LLPS-Mum-4088
Talpid3
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Protein TALPID3 |
| Gene Name: | Talpid3 |
| Ensembl Gene: | ENSMUSG00000034601.17 |
| Ensembl Protein: | ENSMUSP00000114210.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for ciliogenesis and sonic hedgehog/SHH signaling (PubMed:21750036). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (By similarity). Involved in regulation of cell intracellular organization (PubMed:26386247). Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (PubMed:25251415). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000134748.1 | ENSMUSP00000114210.1 |
| Ensembl | ENSMUST00000045907.15 | ENSMUSP00000044701.8 |
| Ensembl | ENSMUST00000149564.7 | ENSMUSP00000118956.1 |
| UniProt | E9PV87, TALD3_MOUSE, B2RWX3 | |
| GeneBank | BC150744, AC159620 | , AAI50745.1 |
| RefSeq | NM_001163378.1 | NP_001156850.1 |
| Entrez | 76967 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MKNVEFSLER GQRLKMPARK LREIVSPNQG NKLAVVEDEL PRVPPALAAN KRLAVETRTS 60 61 SNGTLCGSLD LTSARLYHQP LLESPPASKK SDFSKDAVVR QLPLNKTEEN NAPKANDIFI 120 121 SQYTMGQKDA LRTVLKQKAQ SMPVFKAVKV HLFEDTSTEK NTVAQETETP PNRIDSATTV 180 181 AAATAAAIAT AAPLIKVQSD LEAKVNCVGE LLTKLQETDK QLQRVTEHQA SVQSKQEKVH 240 241 CHDHDKQMNA FMEQHIRHLE KLQQQQIDIQ THFIDAALKA SSLQLGMSTS RAVGKYSGKL 300 301 GSPSVGSSVF SHNTFVSKRV PLSEDTDFDG QKSPLETPAP RRFAPVPVSR DGKITKRESP 360 361 TEEKENMEMN SPKGNVRLLE QVLNSNECLT RKTESSDITS LTQPKMGWNL EKRDSTETLH 420 421 SQIFPSSEER GTAQVPVPKY NDVVHDLGQK KQASDMLQIK QSPVTLRLSD HPHNPALLQT 480 481 TNTRSVLKDA AKILRGVQNN KKVLEENLEA IVRAKDGAAM YSFINALATN REMSEKIRIR 540 541 KQVDEWIKII SAEIQDELMR KDYEQKRFDP KNQRNKKALT MSRDIKANNQ EKTVNRSVIP 600 601 RSHYQKQTQE QFTSPPVRNL PASGPQKERS GLLKSATTLQ DEDYMLQIYG KPVYQGHRST 660 661 LKKGPYLRFS SPSPKAKPQR PRVIELVKGT KVKSAKTQTD FHAASRMKMD SKIQHPITAL 720 721 PHADQQYMVS PSREMPTVSG TLEGHLIPMA ILLGQTQSNS DSMPPAGVTV NKPRPVTVTT 780 781 SIPPASRKGN AGVKKPNVAI VEMKSEKKDP PQLSVQILPS VDIDSVSYSS TDGASSPPSP 840 841 KEASLPPLHT WIQTPDFMKV DEEEVPLPGT NFDEVIDVIQ EEEKRDEIPE CSAPMLEFNR 900 901 SVKVVPTKYN GPSFPPVVSA YHPTTDILDK VIERKETLEN SLIQWVEQEI MSRIISGLFP 960 961 LQQQARLDAS VSVSEASEPS ASDIVAGTSS GALQRMVDAR VPVNSDMVSH FVNEALTETI 1020 1021 AVMLADREAE RQRAAATSVP GDLSGTETNL LARVCAPVAT PQPTPPCSPS PVREHVRVKT 1080 1081 PDSSPCESDP DAASSIKEIR VEKGSDMPAV MLVSTPTRTP VATPPPAAAL TPTLSETSID 1140 1141 KLKLSSPELP KPWDSGDLPL DEENPNSLQE LPHPRAVVMS VANEEPESVD FSAQPAPPEP 1200 1201 APSAPLPEGT KAPSLQRVPS SGSSTLENTL STVTETETLD RHISEGEILF SCGQNLATKR 1260 1261 PGDLFLMNIN DSLSSTLQDA LEMEDDPPSE GQVIRRPHKK RHEDAIVALL TKQQRELLVS 1320 1321 QQEEDLDNSV GELSEGQRLV LKAAEDISAG PSGQMLPPTS PAEPSYQHAD PRLVLQQSDM 1380 1381 ASGNICEDLC ASHGPMSLRE LELQPDSNLI LPITHTTTAV SDGNLPEAAE DFSQYQQKQD 1440 1441 SDIKQVEHKP IQRHLTSVRN KPDSTLSQHQ GGPADLLLIA HVSPARMSVT LPSANLEDCS 1500 1501 QSLSTSSMHG GTESSGTDTF 1520 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAAAAACG TTGAGTTTAG CCTGGAAAGG GGGCAAAGGC TTAAAATGCC AGCGAGGAAA 60 61 CTGCGAGAGA TTGTTTCTCC AAACCAAGGG AATAAATTGG CTGTGGTGGA AGATGAGCTG 120 121 CCCCGTGTTC CTCCAGCCCT GGCTGCAAAT AAACGTCTTG CTGTTGAAAC GAGGACTAGT 180 181 TCTAATGGAA CGTTATGTGG CTCCTTGGAT TTAACTTCTG CAAGACTGTA TCACCAGCCT 240 241 CTGTTAGAAA GTCCTCCTGC GTCCAAGAAA AGTGATTTTT CTAAAGATGC TGTAGTTCGG 300 301 CAGTTACCTT TGAATAAAAC AGAAGAGAAC AACGCACCAA AAGCAAATGA CATCTTTATT 360 361 TCTCAGTACA CCATGGGACA GAAAGATGCT CTGAGAACTG TTTTAAAGCA AAAAGCTCAA 420 421 AGCATGCCTG TTTTTAAGGC GGTGAAAGTA CATCTTTTTG AAGACACGAG TACAGAAAAG 480 481 AATACTGTTG CTCAGGAGAC TGAAACTCCA CCCAATAGAA TTGATTCAGC TACAACTGTG 540 541 GCTGCGGCAA CTGCCGCTGC CATCGCAACA GCAGCTCCTT TGATCAAGGT ACAGAGTGAT 600 601 TTGGAGGCAA AGGTTAATTG TGTTGGAGAG TTACTTACTA AGTTACAGGA GACTGATAAA 660 661 CAGTTACAGC GCGTGACAGA GCACCAAGCC AGCGTTCAGA GTAAGCAAGA GAAAGTGCAC 720 721 TGTCATGACC ACGACAAGCA GATGAACGCG TTCATGGAGC AGCATATCAG GCACCTTGAA 780 781 AAACTACAGC AACAGCAGAT AGACATTCAG ACCCATTTTA TTGATGCTGC ACTCAAGGCT 840 841 AGCAGTCTTC AACTTGGCAT GTCCACGTCC AGAGCAGTGG GGAAGTATTC TGGAAAACTG 900 901 GGAAGCCCTA GTGTTGGGAG CAGTGTTTTT TCACACAACA CATTTGTTTC TAAACGAGTG 960 961 CCTTTAAGTG AAGACACAGA TTTTGATGGG CAGAAATCTC CTTTAGAGAC CCCAGCACCT 1020 1021 CGCAGGTTTG CCCCTGTACC TGTTTCAAGG GATGGAAAAA TAACAAAAAG GGAAAGCCCT 1080 1081 ACAGAAGAAA AAGAAAATAT GGAAATGAAC AGTCCTAAAG GAAATGTAAG ACTGTTGGAA 1140 1141 CAAGTACTGA ATAGTAATGA GTGTTTGACA AGAAAGACTG AATCATCAGA TATAACCTCA 1200 1201 CTAACTCAGC CAAAAATGGG ATGGAATTTA GAGAAAAGAG ACAGCACTGA AACTCTACAT 1260 1261 TCACAAATAT TTCCTTCCTC TGAAGAGCGG GGAACAGCTC AAGTACCCGT GCCGAAGTAT 1320 1321 AATGATGTTG TTCATGATCT TGGCCAGAAG AAACAAGCAA GTGACATGCT CCAGATAAAG 1380 1381 CAATCTCCAG TTACCTTGAG GCTTTCAGAT CATCCGCATA ATCCTGCCTT GCTCCAGACA 1440 1441 ACCAATACAA GGTCTGTCTT GAAAGATGCT GCGAAGATTC TGAGAGGAGT ACAAAACAAT 1500 1501 AAAAAAGTAC TAGAAGAAAA CCTGGAAGCT ATCGTTCGTG CAAAGGATGG AGCTGCTATG 1560 1561 TATTCATTTA TCAATGCTTT AGCTACCAAT AGAGAGATGT CAGAGAAAAT TAGGATCAGA 1620 1621 AAGCAGGTAG ATGAATGGAT TAAAATCATT TCAGCAGAAA TCCAGGATGA ACTTATGAGA 1680 1681 AAAGATTATG AACAAAAGAG ATTTGATCCA AAGAATCAAA GAAACAAGAA AGCTCTAACT 1740 1741 ATGAGTAGAG ATATTAAAGC CAATAACCAA GAAAAAACGG TGAACAGATC TGTAATTCCA 1800 1801 AGAAGCCATT ATCAAAAGCA AACCCAGGAG CAGTTTACAA GTCCACCTGT GAGGAACTTG 1860 1861 CCTGCCTCCG GCCCGCAGAA AGAGAGGAGT GGCCTCTTGA AGTCAGCCAC AACGTTGCAA 1920 1921 GACGAGGATT ATATGTTACA GATATATGGG AAGCCAGTTT ATCAGGGCCA CCGCAGCACT 1980 1981 CTTAAGAAAG GACCGTATCT CAGATTCAGT TCTCCGTCTC CTAAGGCCAA GCCACAGAGG 2040 2041 CCAAGGGTGA TAGAGCTAGT GAAAGGCACT AAAGTCAAGT CAGCAAAAAC ACAAACTGAC 2100 2101 TTTCATGCTG CATCACGTAT GAAAATGGAT TCTAAAATAC AGCATCCCAT CACCGCACTA 2160 2161 CCTCATGCTG ATCAGCAGTA TATGGTCAGC CCAAGCAGAG AAATGCCTAC TGTTTCAGGT 2220 2221 ACCCTGGAAG GTCATCTAAT TCCTATGGCA ATCCTCTTAG GACAAACCCA AAGCAATAGT 2280 2281 GACTCCATGC CACCTGCTGG AGTCACTGTA AACAAGCCAC GCCCCGTGAC TGTGACCACT 2340 2341 TCTATTCCTC CGGCATCTCG AAAAGGGAAC GCTGGAGTCA AGAAACCCAA CGTAGCCATT 2400 2401 GTAGAGATGA AATCAGAGAA GAAGGACCCT CCCCAGCTCT CTGTACAGAT ATTACCTAGT 2460 2461 GTGGATATTG ATAGCGTTTC ATACAGCAGT ACTGACGGGG CTTCCTCTCC ACCAAGTCCC 2520 2521 AAAGAAGCCT CTCTTCCTCC ACTGCACACC TGGATCCAGA CTCCAGACTT TATGAAGGTG 2580 2581 GATGAAGAAG AGGTGCCCCT TCCAGGAACT AACTTTGATG AAGTAATCGA TGTTATTCAG 2640 2641 GAAGAAGAAA AACGTGATGA AATTCCTGAA TGCTCTGCAC CAATGTTGGA GTTTAACAGA 2700 2701 AGTGTTAAAG TTGTTCCTAC AAAATATAAT GGTCCTTCAT TTCCTCCTGT AGTTTCTGCT 2760 2761 TACCATCCCA CTACTGATAT TTTAGATAAA GTAATTGAGA GAAAAGAAAC ATTGGAAAAT 2820 2821 AGTTTAATTC AGTGGGTAGA ACAAGAAATA ATGTCAAGAA TTATCTCTGG GCTCTTTCCA 2880 2881 CTCCAGCAAC AGGCCAGACT TGATGCCAGT GTCTCAGTAA GTGAGGCGAG CGAACCGTCA 2940 2941 GCTTCTGACA TTGTTGCAGG AACAAGCAGT GGAGCGCTCC AGCGTATGGT TGATGCCAGA 3000 3001 GTTCCTGTGA ACTCGGACAT GGTCAGCCAT TTTGTCAATG AAGCTCTGAC TGAGACCATT 3060 3061 GCTGTCATGT TAGCTGACAG AGAAGCAGAG AGGCAAAGGG CTGCTGCCAC AAGTGTTCCT 3120 3121 GGTGATCTTT CAGGAACTGA AACTAACCTG TTGGCAAGAG TTTGTGCTCC AGTAGCGACG 3180 3181 CCGCAGCCCA CTCCCCCCTG CTCACCATCA CCTGTGAGGG AGCACGTGCG AGTGAAAACG 3240 3241 CCAGACTCTT CTCCCTGTGA ATCCGATCCA GATGCGGCTT CTTCTATAAA AGAGATACGC 3300 3301 GTTGAAAAAG GAAGTGATAT GCCTGCTGTC ATGCTTGTTA GTACACCAAC ACGCACTCCT 3360 3361 GTCGCTACCC CTCCTCCAGC AGCAGCTCTT ACCCCAACTT TGTCCGAAAC TTCCATTGAC 3420 3421 AAGTTGAAGT TATCAAGCCC TGAACTTCCC AAGCCATGGG ACAGTGGAGA CCTGCCACTG 3480 3481 GATGAAGAGA ATCCTAACTC TCTTCAAGAG CTTCCTCACC CAAGAGCGGT TGTAATGTCT 3540 3541 GTGGCTAATG AAGAACCTGA GAGTGTGGAC TTTTCTGCTC AGCCTGCACC TCCGGAGCCA 3600 3601 GCTCCCTCAG CACCACTTCC TGAGGGCACC AAGGCCCCTT CCCTCCAGCG AGTACCAAGT 3660 3661 TCAGGTTCAT CCACCCTGGA GAACACTCTG AGCACTGTCA CTGAAACAGA AACGCTAGAC 3720 3721 AGGCATATAT CTGAAGGGGA GATCTTATTT AGCTGTGGTC AAAACTTGGC TACCAAGAGA 3780 3781 CCTGGGGACT TGTTTCTGAT GAACATAAAT GACAGCTTAT CCAGCACTCT GCAGGATGCC 3840 3841 CTTGAAATGG AAGATGACCC TCCCAGTGAA GGGCAGGTGA TTAGGAGGCC CCACAAAAAG 3900 3901 CGTCATGAAG ATGCCATCGT TGCCCTTCTT ACTAAGCAAC AACGGGAGTT ATTAGTTTCA 3960 3961 CAGCAAGAGG AGGACTTGGA TAACAGCGTG GGTGAGCTTA GTGAAGGACA GAGGCTCGTG 4020 4021 CTGAAAGCAG CAGAGGACAT CTCAGCAGGA CCGTCCGGCC AAATGCTGCC GCCCACTTCT 4080 4081 CCTGCAGAGC CCTCCTATCA GCACGCAGAC CCTCGGCTGG TATTGCAGCA GTCTGACATG 4140 4141 GCCTCAGGTG GCCCGGCAGA TCTGCTCCTC ATTGCACATG TGTCACCCGC CAGGATGTCT 4200 4201 GTGACTCTAC CCTCTGCGAA CCTTGAGGAC TGCTCTCAGT CCCTGAGCAC CAGCTCCATG 4260 4261 CATGGCGGCA CCGAATCCTC AGGGACAGAC ACCTTCTGA 4299 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Centriole | |
Cellular Component | Centrosome | |
Cellular Component | Ciliary basal body | |
Cellular Component | Photoreceptor inner segment | |
Biological Process | Cilium assembly | |
Biological Process | Regulation of establishment of protein localization | |
Biological Process | Smoothened signaling pathway |
▼ ANNOTATION
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
| Element | ||||
| microRNA.org | ||||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-4505 | Rattus norvegicus | 85.7 | 0.0 | 2364 |
| LLPS-Poa-4521 | Pongo abelii | 69.02 | 0.0 | 1851 |
| LLPS-Ova-0102 | Ovis aries | 68.68 | 0.0 | 1857 |
| LLPS-Urm-0496 | Ursus maritimus | 68.6 | 0.0 | 1839 |
| LLPS-Pap-0332 | Pan paniscus | 68.52 | 0.0 | 1754 |
| LLPS-Gog-1300 | Gorilla gorilla | 68.18 | 0.0 | 1284 |
| LLPS-Chs-2200 | Chlorocebus sabaeus | 68.13 | 0.0 | 1837 |
| LLPS-Mam-3815 | Macaca mulatta | 67.95 | 0.0 | 1860 |
| LLPS-Man-2700 | Macaca nemestrina | 67.88 | 0.0 | 1856 |
| LLPS-Eqc-0721 | Equus caballus | 67.81 | 0.0 | 1786 |
| LLPS-Maf-4087 | Macaca fascicularis | 67.77 | 0.0 | 1829 |
| LLPS-Mup-1827 | Mustela putorius furo | 67.73 | 0.0 | 1748 |
| LLPS-Hos-1120 | Homo sapiens | 67.49 | 0.0 | 1779 |
| LLPS-Pat-1561 | Pan troglodytes | 67.45 | 0.0 | 1781 |
| LLPS-Bot-2543 | Bos taurus | 67.05 | 0.0 | 1842 |
| LLPS-Orc-3496 | Oryctolagus cuniculus | 66.84 | 0.0 | 1677 |
| LLPS-Nol-4609 | Nomascus leucogenys | 66.73 | 0.0 | 1759 |
| LLPS-Aim-2817 | Ailuropoda melanoleuca | 66.67 | 0.0 | 1758 |
| LLPS-Fud-3317 | Fukomys damarensis | 66.6 | 0.0 | 1713 |
| LLPS-Fec-2257 | Felis catus | 66.41 | 0.0 | 1764 |
| LLPS-Paa-3143 | Papio anubis | 66.38 | 0.0 | 1752 |
| LLPS-Cas-3393 | Carlito syrichta | 66.3 | 0.0 | 1709 |
| LLPS-Caj-2698 | Callithrix jacchus | 66.29 | 0.0 | 1734 |
| LLPS-Mal-2979 | Mandrillus leucophaeus | 65.93 | 0.0 | 1749 |
| LLPS-Rhb-4643 | Rhinopithecus bieti | 65.9 | 0.0 | 1713 |
| LLPS-Aon-0062 | Aotus nancymaae | 65.42 | 0.0 | 1725 |
| LLPS-Caf-4623 | Canis familiaris | 65.23 | 0.0 | 1708 |
| LLPS-Ict-2641 | Ictidomys tridecemlineatus | 65.19 | 0.0 | 1688 |
| LLPS-Cea-1837 | Cercocebus atys | 65.05 | 0.0 | 1701 |
| LLPS-Myl-3852 | Myotis lucifugus | 65.02 | 0.0 | 1649 |
| LLPS-Sus-0803 | Sus scrofa | 64.24 | 0.0 | 1706 |
| LLPS-Cap-1531 | Cavia porcellus | 61.61 | 0.0 | 1598 |
| LLPS-Otg-1954 | Otolemur garnettii | 60.64 | 0.0 | 1520 |
| LLPS-Sah-3517 | Sarcophilus harrisii | 49.9 | 0.0 | 1209 |
| LLPS-Mod-3764 | Monodelphis domestica | 49.82 | 0.0 | 1021 |
| LLPS-Dar-3939 | Danio rerio | 47.93 | 4e-13 | 79.0 |
| LLPS-Ora-1408 | Ornithorhynchus anatinus | 45.04 | 0.0 | 840 |
| LLPS-Tag-3475 | Taeniopygia guttata | 44.31 | 0.0 | 755 |
| LLPS-Anp-2290 | Anas platyrhynchos | 43.24 | 0.0 | 853 |
| LLPS-Gaga-0368 | Gallus gallus | 43.22 | 0.0 | 867 |
| LLPS-Meg-1769 | Meleagris gallopavo | 41.94 | 0.0 | 859 |
| LLPS-Icp-3678 | Ictalurus punctatus | 41.83 | 1e-19 | 100 |
| LLPS-Lac-1013 | Latimeria chalumnae | 41.26 | 2e-35 | 142 |
| LLPS-Fia-1133 | Ficedula albicollis | 40.78 | 0.0 | 752 |
| LLPS-Anc-2181 | Anolis carolinensis | 40.52 | 0.0 | 741 |
| LLPS-Orl-0723 | Oryzias latipes | 39.58 | 2e-07 | 60.5 |
| LLPS-Xet-0266 | Xenopus tropicalis | 39.12 | 0.0 | 634 |
| LLPS-Orn-1055 | Oreochromis niloticus | 38.04 | 1e-18 | 94.4 |
| LLPS-Asm-3678 | Astyanax mexicanus | 37.04 | 7e-79 | 293 |
| LLPS-Leo-0110 | Lepisosteus oculatus | 36.04 | 6e-135 | 462 |
| LLPS-Xim-1663 | Xiphophorus maculatus | 34.97 | 2e-16 | 90.1 |
| LLPS-Pof-2860 | Poecilia formosa | 33.88 | 9e-15 | 84.3 |