LLPS-Mum-3968
Bbs5

▼ OVERVIEW

Status: Unreviewed
Protein Name: Bardet-Biedl syndrome 5 protein homolog
Gene Name: Bbs5
Ensembl Gene: ENSMUSG00000063145.10
Ensembl Protein: ENSMUSP00000107905.2
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSVLDVLWED  RDVRFDVSSQ  QMKTRPGEVL  IDCLDSIEDT  KGNNGDRGRL  LVTNLRIIWH  60
61    SLALPRVNLS  IGYNCILNIT  TRTANSKLRG  QTEALYILTK  CNTTRFEFIF  TNLVPGSPRL  120
121   FTSVIAVHRA  YETSKMYRDF  KLRSAVIQNK  QLRLLPQEHV  YDKINGVWNL  SSDQGNLGTF  180
181   FITNVRIVWH  ANMNDSFNVS  IPYLQIRSIK  IRDSKFGLAL  VIESSQQSGG  YVLGFKIDPV  240
241   EKLQESVKEI  NSLHKVYSAS  PIFGVNYEME  EKPQPLEALT  VEQIQDDVEI  DSDDHTDAFV  300
301   AYFADGNKQQ  DREPVFSEEL  GLAIEKLKDG  FTLQGLWEVM  S  341
Nucleotide CDS Sequence (FASTA)
1     ATGTCTGTGC  TGGACGTGTT  GTGGGAGGAC  CGCGACGTGC  GCTTCGACGT  GTCCTCGCAA  60
61    CAGATGAAAA  CAAGACCCGG  GGAAGTCCTC  ATTGACTGTT  TAGATTCCAT  TGAAGACACA  120
121   AAAGGAAACA  ATGGAGACAG  AGGTAGACTC  TTAGTCACAA  ACTTAAGGAT  CATCTGGCAT  180
181   TCCTTGGCAT  TGCCCAGAGT  CAATCTTTCT  ATTGGTTACA  ACTGCATATT  GAATATCACA  240
241   ACAAGAACTG  CTAACTCTAA  ACTGCGAGGC  CAAACCGAAG  CTCTTTATAT  ATTGACAAAA  300
301   TGCAACACTA  CCCGGTTTGA  GTTTATATTC  ACAAACCTGG  TTCCCGGGAG  CCCCAGACTT  360
361   TTTACTTCTG  TGATCGCAGT  GCACAGAGCA  TATGAAACTT  CTAAAATGTA  CCGTGACTTT  420
421   AAGTTGAGAA  GTGCAGTCAT  TCAGAACAAG  CAGCTGAGGT  TACTACCACA  GGAGCATGTG  480
481   TATGATAAGA  TCAATGGCGT  ATGGAATCTG  TCCAGCGACC  AGGGGAATTT  AGGAACTTTT  540
541   TTTATTACCA  ATGTGAGAAT  TGTGTGGCAT  GCCAATATGA  ATGACAGTTT  TAATGTCAGC  600
601   ATACCATATC  TGCAAATTCG  TTCAATAAAG  ATCAGAGATT  CAAAATTTGG  TTTGGCGCTT  660
661   GTCATAGAAA  GCTCTCAGCA  GAGTGGAGGA  TACGTCCTTG  GCTTTAAAAT  AGACCCTGTG  720
721   GAAAAACTAC  AGGAATCAGT  TAAAGAGATC  AACTCACTTC  ACAAAGTCTA  TTCTGCCAGT  780
781   CCAATATTTG  GAGTGAATTA  TGAAATGGAA  GAAAAGCCAC  AGCCACTTGA  AGCTCTGACT  840
841   GTTGAACAAA  TTCAAGATGA  TGTGGAAATA  GACTCTGATG  ACCACACGGA  TGCTTTTGTG  900
901   GCGTATTTTG  CTGATGGGAA  TAAGCAACAA  GATCGTGAAC  CTGTATTTTC  AGAAGAACTG  960
961   GGGCTTGCAA  TAGAGAAACT  GAAGGATGGA  TTCACACTGC  AGGGACTTTG  GGAAGTGATG  1020
1021  AGTTGA  1026

▼ KEYWORD

ID
Family
Cell membrane
Cell projection
Cilium
Cilium biogenesis/degradation
Complete proteome
Cytoplasm
Cytoskeleton
Membrane
Protein transport
Reference proteome
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axoneme
Cellular Component
BBSome
Cellular Component
Centriolar satellite
Cellular Component
Ciliary basal body
Cellular Component
Ciliary membrane
Cellular Component
Cilium
Molecular Function
Phosphatidylinositol-3-phosphate binding
Molecular Function
RNA polymerase II repressing transcription factor binding
Biological Process
Cilium assembly
Biological Process
Intracellular transport
Biological Process
Protein transport

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-0585Rattus norvegicus99.710.0 703
LLPS-Aim-1088Ailuropoda melanoleuca98.530.0 699
LLPS-Ict-4681Ictidomys tridecemlineatus98.530.0 699
LLPS-Urm-2629Ursus maritimus98.530.0 698
LLPS-Sus-1316Sus scrofa98.240.0 699
LLPS-Cas-1747Carlito syrichta98.240.0 697
LLPS-Fud-2052Fukomys damarensis97.950.0 695
LLPS-Fec-1919Felis catus97.950.0 697
LLPS-Mea-1152Mesocricetus auratus97.732e-54 179
LLPS-Myl-0837Myotis lucifugus97.360.0 690
LLPS-Dio-1339Dipodomys ordii97.070.0 684
LLPS-Paa-3121Papio anubis97.070.0 692
LLPS-Mal-2606Mandrillus leucophaeus97.070.0 692
LLPS-Cea-0547Cercocebus atys97.070.0 692
LLPS-Chs-1608Chlorocebus sabaeus97.070.0 692
LLPS-Maf-3749Macaca fascicularis97.070.0 692
LLPS-Man-1212Macaca nemestrina97.070.0 692
LLPS-Rhb-4662Rhinopithecus bieti97.070.0 692
LLPS-Tut-1461Tursiops truncatus96.570.0 636
LLPS-Ova-4486Ovis aries96.480.0 690
LLPS-Caj-4178Callithrix jacchus96.480.0 689
LLPS-Cap-2785Cavia porcellus96.480.0 682
LLPS-Nol-1859Nomascus leucogenys96.480.0 687
LLPS-Hos-2498Homo sapiens96.480.0 688
LLPS-Pap-2383Pan paniscus96.480.0 688
LLPS-Pat-3140Pan troglodytes96.480.0 688
LLPS-Aon-1652Aotus nancymaae96.190.0 689
LLPS-Eqc-3500Equus caballus96.190.0 684
LLPS-Poa-4404Pongo abelii96.190.0 687
LLPS-Gog-2400Gorilla gorilla95.890.0 686
LLPS-Bot-3843Bos taurus95.60.0 686
LLPS-Loa-3049Loxodonta africana95.310.0 679
LLPS-Ora-3061Ornithorhynchus anatinus95.010.0 679
LLPS-Anp-0932Anas platyrhynchos91.990.0 651
LLPS-Lac-2873Latimeria chalumnae91.180.0 659
LLPS-Tag-3200Taeniopygia guttata91.150.0 655
LLPS-Dar-3173Danio rerio90.590.0 650
LLPS-Xet-2315Xenopus tropicalis90.580.0 626
LLPS-Orn-1835Oreochromis niloticus90.290.0 644
LLPS-Gaga-2032Gallus gallus90.120.0 616
LLPS-Leo-3899Lepisosteus oculatus89.710.0 642
LLPS-Orl-1164Oryzias latipes89.680.0 636
LLPS-Asm-0212Astyanax mexicanus88.820.0 639
LLPS-Scm-2438Scophthalmus maximus88.790.0 633
LLPS-Gaa-3559Gasterosteus aculeatus88.50.0 632
LLPS-Scf-1092Scleropages formosus88.270.0 637
LLPS-Icp-2590Ictalurus punctatus88.240.0 639
LLPS-Tar-3917Takifugu rubripes88.20.0 631
LLPS-Ten-1354Tetraodon nigroviridis87.980.0 630
LLPS-Pof-0353Poecilia formosa87.910.0 626
LLPS-Xim-3141Xiphophorus maculatus87.610.0 622
LLPS-Cii-2313Ciona intestinalis62.94e-162 464
LLPS-Chr-1597Chlamydomonas reinhardtii52.495e-126 373
LLPS-Cae-1712Caenorhabditis elegans46.425e-110 332
LLPS-Drm-2144Drosophila melanogaster46.243e-108 328