DrLLPS - Data resource of LLPS

Overview
Property
Classification
Function
Cross Reference
Sequence
GO
Annotation
Orthology
TOP

Disorder▼
- IUPred2A
Domain▼
PTM▼
Variation▼
Mutation▼
- CGAP
Interaction▼
- HINT
- RISE
- RAIN
- Mentha
- PINA
- IID
- iRefIndex
- MIST
Disease▼
Drug▼
Physicochemical▼
- Compute pI/Mw
- AAindex
Function▼
Proteomics▼
Structure▼
Localization▼
- COMPARTMENTS
Expression▼
Element▼
Methylation▼

LLPS-Mum-3918
Chmp2a

▼ OVERVIEW


Status:	Reviewed
Protein Name:	Charged multivesicular body protein 2a; Chromatin-modifying protein 2a; CHMP2a; Vacuolar protein sorting-associated protein 2; mVps2
Gene Name:	Chmp2a
Ensembl Gene:	ENSMUSG00000033916.5
Ensembl Protein:	ENSMUSP00000148233.1
Organism:	Mus musculus
Taxa ID:	10090
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Postsynaptic density	"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."	Mouse cortex	23071613
Nucleolus	Predicted from orthologs	N/A	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Arabidopsis thaliana	LLPS-Art-0636	Q9SKI2	Client	Nucleolus	60.87	1e-63	204

▼ FUNCTION

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSMUST00000211344.1	ENSMUSP00000148233.1
Ensembl	ENSMUST00000210587.1	ENSMUSP00000148218.1
Ensembl	ENSMUST00000005711.5	ENSMUSP00000005711.4
Ensembl	ENSMUST00000211369.1	ENSMUSP00000147937.1
Ensembl	ENSMUST00000211626.1	ENSMUSP00000147393.1
UniProt		Q9DB34, CHM2A_MOUSE
GeneBank	BC012230, AK005267	BAB23919.1, AAH12230.1
RefSeq	NM_026885.3, XM_006540345.3	NP_081161.1, XP_006540408.1
Entrez	68953

▼ SEQUENCE

Protein Sequence (FASTA)
1 MDLLFGRRKT PEELLRQNQR ALNRAMRELD RERQKLETQE KKIIADIKKM AKQGQMDAVR 60 61 IMAKDLVRTR RYVRKFVLMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM GTMNRQLKLP 120 121 QIQKIMMEFE RQAEIMDMKE EMMNDAIDDA MGDEEDEEES DAVVSQVLDE LGLSLTDELS 180 181 NLPSTGGSLS VAAGGKKAEA TASALADADA DLEERLKNLR RD 222
Nucleotide CDS Sequence (FASTA)
1 ATGGACCTGT TGTTTGGGCG CCGGAAGACG CCAGAGGAAC TACTTCGGCA AAACCAGAGG 60 61 GCCCTGAACC GAGCCATGAG AGAACTGGAC AGGGAACGAC AGAAACTAGA AACCCAGGAA 120 121 AAGAAAATCA TTGCGGACAT CAAAAAGATG GCAAAGCAAG GCCAGATGGA TGCTGTTCGA 180 181 ATCATGGCAA AAGACCTGGT GCGTACCCGG AGATATGTAC GCAAGTTTGT GTTGATGCGG 240 241 GCCAACATCC AAGCTGTGTC CCTCAAGATA CAGACTCTAA AATCCAACAA CTCAATGGCA 300 301 CAAGCCATGA AGGGTGTTAC TAAGGCCATG GGCACTATGA ACAGACAGCT GAAATTACCC 360 361 CAGATCCAGA AGATCATGAT GGAGTTTGAA CGGCAGGCAG AGATCATGGA CATGAAGGAA 420 421 GAAATGATGA ATGACGCAAT TGATGATGCC ATGGGTGATG AGGAAGATGA AGAGGAGAGT 480 481 GATGCTGTTG TGTCCCAGGT CCTGGATGAG CTGGGACTGA GCCTCACAGA TGAGCTGTCA 540 541 AACCTTCCCT CCACTGGAGG CTCACTCAGT GTGGCAGCTG GTGGGAAGAA AGCAGAGGCC 600 601 ACAGCCTCAG CCCTGGCTGA TGCTGATGCA GACCTGGAAG AGAGGCTCAA GAACCTTCGC 660 661 AGGGACTGA 669

▼ KEYWORD

ID	Family
KW-0007	Acetylation
KW-0175	Coiled coil
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0967	Endosome
KW-0472	Membrane
KW-0597	Phosphoprotein
KW-0653	Protein transport
KW-1185	Reference proteome
KW-0813	Transport
KW-0832	Ubl conjugation

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0000785	Cellular Component	Chromatin
GO:0005829	Cellular Component	Cytosol
GO:0000815	Cellular Component	ESCRT III complex
GO:0031902	Cellular Component	Late endosome membrane
GO:0030117	Cellular Component	Membrane coat
GO:0005771	Cellular Component	Multivesicular body
GO:0005635	Cellular Component	Nuclear envelope
GO:0031210	Molecular Function	Phosphatidylcholine binding
GO:0019904	Molecular Function	Protein domain specific binding
GO:0032509	Biological Process	Endosome transport via multivesicular body sorting pathway
GO:0045184	Biological Process	Establishment of protein localization
GO:0010458	Biological Process	Exit from mitosis
GO:0045324	Biological Process	Late endosome to vacuole transport
GO:0010324	Biological Process	Membrane invagination
GO:0061952	Biological Process	Midbody abscission
GO:0007080	Biological Process	Mitotic metaphase plate congression
GO:0060548	Biological Process	Negative regulation of cell death
GO:1903723	Biological Process	Negative regulation of centriole elongation
GO:0031468	Biological Process	Nuclear envelope reassembly
GO:0006997	Biological Process	Nucleus organization
GO:1903543	Biological Process	Positive regulation of exosomal secretion
GO:1902188	Biological Process	Positive regulation of viral release from host cell
GO:0051291	Biological Process	Protein heterooligomerization
GO:0051260	Biological Process	Protein homooligomerization
GO:0051258	Biological Process	Protein polymerization
GO:0015031	Biological Process	Protein transport
GO:0010824	Biological Process	Regulation of centrosome duplication
GO:1901673	Biological Process	Regulation of mitotic spindle assembly
GO:0050792	Biological Process	Regulation of viral process
GO:0039702	Biological Process	Viral budding via host ESCRT complex

▼ KEGG

mmu:68953

▼ ANNOTATION

Disorder
IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	BioGRID
mUbiSiDa	PTMcode

Mutation
CGAP

Interaction
HINT	RISE	RAIN	Mentha	PINA
IID	iRefIndex	MIST

Physicochemical
Compute pI/Mw	AAindex

Function
CGDB	PIRSF	RaftProt

Localization
COMPARTMENTS

Expression
ArrayExpress	GXD	TISSUES

Element
miRWalk	RAID	microRNA.org

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Cas-1066	Carlito syrichta	100.0	1e-104	308
LLPS-Ict-1005	Ictidomys tridecemlineatus	100.0	1e-108	318
LLPS-Poa-2661	Pongo abelii	100.0	1e-108	318
LLPS-Cap-3586	Cavia porcellus	100.0	1e-108	318
LLPS-Mam-0703	Macaca mulatta	100.0	1e-104	308
LLPS-Otg-1561	Otolemur garnettii	100.0	1e-104	308
LLPS-Rhb-3409	Rhinopithecus bieti	100.0	1e-104	308
LLPS-Pat-1635	Pan troglodytes	100.0	1e-104	308
LLPS-Pap-0748	Pan paniscus	100.0	1e-104	308
LLPS-Man-3959	Macaca nemestrina	100.0	1e-104	308
LLPS-Loa-2851	Loxodonta africana	100.0	1e-104	308
LLPS-Ran-2513	Rattus norvegicus	100.0	1e-108	318
LLPS-Mal-3277	Mandrillus leucophaeus	100.0	1e-108	318
LLPS-Paa-0056	Papio anubis	100.0	1e-104	308
LLPS-Aim-3549	Ailuropoda melanoleuca	100.0	7e-105	309
LLPS-Myl-2035	Myotis lucifugus	100.0	1e-104	308
LLPS-Dio-0754	Dipodomys ordii	100.0	1e-108	318
LLPS-Gog-2262	Gorilla gorilla	100.0	1e-104	308
LLPS-Fud-0829	Fukomys damarensis	100.0	1e-108	318
LLPS-Caj-2674	Callithrix jacchus	100.0	1e-108	318
LLPS-Maf-4202	Macaca fascicularis	100.0	1e-104	308
LLPS-Mea-2641	Mesocricetus auratus	100.0	1e-104	308
LLPS-Chs-4481	Chlorocebus sabaeus	100.0	1e-104	308
LLPS-Aon-4485	Aotus nancymaae	100.0	1e-108	318
LLPS-Cea-4704	Cercocebus atys	100.0	1e-104	308
LLPS-Orc-1833	Oryctolagus cuniculus	99.55	1e-107	316
LLPS-Caf-1922	Canis familiaris	98.65	1e-108	318
LLPS-Eqc-2518	Equus caballus	98.65	1e-108	318
LLPS-Fec-3026	Felis catus	98.65	1e-108	318
LLPS-Mup-3927	Mustela putorius furo	98.65	1e-108	318
LLPS-Bot-3683	Bos taurus	98.65	4e-109	320
LLPS-Sus-1033	Sus scrofa	98.2	3e-108	317
LLPS-Ova-1544	Ovis aries	97.75	3e-108	317
LLPS-Sah-1695	Sarcophilus harrisii	97.44	3e-105	310
LLPS-Tut-0983	Tursiops truncatus	97.3	1e-107	316
LLPS-Anc-1829	Anolis carolinensis	93.81	2e-101	300
LLPS-Pes-1760	Pelodiscus sinensis	93.75	2e-81	250
LLPS-Dar-3792	Danio rerio	91.75	4e-99	294
LLPS-Icp-3954	Ictalurus punctatus	91.75	6e-99	294
LLPS-Xet-2913	Xenopus tropicalis	91.24	2e-98	292
LLPS-Orn-1653	Oreochromis niloticus	91.24	5e-98	291
LLPS-Asm-0409	Astyanax mexicanus	91.24	1e-97	290
LLPS-Gaga-3316	Gallus gallus	91.01	1e-93	280
LLPS-Scf-1342	Scleropages formosus	90.72	6e-98	294
LLPS-Nol-3939	Nomascus leucogenys	90.4	1e-101	301
LLPS-Pof-1551	Poecilia formosa	89.69	8e-97	288
LLPS-Gaa-2287	Gasterosteus aculeatus	89.69	1e-97	290
LLPS-Meg-0742	Meleagris gallopavo	89.01	7e-51	167
LLPS-Ten-3022	Tetraodon nigroviridis	88.66	8e-88	265
LLPS-Scm-2508	Scophthalmus maximus	88.66	4e-96	286
LLPS-Xim-3610	Xiphophorus maculatus	88.66	3e-87	264
LLPS-Tar-2691	Takifugu rubripes	88.66	3e-87	264
LLPS-Orl-3363	Oryzias latipes	88.66	2e-95	285
LLPS-Lac-3749	Latimeria chalumnae	87.29	5e-74	233
LLPS-Fia-2200	Ficedula albicollis	80.12	2e-71	222
LLPS-Drm-2328	Drosophila melanogaster	76.92	6e-80	246
LLPS-Cae-0717	Caenorhabditis elegans	72.82	4e-77	239
LLPS-Cis-0146	Ciona savignyi	68.06	4e-68	215
LLPS-Ast-1122	Aspergillus terreus	64.79	6e-15	72.8
LLPS-Cii-0541	Ciona intestinalis	62.44	2e-65	208
LLPS-Prp-1237	Prunus persica	61.33	6e-54	179
LLPS-Nia-1688	Nicotiana attenuata	61.33	3e-54	179
LLPS-Met-2540	Medicago truncatula	61.33	7e-54	179
LLPS-Sot-0036	Solanum tuberosum	61.33	3e-54	180
LLPS-Cus-2265	Cucumis sativus	61.29	1e-56	186
LLPS-Gor-1955	Gossypium raimondii	60.77	2e-53	177
LLPS-Sol-1644	Solanum lycopersicum	60.77	3e-54	180
LLPS-Mua-2396	Musa acuminata	60.22	1e-56	186
LLPS-Dac-2412	Daucus carota	60.0	3e-56	185
LLPS-Viv-0533	Vitis vinifera	59.67	7e-54	179
LLPS-Coc-1778	Corchorus capsularis	59.28	4e-58	189
LLPS-Art-0636	Arabidopsis thaliana	59.28	6e-58	189
LLPS-Arl-2739	Arabidopsis lyrata	59.28	6e-58	189
LLPS-Amt-1253	Amborella trichopoda	59.24	3e-54	179
LLPS-Mae-2627	Manihot esculenta	59.12	9e-54	178
LLPS-Php-2307	Physcomitrella patens	58.95	5e-56	184
LLPS-Pot-2680	Populus trichocarpa	58.85	4e-58	190
LLPS-Tru-0035	Triticum urartu	58.76	5e-57	187
LLPS-Tra-0687	Triticum aestivum	58.76	5e-57	187
LLPS-Brr-1301	Brassica rapa	58.55	9e-57	186
LLPS-Brn-1438	Brassica napus	58.55	9e-57	186
LLPS-Thc-2122	Theobroma cacao	58.42	2e-51	172
LLPS-Org-0263	Oryza glaberrima	58.33	6e-52	174
LLPS-Orbr-0136	Oryza brachyantha	58.33	2e-51	172
LLPS-Ors-1133	Oryza sativa	58.33	6e-52	174
LLPS-Orp-1784	Oryza punctata	58.33	6e-52	174
LLPS-Orgl-0597	Oryza glumaepatula	58.33	6e-52	174
LLPS-Scs-0522	Sclerotinia sclerotiorum	58.33	7e-45	155
LLPS-Usm-0087	Ustilago maydis	57.84	4e-53	177
LLPS-Orr-1122	Oryza rufipogon	57.73	4e-54	179
LLPS-Hea-1577	Helianthus annuus	57.73	3e-56	184
LLPS-Orni-1909	Oryza nivara	57.73	5e-54	179
LLPS-Orb-2382	Oryza barthii	57.73	4e-54	179
LLPS-Ori-2108	Oryza indica	57.73	5e-54	179
LLPS-Chr-0116	Chlamydomonas reinhardtii	57.65	3e-40	143
LLPS-Asc-1681	Aspergillus clavatus	57.61	1e-51	172
LLPS-Crn-1033	Cryptococcus neoformans	57.37	3e-53	178
LLPS-Glm-1246	Glycine max	57.29	5e-55	181
LLPS-Sob-1763	Sorghum bicolor	57.22	7e-55	181
LLPS-Sei-2259	Setaria italica	57.22	1e-54	181
LLPS-Brd-1476	Brachypodium distachyon	57.22	2e-55	182
LLPS-Pytr-1215	Pyrenophora triticirepentis	57.07	3e-48	164
LLPS-Pyt-1055	Pyrenophora teres	57.07	3e-48	164
LLPS-Lem-1084	Leptosphaeria maculans	57.07	3e-48	164
LLPS-Zem-1485	Zea mays	56.7	6e-54	179
LLPS-Phv-2233	Phaseolus vulgaris	56.7	1e-53	178
LLPS-Lep-1270	Leersia perrieri	56.7	2e-54	180
LLPS-Asn-1429	Aspergillus nidulans	56.7	7e-53	176
LLPS-Asni-1234	Aspergillus niger	56.28	8e-50	168
LLPS-Spr-0963	Sporisorium reilianum	55.84	2e-52	176
LLPS-Zyt-1253	Zymoseptoria tritici	55.74	1e-50	170
LLPS-Sem-1299	Selaginella moellendorffii	55.33	2e-53	178
LLPS-Cogr-0615	Colletotrichum graminicola	55.32	1e-42	150
LLPS-Cog-0160	Colletotrichum gloeosporioides	55.32	2e-42	150
LLPS-Coo-1535	Colletotrichum orbiculare	55.32	2e-42	149
LLPS-Dos-1432	Dothistroma septosporum	55.15	1e-50	170
LLPS-Asfu-1343	Aspergillus fumigatus	54.9	3e-52	174
LLPS-Mel-0115	Melampsora laricipopulina	54.89	7e-53	177
LLPS-Pug-0447	Puccinia graminis	54.84	1e-53	178
LLPS-Phn-1314	Phaeosphaeria nodorum	54.64	4e-48	164
LLPS-Nef-0168	Neosartorya fischeri	54.41	8e-52	173
LLPS-Asf-0840	Aspergillus flavus	54.36	2e-49	167
LLPS-Map-0913	Magnaporthe poae	53.9	4e-42	148
LLPS-Via-1181	Vigna angularis	53.65	1e-48	165
LLPS-Tum-1458	Tuber melanosporum	53.33	2e-50	169
LLPS-Gag-1167	Gaeumannomyces graminis	53.19	3e-41	145
LLPS-Miv-0845	Microbotryum violaceum	52.88	1e-52	176
LLPS-Fuo-1200	Fusarium oxysporum	52.43	2e-44	154
LLPS-Gas-0939	Galdieria sulphuraria	52.2	3e-44	153
LLPS-Trv-0830	Trichoderma virens	52.06	2e-47	162
LLPS-Fus-1585	Fusarium solani	51.55	9e-47	160
LLPS-Fuv-1128	Fusarium verticillioides	51.55	3e-47	162
LLPS-Blg-0868	Blumeria graminis	50.82	2e-47	162
LLPS-Yal-1525	Yarrowia lipolytica	50.75	3e-47	161
LLPS-Bro-2165	Brassica oleracea	50.67	6e-50	169
LLPS-Trr-1484	Trichoderma reesei	50.52	2e-45	157
LLPS-Beb-1154	Beauveria bassiana	50.52	1e-42	150
LLPS-Aso-1275	Aspergillus oryzae	50.49	4e-47	162
LLPS-Vir-1896	Vigna radiata	50.46	7e-49	168
LLPS-Nec-1566	Neurospora crassa	50.26	7e-46	158
LLPS-Asg-0371	Ashbya gossypii	48.91	2e-41	147
LLPS-Mao-0021	Magnaporthe oryzae	48.44	3e-43	151
LLPS-Sac-1565	Saccharomyces cerevisiae	46.74	4e-39	140
LLPS-Kop-1334	Komagataella pastoris	46.27	7e-42	147
LLPS-Ved-1341	Verticillium dahliae	43.26	4e-25	103
LLPS-Scc-0400	Schizosaccharomyces cryophilus	41.9	2e-29	114
LLPS-Cym-0840	Cyanidioschyzon merolae	41.76	3e-34	130
LLPS-Scp-1240	Schizosaccharomyces pombe	41.18	2e-29	114
LLPS-Scj-1547	Schizosaccharomyces japonicus	37.82	2e-25	104
LLPS-Abg-0859	Absidia glauca	30.51	2e-09	58.9
LLPS-Mod-1733	Monodelphis domestica	28.17	7e-08	55.1
LLPS-Urm-2373	Ursus maritimus	27.46	3e-08	55.8
LLPS-Osl-0915	Ostreococcus lucimarinus	24.74	3e-07	53.1

LLPS-Mum-3918Chmp2a

Protein Sequence

Nucleotide Sequence

LLPS-Mum-3918
Chmp2a