LLPS-Mum-3508
Chac2
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Putative glutathione-specific gamma-glutamylcyclotransferase 2 |
| Gene Name: | Chac2 |
| Ensembl Gene: | ENSMUSG00000020309.6 |
| Ensembl Protein: | ENSMUSP00000020553.4 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide (PubMed:27913623). Acts specifically on glutathione, but not on other gamma-glutamyl peptides (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000020553.4 | ENSMUSP00000020553.4 |
| Ensembl | ENSMUST00000101394.4 | ENSMUSP00000098942.4 |
| UniProt | Q9CQG1, CHAC2_MOUSE, Q8R3K5, Q9D1T7 | |
| GeneBank | AL662891, BC025100, AK078993, AK021391, AK010914 | BAC37498.1, BAB27264.1, AAH25100.1, BAB32394.1 |
| RefSeq | NM_001290667.1, NM_026527.3 | NP_001277596.1, NP_080803.1 |
| Entrez | 68044 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MWVFGYGSLI WKVDFPYQDK LVGYITNYSR RFWQGSTDHR GVPGKPGRVV TLVEDPGGSV 60 61 WGVAYKLPVG KEEEVKTYLD FREKGGYRTT TVIFYPKDST TKPFSVLLYI GTCDNPNYLG 120 121 PAPLEDIAEQ IFNAAGPSGR NTEYLFELAD SVRKLVPEDA DEHLFSLEKL VKERLEGK 178 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTGGGTGT TTGGTTATGG GTCCCTCATC TGGAAGGTGG ACTTCCCCTA CCAGGACAAG 60 61 CTGGTTGGTT ACATCACAAA CTACAGTCGG CGCTTCTGGC AAGGTAGCAC GGACCACCGC 120 121 GGGGTCCCAG GCAAGGGCAG TGTATGGGGT GTTGCTTACA AACTACCAGT AGGAAAAGAA 180 181 GAGGAAGTAA AAACATACCT TGACTTCAGA GAGAAAGGAG GCTACAGAAC TACGACAGTC 240 241 ATTTTTTATC CAAAAGATTC CACAACAAAA CCATTCAGTG TTTTGCTCTA CATTGGAACA 300 301 TGTGATAATC CTAACTATCT TGGCCCTGCA CCTCTGGAAG ATATTGCTGA ACAAATTTTT 360 361 AATGCAGCTG GTCCAAGTGG AAGAAATACA GAATATCTTT TTGAACTTGC AGATTCTGTT 420 421 AGGAAACTTG TACCAGAAGA TGCAGACGAG CATCTCTTCT CTTTGGAAAA ATTAGTAAAG 480 481 GAACGCTTAG AAGGAAAATA G 501 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Cytosol | |
Molecular Function | Gamma-glutamylcyclotransferase activity | |
Molecular Function | Glutathione specific gamma-glutamylcyclotransferase activity | |
Biological Process | Glutathione catabolic process |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-2792 | Rattus norvegicus | 99.44 | 9e-128 | 363 |
| LLPS-Mea-1715 | Mesocricetus auratus | 98.31 | 7e-126 | 358 |
| LLPS-Otg-0545 | Otolemur garnettii | 96.02 | 2e-123 | 353 |
| LLPS-Dio-3476 | Dipodomys ordii | 95.51 | 3e-122 | 349 |
| LLPS-Ict-0354 | Ictidomys tridecemlineatus | 94.94 | 4e-122 | 349 |
| LLPS-Loa-3664 | Loxodonta africana | 94.94 | 7e-121 | 346 |
| LLPS-Orc-2357 | Oryctolagus cuniculus | 94.94 | 1e-121 | 351 |
| LLPS-Poa-3538 | Pongo abelii | 94.38 | 2e-122 | 350 |
| LLPS-Nol-0629 | Nomascus leucogenys | 93.82 | 4e-122 | 349 |
| LLPS-Pat-2696 | Pan troglodytes | 93.82 | 1e-121 | 348 |
| LLPS-Pap-0470 | Pan paniscus | 93.82 | 1e-121 | 348 |
| LLPS-Hos-4779 | Homo sapiens | 93.82 | 1e-121 | 348 |
| LLPS-Fec-0584 | Felis catus | 93.82 | 1e-121 | 348 |
| LLPS-Ere-0251 | Erinaceus europaeus | 93.82 | 1e-120 | 346 |
| LLPS-Mal-2486 | Mandrillus leucophaeus | 93.82 | 1e-121 | 348 |
| LLPS-Chs-4581 | Chlorocebus sabaeus | 93.82 | 1e-121 | 348 |
| LLPS-Cea-4217 | Cercocebus atys | 93.82 | 1e-121 | 348 |
| LLPS-Sus-3902 | Sus scrofa | 93.82 | 3e-120 | 345 |
| LLPS-Gog-4288 | Gorilla gorilla | 93.82 | 1e-121 | 348 |
| LLPS-Mod-1434 | Monodelphis domestica | 93.29 | 3e-110 | 320 |
| LLPS-Cap-3697 | Cavia porcellus | 93.26 | 5e-120 | 344 |
| LLPS-Mam-2059 | Macaca mulatta | 93.26 | 4e-121 | 347 |
| LLPS-Cas-2903 | Carlito syrichta | 93.26 | 1e-120 | 346 |
| LLPS-Man-3659 | Macaca nemestrina | 93.26 | 4e-121 | 347 |
| LLPS-Rhb-2009 | Rhinopithecus bieti | 93.26 | 1e-120 | 346 |
| LLPS-Mup-3589 | Mustela putorius furo | 93.26 | 4e-121 | 347 |
| LLPS-Maf-3874 | Macaca fascicularis | 93.26 | 4e-121 | 347 |
| LLPS-Aon-0511 | Aotus nancymaae | 93.26 | 9e-122 | 348 |
| LLPS-Fud-2425 | Fukomys damarensis | 93.26 | 3e-120 | 344 |
| LLPS-Caj-3340 | Callithrix jacchus | 93.26 | 3e-122 | 350 |
| LLPS-Caf-2942 | Canis familiaris | 93.02 | 5e-116 | 334 |
| LLPS-Urm-3930 | Ursus maritimus | 92.7 | 9e-121 | 346 |
| LLPS-Ova-4244 | Ovis aries | 92.13 | 4e-119 | 342 |
| LLPS-Myl-1138 | Myotis lucifugus | 91.67 | 7e-117 | 336 |
| LLPS-Sah-3721 | Sarcophilus harrisii | 90.45 | 2e-116 | 335 |
| LLPS-Eqc-4316 | Equus caballus | 89.33 | 3e-115 | 332 |
| LLPS-Aim-3048 | Ailuropoda melanoleuca | 88.64 | 2e-113 | 327 |
| LLPS-Bot-0457 | Bos taurus | 88.2 | 9e-109 | 315 |
| LLPS-Pes-0492 | Pelodiscus sinensis | 88.07 | 1e-112 | 326 |
| LLPS-Anp-2061 | Anas platyrhynchos | 86.49 | 7e-89 | 264 |
| LLPS-Xet-3827 | Xenopus tropicalis | 85.31 | 2e-109 | 317 |
| LLPS-Gaga-2072 | Gallus gallus | 84.66 | 4e-107 | 311 |
| LLPS-Tag-1026 | Taeniopygia guttata | 84.09 | 1e-105 | 308 |
| LLPS-Anc-0424 | Anolis carolinensis | 83.52 | 4e-105 | 310 |
| LLPS-Leo-2763 | Lepisosteus oculatus | 79.55 | 3e-101 | 296 |
| LLPS-Lac-1047 | Latimeria chalumnae | 76.04 | 9e-103 | 301 |
| LLPS-Xim-2515 | Xiphophorus maculatus | 75.14 | 2e-95 | 282 |
| LLPS-Orn-4070 | Oreochromis niloticus | 74.58 | 2e-95 | 281 |
| LLPS-Dar-4182 | Danio rerio | 74.01 | 1e-95 | 282 |
| LLPS-Scf-3225 | Scleropages formosus | 73.86 | 3e-94 | 279 |
| LLPS-Pof-3207 | Poecilia formosa | 73.74 | 1e-95 | 282 |
| LLPS-Icp-0121 | Ictalurus punctatus | 73.45 | 6e-95 | 280 |
| LLPS-Asm-0566 | Astyanax mexicanus | 72.73 | 1e-92 | 275 |
| LLPS-Scm-0522 | Scophthalmus maximus | 71.59 | 7e-88 | 264 |
| LLPS-Ten-3112 | Tetraodon nigroviridis | 70.79 | 2e-89 | 266 |
| LLPS-Gaa-2843 | Gasterosteus aculeatus | 70.06 | 8e-89 | 265 |
| LLPS-Tar-0676 | Takifugu rubripes | 69.44 | 1e-87 | 263 |
| LLPS-Cis-0175 | Ciona savignyi | 61.14 | 8e-79 | 239 |
| LLPS-Cii-1386 | Ciona intestinalis | 61.05 | 6e-78 | 237 |
| LLPS-Sot-2092 | Solanum tuberosum | 50.62 | 2e-42 | 146 |
| LLPS-Gor-1247 | Gossypium raimondii | 50.29 | 1e-46 | 159 |
| LLPS-Paa-4191 | Papio anubis | 50.28 | 1e-53 | 178 |
| LLPS-Tut-1044 | Tursiops truncatus | 50.0 | 2e-52 | 173 |
| LLPS-Orl-3074 | Oryzias latipes | 49.13 | 9e-50 | 166 |
| LLPS-Bro-1708 | Brassica oleracea | 48.89 | 2e-44 | 152 |
| LLPS-Brr-1014 | Brassica rapa | 48.89 | 1e-44 | 152 |
| LLPS-Brn-1421 | Brassica napus | 48.89 | 7e-45 | 153 |
| LLPS-Sem-1534 | Selaginella moellendorffii | 48.77 | 2e-42 | 145 |
| LLPS-Mae-2676 | Manihot esculenta | 48.62 | 3e-47 | 159 |
| LLPS-Sol-2429 | Solanum lycopersicum | 48.07 | 2e-44 | 151 |
| LLPS-Amt-2246 | Amborella trichopoda | 47.83 | 6e-46 | 155 |
| LLPS-Coc-0560 | Corchorus capsularis | 47.54 | 4e-45 | 153 |
| LLPS-Hea-0658 | Helianthus annuus | 47.54 | 2e-47 | 159 |
| LLPS-Nia-1411 | Nicotiana attenuata | 47.51 | 3e-44 | 151 |
| LLPS-Drm-1355 | Drosophila melanogaster | 47.46 | 4e-46 | 159 |
| LLPS-Chr-0454 | Chlamydomonas reinhardtii | 47.16 | 1e-45 | 159 |
| LLPS-Prp-0706 | Prunus persica | 46.96 | 7e-45 | 155 |
| LLPS-Dac-1858 | Daucus carota | 46.96 | 2e-45 | 154 |
| LLPS-Phv-2237 | Phaseolus vulgaris | 46.74 | 3e-41 | 143 |
| LLPS-Cus-0763 | Cucumis sativus | 46.7 | 3e-42 | 146 |
| LLPS-Brd-1898 | Brachypodium distachyon | 46.41 | 2e-45 | 154 |
| LLPS-Thc-1736 | Theobroma cacao | 46.41 | 5e-44 | 150 |
| LLPS-Viv-2493 | Vitis vinifera | 46.2 | 3e-44 | 151 |
| LLPS-Mao-0817 | Magnaporthe oryzae | 46.2 | 7e-50 | 167 |
| LLPS-Art-2994 | Arabidopsis thaliana | 45.9 | 1e-40 | 142 |
| LLPS-Arl-2058 | Arabidopsis lyrata | 45.9 | 1e-39 | 140 |
| LLPS-Glm-1604 | Glycine max | 45.9 | 1e-41 | 144 |
| LLPS-Php-2123 | Physcomitrella patens | 45.86 | 6e-43 | 149 |
| LLPS-Sob-0025 | Sorghum bicolor | 45.51 | 5e-44 | 150 |
| LLPS-Met-2037 | Medicago truncatula | 45.3 | 3e-40 | 140 |
| LLPS-Tra-0465 | Triticum aestivum | 45.3 | 2e-44 | 151 |
| LLPS-Via-1287 | Vigna angularis | 45.11 | 1e-40 | 142 |
| LLPS-Org-0939 | Oryza glaberrima | 44.69 | 4e-44 | 150 |
| LLPS-Ors-1462 | Oryza sativa | 44.69 | 5e-44 | 150 |
| LLPS-Orgl-1373 | Oryza glumaepatula | 44.69 | 4e-44 | 150 |
| LLPS-Orb-1117 | Oryza barthii | 44.69 | 4e-44 | 150 |
| LLPS-Ori-1265 | Oryza indica | 44.69 | 4e-44 | 150 |
| LLPS-Orni-2316 | Oryza nivara | 44.69 | 4e-44 | 150 |
| LLPS-Gag-0501 | Gaeumannomyces graminis | 44.02 | 4e-47 | 161 |
| LLPS-Abg-1612 | Absidia glauca | 43.78 | 1e-44 | 152 |
| LLPS-Vir-0820 | Vigna radiata | 43.64 | 2e-34 | 127 |
| LLPS-Cog-0723 | Colletotrichum gloeosporioides | 43.33 | 4e-30 | 115 |
| LLPS-Fuo-1580 | Fusarium oxysporum | 43.24 | 1e-30 | 116 |
| LLPS-Fuv-0371 | Fusarium verticillioides | 43.24 | 1e-30 | 116 |
| LLPS-Pot-0703 | Populus trichocarpa | 42.72 | 4e-42 | 148 |
| LLPS-Pug-0256 | Puccinia graminis | 42.7 | 7e-36 | 130 |
| LLPS-Miv-1435 | Microbotryum violaceum | 42.55 | 2e-37 | 134 |
| LLPS-Gas-1263 | Galdieria sulphuraria | 42.33 | 2e-42 | 147 |
| LLPS-Cogr-0904 | Colletotrichum graminicola | 42.18 | 6e-26 | 103 |
| LLPS-Orm-0479 | Oryza meridionalis | 42.17 | 7e-37 | 133 |
| LLPS-Orr-1295 | Oryza rufipogon | 42.17 | 1e-36 | 132 |
| LLPS-Lep-0991 | Leersia perrieri | 42.17 | 6e-37 | 133 |
| LLPS-Yal-1241 | Yarrowia lipolytica | 42.08 | 2e-41 | 145 |
| LLPS-Trr-1387 | Trichoderma reesei | 41.9 | 9e-38 | 134 |
| LLPS-Mua-2468 | Musa acuminata | 41.85 | 7e-35 | 126 |
| LLPS-Orp-2095 | Oryza punctata | 41.57 | 5e-36 | 130 |
| LLPS-Orbr-2120 | Oryza brachyantha | 41.57 | 2e-36 | 132 |
| LLPS-Sei-1929 | Setaria italica | 41.57 | 1e-35 | 129 |
| LLPS-Hov-0469 | Hordeum vulgare | 41.57 | 1e-34 | 127 |
| LLPS-Osl-0717 | Ostreococcus lucimarinus | 41.44 | 3e-32 | 120 |
| LLPS-Mel-0184 | Melampsora laricipopulina | 40.98 | 1e-34 | 126 |
| LLPS-Cym-1147 | Cyanidioschyzon merolae | 40.98 | 1e-33 | 125 |
| LLPS-Asn-0617 | Aspergillus nidulans | 40.89 | 9e-40 | 142 |
| LLPS-Aso-0968 | Aspergillus oryzae | 40.85 | 1e-24 | 100 |
| LLPS-Fus-0802 | Fusarium solani | 40.67 | 6e-28 | 109 |
| LLPS-Asf-1552 | Aspergillus flavus | 40.0 | 1e-16 | 78.2 |
| LLPS-Nec-0333 | Neurospora crassa | 39.9 | 9e-43 | 149 |
| LLPS-Dos-1464 | Dothistroma septosporum | 39.81 | 7e-43 | 149 |
| LLPS-Coo-1626 | Colletotrichum orbiculare | 39.51 | 1e-28 | 111 |
| LLPS-Trv-1622 | Trichoderma virens | 39.13 | 2e-32 | 121 |
| LLPS-Zyt-1372 | Zymoseptoria tritici | 38.61 | 4e-40 | 141 |
| LLPS-Asni-1587 | Aspergillus niger | 38.59 | 8e-29 | 112 |
| LLPS-Tru-1001 | Triticum urartu | 38.42 | 3e-34 | 126 |
| LLPS-Map-0672 | Magnaporthe poae | 38.02 | 4e-33 | 124 |
| LLPS-Cae-1252 | Caenorhabditis elegans | 37.99 | 1e-29 | 114 |
| LLPS-Scj-1532 | Schizosaccharomyces japonicus | 37.91 | 2e-31 | 119 |
| LLPS-Scc-1598 | Schizosaccharomyces cryophilus | 37.7 | 8e-36 | 130 |
| LLPS-Crn-1412 | Cryptococcus neoformans | 37.44 | 4e-36 | 131 |
| LLPS-Scp-0551 | Schizosaccharomyces pombe | 37.31 | 6e-33 | 122 |
| LLPS-Phn-1520 | Phaeosphaeria nodorum | 36.97 | 1e-38 | 139 |
| LLPS-Blg-0051 | Blumeria graminis | 36.84 | 4e-19 | 84.0 |
| LLPS-Asg-0650 | Ashbya gossypii | 36.78 | 6e-28 | 109 |
| LLPS-Ast-1415 | Aspergillus terreus | 36.73 | 2e-21 | 93.2 |
| LLPS-Asc-1645 | Aspergillus clavatus | 36.63 | 2e-20 | 89.7 |
| LLPS-Tum-1545 | Tuber melanosporum | 36.36 | 6e-27 | 106 |
| LLPS-Scs-0847 | Sclerotinia sclerotiorum | 36.36 | 8e-26 | 104 |
| LLPS-Asfu-1613 | Aspergillus fumigatus | 36.21 | 2e-31 | 120 |
| LLPS-Ved-0195 | Verticillium dahliae | 35.5 | 1e-23 | 98.6 |
| LLPS-Kop-0599 | Komagataella pastoris | 34.95 | 3e-26 | 105 |
| LLPS-Nef-1463 | Neosartorya fischeri | 34.51 | 9e-25 | 102 |
| LLPS-Lem-1045 | Leptosphaeria maculans | 34.07 | 1e-21 | 93.2 |
| LLPS-Zem-2283 | Zea mays | 33.33 | 2e-31 | 119 |
| LLPS-Sac-0324 | Saccharomyces cerevisiae | 33.0 | 1e-26 | 106 |
| LLPS-Pytr-1506 | Pyrenophora triticirepentis | 31.28 | 4e-19 | 85.5 |