LLPS-Mum-3915
Actr3b

▼ OVERVIEW

Status: Unreviewed
Protein Name: Actin-related protein 3B; ARP3-beta; Actin-like protein 3B
Gene Name: Actr3b
Ensembl Gene: ENSMUSG00000056367.14
Ensembl Protein: ENSMUSP00000085578.4
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAGSLPPCVV  DCGTGYTKLG  YAGNTEPQFI  IPSCIAIRES  AKVVDQAQRR  VLRGVDDLDF  60
61    FIGDEAIDKP  TYATKWPIRH  GIVEDWDLME  RFMEQVVFKY  LRAEPEDHYF  LMTEPPLNTP  120
121   ENREYLAEIM  FESFNVPGLY  IAVQAVLALA  ASWTSRQVGE  RTLTGIVIDS  GDGVTHVIPV  180
181   AEGYVIGSCI  KHIPIAGRDI  TYFIQQLLRE  REVGIPPEQS  LETAKAIKEK  YCYICPDIVR  240
241   EFAKYDVDPR  KWIKQYTGIN  AINQKKFIID  VGYERFLGPE  IFFHPEFANP  DFMESISDVV  300
301   DEVIQSCPID  VRRPLYKNVV  LSGGSTMFRD  FGRRLQRDLK  RVVDARLKLS  QELSGGRIKP  360
361   KPVEVQVVTH  HMQRYAVWFG  GSMLASTPEF  FQVCHTKKDY  EEYGPSICRH  NPVFGVMS  418
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGGCT  CGCTGCCTCC  CTGCGTGGTT  GACTGCGGCA  CCGGGTACAC  CAAGCTTGGC  60
61    TACGCAGGCA  ACACTGAACC  ACAGTTCATT  ATCCCGTCAT  GTATCGCCAT  CCGAGAATCT  120
121   GCAAAGGTAG  TTGATCAAGC  CCAAAGGAGG  GTGTTGAGAG  GAGTCGATGA  CCTTGATTTC  180
181   TTCATAGGGG  ATGAAGCCAT  TGATAAACCT  ACCTACGCTA  CCAAGTGGCC  TATACGACAT  240
241   GGCATCGTTG  AAGACTGGGA  TCTTATGGAA  AGGTTCATGG  AACAAGTGGT  CTTTAAGTAT  300
301   CTTCGTGCTG  AACCTGAGGA  CCACTACTTT  TTAATGACAG  AACCTCCACT  GAACACACCA  360
361   GAAAACAGAG  AGTACCTTGC  AGAAATCATG  TTTGAATCAT  TTAATGTACC  AGGACTCTAC  420
421   ATTGCAGTAC  AGGCAGTGCT  GGCTCTGGCA  GCCTCTTGGA  CATCCCGGCA  AGTTGGTGAA  480
481   CGCACACTAA  CGGGGATAGT  TATAGACAGT  GGAGACGGTG  TCACCCATGT  TATCCCGGTG  540
541   GCAGAAGGTT  ATGTAATTGG  AAGCTGCATC  AAACACATCC  CAATTGCAGG  TAGAGATATT  600
601   ACGTATTTCA  TTCAACAGCT  GCTAAGGGAG  AGGGAGGTGG  GAATCCCTCC  TGAGCAGTCA  660
661   CTGGAAACCG  CAAAAGCCAT  CAAGGAGAAG  TACTGCTACA  TTTGCCCGGA  TATTGTCAGA  720
721   GAATTTGCTA  AGTATGACGT  AGATCCTCGG  AAGTGGATCA  AACAGTACAC  AGGGATCAAT  780
781   GCCATCAACC  AGAAGAAGTT  CATTATAGAT  GTTGGTTATG  AAAGGTTCCT  GGGACCAGAA  840
841   ATATTCTTTC  ACCCTGAGTT  TGCCAACCCA  GACTTTATGG  AGTCCATCTC  GGATGTTGTC  900
901   GATGAAGTCA  TACAGAGCTG  TCCCATAGAT  GTGCGCCGGC  CGCTGTATAA  GAACGTCGTT  960
961   CTTTCTGGAG  GCTCCACAAT  GTTCAGAGAT  TTTGGACGTC  GTCTGCAGAG  AGATTTGAAA  1020
1021  AGAGTGGTGG  ACGCCAGGTT  AAAGCTGAGC  CAAGAGCTCA  GTGGAGGCAG  GATAAAGCCT  1080
1081  AAACCTGTGG  AGGTGCAGGT  GGTCACGCAC  CACATGCAGC  GCTATGCCGT  GTGGTTTGGA  1140
1141  GGCTCGATGC  TAGCCTCAAC  TCCGGAGTTC  TTTCAGGTCT  GTCACACCAA  GAAGGACTAT  1200
1201  GAGGAATACG  GCCCAAGCAT  CTGCCGCCAC  AACCCTGTCT  TCGGAGTCAT  GTCCTAG  1257

▼ KEYWORD

ID
Family
Actin-binding
Alternative splicing
ATP-binding
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Arp2/3 protein complex
Cellular Component
Cell projection
Cellular Component
Cytoplasm
Molecular Function
Actin binding
Molecular Function
ATP binding
Biological Process
Arp2/3 complex-mediated actin nucleation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Otg-4510Otolemur garnettii98.70.0 788
LLPS-Cea-3189Cercocebus atys98.560.0 859
LLPS-Chs-3904Chlorocebus sabaeus98.560.0 859
LLPS-Mea-4337Mesocricetus auratus98.560.0 859
LLPS-Caj-0423Callithrix jacchus98.560.0 859
LLPS-Mam-2613Macaca mulatta98.560.0 859
LLPS-Poa-2597Pongo abelii98.560.0 859
LLPS-Man-1637Macaca nemestrina98.560.0 859
LLPS-Hos-3816Homo sapiens98.560.0 859
LLPS-Pat-2685Pan troglodytes98.560.0 859
LLPS-Cap-4500Cavia porcellus98.090.0 828
LLPS-Caf-3827Canis familiaris98.090.0 857
LLPS-Orc-2207Oryctolagus cuniculus98.090.0 855
LLPS-Ora-1049Ornithorhynchus anatinus98.010.0 827
LLPS-Urm-3993Ursus maritimus98.010.0 825
LLPS-Mod-2628Monodelphis domestica97.850.0 832
LLPS-Dio-3498Dipodomys ordii97.540.0 806
LLPS-Tut-1273Tursiops truncatus97.370.0 832
LLPS-Fud-0993Fukomys damarensis97.370.0 831
LLPS-Sah-4063Sarcophilus harrisii97.30.0 806
LLPS-Bot-2127Bos taurus96.890.0 828
LLPS-Rhb-4491Rhinopithecus bieti96.630.0 810
LLPS-Cas-3290Carlito syrichta96.370.0 805
LLPS-Fia-3258Ficedula albicollis96.050.0 794
LLPS-Gaga-3350Gallus gallus95.690.0 817
LLPS-Tag-2951Taeniopygia guttata95.220.0 814
LLPS-Anp-0807Anas platyrhynchos94.240.0 798
LLPS-Meg-1530Meleagris gallopavo93.540.0 795
LLPS-Leo-2085Lepisosteus oculatus92.340.0 799
LLPS-Dar-1185Danio rerio92.249e-139 403
LLPS-Anc-1461Anolis carolinensis91.870.0 795
LLPS-Scf-1031Scleropages formosus90.910.0 786
LLPS-Ova-1375Ovis aries90.570.0 756
LLPS-Loa-1410Loxodonta africana90.570.0 756
LLPS-Aim-1555Ailuropoda melanoleuca90.430.0 783
LLPS-Mup-1039Mustela putorius furo90.430.0 783
LLPS-Mal-2409Mandrillus leucophaeus90.430.0 783
LLPS-Paa-1911Papio anubis90.430.0 783
LLPS-Sus-1560Sus scrofa90.430.0 783
LLPS-Aon-2803Aotus nancymaae90.430.0 783
LLPS-Maf-1122Macaca fascicularis90.430.0 783
LLPS-Gog-1847Gorilla gorilla90.430.0 783
LLPS-Eqc-1276Equus caballus90.430.0 783
LLPS-Ict-0421Ictidomys tridecemlineatus90.430.0 783
LLPS-Fec-0908Felis catus90.430.0 783
LLPS-Pap-1282Pan paniscus90.430.0 783
LLPS-Pes-0436Pelodiscus sinensis90.430.0 785
LLPS-Myl-0538Myotis lucifugus90.320.0 754
LLPS-Nol-0381Nomascus leucogenys90.190.0 776
LLPS-Icp-2013Ictalurus punctatus89.710.0 782
LLPS-Asm-1921Astyanax mexicanus89.710.0 782
LLPS-Lac-3239Latimeria chalumnae89.710.0 783
LLPS-Pof-0785Poecilia formosa89.470.0 780
LLPS-Orl-1003Oryzias latipes89.230.0 778
LLPS-Orn-1413Oreochromis niloticus89.230.0 778
LLPS-Ten-0034Tetraodon nigroviridis89.00.0 779
LLPS-Scm-1457Scophthalmus maximus89.00.0 779
LLPS-Tar-0979Takifugu rubripes88.890.0 714
LLPS-Gaa-1026Gasterosteus aculeatus88.760.0 778
LLPS-Ran-0338Rattus norvegicus87.590.0 754
LLPS-Xim-2632Xiphophorus maculatus85.820.0 714
LLPS-Cis-1681Ciona savignyi80.991e-164 471
LLPS-Drm-0292Drosophila melanogaster78.950.0 701
LLPS-Cae-0995Caenorhabditis elegans72.580.0 657
LLPS-Abg-0367Absidia glauca63.360.0 543
LLPS-Miv-1332Microbotryum violaceum62.870.0 545
LLPS-Crn-1028Cryptococcus neoformans61.480.0 533
LLPS-Spr-0233Sporisorium reilianum60.755e-177 509
LLPS-Usm-0520Ustilago maydis60.751e-176 508
LLPS-Yal-0277Yarrowia lipolytica60.04e-173 498
LLPS-Pug-0159Puccinia graminis60.00.0 525
LLPS-Amt-0980Amborella trichopoda59.950.0 530
LLPS-Mel-0976Melampsora laricipopulina59.860.0 523
LLPS-Scj-0979Schizosaccharomyces japonicus59.325e-164 476
LLPS-Art-3026Arabidopsis thaliana59.250.0 524
LLPS-Nia-1071Nicotiana attenuata59.250.0 522
LLPS-Phv-0918Phaseolus vulgaris59.060.0 520
LLPS-Arl-0614Arabidopsis lyrata59.020.0 522
LLPS-Coc-0189Corchorus capsularis58.881e-179 516
LLPS-Pot-0980Populus trichocarpa58.880.0 523
LLPS-Viv-0169Vitis vinifera58.841e-179 515
LLPS-Sot-0050Solanum tuberosum58.640.0 523
LLPS-Sol-0784Solanum lycopersicum58.640.0 525
LLPS-Hea-0119Helianthus annuus58.62e-179 514
LLPS-Ast-0622Aspergillus terreus58.543e-170 492
LLPS-Aso-0329Aspergillus oryzae58.534e-172 496
LLPS-Asf-0987Aspergillus flavus58.534e-172 496
LLPS-Brn-0559Brassica napus58.418e-180 516
LLPS-Glm-0703Glycine max58.413e-179 514
LLPS-Brr-2649Brassica rapa58.418e-180 516
LLPS-Brd-1797Brachypodium distachyon58.372e-177 509
LLPS-Kop-0673Komagataella pastoris58.288e-169 488
LLPS-Asni-0757Aspergillus niger58.182e-170 492
LLPS-Bro-0934Brassica oleracea58.189e-179 513
LLPS-Cus-0428Cucumis sativus58.140.0 518
LLPS-Scc-0488Schizosaccharomyces cryophilus58.142e-169 489
LLPS-Mua-0468Musa acuminata58.140.0 519
LLPS-Gor-2175Gossypium raimondii58.123e-178 512
LLPS-Asn-0744Aspergillus nidulans58.033e-169 489
LLPS-Php-1218Physcomitrella patens58.021e-180 517
LLPS-Ved-0667Verticillium dahliae57.956e-168 486
LLPS-Nef-1011Neosartorya fischeri57.954e-171 494
LLPS-Vir-0441Vigna radiata57.948e-177 508
LLPS-Scp-1093Schizosaccharomyces pombe57.773e-170 491
LLPS-Asfu-0742Aspergillus fumigatus57.733e-170 491
LLPS-Tra-1721Triticum aestivum57.712e-174 502
LLPS-Dac-0970Daucus carota57.712e-176 507
LLPS-Hov-1101Hordeum vulgare57.694e-169 489
LLPS-Prp-0744Prunus persica57.681e-179 515
LLPS-Met-0573Medicago truncatula57.673e-180 517
LLPS-Lem-0275Leptosphaeria maculans57.52e-161 469
LLPS-Asc-0180Aspergillus clavatus57.57e-169 488
LLPS-Cog-0816Colletotrichum gloeosporioides57.59e-168 485
LLPS-Mao-0076Magnaporthe oryzae57.42e-166 482
LLPS-Put-0294Puccinia triticina57.45e-172 496
LLPS-Sem-1592Selaginella moellendorffii57.311e-170 492
LLPS-Pyt-0471Pyrenophora teres57.273e-161 469
LLPS-Nec-1015Neurospora crassa57.274e-168 486
LLPS-Coo-0180Colletotrichum orbiculare57.272e-166 482
LLPS-Cogr-1391Colletotrichum graminicola57.276e-167 483
LLPS-Via-1306Vigna angularis57.211e-161 469
LLPS-Ori-1489Oryza indica57.217e-179 513
LLPS-Org-1486Oryza glaberrima57.217e-179 513
LLPS-Ors-1085Oryza sativa57.217e-179 513
LLPS-Zem-0019Zea mays57.048e-173 498
LLPS-Sac-0451Saccharomyces cerevisiae57.022e-168 487
LLPS-Lep-0022Leersia perrieri56.983e-180 516
LLPS-Orbr-0071Oryza brachyantha56.983e-178 512
LLPS-Fuv-0209Fusarium verticillioides56.827e-166 481
LLPS-Map-0922Magnaporthe poae56.827e-165 478
LLPS-Thc-1066Theobroma cacao56.822e-174 505
LLPS-Fuo-0450Fusarium oxysporum56.825e-166 481
LLPS-Sob-0191Sorghum bicolor56.813e-176 507
LLPS-Trv-0139Trichoderma virens56.691e-167 485
LLPS-Trr-0636Trichoderma reesei56.691e-167 485
LLPS-Orp-1293Oryza punctata56.662e-170 491
LLPS-Gag-0045Gaeumannomyces graminis56.592e-164 477
LLPS-Asg-1416Ashbya gossypii56.582e-168 488
LLPS-Blg-0330Blumeria graminis56.566e-167 483
LLPS-Fus-0954Fusarium solani56.535e-165 478
LLPS-Mae-0900Manihot esculenta56.444e-173 498
LLPS-Zyt-0315Zymoseptoria tritici56.263e-166 481
LLPS-Dos-0616Dothistroma septosporum55.916e-167 483
LLPS-Tum-0830Tuber melanosporum55.01e-156 456
LLPS-Orgl-0382Oryza glumaepatula54.193e-173 500
LLPS-Orb-0877Oryza barthii54.193e-173 500
LLPS-Orni-1348Oryza nivara54.193e-173 500
LLPS-Orr-1245Oryza rufipogon54.193e-173 500
LLPS-Osl-0140Ostreococcus lucimarinus54.092e-157 458
LLPS-Sei-1048Setaria italica52.421e-142 419
LLPS-Orm-1700Oryza meridionalis51.582e-169 491
LLPS-Phn-0206Phaeosphaeria nodorum51.437e-122 370
LLPS-Scs-1048Sclerotinia sclerotiorum51.262e-132 394
LLPS-Chr-0768Chlamydomonas reinhardtii46.533e-139 413
LLPS-Tru-1865Triticum urartu46.271e-110 337
LLPS-Xet-3007Xenopus tropicalis36.219e-80 257
LLPS-Cii-0697Ciona intestinalis35.932e-79 257