LLPS-Mum-4323
Igfbp4

▼ OVERVIEW

Status: Unreviewed
Protein Name: Insulin-like growth factor-binding protein 4
Gene Name: Igfbp4, Igfbp-4
Ensembl Gene: ENSMUSG00000017493.12
Ensembl Protein: ENSMUSP00000017637.6
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLPFGLVAAL  LLAAGPRPSL  GDEAIHCPPC  SEEKLARCRP  PVGCEELVRE  PGCGCCATCA  60
61    LGLGMPCGVY  TPRCGSGMRC  YPPRGVEKPL  RTLMHGQGVC  TELSEIEAIQ  ESLQTSDKDE  120
121   SEHPNNSFNP  CSAHDHRCLQ  KHMAKIRDRS  KMKIVGTPRE  EPRPVPQGSC  QSELHRALER  180
181   LAASQSRTHE  DLFIIPIPNC  DRNGNFHPKQ  CHPALDGQRG  KCWCVDRKTG  VKLPGGLEPK  240
241   GELDCHQLAD  SFQE  254
Nucleotide CDS Sequence (FASTA)
1     ATGCTGCCCT  TCGGCCTCGT  GGCCGCCCTG  CTGCTGGCCG  CAGGGCCTCG  GCCGAGCCTG  60
61    GGCGACGAAG  CCATCCACTG  CCCCCCTTGC  TCCGAGGAGA  AGCTGGCGCG  CTGCCGCCCC  120
121   CCCGTGGGTT  GCGAGGAGTT  GGTGCGGGAG  CCAGGCTGCG  GTTGTTGCGC  CACTTGCGCC  180
181   CTGGGCTTGG  GGATGCCCTG  CGGGGTGTAC  ACCCCACGCT  GTGGCTCAGG  CATGCGCTGC  240
241   TACCCTCCCC  GGGGGGTGGA  GAAGCCCCTG  CGTACATTGA  TGCACGGGCA  AGGCGTGTGC  300
301   ACGGAGCTGT  CGGAAATCGA  AGCCATCCAG  GAAAGCCTGC  AGACCTCTGA  CAAGGATGAG  360
361   AGCGAACATC  CCAACAACAG  CTTCAACCCC  TGCAGTGCCC  ATGATCACAG  GTGCCTGCAG  420
421   AAGCATATGG  CCAAAATTAG  AGATCGGAGC  AAGATGAAGA  TCGTGGGGAC  ACCTCGGGAG  480
481   GAACCCCGTC  CTGTGCCCCA  GGGTTCCTGC  CAGAGCGAGC  TGCACCGGGC  CCTGGAGCGG  540
541   CTGGCCGCCT  CACAGAGCCG  TACCCACGAA  GACCTCTTCA  TCATCCCCAT  TCCAAACTGT  600
601   GACCGCAACG  GCAACTTCCA  CCCCAAACAG  TGTCACCCCG  CCCTGGACGG  ACAGCGTGGC  660
661   AAGTGCTGGT  GTGTGGATCG  GAAGACAGGG  GTGAAGCTTC  CTGGGGGTTT  GGAACCCAAG  720
721   GGGGAGCTGG  ACTGCCACCA  GCTGGCTGAC  AGCTTCCAAG  AGTGA  765

▼ KEYWORD

ID
Family
Complete proteome
Disulfide bond
Glycoprotein
Growth factor binding
Phosphoprotein
Reference proteome
Secreted
Signal

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Extracellular space
Molecular Function
Insulin-like growth factor binding
Molecular Function
Insulin-like growth factor I binding
Molecular Function
Insulin-like growth factor II binding
Biological Process
Inflammatory response
Biological Process
Positive regulation of insulin-like growth factor receptor signaling pathway
Biological Process
Positive regulation of MAPK cascade
Biological Process
Regulation of cell growth
Biological Process
Regulation of glucose metabolic process
Biological Process
Regulation of growth
Biological Process
Regulation of insulin-like growth factor receptor signaling pathway
Biological Process
Type B pancreatic cell proliferation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-4712Rattus norvegicus98.714e-155 439
LLPS-Mea-3347Mesocricetus auratus98.283e-155 439
LLPS-Ict-4077Ictidomys tridecemlineatus91.983e-144 412
LLPS-Paa-3904Papio anubis91.563e-143 409
LLPS-Caf-1435Canis familiaris91.142e-143 410
LLPS-Poa-3392Pongo abelii91.146e-143 409
LLPS-Eqc-0299Equus caballus91.144e-143 411
LLPS-Mam-4016Macaca mulatta91.142e-142 407
LLPS-Nol-3010Nomascus leucogenys91.142e-142 407
LLPS-Hos-0734Homo sapiens91.142e-142 407
LLPS-Fec-4394Felis catus91.143e-144 412
LLPS-Man-3296Macaca nemestrina91.142e-142 407
LLPS-Rhb-0495Rhinopithecus bieti91.141e-142 407
LLPS-Mup-4537Mustela putorius furo91.147e-144 412
LLPS-Aim-4362Ailuropoda melanoleuca91.141e-143 410
LLPS-Maf-0382Macaca fascicularis91.142e-142 407
LLPS-Chs-4333Chlorocebus sabaeus91.142e-142 407
LLPS-Cea-4289Cercocebus atys91.142e-142 407
LLPS-Gog-4461Gorilla gorilla91.142e-142 407
LLPS-Pat-1926Pan troglodytes90.725e-142 406
LLPS-Tut-1841Tursiops truncatus90.723e-143 409
LLPS-Loa-2765Loxodonta africana90.33e-141 404
LLPS-Otg-4659Otolemur garnettii90.32e-142 407
LLPS-Ova-2081Ovis aries90.32e-142 409
LLPS-Orc-2574Oryctolagus cuniculus89.871e-140 402
LLPS-Sus-2715Sus scrofa89.454e-141 404
LLPS-Mal-1335Mandrillus leucophaeus89.181e-123 357
LLPS-Bot-3207Bos taurus88.66e-108 320
LLPS-Pap-2949Pan paniscus88.571e-84 256
LLPS-Anp-1860Anas platyrhynchos88.242e-48 161
LLPS-Dio-3714Dipodomys ordii88.193e-137 394
LLPS-Myl-2251Myotis lucifugus87.761e-138 397
LLPS-Cap-4179Cavia porcellus86.521e-84 256
LLPS-Caj-1440Callithrix jacchus85.238e-132 380
LLPS-Fud-0084Fukomys damarensis84.46e-80 244
LLPS-Aon-2132Aotus nancymaae81.436e-121 352
LLPS-Sah-0017Sarcophilus harrisii79.928e-128 370
LLPS-Mod-2070Monodelphis domestica79.084e-126 365
LLPS-Meg-2046Meleagris gallopavo76.982e-70 219
LLPS-Ere-0843Erinaceus europaeus76.672e-77 238
LLPS-Anc-3621Anolis carolinensis75.318e-114 335
LLPS-Gaga-1913Gallus gallus75.07e-87 266
LLPS-Ora-1030Ornithorhynchus anatinus74.657e-69 216
LLPS-Fia-2817Ficedula albicollis73.972e-104 309
LLPS-Tag-3116Taeniopygia guttata73.684e-87 264
LLPS-Urm-1372Ursus maritimus71.652e-86 265
LLPS-Pes-3213Pelodiscus sinensis70.02e-103 308
LLPS-Ten-3666Tetraodon nigroviridis63.912e-85 262
LLPS-Tar-2196Takifugu rubripes62.614e-84 259
LLPS-Scm-3527Scophthalmus maximus62.113e-82 254
LLPS-Xet-0403Xenopus tropicalis62.037e-88 268
LLPS-Pof-0577Poecilia formosa61.749e-82 253
LLPS-Xim-3391Xiphophorus maculatus60.873e-80 249
LLPS-Orl-0981Oryzias latipes60.432e-77 241
LLPS-Orn-1978Oreochromis niloticus60.092e-82 254
LLPS-Leo-1156Lepisosteus oculatus58.372e-80 249
LLPS-Gaa-1107Gasterosteus aculeatus52.945e-65 211