LLPS-Mum-3682
Hbegf

▼ OVERVIEW

Status: Unreviewed
Protein Name: Proheparin-binding EGF-like growth factor
Gene Name: Hbegf, Dtr, Hegfl
Ensembl Gene: ENSMUSG00000024486.5
Ensembl Protein: ENSMUSP00000025363.5
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKLLPSVMLK  LFLAAVLSAL  VTGESLERLR  RGLAAATSNP  DPPTGSTNQL  LPTGGDRAQG  60
61    VQDLEGTDLN  LFKVAFSSKP  QGLATPSKER  NGKKKKKGKG  LGKKRDPCLR  KYKDYCIHGE  120
121   CRYLQEFRTP  SCKCLPGYHG  HRCHGLTLPV  ENPLYTYDHT  TVLAVVAVVL  SSVCLLVIVG  180
181   LLMFRYHRRG  GYDLESEEKV  KLGVASSH  208
Nucleotide CDS Sequence (FASTA)
1     ATGAAGCTGC  TGCCGTCGGT  GATGCTGAAG  CTCTTTCTGG  CCGCAGTGTT  GTCCGCGTTG  60
61    GTGACCGGTG  AGAGTCTGGA  GCGGCTTCGG  AGAGGTCTGG  CGGCAGCAAC  CAGCAACCCT  120
121   GACCCTCCCA  CTGGATCCAC  AAACCAGCTG  CTACCCACGG  GAGGTGATCG  TGCTCAGGGG  180
181   GTCCAGGACT  TGGAAGGGAC  AGATCTGAAC  CTTTTCAAAG  TTGCTTTCTC  CTCCAAGCCA  240
241   CAAGGCCTGG  CCACCCCAAG  CAAAGAAAGG  AATGGGAAAA  AGAAGAAGAA  AGGAAAGGGG  300
301   TTAGGGAAGA  AGAGAGACCC  ATGCCTCAGG  AAATACAAGG  ACTACTGCAT  CCACGGGGAG  360
361   TGCAGATACC  TGCAGGAGTT  CCGTACTCCC  TCTTGCAAAT  GCCTCCCTGG  TTACCACGGA  420
421   CACAGGTGTC  ATGGGCTGAC  TCTACCAGTG  GAGAATCCCC  TATACACATA  TGACCACACT  480
481   ACAGTCTTGG  CTGTGGTGGC  TGTAGTACTG  TCGTCCGTCT  GTCTTCTTGT  CATCGTGGGA  540
541   CTTCTCATGT  TTAGGTACCA  CAGGAGAGGA  GGTTATGACT  TGGAAAGTGA  AGAGAAAGTG  600
601   AAGTTGGGCG  TGGCTAGCTC  CCACTGA  627

▼ KEYWORD

ID
Family
Cell membrane
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Heparin-binding
Membrane
Reference proteome
Secreted
Signal
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell surface
Cellular Component
Extracellular region
Cellular Component
Extracellular space
Cellular Component
Integral component of plasma membrane
Molecular Function
Epidermal growth factor receptor binding
Molecular Function
Growth factor activity
Molecular Function
Heparin binding
Biological Process
Angiogenesis
Biological Process
Blastocyst growth
Biological Process
Cell chemotaxis
Biological Process
Cell migration
Biological Process
Epidermal growth factor receptor signaling pathway
Biological Process
Negative regulation of elastin biosynthetic process
Biological Process
Positive regulation of cell growth
Biological Process
Positive regulation of cell migration
Biological Process
Positive regulation of cell population proliferation
Biological Process
Positive regulation of keratinocyte migration
Biological Process
Positive regulation of peptidyl-tyrosine phosphorylation
Biological Process
Positive regulation of protein kinase B signaling
Biological Process
Positive regulation of smooth muscle cell proliferation
Biological Process
Positive regulation of wound healing
Biological Process
Regulation of heart contraction
Biological Process
Wound healing, spreading of epidermal cells

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-1694Rattus norvegicus92.313e-104 306
LLPS-Fud-3844Fukomys damarensis85.583e-96 286
LLPS-Ict-3240Ictidomys tridecemlineatus85.581e-97 290
LLPS-Mea-3408Mesocricetus auratus84.133e-90 270
LLPS-Cap-1895Cavia porcellus82.691e-93 279
LLPS-Nol-2491Nomascus leucogenys81.736e-92 275
LLPS-Fec-2671Felis catus81.732e-86 261
LLPS-Poa-4167Pongo abelii81.252e-91 274
LLPS-Pat-4497Pan troglodytes81.253e-91 273
LLPS-Pap-4693Pan paniscus81.253e-91 273
LLPS-Dio-3148Dipodomys ordii80.771e-88 266
LLPS-Aon-3152Aotus nancymaae80.772e-91 274
LLPS-Gog-4564Gorilla gorilla80.777e-90 270
LLPS-Hos-2023Homo sapiens80.772e-90 271
LLPS-Mup-1084Mustela putorius furo80.294e-85 258
LLPS-Caf-2077Canis familiaris80.291e-84 256
LLPS-Otg-1383Otolemur garnettii80.295e-89 268
LLPS-Caj-3146Callithrix jacchus79.93e-81 250
LLPS-Cas-4004Carlito syrichta79.98e-88 265
LLPS-Eqc-0824Equus caballus79.862e-63 208
LLPS-Paa-0353Papio anubis79.812e-76 236
LLPS-Cea-4581Cercocebus atys79.815e-77 237
LLPS-Chs-1112Chlorocebus sabaeus79.815e-77 237
LLPS-Urm-1174Ursus maritimus79.384e-75 232
LLPS-Mal-1282Mandrillus leucophaeus79.331e-75 234
LLPS-Sus-3540Sus scrofa79.331e-83 254
LLPS-Maf-0134Macaca fascicularis79.331e-76 236
LLPS-Mam-3076Macaca mulatta79.331e-76 236
LLPS-Man-0168Macaca nemestrina79.331e-76 236
LLPS-Rhb-4408Rhinopithecus bieti79.331e-78 241
LLPS-Orc-1155Oryctolagus cuniculus79.059e-82 249
LLPS-Aim-2618Ailuropoda melanoleuca78.872e-74 230
LLPS-Tut-1936Tursiops truncatus78.851e-73 228
LLPS-Myl-3060Myotis lucifugus78.851e-85 259
LLPS-Loa-3044Loxodonta africana78.372e-87 263
LLPS-Bot-2162Bos taurus77.49e-85 257
LLPS-Ova-2056Ovis aries77.47e-85 257
LLPS-Anp-1321Anas platyrhynchos74.443e-34 124
LLPS-Tag-2573Taeniopygia guttata72.834e-34 124
LLPS-Pes-1697Pelodiscus sinensis71.946e-44 150
LLPS-Meg-3144Meleagris gallopavo71.111e-43 149
LLPS-Mod-3624Monodelphis domestica68.69e-70 218
LLPS-Sah-0859Sarcophilus harrisii66.841e-59 193
LLPS-Pof-3372Poecilia formosa63.734e-25 103
LLPS-Ora-2621Ornithorhynchus anatinus59.694e-45 155
LLPS-Ten-0872Tetraodon nigroviridis59.222e-25 101
LLPS-Xim-1947Xiphophorus maculatus58.112e-28 112
LLPS-Orl-2599Oryzias latipes58.116e-26 105
LLPS-Lac-1184Latimeria chalumnae57.755e-26 105
LLPS-Asm-2733Astyanax mexicanus57.253e-25 103
LLPS-Tar-0968Takifugu rubripes56.761e-29 115
LLPS-Dar-2049Danio rerio56.315e-24 100
LLPS-Fia-1492Ficedula albicollis55.882e-47 161
LLPS-Gaga-0716Gallus gallus54.673e-44 153
LLPS-Scm-1439Scophthalmus maximus54.055e-27 108
LLPS-Icp-3480Ictalurus punctatus53.331e-2091.3
LLPS-Orn-3253Oreochromis niloticus50.682e-24 102
LLPS-Gaa-2673Gasterosteus aculeatus50.371e-2399.0
LLPS-Anc-1704Anolis carolinensis50.241e-38 138
LLPS-Leo-3432Lepisosteus oculatus44.552e-30 117
LLPS-Scf-2455Scleropages formosus42.551e-27 110