LLPS-Mum-4143
Anxa4
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Annexin A4; Annexin IV; Annexin-4 |
| Gene Name: | Anxa4, Anx4 |
| Ensembl Gene: | ENSMUSG00000029994.17 |
| Ensembl Protein: | ENSMUSP00000144961.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000204398.1 | ENSMUSP00000144961.1 |
| Ensembl | ENSMUST00000123732.3 | ENSMUSP00000115346.1 |
| Ensembl | ENSMUST00000113675.7 | ENSMUSP00000109305.1 |
| Ensembl | ENSMUST00000204441.2 | ENSMUSP00000145421.1 |
| Ensembl | ENSMUST00000001187.14 | ENSMUSP00000001187.8 |
| Ensembl | ENSMUST00000155456.7 | ENSMUSP00000117378.1 |
| Ensembl | ENSMUST00000127152.8 | ENSMUSP00000138194.1 |
| UniProt | P97429, ANXA4_MOUSE, Q3UCL0 | |
| GeneBank | AK151236, U72941, AK167338, AK150614, AK132293, AK168917, AK168390, AK150486, CH466523, AK170447, AK168487, AK151054 | BAE41805.1, BAE21085.1, AAB40697.1, BAE30071.1, EDK99195.1, BAE39439.1, BAE29602.1, BAE30228.1, BAE40374.1, BAE29705.1, BAE40316.1, BAE40730.1 |
| RefSeq | NM_001331120.1, NM_013471.2, XM_006505397.2, XM_006505398.2 | NP_001318049.1, NP_038499.2, XP_006505460.1, XP_006505461.1 |
| Entrez | 11746 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEAKGGTVKA ASGFNATEDA QTLRKAMKGL GTDEDAIIGI LAYRNTAQRQ EIRSAYKSTI 60 61 GRDLIEDLKS ELSSNFEQVI LGLMTPTVLY DVQELRRAMK GAGTDEGCLI EILASRTPEE 120 121 IRRINQTYQQ QYGRSLEEDI CSDTSFMFQR VLVSLSAAGR DEGNYLDDAL MKQDAQELYE 180 181 AGEKRWGTDE VKFLSILCSR NRNHLLHVFD EYKRISQKDI EQSIKSETSG SFEDALLAIV 240 241 KCMRSKPSYF AERLYKSMKG LGTDDNTLIR VMVSRAEIDM LDIRASFKRL YGKSLYSFIK 300 301 GDTSGDYRKV LLVLCGGDD 319 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAAGCCA AAGGAGGAAC CGTGAAAGCT GCTTCAGGAT TCAACGCAAC TGAAGATGCC 60 61 CAGACCCTGA GGAAGGCCAT GAAAGGCCTC GGTACTGATG AAGATGCCAT TATCGGAATC 120 121 TTAGCCTACA GAAACACCGC CCAGCGCCAG GAGATCAGGA GTGCCTACAA GAGCACCATT 180 181 GGCAGGGACC TGATTGAGGA CTTGAAGTCG GAGCTGAGCA GCAACTTTGA GCAGGTGATC 240 241 CTGGGGCTGA TGACACCCAC AGTGCTGTAT GACGTACAGG AGCTGCGGAG GGCCATGAAG 300 301 GGAGCTGGCA CGGACGAGGG CTGTCTGATT GAGATCCTGG CCTCTCGTAC CCCTGAGGAG 360 361 ATCCGTCGAA TCAACCAGAC ATACCAGCAG CAATATGGAA GGAGCCTTGA AGAGGACATC 420 421 TGCTCTGACA CATCCTTCAT GTTCCAGCGA GTACTGGTGT CCCTGTCGGC GGCTGGCAGG 480 481 GATGAAGGAA ATTACCTTGA TGATGCTCTT ATGAAGCAGG ACGCCCAGGA ACTGTATGAG 540 541 GCTGGAGAGA AGAGATGGGG GACAGACGAG GTGAAATTCC TAAGCATTCT CTGTTCCCGG 600 601 AACCGGAACC ATCTGCTCCA CGTGTTTGAT GAATACAAAA GAATCTCACA GAAGGACATT 660 661 GAACAGAGCA TTAAGTCTGA GACATCTGGA AGCTTTGAAG ATGCCCTGTT GGCTATAGTG 720 721 AAGTGCATGC GGAGTAAACC TTCATATTTC GCTGAGAGAC TTTATAAATC CATGAAGGGC 780 781 TTAGGCACTG ATGACAACAC CCTCATCAGA GTGATGGTCT CAAGAGCAGA GATTGACATG 840 841 CTGGACATCC GGGCGAGCTT CAAGAGGCTC TACGGGAAGT CTTTGTACTC TTTCATCAAG 900 901 GGTGACACTT CCGGAGACTA CAGGAAGGTT CTGCTCGTTC TCTGTGGAGG AGATGATTAA 960 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Apical plasma membrane | |
Cellular Component | Cell surface | |
Cellular Component | Collagen-containing extracellular matrix | |
Cellular Component | Cytoplasm | |
Cellular Component | Cytosol | |
Cellular Component | Nuclear membrane | |
Cellular Component | Nucleus | |
Cellular Component | Perinuclear region of cytoplasm | |
Cellular Component | Plasma membrane | |
Cellular Component | Vesicle membrane | |
Molecular Function | Calcium ion binding | |
Molecular Function | Calcium-dependent phospholipid binding | |
Molecular Function | Calcium-dependent protein binding | |
Molecular Function | Chondroitin sulfate binding | |
Molecular Function | Heparin binding | |
Molecular Function | Identical protein binding | |
Molecular Function | NF-kappaB binding | |
Biological Process | Epithelial cell differentiation | |
Biological Process | Kidney development | |
Biological Process | Negative regulation of interleukin-8 secretion | |
Biological Process | Negative regulation of NF-kappaB transcription factor activity | |
Biological Process | Notch signaling pathway | |
Biological Process | Regulation of transcription by RNA polymerase II |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-1021 | Rattus norvegicus | 94.67 | 0.0 | 625 |
| LLPS-Mal-4738 | Mandrillus leucophaeus | 92.72 | 0.0 | 607 |
| LLPS-Cea-4592 | Cercocebus atys | 92.72 | 0.0 | 607 |
| LLPS-Caj-2875 | Callithrix jacchus | 92.48 | 0.0 | 612 |
| LLPS-Paa-0128 | Papio anubis | 92.41 | 0.0 | 606 |
| LLPS-Chs-2123 | Chlorocebus sabaeus | 92.41 | 0.0 | 606 |
| LLPS-Maf-2527 | Macaca fascicularis | 92.41 | 0.0 | 605 |
| LLPS-Man-4267 | Macaca nemestrina | 92.41 | 0.0 | 605 |
| LLPS-Nol-3737 | Nomascus leucogenys | 92.16 | 0.0 | 609 |
| LLPS-Hos-1931 | Homo sapiens | 92.16 | 0.0 | 608 |
| LLPS-Pap-2140 | Pan paniscus | 92.16 | 0.0 | 609 |
| LLPS-Pat-0375 | Pan troglodytes | 92.16 | 0.0 | 608 |
| LLPS-Mam-3018 | Macaca mulatta | 92.09 | 0.0 | 603 |
| LLPS-Gog-2331 | Gorilla gorilla | 91.85 | 0.0 | 608 |
| LLPS-Aon-3535 | Aotus nancymaae | 91.85 | 0.0 | 607 |
| LLPS-Mea-1898 | Mesocricetus auratus | 91.77 | 0.0 | 597 |
| LLPS-Cas-3568 | Carlito syrichta | 91.77 | 0.0 | 601 |
| LLPS-Rhb-4056 | Rhinopithecus bieti | 91.54 | 0.0 | 605 |
| LLPS-Sus-0671 | Sus scrofa | 91.32 | 0.0 | 548 |
| LLPS-Ict-1668 | Ictidomys tridecemlineatus | 91.22 | 0.0 | 608 |
| LLPS-Bot-3130 | Bos taurus | 90.91 | 0.0 | 603 |
| LLPS-Otg-2690 | Otolemur garnettii | 90.85 | 0.0 | 602 |
| LLPS-Dio-1523 | Dipodomys ordii | 90.82 | 0.0 | 594 |
| LLPS-Aim-4014 | Ailuropoda melanoleuca | 90.54 | 0.0 | 595 |
| LLPS-Caf-1965 | Canis familiaris | 90.28 | 0.0 | 600 |
| LLPS-Orc-3235 | Oryctolagus cuniculus | 89.97 | 0.0 | 605 |
| LLPS-Myl-3715 | Myotis lucifugus | 89.87 | 0.0 | 591 |
| LLPS-Fec-4719 | Felis catus | 89.66 | 0.0 | 597 |
| LLPS-Urm-3418 | Ursus maritimus | 89.38 | 0.0 | 588 |
| LLPS-Cap-2493 | Cavia porcellus | 89.34 | 0.0 | 591 |
| LLPS-Fud-3795 | Fukomys damarensis | 88.71 | 0.0 | 597 |
| LLPS-Loa-0295 | Loxodonta africana | 88.05 | 0.0 | 588 |
| LLPS-Mod-3937 | Monodelphis domestica | 85.22 | 0.0 | 571 |
| LLPS-Mup-4474 | Mustela putorius furo | 83.9 | 0.0 | 545 |
| LLPS-Ova-1045 | Ovis aries | 83.6 | 0.0 | 540 |
| LLPS-Eqc-3693 | Equus caballus | 81.18 | 0.0 | 583 |
| LLPS-Sah-3231 | Sarcophilus harrisii | 81.01 | 0.0 | 533 |
| LLPS-Gaga-1988 | Gallus gallus | 76.82 | 3e-158 | 454 |
| LLPS-Meg-1096 | Meleagris gallopavo | 76.65 | 2e-141 | 407 |
| LLPS-Anp-2987 | Anas platyrhynchos | 76.57 | 7e-168 | 476 |
| LLPS-Tag-2654 | Taeniopygia guttata | 75.33 | 7e-163 | 464 |
| LLPS-Pes-2594 | Pelodiscus sinensis | 74.52 | 8e-171 | 484 |
| LLPS-Fia-0226 | Ficedula albicollis | 72.93 | 5e-165 | 469 |
| LLPS-Orl-0674 | Oryzias latipes | 66.77 | 2e-155 | 445 |
| LLPS-Scf-2415 | Scleropages formosus | 66.13 | 1e-150 | 433 |
| LLPS-Orn-2154 | Oreochromis niloticus | 66.13 | 1e-150 | 433 |
| LLPS-Pof-3525 | Poecilia formosa | 65.92 | 4e-152 | 437 |
| LLPS-Ten-1544 | Tetraodon nigroviridis | 64.86 | 5e-149 | 429 |
| LLPS-Tar-1354 | Takifugu rubripes | 64.22 | 2e-146 | 422 |
| LLPS-Scm-2032 | Scophthalmus maximus | 64.1 | 1e-145 | 421 |
| LLPS-Xim-1874 | Xiphophorus maculatus | 64.07 | 8e-130 | 383 |
| LLPS-Dar-4121 | Danio rerio | 63.9 | 4e-148 | 427 |
| LLPS-Lac-0601 | Latimeria chalumnae | 62.04 | 4e-136 | 396 |
| LLPS-Leo-2948 | Lepisosteus oculatus | 57.32 | 1e-124 | 375 |
| LLPS-Gaa-3810 | Gasterosteus aculeatus | 56.23 | 2e-110 | 342 |
| LLPS-Asm-0968 | Astyanax mexicanus | 55.73 | 1e-116 | 352 |
| LLPS-Anc-1453 | Anolis carolinensis | 55.44 | 2e-110 | 337 |
| LLPS-Poa-2258 | Pongo abelii | 54.78 | 4e-114 | 351 |
| LLPS-Icp-3351 | Ictalurus punctatus | 54.46 | 1e-116 | 352 |
| LLPS-Xet-3418 | Xenopus tropicalis | 50.96 | 7e-103 | 322 |
| LLPS-Ora-0425 | Ornithorhynchus anatinus | 48.09 | 3e-105 | 317 |