | 91.83 | 0.0 | 1169 |
| LLPS-Loa-1182 | Loxodonta africana | 91.73 | 0.0 | 1166 |
| LLPS-Rhb-0393 | Rhinopithecus bieti | 91.58 | 0.0 | 1149 |
| LLPS-Mal-1645 | Mandrillus leucophaeus | 91.57 | 0.0 | 1109 |
| LLPS-Gog-0138 | Gorilla gorilla | 91.56 | 0.0 | 1152 |
| LLPS-Sus-4096 | Sus scrofa | 91.21 | 0.0 | 675 |
| LLPS-Sah-3516 | Sarcophilus harrisii | 90.95 | 0.0 | 1160 |
| LLPS-Nol-0288 | Nomascus leucogenys | 90.84 | 0.0 | 1136 |
| LLPS-Mod-2502 | Monodelphis domestica | 90.61 | 0.0 | 1155 |
| LLPS-Cea-0204 | Cercocebus atys | 90.55 | 0.0 | 1176 |
| LLPS-Pes-0372 | Pelodiscus sinensis | 89.19 | 0.0 | 1053 |
| LLPS-Ora-0602 | Ornithorhynchus anatinus | 89.19 | 0.0 | 1055 |
| LLPS-Fud-2156 | Fukomys damarensis | 88.35 | 0.0 | 1111 |
| LLPS-Anp-1384 | Anas platyrhynchos | 88.01 | 0.0 | 1045 |
| LLPS-Paa-0179 | Papio anubis | 87.71 | 0.0 | 1079 |
| LLPS-Urm-0399 | Ursus maritimus | 87.5 | 0.0 | 1093 |
| LLPS-Gaga-2115 | Gallus gallus | 86.79 | 0.0 | 1105 |
| LLPS-Fia-0632 | Ficedula albicollis | 85.98 | 0.0 | 1006 |
| LLPS-Tag-2270 | Taeniopygia guttata | 84.49 | 0.0 | 1004 |
| LLPS-Anc-1156 | Anolis carolinensis | 83.12 | 0.0 | 1013 |
| LLPS-Lac-0728 | Latimeria chalumnae | 82.53 | 0.0 | 1030 |
| LLPS-Meg-1146 | Meleagris gallopavo | 81.86 | 0.0 | 983 |
| LLPS-Leo-0408 | Lepisosteus oculatus | 80.5 | 0.0 | 1031 |
| LLPS-Asm-3569 | Astyanax mexicanus | 78.78 | 0.0 | 973 |
| LLPS-Icp-2129 | Ictalurus punctatus | 77.6 | 0.0 | 982 |
| LLPS-Dio-1073 | Dipodomys ordii | 77.54 | 0.0 | 842 |
| LLPS-Scf-0781 | Scleropages formosus | 76.64 | 0.0 | 974 |
| LLPS-Orn-1256 | Oreochromis niloticus | 76.35 | 0.0 | 955 |
| LLPS-Dar-3669 | Danio rerio | 76.3 | 0.0 | 942 |
| LLPS-Gaa-0932 | Gasterosteus aculeatus | 76.14 | 0.0 | 920 |
| LLPS-Pof-2217 | Poecilia formosa | 75.24 | 0.0 | 944 |
| LLPS-Scm-0061 | Scophthalmus maximus | 74.88 | 0.0 | 943 |
| LLPS-Orl-0103 | Oryzias latipes | 74.57 | 0.0 | 945 |
| LLPS-Xet-0007 | Xenopus tropicalis | 74.29 | 0.0 | 865 |
| LLPS-Xim-0044 | Xiphophorus maculatus | 73.5 | 0.0 | 945 |
| LLPS-Tar-3806 | Takifugu rubripes | 71.18 | 0.0 | 901 |
| LLPS-Ten-1085 | Tetraodon nigroviridis | 66.31 | 0.0 | 825 |
| LLPS-Cii-0047 | Ciona intestinalis | 61.17 | 0.0 | 668 |
| LLPS-Chr-0701 | Chlamydomonas reinhardtii | 61.03 | 2e-71 | 251 |
| LLPS-Drm-0726 | Drosophila melanogaster | 48.66 | 0.0 | 585 |
| LLPS-Cym-0421 | Cyanidioschyzon merolae | 48.5 | 3e-54 | 202 |
| LLPS-Abg-1300 | Absidia glauca | 48.33 | 1e-137 | 422 |
| LLPS-Phn-0039 | Phaeosphaeria nodorum | 46.74 | 1e-121 | 380 |
| LLPS-Mel-0568 | Melampsora laricipopulina | 46.61 | 5e-118 | 370 |
| LLPS-Usm-1328 | Ustilago maydis | 45.54 | 8e-43 | 164 |
| LLPS-Spr-1370 | Sporisorium reilianum | 45.32 | 7e-45 | 170 |
| LLPS-Pytr-1429 | Pyrenophora triticirepentis | 45.31 | 3e-121 | 381 |
| LLPS-Yal-1372 | Yarrowia lipolytica | 45.21 | 2e-40 | 157 |
| LLPS-Asn-0066 | Aspergillus nidulans | 44.96 | 9e-131 | 405 |
| LLPS-Tum-1121 | Tuber melanosporum | 44.86 | 1e-120 | 379 |
| LLPS-Lem-0370 | Leptosphaeria maculans | 44.83 | 6e-116 | 366 |
| LLPS-Crn-1540 | Cryptococcus neoformans | 44.8 | 9e-102 | 331 |
| LLPS-Cae-0178 | Caenorhabditis elegans | 44.71 | 9e-160 | 479 |
| LLPS-Scc-0823 | Schizosaccharomyces cryophilus | 44.52 | 6e-108 | 346 |
| LLPS-Gag-0576 | Gaeumannomyces graminis | 44.26 | 7e-38 | 150 |
| LLPS-Fuo-1168 | Fusarium oxysporum | 44.22 | 8e-131 | 407 |
| LLPS-Scp-1441 | Schizosaccharomyces pombe | 44.14 | 2e-115 | 365 |
| LLPS-Pug-0957 | Puccinia graminis | 43.95 | 9e-116 | 368 |
| LLPS-Asni-1112 | Aspergillus niger | 43.95 | 8e-129 | 400 |
| LLPS-Zyt-0491 | Zymoseptoria tritici | 43.92 | 5e-39 | 152 |
| LLPS-Pyt-0666 | Pyrenophora teres | 43.82 | 8e-123 | 385 |
| LLPS-Mao-1131 | Magnaporthe oryzae | 43.76 | 1e-126 | 396 |
| LLPS-Ors-1739 | Oryza sativa | 43.62 | 1e-37 | 149 |
| LLPS-Orm-1077 | Oryza meridionalis | 43.62 | 7e-38 | 150 |
| LLPS-Ori-1808 | Oryza indica | 43.62 | 1e-37 | 149 |
| LLPS-Orgl-1260 | Oryza glumaepatula | 43.62 | 1e-37 | 150 |
| LLPS-Fus-0211 | Fusarium solani | 43.6 | 3e-130 | 405 |
| LLPS-Fuv-1086 | Fusarium verticillioides | 43.41 | 3e-117 | 369 |
| LLPS-Scj-0157 | Schizosaccharomyces japonicus | 43.38 | 5e-103 | 333 |
| LLPS-Scs-0022 | Sclerotinia sclerotiorum | 43.24 | 2e-125 | 393 |
| LLPS-Trv-1489 | Trichoderma virens | 43.05 | 4e-120 | 379 |
| LLPS-Asc-1122 | Aspergillus clavatus | 42.93 | 1e-129 | 402 |
| LLPS-Chc-1170 | Chondrus crispus | 42.93 | 4e-41 | 159 |
| LLPS-Gas-0914 | Galdieria sulphuraria | 42.93 | 2e-39 | 154 |
| LLPS-Aso-0891 | Aspergillus oryzae | 42.91 | 2e-126 | 394 |
| LLPS-Asf-0444 | Aspergillus flavus | 42.86 | 2e-124 | 389 |
| LLPS-Miv-1097 | Microbotryum violaceum | 42.8 | 4e-114 | 363 |
| LLPS-Trr-0801 | Trichoderma reesei | 42.7 | 1e-117 | 373 |
| LLPS-Kop-0930 | Komagataella pastoris | 42.51 | 8e-44 | 164 |
| LLPS-Put-0622 | Puccinia triticina | 42.36 | 1e-39 | 157 |
| LLPS-Brn-1491 | Brassica napus | 42.25 | 9e-127 | 395 |
| LLPS-Art-2712 | Arabidopsis thaliana | 42.2 | 1e-126 | 397 |
| LLPS-Brr-2110 | Brassica rapa | 42.05 | 2e-128 | 399 |
| LLPS-Nef-0817 | Neosartorya fischeri | 41.94 | 2e-125 | 391 |
| LLPS-Php-0812 | Physcomitrella patens | 41.92 | 3e-133 | 412 |
| LLPS-Bro-0635 | Brassica oleracea | 41.86 | 1e-127 | 397 |
| LLPS-Brd-0452 | Brachypodium distachyon | 41.85 | 2e-126 | 394 |
| LLPS-Blg-0665 | Blumeria graminis | 41.63 | 2e-120 | 379 |
| LLPS-Coo-0916 | Colletotrichum orbiculare | 41.62 | 6e-39 | 153 |
| LLPS-Cogr-0417 | Colletotrichum graminicola | 41.48 | 2e-124 | 392 |
| LLPS-Map-1027 | Magnaporthe poae | 41.45 | 3e-123 | 388 |
| LLPS-Cog-1170 | Colletotrichum gloeosporioides | 41.41 | 3e-38 | 152 |
| LLPS-Nec-0912 | Neurospora crassa | 41.24 | 2e-132 | 410 |
| LLPS-Lep-2025 | Leersia perrieri | 41.07 | 4e-124 | 389 |
| LLPS-Arl-1267 | Arabidopsis lyrata | 40.92 | 1e-121 | 383 |
| LLPS-Ast-0393 | Aspergillus terreus | 40.88 | 1e-107 | 343 |
| LLPS-Ved-0305 | Verticillium dahliae | 40.67 | 6e-128 | 397 |
| LLPS-Tru-1498 | Triticum urartu | 40.65 | 3e-120 | 379 |
| LLPS-Orbr-1377 | Oryza brachyantha | 40.58 | 2e-125 | 392 |
| LLPS-Tra-1505 | Triticum aestivum | 40.55 | 2e-123 | 386 |
| LLPS-Sem-0881 | Selaginella moellendorffii | 40.5 | 7e-130 | 402 |
| LLPS-Asfu-0674 | Aspergillus fumigatus | 40.41 | 1e-123 | 387 |
| LLPS-Beb-0525 | Beauveria bassiana | 40.25 | 1e-133 | 415 |
| LLPS-Sei-1276 | Setaria italica | 40.14 | 6e-121 | 383 |
| LLPS-Zem-1032 | Zea mays | 40.0 | 5e-119 | 375 |
| LLPS-Nia-1299 | Nicotiana attenuata | 39.89 | 9e-123 | 385 |
| LLPS-Hov-0607 | Hordeum vulgare | 39.64 | 2e-122 | 385 |
| LLPS-Gor-1079 | Gossypium raimondii | 39.53 | 3e-120 | 379 |
| LLPS-Amt-1902 | Amborella trichopoda | 39.52 | 7e-127 | 396 |
| LLPS-Orp-0109 | Oryza punctata | 39.39 | 5e-122 | 383 |
| LLPS-Org-1552 | Oryza glaberrima | 39.17 | 3e-120 | 379 |
| LLPS-Orr-0179 | Oryza rufipogon | 39.06 | 6e-120 | 377 |
| LLPS-Orb-0366 | Oryza barthii | 39.06 | 7e-120 | 377 |
| LLPS-Thc-0767 | Theobroma cacao | 38.94 | 3e-123 | 386 |
| LLPS-Viv-2007 | Vitis vinifera | 38.79 | 2e-124 | 389 |
| LLPS-Sol-1072 | Solanum lycopersicum | 38.75 | 2e-125 | 392 |
| LLPS-Dos-1308 | Dothistroma septosporum | 38.58 | 8e-108 | 346 |
| LLPS-Mae-1035 | Manihot esculenta | 38.56 | 4e-124 | 389 |
| LLPS-Sot-0235 | Solanum tuberosum | 38.55 | 4e-122 | 384 |
| LLPS-Osl-1199 | Ostreococcus lucimarinus | 38.53 | 2e-109 | 347 |
| LLPS-Prp-1659 | Prunus persica | 38.46 | 9e-125 | 390 |
| LLPS-Orni-1456 | Oryza nivara | 38.23 | 1e-116 | 369 |
| LLPS-Coc-0520 | Corchorus capsularis | 38.22 | 1e-125 | 393 |
| LLPS-Met-1278 | Medicago truncatula | 38.2 | 9e-131 | 405 |
| LLPS-Glm-1016 | Glycine max | 37.92 | 2e-128 | 399 |
| LLPS-Cus-0282 | Cucumis sativus | 37.87 | 2e-126 | 394 |
| LLPS-Asg-0158 | Ashbya gossypii | 37.74 | 5e-93 | 306 |
| LLPS-Mua-0342 | Musa acuminata | 37.72 | 2e-120 | 379 |
| LLPS-Via-0976 | Vigna angularis | 37.48 | 2e-127 | 397 |
| LLPS-Phv-1313 | Phaseolus vulgaris | 37.29 | 8e-128 | 398 |
| LLPS-Hea-0087 | Helianthus annuus | 37.25 | 4e-127 | 396 |
| LLPS-Dac-1209 | Daucus carota | 36.97 | 6e-123 | 385 |
| LLPS-Pot-2512 | Populus trichocarpa | 36.92 | 1e-120 | 380 |
| LLPS-Sob-0537 | Sorghum bicolor | 36.88 | 6e-119 | 375 |
| LLPS-Vir-1357 | Vigna radiata | 35.06 | 7e-119 | 377 |
| LLPS-Sac-1452 | Saccharomyces cerevisiae | 34.06 | 5e-92 | 304 |
| LLPS-Tut-1525 | Tursiops truncatus | 30.38 | 3e-41 | 165 |