LLPS-Mum-3860
Rita1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | RBPJ-interacting and tubulin-associated protein 1; RBPJ-interacting and tubulin-associated protein |
| Gene Name: | Rita1, Rita |
| Ensembl Gene: | ENSMUSG00000029600.10 |
| Ensembl Protein: | ENSMUSP00000107515.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000111884.7 | ENSMUSP00000107515.1 |
| Ensembl | ENSMUST00000140554.1 | ENSMUSP00000116344.1 |
| Ensembl | ENSMUST00000177800.7 | ENSMUSP00000136946.1 |
| Ensembl | ENSMUST00000156356.1 | ENSMUSP00000122910.1 |
| Ensembl | ENSMUST00000031599.8 | ENSMUSP00000031599.2 |
| UniProt | Q9D1H0, RITA1_MOUSE | |
| GeneBank | BC021365, AK003581 | BAB22871.1, AAH21365.1 |
| RefSeq | NM_029096.3, NM_133908.1 | NP_083372.1, NP_598669.1 |
| Entrez | 100764 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MKALHLQHRS PTSYRVKARA SYVDETLFGS PARTRPAQPD FDPPWVQNCN RSRGVGPGPP 60 61 KGSLAKRDCE SPSSRGSTPN LTPRKKNKYR LIGHAPSYCD ESLFGTSKEG SRMAVGDAAK 120 121 LRTLFWTPPA TPRGSHTPCP RETPLRAIHP AGPSRTEPRV TAGSQMSSQD GLCVPCSLGQ 180 181 RRSHSLTHLT VPSTGHPASS APQTNGPWSP RPNTSGATVQ SPLVTSKACS GRVSGPAPPR 240 241 RGACPPKPKP PWK 253 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAAAGCCC TCCACCTTCA GCACCGCAGT CCCACCAGCT ACAGGGTCAA GGCCAGGGCA 60 61 TCCTATGTGG ATGAGACCCT GTTTGGCAGC CCAGCAAGAA CCAGACCTGC CCAACCAGAC 120 121 TTTGACCCAC CCTGGGTGCA GAATTGTAAC CGATCCAGAG GAGTGGGCCC AGGACCACCG 180 181 AAGGGCTCTC TGGCCAAGAG AGACTGTGAG TCCCCCTCTT CCAGGGGCAG CACCCCAAAC 240 241 CTCACACCAA GGAAGAAAAA CAAATACAGG CTGATTGGCC ATGCCCCATC CTACTGCGAT 300 301 GAGTCACTGT TTGGCACTAG CAAGGAGGGG TCTCGGATGG CCGTGGGGGA TGCTGCAAAG 360 361 CTCCGGACCC TTTTCTGGAC CCCACCAGCC ACCCCTAGGG GCAGCCACAC ACCTTGCCCC 420 421 AGGGAGACCC CTCTGCGAGC CATTCACCCA GCTGGACCCT CCAGGACAGA GCCCAGAGTG 480 481 ACTGCAGGCT CCCAGATGTC ATCCCAGGAT GGGTTGTGTG TTCCCTGCTC TCTGGGACAG 540 541 AGGCGGTCCC ATTCACTCAC CCACCTAACT GTCCCCAGCA CGGGTCATCC AGCTTCCAGT 600 601 GCTCCCCAGA CCAATGGGCC TTGGAGTCCC CGGCCTAACA CATCAGGGGC GACTGTCCAG 660 661 AGTCCCCTGG TCACTTCCAA GGCATGCTCA GGTCGTGTTT CGGGGCCAGC TCCCCCTCGG 720 721 CGAGGGGCCT GTCCTCCCAA GCCGAAGCCT CCTTGGAAGT GA 762 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Centrosome | |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleus | |
Molecular Function | Tubulin binding | |
Biological Process | Negative regulation of Notch signaling pathway | |
Biological Process | Neurogenesis | |
Biological Process | Notch signaling pathway | |
Biological Process | Nuclear export |
▼ ANNOTATION
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CGDB | CellMarker | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-1496 | Rattus norvegicus | 84.94 | 2e-137 | 394 |
| LLPS-Mea-0593 | Mesocricetus auratus | 78.66 | 3e-126 | 366 |
| LLPS-Dio-4110 | Dipodomys ordii | 68.54 | 1e-29 | 112 |
| LLPS-Paa-4553 | Papio anubis | 67.78 | 1e-100 | 303 |
| LLPS-Man-3785 | Macaca nemestrina | 67.78 | 5e-101 | 303 |
| LLPS-Mam-2971 | Macaca mulatta | 67.78 | 5e-101 | 303 |
| LLPS-Cea-4866 | Cercocebus atys | 67.36 | 2e-100 | 301 |
| LLPS-Maf-4785 | Macaca fascicularis | 67.36 | 3e-100 | 301 |
| LLPS-Pap-2802 | Pan paniscus | 67.36 | 2e-98 | 296 |
| LLPS-Rhb-3899 | Rhinopithecus bieti | 67.36 | 9e-100 | 300 |
| LLPS-Aim-3649 | Ailuropoda melanoleuca | 66.95 | 2e-90 | 275 |
| LLPS-Mal-1131 | Mandrillus leucophaeus | 66.95 | 3e-99 | 298 |
| LLPS-Pat-2323 | Pan troglodytes | 66.95 | 3e-97 | 293 |
| LLPS-Urm-0451 | Ursus maritimus | 66.95 | 2e-89 | 273 |
| LLPS-Poa-4368 | Pongo abelii | 66.95 | 4e-98 | 295 |
| LLPS-Hos-2400 | Homo sapiens | 66.53 | 9e-96 | 290 |
| LLPS-Chs-1591 | Chlorocebus sabaeus | 66.11 | 8e-97 | 292 |
| LLPS-Gog-4768 | Gorilla gorilla | 65.69 | 5e-95 | 288 |
| LLPS-Mup-3701 | Mustela putorius furo | 65.69 | 3e-92 | 280 |
| LLPS-Cas-0435 | Carlito syrichta | 65.69 | 3e-90 | 276 |
| LLPS-Nol-3329 | Nomascus leucogenys | 65.5 | 2e-65 | 209 |
| LLPS-Caj-2662 | Callithrix jacchus | 64.85 | 2e-94 | 286 |
| LLPS-Otg-4474 | Otolemur garnettii | 64.81 | 6e-92 | 279 |
| LLPS-Fec-3629 | Felis catus | 64.44 | 4e-91 | 278 |
| LLPS-Bot-4009 | Bos taurus | 64.02 | 1e-82 | 256 |
| LLPS-Loa-2993 | Loxodonta africana | 63.6 | 1e-89 | 273 |
| LLPS-Caf-3479 | Canis familiaris | 63.6 | 2e-88 | 270 |
| LLPS-Tut-2228 | Tursiops truncatus | 63.18 | 8e-88 | 268 |
| LLPS-Eqc-1021 | Equus caballus | 62.34 | 3e-88 | 269 |
| LLPS-Sus-1690 | Sus scrofa | 61.92 | 9e-88 | 270 |
| LLPS-Fud-1210 | Fukomys damarensis | 60.43 | 4e-78 | 243 |
| LLPS-Cap-1356 | Cavia porcellus | 60.17 | 3e-79 | 247 |
| LLPS-Ict-0788 | Ictidomys tridecemlineatus | 59.57 | 2e-70 | 224 |
| LLPS-Myl-3153 | Myotis lucifugus | 57.45 | 4e-73 | 230 |
| LLPS-Ova-4040 | Ovis aries | 56.6 | 5e-66 | 212 |
| LLPS-Ere-0351 | Erinaceus europaeus | 55.23 | 2e-67 | 216 |
| LLPS-Aon-3508 | Aotus nancymaae | 54.55 | 7e-66 | 212 |
| LLPS-Orc-1783 | Oryctolagus cuniculus | 51.04 | 6e-62 | 202 |
| LLPS-Fia-0148 | Ficedula albicollis | 50.79 | 1e-08 | 57.4 |
| LLPS-Mod-2010 | Monodelphis domestica | 44.49 | 1e-45 | 160 |
| LLPS-Sah-1510 | Sarcophilus harrisii | 43.64 | 1e-42 | 154 |
| LLPS-Anc-3801 | Anolis carolinensis | 38.2 | 5e-22 | 96.7 |
| LLPS-Cii-0506 | Ciona intestinalis | 38.18 | 2e-07 | 55.1 |
| LLPS-Xet-1349 | Xenopus tropicalis | 38.16 | 3e-14 | 73.6 |
| LLPS-Lac-3640 | Latimeria chalumnae | 38.1 | 2e-24 | 103 |
| LLPS-Cis-1093 | Ciona savignyi | 33.09 | 9e-08 | 54.7 |