LLPS-Mum-4472
Mterf3

▼ OVERVIEW


Status: Unreviewed
Protein Name: Transcription termination factor 3, mitochondrial; Mitochondrial transcription termination factor 3; mTERF3; mTERF domain-containing protein 1, mitochondrial
Gene Name: Mterf3, Mterfd1, CGI-12
Ensembl Gene: ENSMUSG00000021519.11
Ensembl Protein: ENSMUSP00000133433.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Mitochondrial RNA granulePredicted from orthologs(View)

▼ FUNCTION


Binds promoter DNA and regulates initiation of transcription (By similarity). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes (PubMed:17662942, PubMed:23300484). Required for normal mitochondrial function (PubMed:17662942, PubMed:23300484). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (PubMed:17662942, PubMed:23300484).

▼ SEQUENCE


Protein Sequence (FASTA)
1     MALLAQQLPR  RFNSVKLTSF  IKAKQVTKRS  ARAGKAVLPG  FSAQPLLSSD  TSFLRRGIKT  60
61    YRTLFWNRFH  SASTNRTKSS  AESTLLPSVA  EQQERILSLE  SELPLEEVDD  LPPLSPLQSV  120
121   SEEEAIQIAA  YSPLPISSFT  LADYVDHSKT  LQKLVQLGVD  LSKIEKHPDA  ANLLLRLDFE  180
181   KHIKQILLFL  KDLGLEDNQL  GPFLTKNYAI  FSEDLENLKT  RVAYLQSKNF  SKTDIARMVK  240
241   NAPFLLSFSV  ERLDNRLGFF  QKELELNVKK  TRDLVVRLPR  LLTGSLEPVK  ENMKVYHLEL  300
301   GFKHNEIQHM  VIKIPKMLTA  NKRKLTEIFD  YVHNVMNIPH  HIIVKFPQLF  NTRVFKIKER  360
361   HLFLAYLGRA  QYDPAKPNYV  SLDKFVSFPD  KIFCKEIAKA  SLNDFEKFLK  TL  412
Nucleotide CDS Sequence (FASTA)
1     ATGGCTCTGT  TAGCCCAACA  GTTACCCAGA  CGGTTCAACT  CAGTTAAGTT  GACTAGCTTC  60
61    ATTAAAGCCA  AACAAGTCAC  CAAACGCTCT  GCAAGAGCAG  GAAAAGCCGT  GTTGCCCGGC  120
121   TTCTCAGCTC  AGCCTCTGCT  CTCCTCTGAC  ACGAGCTTTC  TCCGGCGGGG  AATTAAGACT  180
181   TACAGGACTT  TGTTCTGGAA  TCGTTTCCAT  TCTGCCAGCA  CAAATAGGAC  AAAGAGTTCT  240
241   GCCGAAAGCA  CTCTGCTTCC  TTCAGTGGCT  GAACAGCAGG  AGAGGATACT  TAGTCTTGAA  300
301   TCAGAGCTGC  CTCTTGAAGA  AGTGGATGAC  CTGCCTCCAT  TGTCTCCGTT  ACAGTCAGTT  360
361   TCAGAGGAGG  AGGCTATTCA  GATTGCTGCG  TACTCTCCGC  TGCCCATCTC  CTCCTTCACA  420
421   CTTGCAGATT  ACGTAGACCA  TTCCAAGACT  CTGCAGAAGC  TAGTGCAGCT  TGGAGTGGAT  480
481   TTGTCTAAGA  TAGAAAAACA  TCCAGATGCA  GCCAACCTCC  TTCTAAGGCT  GGATTTTGAA  540
541   AAGCACATTA  AGCAAATACT  GCTATTTCTT  AAAGATTTGG  GTTTAGAAGA  TAACCAGCTG  600
601   GGACCATTTC  TGACAAAAAA  TTATGCTATT  TTCTCTGAAG  ACCTTGAAAA  CCTTAAGACC  660
661   AGAGTAGCTT  ATCTACAGTC  AAAAAATTTC  AGTAAGACAG  ACATTGCACG  GATGGTCAAA  720
721   AATGCACCAT  TTCTGTTGAG  CTTCTCCGTG  GAAAGACTAG  ATAACAGACT  GGGATTTTTT  780
781   CAGAAAGAAC  TTGAACTGAA  TGTGAAGAAG  ACTAGAGATC  TGGTTGTTCG  CCTTCCAAGG  840
841   CTACTAACAG  GAAGTCTGGA  GCCTGTGAAG  GAAAACATGA  AGGTTTATCA  TCTTGAACTT  900
901   GGTTTTAAAC  ATAATGAAAT  TCAACATATG  GTCATCAAGA  TTCCTAAGAT  GCTAACTGCA  960
961   AACAAAAGAA  AACTTACAGA  GATTTTTGAT  TATGTACACA  ATGTGATGAA  TATTCCCCAC  1020
1021  CACATCATCG  TCAAGTTTCC  ACAGTTATTT  AACACAAGAG  TGTTTAAAAT  TAAAGAAAGA  1080
1081  CACTTGTTTC  TTGCCTACCT  GGGAAGAGCA  CAGTATGACC  CAGCAAAACC  TAACTATGTT  1140
1141  TCTTTGGACA  AGTTCGTATC  TTTTCCTGAT  AAAATATTTT  GTAAAGAGAT  TGCCAAAGCT  1200
1201  TCACTAAATG  ATTTTGAGAA  ATTCTTAAAA  ACGCTTTAG  1239

▼ KEYWORD


ID
Family
Complete proteome
DNA-binding
Mitochondrion
Reference proteome
Ribosome biogenesis
Transcription
Transcription regulation
Transit peptide

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Mitochondrion
Cellular Component
Nucleoplasm
Molecular Function
Double-stranded DNA binding
Molecular Function
Transcription regulatory region DNA binding
Biological Process
Mitochondrial ribosome assembly
Biological Process
Mitochondrial transcription
Biological Process
Mitochondrial translation
Biological Process
Negative regulation of transcription, DNA-templated

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-0877Rattus norvegicus87.650.0 672
LLPS-Mea-2618Mesocricetus auratus79.470.0 622
LLPS-Ict-2723Ictidomys tridecemlineatus78.420.0 611
LLPS-Cap-4432Cavia porcellus78.420.0 610
LLPS-Aim-3574Ailuropoda melanoleuca78.020.0 622
LLPS-Fec-2324Felis catus77.940.0 609
LLPS-Eqc-3817Equus caballus77.940.0 613
LLPS-Fud-2384Fukomys damarensis77.940.0 612
LLPS-Urm-1299Ursus maritimus77.780.0 618
LLPS-Tut-1824Tursiops truncatus77.780.0 601
LLPS-Caf-2892Canis familiaris77.70.0 611
LLPS-Caj-4438Callithrix jacchus77.70.0 614
LLPS-Aon-1042Aotus nancymaae77.220.0 607
LLPS-Mup-3968Mustela putorius furo77.220.0 606
LLPS-Otg-4324Otolemur garnettii76.260.0 607
LLPS-Pap-3558Pan paniscus76.020.0 595
LLPS-Pat-3984Pan troglodytes76.020.0 595
LLPS-Hos-2460Homo sapiens76.020.0 595
LLPS-Cas-1727Carlito syrichta76.020.0 600
LLPS-Nol-4624Nomascus leucogenys76.020.0 594
LLPS-Loa-4046Loxodonta africana75.850.0 600
LLPS-Orc-1128Oryctolagus cuniculus75.780.0 591
LLPS-Gog-3967Gorilla gorilla75.780.0 595
LLPS-Dio-3420Dipodomys ordii75.360.0 589
LLPS-Man-3818Macaca nemestrina75.30.0 585
LLPS-Mam-0923Macaca mulatta75.30.0 585
LLPS-Maf-2888Macaca fascicularis75.30.0 585
LLPS-Chs-2187Chlorocebus sabaeus75.30.0 583
LLPS-Poa-4606Pongo abelii75.060.0 590
LLPS-Paa-3976Papio anubis75.060.0 584
LLPS-Mal-3224Mandrillus leucophaeus75.060.0 582
LLPS-Rhb-4498Rhinopithecus bieti74.70.0 579
LLPS-Cea-4497Cercocebus atys74.580.0 582
LLPS-Myl-4026Myotis lucifugus74.220.0 585
LLPS-Bot-3577Bos taurus73.860.0 586
LLPS-Ova-3703Ovis aries73.140.0 584
LLPS-Pes-0387Pelodiscus sinensis71.886e-100 303
LLPS-Sus-1142Sus scrofa71.880.0 588
LLPS-Fia-2756Ficedula albicollis66.893e-145 427
LLPS-Leo-3665Lepisosteus oculatus66.554e-140 410
LLPS-Tag-3040Taeniopygia guttata66.441e-144 421
LLPS-Mod-4037Monodelphis domestica66.177e-170 489
LLPS-Anc-1982Anolis carolinensis66.12e-139 416
LLPS-Sah-3373Sarcophilus harrisii65.383e-174 501
LLPS-Gaga-3774Gallus gallus64.411e-138 410
LLPS-Meg-1828Meleagris gallopavo62.182e-89 276
LLPS-Scf-4133Scleropages formosus62.035e-131 391
LLPS-Ora-1796Ornithorhynchus anatinus61.392e-161 468
LLPS-Anp-2540Anas platyrhynchos61.196e-147 431
LLPS-Dar-1934Danio rerio60.342e-126 378
LLPS-Gaa-1683Gasterosteus aculeatus59.044e-125 375
LLPS-Orn-1872Oreochromis niloticus58.985e-126 378
LLPS-Asm-1529Astyanax mexicanus58.981e-126 380
LLPS-Pof-0904Poecilia formosa58.649e-125 375
LLPS-Icp-0563Ictalurus punctatus58.649e-125 374
LLPS-Scm-2789Scophthalmus maximus58.362e-122 369
LLPS-Tar-1504Takifugu rubripes57.295e-116 352
LLPS-Ten-3387Tetraodon nigroviridis56.661e-121 362
LLPS-Xim-2957Xiphophorus maculatus56.271e-119 362
LLPS-Lac-3353Latimeria chalumnae55.028e-144 423
LLPS-Orl-3173Oryzias latipes54.581e-117 357
LLPS-Drm-1247Drosophila melanogaster41.31e-65 219
LLPS-Cis-1745Ciona savignyi30.982e-29 122
LLPS-Cae-1482Caenorhabditis elegans30.642e-42 159
LLPS-Cii-2221Ciona intestinalis29.765e-36 141
LLPS-Php-1532Physcomitrella patens28.466e-1786.7
LLPS-Coc-1880Corchorus capsularis26.793e-0962.8
LLPS-Gor-1726Gossypium raimondii26.497e-0858.5
LLPS-Nia-1340Nicotiana attenuata26.452e-1066.6
LLPS-Sol-1265Solanum lycopersicum26.453e-1272.4
LLPS-Sot-1790Solanum tuberosum26.452e-1271.6
LLPS-Mae-1987Manihot esculenta26.097e-1064.7
LLPS-Hea-0969Helianthus annuus25.936e-1064.7
LLPS-Vir-1689Vigna radiata25.571e-0757.8
LLPS-Thc-0627Theobroma cacao25.53e-0859.7
LLPS-Lep-0166Leersia perrieri25.459e-0652.0
LLPS-Prp-1046Prunus persica25.361e-0757.8
LLPS-Glm-0148Glycine max25.362e-0963.5
LLPS-Cus-0861Cucumis sativus25.362e-0757.4
LLPS-Arl-1868Arabidopsis lyrata25.363e-0963.2
LLPS-Pot-2407Populus trichocarpa25.04e-0756.2
LLPS-Art-2053Arabidopsis thaliana24.913e-0962.8
LLPS-Met-0914Medicago truncatula24.681e-0861.2
LLPS-Dac-1839Daucus carota24.461e-0757.4
LLPS-Amt-2297Amborella trichopoda24.342e-0860.5
LLPS-Phv-0618Phaseolus vulgaris23.267e-0858.5