LLPS-Mum-3901
Sept3

▼ OVERVIEW

Status: Reviewed
Protein Name: Neuronal-specific septin-3
Gene Name: Sept3, Sep3
Ensembl Gene: ENSMUSG00000022456.16
Ensembl Protein: ENSMUSP00000154918.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSELVPEPRP  KPAVPMKPVS  INSNLLGYIG  IDTIIEQMRK  KTMKTGFDFN  IMVVGQSGLG  60
61    KSTLVNTLFK  SQVSRKASSW  NREEKIPKTV  EIKAIGHVIE  EGGVKMKLTV  IDTPGFGDQI  120
121   NNENCWEPIE  KYINEQYEKF  LKEEVNIARK  KRIPDTRVHC  CLYFISPTGH  SLRPLDLEFM  180
181   KHLSKVVNII  PVIAKADTMT  LEEKSEFKQR  VRKELEVNGI  EFYPQKEFDE  DLEDKTENDK  240
241   IRQESMPFAV  VGSDKEYQVN  GKRVLGRKTP  WGIIEVENLN  HCEFALLRDF  VIRTHLQDLK  300
301   EVTHNIHYET  YRAKRLNDNG  GLPPNKKLCA  SLKRSGEGFN  L  341
Nucleotide CDS Sequence (FASTA)
1     ATGTCTGAGC  TGGTACCTGA  GCCCAGGCCT  AAGCCGGCGG  TGCCCATGAA  GCCGGTCAGC  60
61    ATCAACTCCA  ACCTGCTAGG  CTACATTGGC  ATTGACACCA  TTATCGAGCA  GATGCGCAAG  120
121   AAGACCATGA  AGACTGGCTT  TGACTTCAAC  ATCATGGTCG  TTGGCCAGAG  TGGACTGGGC  180
181   AAGTCAACAC  TGGTCAACAC  CCTCTTCAAG  TCCCAAGTGA  GCCGAAAGGC  CTCCAGCTGG  240
241   AACCGGGAGG  AGAAGATCCC  CAAGACAGTG  GAGATCAAAG  CGATTGGGCA  TGTGATAGAG  300
301   GAAGGTGGTG  TCAAAATGAA  GCTGACAGTC  ATCGACACAC  CAGGCTTTGG  AGACCAGATC  360
361   AACAATGAAA  ACTGCTGGGA  GCCCATTGAG  AAATACATCA  ACGAACAGTA  CGAAAAGTTC  420
421   CTGAAGGAGG  AGGTGAACAT  TGCCAGGAAG  AAACGCATCC  CTGACACCCG  TGTCCACTGC  480
481   TGCCTCTACT  TCATCTCCCC  GACAGGACAC  TCCTTACGAC  CACTGGATCT  TGAGTTCATG  540
541   AAACATCTCA  GCAAAGTGGT  GAACATCATT  CCTGTCATTG  CCAAGGCTGA  TACCATGACC  600
601   CTGGAGGAGA  AGTCGGAATT  CAAGCAGAGG  GTTCGCAAAG  AACTTGAAGT  AAACGGCATT  660
661   GAATTCTACC  CTCAGAAGGA  ATTTGATGAG  GATTTGGAGG  ACAAGACAGA  GAATGACAAA  720
721   ATCCGGCAGG  AGAGCATGCC  CTTCGCCGTG  GTGGGGAGTG  ACAAGGAGTA  CCAAGTGAAC  780
781   GGCAAGAGGG  TCCTCGGGAG  GAAAACACCC  TGGGGGATCA  TCGAAGTGGA  AAACCTCAAC  840
841   CACTGTGAGT  TTGCCCTGCT  CCGAGACTTC  GTCATCAGGA  CTCACCTCCA  GGACCTCAAA  900
901   GAAGTAACAC  ACAACATCCA  CTATGAGACT  TACAGGGCCA  AGAGGCTCAA  TGACAATGGA  960
961   GGCCTCCCTC  CGGTGAGCGT  GGACACAGAG  GAAAGCCACG  ACAGTAACCC  GTGA  1014

▼ KEYWORD

ID
Family
Alternative splicing
Cell cycle
Cell division
Cell junction
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
GTP-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Synapse

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell junction
Cellular Component
Cytosol
Cellular Component
Microtubule cytoskeleton
Cellular Component
Neuron projection
Cellular Component
Presynapse
Cellular Component
Presynaptic cytoskeleton
Cellular Component
Presynaptic membrane
Cellular Component
Septin complex
Cellular Component
Septin ring
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
Identical protein binding
Biological Process
Cytoskeleton-dependent cytokinesis

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Fec-2994Felis catus100.00.0 665
LLPS-Poa-1918Pongo abelii99.660.0 598
LLPS-Ere-0822Erinaceus europaeus99.380.0 665
LLPS-Tag-3059Taeniopygia guttata98.630.0 591
LLPS-Cas-1441Carlito syrichta98.190.0 670
LLPS-Tut-1729Tursiops truncatus98.180.0 666
LLPS-Paa-3637Papio anubis97.890.0 670
LLPS-Maf-0764Macaca fascicularis97.890.0 670
LLPS-Chs-2352Chlorocebus sabaeus97.890.0 670
LLPS-Cea-4185Cercocebus atys97.890.0 670
LLPS-Caf-0215Canis familiaris97.890.0 671
LLPS-Cap-2569Cavia porcellus97.890.0 670
LLPS-Mam-2542Macaca mulatta97.890.0 670
LLPS-Ict-3717Ictidomys tridecemlineatus97.890.0 670
LLPS-Man-1809Macaca nemestrina97.890.0 670
LLPS-Otg-2400Otolemur garnettii97.890.0 670
LLPS-Rhb-3094Rhinopithecus bieti97.890.0 669
LLPS-Ran-4250Rattus norvegicus97.590.0 670
LLPS-Gog-3399Gorilla gorilla97.590.0 668
LLPS-Pat-4788Pan troglodytes97.590.0 668
LLPS-Urm-4008Ursus maritimus97.590.0 684
LLPS-Pap-2644Pan paniscus97.590.0 668
LLPS-Anc-1267Anolis carolinensis97.530.0 658
LLPS-Aim-1164Ailuropoda melanoleuca97.290.0 667
LLPS-Ova-1532Ovis aries97.290.0 666
LLPS-Caj-1226Callithrix jacchus97.290.0 666
LLPS-Nol-3768Nomascus leucogenys97.290.0 668
LLPS-Orc-1057Oryctolagus cuniculus97.290.0 676
LLPS-Meg-2999Meleagris gallopavo97.220.0 652
LLPS-Anp-1517Anas platyrhynchos97.220.0 646
LLPS-Pes-3690Pelodiscus sinensis97.220.0 657
LLPS-Fia-2419Ficedula albicollis97.220.0 654
LLPS-Myl-3446Myotis lucifugus96.990.0 660
LLPS-Gaga-2576Gallus gallus96.910.0 652
LLPS-Loa-1129Loxodonta africana96.710.0 663
LLPS-Bot-1212Bos taurus96.690.0 659
LLPS-Sah-3734Sarcophilus harrisii96.30.0 653
LLPS-Fud-2666Fukomys damarensis96.130.0 659
LLPS-Xim-2327Xiphophorus maculatus87.670.0 550
LLPS-Orn-1715Oreochromis niloticus87.330.0 555
LLPS-Tar-2315Takifugu rubripes87.090.0 556
LLPS-Ten-3390Tetraodon nigroviridis86.420.0 555
LLPS-Asm-3801Astyanax mexicanus85.980.0 585
LLPS-Scm-2281Scophthalmus maximus85.760.0 552
LLPS-Gaa-3393Gasterosteus aculeatus85.430.0 547
LLPS-Scf-4027Scleropages formosus80.860.0 576
LLPS-Dar-2922Danio rerio80.520.0 574
LLPS-Mal-2379Mandrillus leucophaeus72.643e-159 467
LLPS-Aon-3749Aotus nancymaae72.641e-160 469
LLPS-Hos-2360Homo sapiens72.647e-161 470
LLPS-Mup-3423Mustela putorius furo72.544e-159 466
LLPS-Eqc-3789Equus caballus72.457e-157 461
LLPS-Mod-3235Monodelphis domestica71.868e-159 464
LLPS-Orl-3307Oryzias latipes71.776e-158 464
LLPS-Leo-2039Lepisosteus oculatus71.772e-160 469
LLPS-Sus-1764Sus scrofa71.675e-161 462
LLPS-Lac-2784Latimeria chalumnae71.384e-161 470
LLPS-Icp-2879Ictalurus punctatus70.755e-157 458
LLPS-Mea-0688Mesocricetus auratus70.745e-162 464
LLPS-Xet-1683Xenopus tropicalis69.115e-158 461
LLPS-Ora-3067Ornithorhynchus anatinus68.852e-162 464
LLPS-Dio-3116Dipodomys ordii68.08e-162 463
LLPS-Cii-1912Ciona intestinalis57.196e-124 367
LLPS-Abg-1751Absidia glauca53.746e-121 360
LLPS-Cis-1981Ciona savignyi53.197e-120 356
LLPS-Scj-0082Schizosaccharomyces japonicus52.46e-111 333
LLPS-Mel-0800Melampsora laricipopulina52.385e-113 338
LLPS-Put-0551Puccinia triticina52.382e-111 334
LLPS-Pug-1394Puccinia graminis52.385e-111 333
LLPS-Crn-1509Cryptococcus neoformans51.542e-108 327
LLPS-Cog-0301Colletotrichum gloeosporioides51.371e-110 332
LLPS-Spr-1514Sporisorium reilianum51.021e-108 327
LLPS-Yal-1452Yarrowia lipolytica50.698e-110 332
LLPS-Fuv-0029Fusarium verticillioides50.692e-110 332
LLPS-Coo-1428Colletotrichum orbiculare50.697e-111 333
LLPS-Ved-1263Verticillium dahliae50.696e-110 331
LLPS-Beb-0622Beauveria bassiana50.684e-109 329
LLPS-Trv-0639Trichoderma virens50.522e-110 332
LLPS-Cogr-1189Colletotrichum graminicola50.529e-110 330
LLPS-Trr-0344Trichoderma reesei50.521e-110 332
LLPS-Kop-1510Komagataella pastoris50.349e-102 309
LLPS-Dos-0509Dothistroma septosporum50.343e-108 327
LLPS-Miv-1336Microbotryum violaceum50.163e-111 334