LLPS-Mum-4307
Kiaa1107

▼ OVERVIEW

Status: Unreviewed
Protein Name: AP2-interacting clathrin-endocytosis protein
Gene Name: Kiaa1107
Ensembl Gene: ENSMUSG00000111375.4
Ensembl Protein: ENSMUSP00000149290.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAHCGAGGAA  PVALLSSPGH  GRKGLPRKGP  GERRRLKAAV  SEQLSRDVLR  LLREEIHTDT  60
61    ILSVSGSLFK  VHKAVLLARA  PGFHSHIIEH  TSSDLTNELV  PVDGVEASEF  KAFLQIVYSS  120
121   NKNIKNYEEE  IVKKLKVGSL  MPEKGPDVSF  PRYRTSSDCF  LGKGEIPEDI  TGGGDCFISK  180
181   ADSDLEPASE  LGGDLLKLYL  SQHYPDIDIC  VDGRSFRAHR  AILSARSSYF  AAMLSGCWAE  240
241   SSQECITLQG  ITHVEMNVMM  HFIYGGTLDF  PEKANVGQIL  NVADMYGLEG  LREVAIYVLR  300
301   RDYCNFFQKP  VPRTWASILE  CLIIAHSVGV  ESLFADCMNC  IISHFARFWS  ERSFANVPPE  360
361   IQKTCLSMQI  QSLNHGNAAF  LLMESDRLIM  GLPRVKWTEA  ALSMASQLQE  ECVTFIVENF  420
421   SQIIESENFT  LLLQSQAMSS  TAHLLDKIFK  AIEDNITAEN  SCSLLMALDT  LLNSESTKEM  480
481   GFTCRIQAVR  GKLWAFLVQS  FYAVRHTGSW  KLMHLDDQQK  IQVAALDKGD  DRRLGRKPVL  540
541   TSSQQRRQGS  DVDVLKIKPW  TENNKKPCQT  SLSTNQKMRS  DGLGASGHAS  STNRNSINKV  600
601   SKHGDSTKMS  KVVKEMKTGG  KYVSGKSKTM  VKPQTENSDH  TKIEGLSSTV  VGRPSRVTAA  660
661   GRKDPVHGKG  VQNQEVETTG  ARPKVLTANL  NVQARAKPLQ  TLRGKDSTCP  ASVGPSSRST  720
721   HSSTELLASM  GSVDETKENG  SVEDKCRDGK  PYVSDSPGQM  VSNGVMSTAA  VKSRAVARIT  780
781   NGTASNKSFT  HEQDSHGNSS  VIKRGDGKGL  SASAPQTAAK  KRGSSNGCTA  AQPRTKSAPP  840
841   TLAQAQGSQG  ESPHSVKSSV  SSRQSDENVT  RLRHGTDKQI  PKRKVVKQGH  TTLQKVNAKL  900
901   VPMPKIPSQP  KKGGTVNSKD  SKQKVLPGQI  MLQSHASQRP  SKPEVAEKSV  LHGVSDSRNH  960
961   VSKQRPHESP  CTLACDTSGP  EVSQIPCRPQ  PQSPLGSQEK  KRLELACQDR  STLGDSVKRE  1020
1021  LRSELAGIEQ  SHTSAYKDSS  QCNGNPNCGS  IAALKSVISN  PNENLINSNP  VHNSDSANTE  1080
1081  QAYLSDRERE  TGRENTDTEP  SMSCINGKAF  LCVPEGTSST  LNPTQSDRRL  TFHGAAQSQL  1140
1141  PDDCATEDSK  CATVTSAVSS  KCLLGQPSEK  NCKNMEMSET  PESHGTPEAP  FVGPWDLNTG  1200
1201  ATHQRESPES  DTGSATTSSD  DIKPRSEDYD  AGGSQDDEGS  HDRGISKCST  ALCHDFLGRS  1260
1261  SSDTSTPEEL  KVHEGDLRTE  VRVRKQGGGD  HQIHSASDDE  IPRKKPEPWS  RSTIGYPREK  1320
1321  GSTPRGSIPS  AQEGDQVSSS  ADETEDERSE  AENVGENSSP  CSSGTQQVQG  IINLAFDDGA  1380
1381  EHESREFSAT  KKFRRSVLLS  VDECEEVGSD  EGEGHTPFQP  SLDSLSPSDV  FDGVSYEHHG  1440
1441  RTGYSRFFKE  NEATTAEHNH  NKGNGGYKNE  SFLLNSRSKD  FEKQDKQCVS  TDQKTRLDVP  1500
1501  PKGSQQLFPE  NEEVISKREA  AHSFQQHSTF  MDGDTKSQER  PCHLELHQRE  LSSNIPKISS  1560
1561  VKSLDSCPSQ  GLPQEGQVKE  SRPTPPKGAN  NAVFSGDIDD  CDTMAQTSMY  DHRPSKTLSP  1620
1621  IYEMSLTAAC  EQEVESETHV  ADRGSEDEQH  FAKQDWTLLR  QLLSEQDANL  NITSSLPEDL  1680
1681  SLAQYLINQT  LLLARDSSKP  QGSAHADTWN  RWSELSSPLD  DSATSATTAS  VSSTDCSPQG  1740
1741  EWTILELETQ  H  1751
Nucleotide CDS Sequence (FASTA)
1     ATGCACTTAG  ATGATCAGCA  GAAAATTCAA  GTAGCTGCAC  TTGACAAAGG  TGATGACCGC  60
61    AGACTTGGCA  GGAAGCCTGT  GCTCACCAGC  TCTCAGCAAA  GGAGACAAGG  CTCTGATGTT  120
121   GATGTTTTAA  AAATAAAACC  TTGGACAGAA  AATAACAAAA  AACCGTGTCA  GACCTCTCTC  180
181   TCTACTAATC  AGAAGATGAG  ATCCGATGGA  TTGGGAGCAT  CAGGACATGC  ATCAAGCACT  240
241   AACAGAAACA  GTATAAATAA  AGTGTCCAAG  CATGGTGACA  GTACAAAAAT  GTCCAAAGTT  300
301   GTGAAAGAGA  TGAAAACTGG  GGGAAAATAT  GTCTCTGGCA  AGTCTAAAAC  TATGGTAAAG  360
361   CCCCAAACAG  AAAACAGTGA  TCATACAAAG  ATAGAAGGTT  TGTCATCCAC  TGTTGTGGGA  420
421   AGACCATCAA  GAGTGACAGC  AGCTGGACGG  AAGGACCCAG  TACATGGAAA  AGGAGTCCAG  480
481   AACCAAGAAG  TGGAGACCAC  AGGGGCAAGA  CCTAAGGTAC  TCACTGCAAA  CCTGAACGTG  540
541   CAAGCCAGAG  CCAAGCCTTT  GCAAACACTG  AGAGGAAAAG  ATTCCACATG  CCCCGCCTCT  600
601   GTAGGGCCCT  CCAGTAGATC  TACACATTCC  AGCACGGAGC  TTCTGGCTTC  CATGGGCTCT  660
661   GTGGATGAGA  CAAAGGAAAA  CGGATCAGTA  GAAGACAAGT  GTCGTGATGG  GAAGCCATAC  720
721   GTTAGTGATT  CCCCAGGACA  GATGGTGAGC  AATGGAGTAA  TGTCAACTGC  AGCAGTAAAG  780
781   TCTCGAGCAG  TTGCAAGAAT  TACCAATGGA  ACAGCCAGTA  ACAAAAGCTT  TACTCATGAA  840
841   CAAGACTCTC  ACGGGAATAG  CAGTGTAATA  AAAAGAGGGG  ATGGCAAAGG  ACTTAGTGCT  900
901   TCAGCACCAC  AGACAGCTGC  GAAGAAAAGA  GGGAGCAGCA  ATGGATGCAC  AGCAGCTCAG  960
961   CCACGGACGA  AGAGCGCCCC  TCCCACCCTG  GCTCAAGCTC  AAGATCAAAA  GACCAGGTTA  1020
1021  GATGTCCCAC  CCAAAGGAAG  CCAACAGCTT  TTTCCGGAAA  ACGAAGAAGT  GATAAGTAAA  1080
1081  CGGGAGGCGG  CTCACAGCTT  TCAGCAGCAC  AGCACATTCA  TGGATGGGGA  CACTAAGTCT  1140
1141  CAAGAACGAC  CGTGTCATTT  GGAGCTCCAT  CAGAGAGAAC  TCAGCTCCAA  TATACCAAAG  1200
1201  ATCAGCTCAG  TGAAATCTCT  GGACTCCTGT  CCCAGCCAGG  GGCTGCCTCA  GGAAGGGCAA  1260
1261  GTGAAAGAGA  GCCGTCCCAC  GCCTCCCAAG  GGAGCTAATA  ACGCTGTGTT  CTCAGGTAAT  1320
1321  GTACAGAAGT  AG  1332

▼ KEYWORD

ID
Family
Cell junction
Cell membrane
Cell projection
Complete proteome
Cytoplasmic vesicle
Endocytosis
Membrane
Reference proteome
Synapse

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axon
Cellular Component
Cell body
Cellular Component
Cell junction
Cellular Component
Clathrin-coated vesicle
Cellular Component
Neuron projection terminus
Cellular Component
Postsynapse
Cellular Component
Presynapse
Cellular Component
Presynaptic membrane
Cellular Component
Synaptic vesicle
Biological Process
Clathrin-dependent synaptic vesicle endocytosis
Biological Process
Neuron projection development
Biological Process
Synaptic vesicle budding from endosome
Biological Process
Synaptic vesicle endocytosis
Biological Process
Synaptic vesicle recycling via endosome

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-4794Rattus norvegicus79.810.02082
LLPS-Mea-0400Mesocricetus auratus71.310.02353
LLPS-Hos-1630Homo sapiens64.680.02134
LLPS-Fec-1887Felis catus64.260.01773
LLPS-Cea-2574Cercocebus atys64.00.01740
LLPS-Eqc-0564Equus caballus63.770.02104
LLPS-Ict-3463Ictidomys tridecemlineatus62.980.01563
LLPS-Orc-1772Oryctolagus cuniculus62.970.02063
LLPS-Caf-0956Canis familiaris62.970.02066
LLPS-Paa-1849Papio anubis62.920.01560
LLPS-Maf-3084Macaca fascicularis62.770.01559
LLPS-Mal-1207Mandrillus leucophaeus62.770.01554
LLPS-Bot-4119Bos taurus62.760.02045
LLPS-Pap-0905Pan paniscus62.750.01559
LLPS-Pat-2623Pan troglodytes62.750.01561
LLPS-Gog-3105Gorilla gorilla62.720.01555
LLPS-Mam-1691Macaca mulatta62.70.01558
LLPS-Man-3044Macaca nemestrina62.630.01548
LLPS-Ova-3759Ovis aries62.60.02024
LLPS-Nol-4030Nomascus leucogenys62.540.01558
LLPS-Urm-0730Ursus maritimus62.240.02020
LLPS-Rhb-3121Rhinopithecus bieti61.940.01543
LLPS-Chs-1439Chlorocebus sabaeus61.410.01441
LLPS-Cap-3798Cavia porcellus61.290.01514
LLPS-Aon-4765Aotus nancymaae61.280.01523
LLPS-Mup-3411Mustela putorius furo61.210.01499
LLPS-Fud-1673Fukomys damarensis61.120.01479
LLPS-Aim-2003Ailuropoda melanoleuca60.990.01504
LLPS-Caj-3527Callithrix jacchus60.880.01473
LLPS-Myl-1392Myotis lucifugus60.880.01474
LLPS-Poa-4298Pongo abelii60.680.01061
LLPS-Otg-2196Otolemur garnettii60.340.01472
LLPS-Tut-1382Tursiops truncatus60.130.01308
LLPS-Sus-2340Sus scrofa59.580.01918
LLPS-Cas-2128Carlito syrichta59.020.01423
LLPS-Loa-0971Loxodonta africana58.630.01398
LLPS-Dio-3875Dipodomys ordii58.270.01212
LLPS-Anp-2565Anas platyrhynchos56.263e-159 533
LLPS-Pes-3536Pelodiscus sinensis56.210.0 587
LLPS-Ere-0107Erinaceus europaeus53.860.01116
LLPS-Sah-3597Sarcophilus harrisii52.710.01442
LLPS-Leo-2824Lepisosteus oculatus52.41e-47 192
LLPS-Mod-1868Monodelphis domestica51.90.01618
LLPS-Lac-0265Latimeria chalumnae47.471e-120 421
LLPS-Ora-1329Ornithorhynchus anatinus45.930.0 894
LLPS-Icp-2903Ictalurus punctatus45.568e-34 146
LLPS-Xet-1740Xenopus tropicalis45.122e-107 379
LLPS-Gaga-0621Gallus gallus45.00.0 720
LLPS-Fia-3733Ficedula albicollis44.770.0 927
LLPS-Tag-3588Taeniopygia guttata44.740.0 924
LLPS-Scf-3058Scleropages formosus44.553e-44 179
LLPS-Meg-0065Meleagris gallopavo44.310.0 903
LLPS-Anc-3558Anolis carolinensis44.060.0 924
LLPS-Asm-3437Astyanax mexicanus39.613e-75 281
LLPS-Sob-1986Sorghum bicolor39.362e-0759.3
LLPS-Scm-3471Scophthalmus maximus39.122e-40 167
LLPS-Pof-3899Poecilia formosa38.558e-76 283
LLPS-Dar-0725Danio rerio38.252e-69 263
LLPS-Orl-2932Oryzias latipes38.134e-57 223
LLPS-Orn-2026Oreochromis niloticus38.062e-69 263
LLPS-Xim-1359Xiphophorus maculatus37.913e-76 285
LLPS-Drm-0578Drosophila melanogaster35.851e-0967.4
LLPS-Gaa-1687Gasterosteus aculeatus35.745e-56 203
LLPS-Ten-2066Tetraodon nigroviridis35.691e-64 248
LLPS-Tar-3453Takifugu rubripes35.652e-66 253
LLPS-Fus-0781Fusarium solani34.441e-0963.9
LLPS-Cii-1752Ciona intestinalis34.268e-0860.5
LLPS-Amt-2113Amborella trichopoda33.331e-0657.0
LLPS-Phv-1483Phaseolus vulgaris31.622e-0656.6
LLPS-Orm-1596Oryza meridionalis31.158e-0757.8
LLPS-Pot-1846Populus trichocarpa30.778e-0654.7
LLPS-Pug-1499Puccinia graminis22.431e-1380.9
LLPS-Spr-0399Sporisorium reilianum21.743e-1276.6