LLPS-Mum-3465
Ube2c

▼ OVERVIEW

Status: Unreviewed
Protein Name: Ubiquitin-conjugating enzyme E2 C; (E3-independent) E2 ubiquitin-conjugating enzyme C
Gene Name: Ube2c, Ubch10
Ensembl Gene: ENSMUSG00000001403.13
Ensembl Protein: ENSMUSP00000001439.6
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MASQNRDPAA  ASVAAVRKGA  EPCGGAARGP  VGKRLQQELM  ILMTSGDKGI  SAFPESDNLF  60
61    KWVGTIHGAA  GTVYEDLRYK  LSLEFPSGYP  YNAPTVKFLT  PCYHPNVDTQ  GNICLDILKD  120
121   KWSALYDVRT  ILLSIQSLLG  EPNIDSPLNT  HAAELWKNPT  AFKKYLQETY  SKQVSSQDP  179
Nucleotide CDS Sequence (FASTA)
1     ATGGCCTCAC  AAAACCGCGA  CCCAGCTGCT  GCCAGCGTTG  CCGCGGTTCG  AAAAGGAGCC  60
61    GAGCCCTGCG  GGGGCGCCGC  CCGAGGCCCT  GTGGGCAAGC  GGCTACAGCA  GGAACTGATG  120
121   ATCCTCATGA  CATCTGGTGA  CAAAGGAATC  TCCGCCTTCC  CTGAGTCAGA  CAACCTGTTC  180
181   AAGTGGGTGG  GGACCATCCA  CGGAGCAGCC  GGCACCGTAT  ATGAAGACCT  GAGGTACAAA  240
241   CTCTCCCTAG  AGTTCCCCAG  CGGCTACCCT  TACAACGCAC  CCACAGTGAA  GTTCCTCACA  300
301   CCCTGCTACC  ACCCCAACGT  GGACACCCAG  GGCAACATCT  GCCTGGACAT  CCTCAAGGAT  360
361   AAGTGGTCTG  CACTATATGA  TGTCAGGACT  ATCTTGCTCT  CTATCCAGAG  CCTGCTAGGA  420
421   GAACCCAACA  TCGATAGCCC  TTTGAACACA  CACGCTGCGG  AACTCTGGAA  AAACCCCACA  480
481   GTCACAGAGC  CCAAAGGAGC  AGCCTTTCCC  GTGTGA  516

▼ KEYWORD

ID
Family
Acetylation
ATP-binding
Cell cycle
Cell division
Complete proteome
Mitosis
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase
Ubl conjugation
Ubl conjugation pathway

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Anaphase-promoting complex
Cellular Component
Cytosol
Cellular Component
Nucleus
Cellular Component
Plasma membrane
Cellular Component
Ubiquitin ligase complex
Molecular Function
ATP binding
Molecular Function
Ubiquitin conjugating enzyme activity
Molecular Function
Ubiquitin-like protein ligase binding
Molecular Function
Ubiquitin-protein transferase activity
Biological Process
Anaphase-promoting complex-dependent catabolic process
Biological Process
Cell division
Biological Process
Exit from mitosis
Biological Process
Free ubiquitin chain polymerization
Biological Process
Positive regulation of exit from mitosis
Biological Process
Protein K11-linked ubiquitination
Biological Process
Protein K48-linked ubiquitination
Biological Process
Protein ubiquitination
Biological Process
Ubiquitin-dependent protein catabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Caf-3724Canis familiaris97.771e-121 348
LLPS-Fec-0515Felis catus97.213e-121 347
LLPS-Ict-1319Ictidomys tridecemlineatus97.213e-121 347
LLPS-Fud-0435Fukomys damarensis97.214e-123 352
LLPS-Ran-0189Rattus norvegicus97.212e-122 350
LLPS-Bot-3094Bos taurus96.891e-108 315
LLPS-Ova-2802Ovis aries96.696e-120 344
LLPS-Cap-0234Cavia porcellus96.653e-122 350
LLPS-Sus-2913Sus scrofa96.653e-121 347
LLPS-Cas-2988Carlito syrichta96.097e-120 343
LLPS-Caj-4579Callithrix jacchus96.094e-122 349
LLPS-Mup-2727Mustela putorius furo96.091e-119 343
LLPS-Aim-1496Ailuropoda melanoleuca95.587e-119 341
LLPS-Myl-3128Myotis lucifugus95.586e-119 341
LLPS-Man-1728Macaca nemestrina95.535e-122 349
LLPS-Pat-3626Pan troglodytes95.531e-121 348
LLPS-Pap-0876Pan paniscus95.531e-121 348
LLPS-Hos-3918Homo sapiens95.531e-121 348
LLPS-Rhb-0792Rhinopithecus bieti95.535e-122 349
LLPS-Mam-1971Macaca mulatta95.535e-122 349
LLPS-Poa-0323Pongo abelii95.531e-121 348
LLPS-Chs-2582Chlorocebus sabaeus95.535e-122 349
LLPS-Maf-3674Macaca fascicularis95.535e-122 349
LLPS-Gog-4779Gorilla gorilla95.531e-121 348
LLPS-Paa-1473Papio anubis95.535e-122 349
LLPS-Otg-3949Otolemur garnettii95.055e-120 344
LLPS-Loa-1419Loxodonta africana94.485e-119 342
LLPS-Orc-3641Oryctolagus cuniculus93.333e-115 332
LLPS-Eqc-0407Equus caballus92.743e-111 322
LLPS-Dio-2588Dipodomys ordii92.742e-115 332
LLPS-Mod-3881Monodelphis domestica92.228e-114 328
LLPS-Mal-0324Mandrillus leucophaeus92.181e-116 335
LLPS-Urm-2011Ursus maritimus91.623e-111 322
LLPS-Pes-2564Pelodiscus sinensis91.514e-67 207
LLPS-Sah-3812Sarcophilus harrisii91.033e-92 274
LLPS-Fia-3847Ficedula albicollis86.677e-64 199
LLPS-Cea-3576Cercocebus atys85.964e-104 303
LLPS-Nol-3583Nomascus leucogenys84.927e-103 300
LLPS-Gaga-2899Gallus gallus82.583e-104 304
LLPS-Aon-2417Aotus nancymaae79.632e-113 328
LLPS-Xet-3616Xenopus tropicalis79.332e-97 286
LLPS-Asm-1316Astyanax mexicanus78.572e-70 218
LLPS-Icp-2768Ictalurus punctatus78.248e-90 267
LLPS-Dar-3848Danio rerio75.884e-86 258
LLPS-Leo-3643Lepisosteus oculatus75.883e-84 259
LLPS-Mea-3327Mesocricetus auratus75.333e-70 216
LLPS-Orn-0373Oreochromis niloticus74.864e-85 255
LLPS-Scm-0029Scophthalmus maximus73.567e-86 259
LLPS-Pof-3122Poecilia formosa72.993e-86 258
LLPS-Xim-3770Xiphophorus maculatus72.993e-86 258
LLPS-Gaa-2178Gasterosteus aculeatus72.739e-84 252
LLPS-Orl-0564Oryzias latipes72.413e-83 251
LLPS-Ten-0953Tetraodon nigroviridis70.998e-66 204
LLPS-Osl-0147Ostreococcus lucimarinus70.82e-66 206
LLPS-Orbr-1542Oryza brachyantha70.657e-42 142
LLPS-Vir-1599Vigna radiata69.531e-60 192
LLPS-Hov-1894Hordeum vulgare69.343e-64 202
LLPS-Lac-2478Latimeria chalumnae68.726e-83 250
LLPS-Orb-0721Oryza barthii67.188e-61 192
LLPS-Viv-1847Vitis vinifera67.143e-63 199
LLPS-Mae-0673Manihot esculenta67.141e-63 201
LLPS-Brd-1961Brachypodium distachyon67.113e-68 213
LLPS-Pot-2669Populus trichocarpa66.432e-63 200
LLPS-Gor-1344Gossypium raimondii66.435e-63 199
LLPS-Thc-0539Theobroma cacao66.433e-63 200
LLPS-Php-2519Physcomitrella patens66.438e-65 204
LLPS-Drm-0089Drosophila melanogaster66.436e-65 204
LLPS-Mua-1606Musa acuminata66.422e-60 192
LLPS-Ori-2156Oryza indica66.415e-60 190
LLPS-Sem-1478Selaginella moellendorffii66.181e-62 198
LLPS-Asc-0744Aspergillus clavatus66.145e-44 150
LLPS-Ors-0693Oryza sativa65.759e-66 206
LLPS-Orm-1043Oryza meridionalis65.752e-65 206
LLPS-Orni-2032Oryza nivara65.759e-66 206
LLPS-Orgl-0675Oryza glumaepatula65.759e-66 206
LLPS-Nia-1337Nicotiana attenuata65.712e-62 197
LLPS-Prp-2471Prunus persica65.713e-62 197
LLPS-Glm-2444Glycine max65.716e-63 199
LLPS-Met-1647Medicago truncatula65.718e-63 198
LLPS-Tum-1571Tuber melanosporum65.693e-48 161
LLPS-Tru-0547Triticum urartu65.525e-50 164
LLPS-Asfu-1192Aspergillus fumigatus65.358e-43 147
LLPS-Tra-1798Triticum aestivum65.335e-67 209
LLPS-Orp-1588Oryza punctata65.312e-64 203
LLPS-Sot-2097Solanum tuberosum65.284e-63 199
LLPS-Sei-2332Setaria italica65.075e-66 207
LLPS-Phv-1443Phaseolus vulgaris65.09e-63 198
LLPS-Dac-2418Daucus carota65.04e-59 194
LLPS-Via-0821Vigna angularis65.09e-63 198
LLPS-Fus-0905Fusarium solani64.933e-52 171
LLPS-Amt-1024Amborella trichopoda64.291e-61 196
LLPS-Scs-0841Sclerotinia sclerotiorum64.186e-52 171
LLPS-Blg-1512Blumeria graminis64.184e-52 171
LLPS-Coc-1082Corchorus capsularis64.089e-60 191
LLPS-Hea-1356Helianthus annuus63.572e-59 190
LLPS-Fuv-1048Fusarium verticillioides63.434e-50 166
LLPS-Zem-2115Zea mays63.336e-65 204
LLPS-Orr-2305Oryza rufipogon62.992e-63 201
LLPS-Mel-1435Melampsora laricipopulina62.861e-57 185
LLPS-Lep-0343Leersia perrieri62.821e-64 204
LLPS-Sol-2409Solanum lycopersicum62.765e-56 181
LLPS-Nef-1664Neosartorya fischeri62.327e-44 150
LLPS-Sac-1643Saccharomyces cerevisiae62.021e-48 161
LLPS-Kop-1291Komagataella pastoris61.978e-55 179
LLPS-Scc-0745Schizosaccharomyces cryophilus61.815e-58 186
LLPS-Sob-0118Sorghum bicolor61.783e-65 205
LLPS-Gag-0994Gaeumannomyces graminis61.761e-48 162
LLPS-Asf-1588Aspergillus flavus61.593e-43 148
LLPS-Phn-0911Phaeosphaeria nodorum61.422e-49 163
LLPS-Ved-0485Verticillium dahliae61.279e-51 167
LLPS-Aso-0793Aspergillus oryzae61.191e-40 141
LLPS-Beb-0589Beauveria bassiana61.152e-51 169
LLPS-Trr-1599Trichoderma reesei60.267e-52 171
LLPS-Cog-0966Colletotrichum gloeosporioides60.262e-52 172
LLPS-Trv-1269Trichoderma virens60.268e-52 170
LLPS-Map-0124Magnaporthe poae60.263e-53 174
LLPS-Coo-0690Colletotrichum orbiculare60.263e-52 171
LLPS-Ast-0129Aspergillus terreus60.02e-43 149
LLPS-Scj-1018Schizosaccharomyces japonicus59.874e-58 186
LLPS-Cis-1307Ciona savignyi59.773e-67 210
LLPS-Brr-0606Brassica rapa59.745e-61 194
LLPS-Bro-1916Brassica oleracea59.745e-61 194
LLPS-Brn-0743Brassica napus59.745e-61 194
LLPS-Arl-2963Arabidopsis lyrata59.744e-60 191
LLPS-Asni-1334Aspergillus niger59.467e-44 150
LLPS-Art-3006Arabidopsis thaliana59.098e-60 191
LLPS-Cogr-1448Colletotrichum graminicola58.942e-50 167
LLPS-Mao-0804Magnaporthe oryzae58.784e-49 163
LLPS-Cus-2085Cucumis sativus58.331e-63 201
LLPS-Miv-0940Microbotryum violaceum58.115e-52 172
LLPS-Nec-0843Neurospora crassa57.694e-52 171
LLPS-Pyt-0038Pyrenophora teres57.643e-53 173
LLPS-Fuo-1269Fusarium oxysporum56.719e-51 167
LLPS-Yal-1492Yarrowia lipolytica56.076e-57 183
LLPS-Cii-1865Ciona intestinalis55.963e-34 124
LLPS-Lem-0069Leptosphaeria maculans55.631e-50 167
LLPS-Asn-1183Aspergillus nidulans55.421e-51 170
LLPS-Scp-1480Schizosaccharomyces pombe55.239e-58 186
LLPS-Chc-0025Chondrus crispus55.11e-51 169
LLPS-Dos-1510Dothistroma septosporum54.676e-44 150
LLPS-Zyt-1042Zymoseptoria tritici52.525e-40 139
LLPS-Cym-0483Cyanidioschyzon merolae51.615e-48 161
LLPS-Meg-3267Meleagris gallopavo50.464e-33 121
LLPS-Ora-2974Ornithorhynchus anatinus50.464e-33 121
LLPS-Gas-0478Galdieria sulphuraria48.84e-33 121
LLPS-Org-1132Oryza glaberrima48.05e-32 118
LLPS-Spr-1003Sporisorium reilianum47.621e-31 117
LLPS-Anc-3346Anolis carolinensis46.094e-35 126
LLPS-Tut-2086Tursiops truncatus46.093e-35 127
LLPS-Chr-0679Chlamydomonas reinhardtii45.262e-32 120
LLPS-Tag-3007Taeniopygia guttata42.752e-32 119
LLPS-Pytr-1268Pyrenophora triticirepentis42.552e-33 122
LLPS-Scf-3421Scleropages formosus42.368e-35 125