LLPS-Mum-4126
Eno3
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Beta-enolase; 2-phospho-D-glycerate hydro-lyase; Enolase 3; Muscle-specific enolase; MSE; Skeletal muscle enolase |
| Gene Name: | Eno3, Eno-3 |
| Ensembl Gene: | ENSMUSG00000060600.15 |
| Ensembl Protein: | ENSMUSP00000121640.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
| Nucleolus | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Appears to have a function in striated muscle development and regeneration. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000134087.7 | ENSMUSP00000121640.1 |
| Ensembl | ENSMUST00000108548.7 | ENSMUSP00000104188.1 |
| Ensembl | ENSMUST00000126241.7 | ENSMUSP00000123688.1 |
| Ensembl | ENSMUST00000157027.7 | ENSMUSP00000115726.1 |
| Ensembl | ENSMUST00000170716.7 | ENSMUSP00000128714.1 |
| Ensembl | ENSMUST00000072841.11 | ENSMUSP00000072620.5 |
| Ensembl | ENSMUST00000179055.1 | ENSMUSP00000137559.1 |
| UniProt | P21550, ENOB_MOUSE | |
| GeneBank | X61600, BC013460, M20745, X62667, AK002485, X57747 | BAB22137.1, CAA44540.1, AAA37554.1, CAA40913.1, AAH13460.1, CAA43797.1 |
| RefSeq | NM_001136062.2, NM_001276285.1, NM_007933.3, XM_006532162.3 | NP_001129534.1, NP_001263214.1, NP_031959.1, XP_006532225.1 |
| Entrez | 13808 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAMQKIFARE ILDSRGNPTV EVDLHTAKGR FRAAVPSGAS TGIYEALELR DGDKARYLGK 60 61 GVLKAVEHIN KTLGPALLEK KLSVVDQEKV DKFMIELDGT ENKSKFGANA ILGVSLAVCK 120 121 AGAAEKGVPL YRHIADLAGN PDLVLPVPAF NVINGGSHAG NKLAMQEFMI LPVGASSFKE 180 181 AMRIGAEVYH HLKGVIKAKY GKDATNVGDE GGFAPNILEN NEALELLKTA IQAAGYPDKV 240 241 VIGMDVAASE FYRNGKYDLD FKSPDDPARH ISGEKLGELY KNFIQNYPVV SIEDPFDQDD 300 301 WATWTSFLSG VDIQIVGDDL TVTNPKRIAQ AVEKKACNCL LLKVNQIGSV TESIQACKLA 360 361 QSNGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL MRIEEALGDK 420 421 AVFAGRKFRN PKAK 434 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCATGC AAAAAATCTT CGCCCGGGAA ATCCTGGACT CCAGGGGCAA CCCCACGGTG 60 61 GAGGTGGACC TGCACACAGC CAAGGGTCGA TTCCGAGCAG CTGTGCCCAG TGGAGCTTCC 120 121 ACGGGTATCT ATGAAGCACT GGAACTCCGA GATGGAGACA AAGCACGATA CCTGGGGAAA 180 181 GGAGTGCTGA AGGCTGTGGA ACACATCAAC AAGACTCTAG GTCCTGCTCT GCTGGAAAAG 240 241 AAACTAAGTG TTGTGGATCA AGAAAAAGTT GACAAGTTCA TGATTGAGCT GGACGGGACC 300 301 GAGAATAAGT CCAAGTTTGG GGCCAACGCC ATCCTGGGTG TGTCCCTGGC TGTCTGCAAG 360 361 GCTGGAGCAG CTGAGAAAGG GGTCCCTCTC TACCGACACA TCGCAGATCT TGCAGGCAAT 420 421 CCCGACCTCG TACTCCCTGT GCCTGCCTTT AATGTGATCA ACGGCGGCTC TCATGCTGGA 480 481 AACAAGCTGG CCATGCAGGA GTTCATGATT CTGCCAGTGG GAGCCAGCTC TTTCAAGGAA 540 541 GCCATGCGCA TCGGCGCTGA GGTCTACCAC CACCTCAAGG GGGTCATCAA GGCCAAGTAT 600 601 GGGAAGGACG CCACCAACGT GGGGGATGAG GGTGGCTTTG CACCCAACAT CCTGGAGAAC 660 661 AATGAGGCCC TGGAGCTGCT AAAGACAGCC ATCCAGGCAG CCGGTTACCC GGACAAGGTG 720 721 GTGATCGGCA TGGATGTAGC TGCGTCTGAA TTCTACCGCA ACGGCAAGTA TGATCTGGAC 780 781 TTCAAGTCAC CCGATGACCC TGCCAGGCAC ATCAGTGGGG AGAAGCTTGG GGAGCTGTAC 840 841 AAGAACTTCA TCCAGAACTA TCCCGTGGTC TCCATTGAGG ACCCCTTTGA CCAGGATGAC 900 901 TGGGCCACAT GGACCTCATT CCTCTCTGGG GTGGACATCC AGATTGTGGG AGATGACCTC 960 961 ACGGTAACCA ACCCCAAGAG GATTGCTCAG GCTGTGGAGA AGAAGGCCTG CAATTGCCTG 1020 1021 CTCCTGAAGG TCAACCAGAT CGGCTCCGTG ACGGAGTCCA TCCAGGCCTG TAAACTTGCA 1080 1081 CAATCTAATG GCTGGGGAGT GATGGTGAGC CACCGCTCTG GGGAGACCGA AGACACTTTC 1140 1141 ATCGCTGACC TTGTGGTGGG ACTCTGCACA GGACAGATCA AGACTGGTGC TCCCTGCCGT 1200 1201 TCAGAGCGTC TGGCAAAATA CAACCAGCTT ATGAGGATTG AGGAGGCTCT TGGGGACAAA 1260 1261 GCTGTCTTTG CTGGAAGAAA GTTCCGTAAT CCAAAGGCCA AATGA 1305 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Membrane | |
Cellular Component | Phosphopyruvate hydratase complex | |
Cellular Component | Plasma membrane | |
Molecular Function | Magnesium ion binding | |
Molecular Function | Phosphopyruvate hydratase activity | |
Molecular Function | Protein heterodimerization activity | |
Molecular Function | Protein homodimerization activity | |
Biological Process | Aging | |
Biological Process | Glycolytic process | |
Biological Process | Response to drug | |
Biological Process | Skeletal muscle tissue regeneration |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CGDB | PIRSF | CellMarker | ||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mea-3067 | Mesocricetus auratus | 99.54 | 0.0 | 862 |
| LLPS-Cas-1684 | Carlito syrichta | 99.31 | 0.0 | 861 |
| LLPS-Ran-1881 | Rattus norvegicus | 99.31 | 0.0 | 861 |
| LLPS-Aim-2875 | Ailuropoda melanoleuca | 98.85 | 0.0 | 858 |
| LLPS-Mup-4126 | Mustela putorius furo | 98.85 | 0.0 | 858 |
| LLPS-Aon-0259 | Aotus nancymaae | 98.85 | 0.0 | 860 |
| LLPS-Fec-4066 | Felis catus | 98.62 | 0.0 | 857 |
| LLPS-Chs-2541 | Chlorocebus sabaeus | 98.62 | 0.0 | 856 |
| LLPS-Bot-2461 | Bos taurus | 98.54 | 0.0 | 810 |
| LLPS-Ict-1341 | Ictidomys tridecemlineatus | 98.39 | 0.0 | 854 |
| LLPS-Rhb-2872 | Rhinopithecus bieti | 98.39 | 0.0 | 850 |
| LLPS-Paa-0950 | Papio anubis | 98.39 | 0.0 | 855 |
| LLPS-Ova-2974 | Ovis aries | 98.39 | 0.0 | 856 |
| LLPS-Myl-2762 | Myotis lucifugus | 98.39 | 0.0 | 854 |
| LLPS-Maf-3724 | Macaca fascicularis | 98.39 | 0.0 | 855 |
| LLPS-Fud-0511 | Fukomys damarensis | 98.39 | 0.0 | 857 |
| LLPS-Mal-0420 | Mandrillus leucophaeus | 98.16 | 0.0 | 853 |
| LLPS-Caj-3613 | Callithrix jacchus | 98.16 | 0.0 | 854 |
| LLPS-Cap-3438 | Cavia porcellus | 97.93 | 0.0 | 852 |
| LLPS-Loa-2954 | Loxodonta africana | 97.93 | 0.0 | 854 |
| LLPS-Otg-1355 | Otolemur garnettii | 97.93 | 0.0 | 853 |
| LLPS-Poa-4177 | Pongo abelii | 97.7 | 0.0 | 851 |
| LLPS-Hos-2046 | Homo sapiens | 97.7 | 0.0 | 850 |
| LLPS-Pap-3020 | Pan paniscus | 97.7 | 0.0 | 850 |
| LLPS-Pat-2747 | Pan troglodytes | 97.7 | 0.0 | 850 |
| LLPS-Mod-4279 | Monodelphis domestica | 97.7 | 0.0 | 852 |
| LLPS-Sah-0965 | Sarcophilus harrisii | 97.7 | 0.0 | 851 |
| LLPS-Mam-1307 | Macaca mulatta | 97.67 | 0.0 | 839 |
| LLPS-Gog-1111 | Gorilla gorilla | 97.47 | 0.0 | 849 |
| LLPS-Sus-4294 | Sus scrofa | 96.91 | 0.0 | 748 |
| LLPS-Nol-3400 | Nomascus leucogenys | 94.37 | 0.0 | 784 |
| LLPS-Eqc-4577 | Equus caballus | 93.89 | 0.0 | 808 |
| LLPS-Pes-0282 | Pelodiscus sinensis | 91.01 | 0.0 | 797 |
| LLPS-Leo-3648 | Lepisosteus oculatus | 89.4 | 0.0 | 780 |
| LLPS-Orn-3870 | Oreochromis niloticus | 87.04 | 0.0 | 764 |
| LLPS-Asm-2476 | Astyanax mexicanus | 87.04 | 0.0 | 768 |
| LLPS-Pof-3537 | Poecilia formosa | 86.34 | 0.0 | 759 |
| LLPS-Xim-1730 | Xiphophorus maculatus | 86.34 | 0.0 | 758 |
| LLPS-Icp-1112 | Ictalurus punctatus | 86.34 | 0.0 | 760 |
| LLPS-Scf-1905 | Scleropages formosus | 86.11 | 0.0 | 757 |
| LLPS-Dar-3375 | Danio rerio | 85.88 | 0.0 | 759 |
| LLPS-Lac-3473 | Latimeria chalumnae | 85.48 | 0.0 | 757 |
| LLPS-Gaga-3950 | Gallus gallus | 84.95 | 0.0 | 747 |
| LLPS-Ora-0370 | Ornithorhynchus anatinus | 84.76 | 0.0 | 602 |
| LLPS-Anp-1042 | Anas platyrhynchos | 84.73 | 0.0 | 720 |
| LLPS-Fia-0402 | Ficedula albicollis | 84.49 | 0.0 | 747 |
| LLPS-Meg-2681 | Meleagris gallopavo | 84.33 | 0.0 | 740 |
| LLPS-Xet-0672 | Xenopus tropicalis | 84.22 | 0.0 | 741 |
| LLPS-Man-0253 | Macaca nemestrina | 84.16 | 0.0 | 692 |
| LLPS-Dio-1648 | Dipodomys ordii | 83.87 | 0.0 | 742 |
| LLPS-Ere-0325 | Erinaceus europaeus | 83.87 | 0.0 | 740 |
| LLPS-Caf-2416 | Canis familiaris | 83.76 | 0.0 | 736 |
| LLPS-Orc-3349 | Oryctolagus cuniculus | 83.76 | 0.0 | 736 |
| LLPS-Orl-0882 | Oryzias latipes | 83.76 | 0.0 | 738 |
| LLPS-Urm-1005 | Ursus maritimus | 83.53 | 0.0 | 737 |
| LLPS-Cea-0791 | Cercocebus atys | 83.53 | 0.0 | 736 |
| LLPS-Gaa-0105 | Gasterosteus aculeatus | 82.83 | 0.0 | 731 |
| LLPS-Scm-1448 | Scophthalmus maximus | 81.9 | 0.0 | 727 |
| LLPS-Tar-1748 | Takifugu rubripes | 81.9 | 0.0 | 728 |
| LLPS-Ten-3562 | Tetraodon nigroviridis | 80.74 | 0.0 | 700 |
| LLPS-Cae-0451 | Caenorhabditis elegans | 73.44 | 0.0 | 639 |
| LLPS-Drm-0486 | Drosophila melanogaster | 72.98 | 0.0 | 617 |
| LLPS-Cis-1697 | Ciona savignyi | 72.5 | 0.0 | 626 |
| LLPS-Cii-0024 | Ciona intestinalis | 72.27 | 0.0 | 609 |
| LLPS-Sot-0576 | Solanum tuberosum | 71.14 | 0.0 | 597 |
| LLPS-Nia-1994 | Nicotiana attenuata | 71.11 | 0.0 | 595 |
| LLPS-Arl-2457 | Arabidopsis lyrata | 71.03 | 0.0 | 594 |
| LLPS-Sol-0119 | Solanum lycopersicum | 70.91 | 0.0 | 595 |
| LLPS-Bro-1083 | Brassica oleracea | 70.8 | 0.0 | 587 |
| LLPS-Brr-0546 | Brassica rapa | 70.8 | 0.0 | 587 |
| LLPS-Abg-1975 | Absidia glauca | 70.77 | 0.0 | 609 |
| LLPS-Gor-0442 | Gossypium raimondii | 70.71 | 0.0 | 582 |
| LLPS-Art-1389 | Arabidopsis thaliana | 70.57 | 0.0 | 590 |
| LLPS-Mae-1003 | Manihot esculenta | 70.48 | 0.0 | 579 |
| LLPS-Thc-1368 | Theobroma cacao | 70.48 | 0.0 | 580 |
| LLPS-Prp-2197 | Prunus persica | 70.41 | 0.0 | 578 |
| LLPS-Glm-1842 | Glycine max | 70.3 | 0.0 | 597 |
| LLPS-Hea-1953 | Helianthus annuus | 70.29 | 0.0 | 588 |
| LLPS-Viv-1659 | Vitis vinifera | 70.27 | 0.0 | 583 |
| LLPS-Via-0305 | Vigna angularis | 70.27 | 0.0 | 587 |
| LLPS-Sem-1054 | Selaginella moellendorffii | 69.91 | 0.0 | 590 |
| LLPS-Cus-1586 | Cucumis sativus | 69.84 | 0.0 | 590 |
| LLPS-Org-1449 | Oryza glaberrima | 69.61 | 0.0 | 585 |
| LLPS-Tru-1681 | Triticum urartu | 69.61 | 0.0 | 586 |
| LLPS-Ors-2183 | Oryza sativa | 69.55 | 0.0 | 580 |
| LLPS-Ori-1876 | Oryza indica | 69.55 | 0.0 | 580 |
| LLPS-Sei-1667 | Setaria italica | 69.52 | 0.0 | 595 |
| LLPS-Brd-1212 | Brachypodium distachyon | 69.39 | 0.0 | 585 |
| LLPS-Lep-0142 | Leersia perrieri | 69.34 | 0.0 | 576 |
| LLPS-Orr-1825 | Oryza rufipogon | 69.3 | 0.0 | 586 |
| LLPS-Orm-0875 | Oryza meridionalis | 69.3 | 0.0 | 586 |
| LLPS-Orp-0279 | Oryza punctata | 69.3 | 0.0 | 586 |
| LLPS-Orgl-2157 | Oryza glumaepatula | 69.3 | 0.0 | 586 |
| LLPS-Orni-0019 | Oryza nivara | 69.3 | 0.0 | 587 |
| LLPS-Mua-1516 | Musa acuminata | 69.3 | 0.0 | 585 |
| LLPS-Sob-1333 | Sorghum bicolor | 69.27 | 0.0 | 577 |
| LLPS-Zem-1013 | Zea mays | 69.16 | 0.0 | 582 |
| LLPS-Hov-0154 | Hordeum vulgare | 69.16 | 0.0 | 579 |
| LLPS-Met-1236 | Medicago truncatula | 69.16 | 0.0 | 578 |
| LLPS-Php-0905 | Physcomitrella patens | 69.16 | 0.0 | 584 |
| LLPS-Coc-1561 | Corchorus capsularis | 69.14 | 0.0 | 590 |
| LLPS-Vir-1837 | Vigna radiata | 69.14 | 0.0 | 587 |
| LLPS-Tra-0714 | Triticum aestivum | 68.93 | 0.0 | 580 |
| LLPS-Pot-0428 | Populus trichocarpa | 68.87 | 0.0 | 585 |
| LLPS-Phv-1828 | Phaseolus vulgaris | 68.68 | 0.0 | 583 |
| LLPS-Amt-1545 | Amborella trichopoda | 68.62 | 0.0 | 580 |
| LLPS-Brn-2138 | Brassica napus | 68.31 | 0.0 | 582 |
| LLPS-Miv-1588 | Microbotryum violaceum | 67.6 | 0.0 | 582 |
| LLPS-Pug-1193 | Puccinia graminis | 66.44 | 0.0 | 578 |