LLPS-Mum-3440
Stx1b
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Syntaxin-1B |
| Gene Name: | Stx1b, Stx1b1, Stx1b2 |
| Ensembl Gene: | ENSMUSG00000030806.6 |
| Ensembl Protein: | ENSMUSP00000101874.3 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
| Centrosome/Spindle pole body | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000106267.4 | ENSMUSP00000101874.3 |
| Ensembl | ENSMUST00000156135.2 | ENSMUSP00000145698.1 |
| UniProt | P61264, STX1B_MOUSE, A2RSB4, O35525, P32853 | |
| GeneBank | D29743, BC132042, BC132068, D45207, AC149222 | BAA25986.1, AAI32069.1, AAI32043.1, BAA06162.1 |
| RefSeq | NM_024414.2 | NP_077725.1 |
| Entrez | 56216 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV EQVKKQHSAI 60 61 LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE QEEGLNRSSA DLRIRKTQHS 120 121 TLSRKFVEVM TEYNATQSKY RDRCKDRIQR QLEITGRTTT NEELEDMLES GKLAIFTDDI 180 181 KMDSQMTKQA LNEIETRHNE IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV 240 241 DYVERAVSDT KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL 288 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAAGGATC GGACTCAGGA GCTGCGGAGT GCGAAAGACA GTGATGATGA AGAGGAGGTG 60 61 GTCCACGTGG ATCGAGACCA CTTTATGGAT GAGTTCTTCG AGCAGGTGGA AGAGATCCGA 120 121 GGCTGCATCG AGAAACTGTC TGAGGATGTG GAGCAAGTGA AGAAACAGCA CAGCGCCATT 180 181 CTTGCCGCCC CCAACCCCGA TGAGAAGACT AAACAGGAGT TGGAGGACCT CACGGCAGAC 240 241 ATCAAAAAGA CGGCAAACAA GGTCCGGTCC AAGTTGAAAG CGATCGAGCA AAGCATTGAG 300 301 CAGGAAGAGG GGCTGAATCG TTCCTCTGCG GACCTGCGCA TCCGTAAGAC CCAGCACTCC 360 361 ACACTCTCAC GGAAGTTCGT GGAGGTAATG ACCGAATATA ATGCAACTCA GTCCAAGTAC 420 421 CGGGACCGCT GCAAGGACCG AATCCAGAGG CAGCTGGAGA TCACTGGCAG GACTACTACC 480 481 AATGAAGAAC TAGAAGACAT GTTGGAAAGC GGGAAGCTGG CCATCTTCAC TGATGATATC 540 541 AAAATGGACT CGCAGATGAC AAAGCAAGCT CTGAATGAGA TCGAGACAAG GCACAATGAG 600 601 ATCATCAAAC TGGAAACCAG CATTCGAGAG CTGCACGACA TGTTTGTGGA CATGGCCATG 660 661 CTCGTAGAGA GCCAGGGTGA GATGATCGAC CGAATTGAGT ACAACGTGGA ACATTCCGTG 720 721 GACTACGTGG AACGAGCCGT GTCTGACACC AAGAAAGCTG TGAAGTATCA GAGCAAGGCC 780 781 AGGAGGAAGA AAATTATGAT CATCATTTGC TGTGTGGTGC TGGGGGTGGT CTTGGCGTCA 840 841 TCCATTGGGG GGACACTGGG CTTGTAG 867 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Axon | |
Cellular Component | Centrosome | |
Cellular Component | Cytoplasm | |
Cellular Component | Endomembrane system | |
Cellular Component | Integral component of membrane | |
Cellular Component | Integral component of presynaptic membrane | |
Cellular Component | Membrane | |
Cellular Component | Neuromuscular junction | |
Cellular Component | Nuclear lamina | |
Cellular Component | Nucleoplasm | |
Cellular Component | Nucleus | |
Cellular Component | Plasma membrane | |
Cellular Component | Presynapse | |
Cellular Component | Presynaptic active zone membrane | |
Cellular Component | Presynaptic membrane | |
Cellular Component | SNARE complex | |
Cellular Component | Synaptic vesicle | |
Molecular Function | Protein domain specific binding | |
Molecular Function | Protein kinase binding | |
Molecular Function | Signaling receptor binding | |
Molecular Function | SNAP receptor activity | |
Molecular Function | SNARE binding | |
Biological Process | Calcium ion-regulated exocytosis of neurotransmitter | |
Biological Process | Exocytic insertion of neurotransmitter receptor to postsynaptic membrane | |
Biological Process | Exocytosis | |
Biological Process | Intracellular protein transport | |
Biological Process | Negative regulation of macropinocytosis | |
Biological Process | Negative regulation of neuron projection development | |
Biological Process | Negative regulation of synaptic vesicle recycling | |
Biological Process | Positive regulation of excitatory postsynaptic potential | |
Biological Process | Positive regulation of neurotransmitter secretion | |
Biological Process | Positive regulation of spontaneous neurotransmitter secretion | |
Biological Process | Protein localization to membrane | |
Biological Process | Protein transport | |
Biological Process | Regulation of exocytosis | |
Biological Process | Regulation of gene expression | |
Biological Process | Regulation of synaptic activity | |
Biological Process | Regulation of synaptic vesicle priming | |
Biological Process | Spontaneous neurotransmitter secretion | |
Biological Process | Synaptic vesicle docking | |
Biological Process | Synaptic vesicle exocytosis | |
Biological Process | Synaptic vesicle fusion to presynaptic active zone membrane | |
Biological Process | Vesicle docking | |
Biological Process | Vesicle docking involved in exocytosis | |
Biological Process | Vesicle fusion | |
Biological Process | Vesicle-mediated transport |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CGDB | PIRSF | CellMarker | RaftProt | |
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Sah-4108 | Sarcophilus harrisii | 100.0 | 0.0 | 514 |
| LLPS-Cea-1485 | Cercocebus atys | 100.0 | 0.0 | 514 |
| LLPS-Sus-3800 | Sus scrofa | 100.0 | 0.0 | 514 |
| LLPS-Mea-4534 | Mesocricetus auratus | 100.0 | 5e-177 | 498 |
| LLPS-Maf-3221 | Macaca fascicularis | 100.0 | 0.0 | 514 |
| LLPS-Fud-1318 | Fukomys damarensis | 100.0 | 2e-177 | 498 |
| LLPS-Caj-3044 | Callithrix jacchus | 100.0 | 0.0 | 514 |
| LLPS-Gog-2490 | Gorilla gorilla | 100.0 | 2e-177 | 499 |
| LLPS-Dio-1044 | Dipodomys ordii | 100.0 | 2e-177 | 498 |
| LLPS-Paa-3809 | Papio anubis | 100.0 | 0.0 | 514 |
| LLPS-Mup-3103 | Mustela putorius furo | 100.0 | 4e-177 | 498 |
| LLPS-Ran-0807 | Rattus norvegicus | 100.0 | 0.0 | 514 |
| LLPS-Ere-0666 | Erinaceus europaeus | 100.0 | 2e-106 | 313 |
| LLPS-Man-3205 | Macaca nemestrina | 100.0 | 0.0 | 514 |
| LLPS-Pap-2743 | Pan paniscus | 100.0 | 2e-177 | 499 |
| LLPS-Hos-1693 | Homo sapiens | 100.0 | 0.0 | 514 |
| LLPS-Mod-0077 | Monodelphis domestica | 100.0 | 2e-177 | 498 |
| LLPS-Fec-1777 | Felis catus | 100.0 | 0.0 | 514 |
| LLPS-Rhb-3234 | Rhinopithecus bieti | 100.0 | 2e-177 | 498 |
| LLPS-Mam-4085 | Macaca mulatta | 100.0 | 3e-177 | 498 |
| LLPS-Poa-0413 | Pongo abelii | 100.0 | 1e-180 | 518 |
| LLPS-Caf-4105 | Canis familiaris | 100.0 | 1e-177 | 499 |
| LLPS-Eqc-0608 | Equus caballus | 100.0 | 4e-177 | 498 |
| LLPS-Cap-3136 | Cavia porcellus | 100.0 | 0.0 | 514 |
| LLPS-Ict-2969 | Ictidomys tridecemlineatus | 100.0 | 2e-177 | 498 |
| LLPS-Nol-4119 | Nomascus leucogenys | 100.0 | 2e-177 | 499 |
| LLPS-Bot-4213 | Bos taurus | 99.62 | 1e-174 | 496 |
| LLPS-Pes-3233 | Pelodiscus sinensis | 99.62 | 1e-176 | 496 |
| LLPS-Xet-3620 | Xenopus tropicalis | 99.62 | 1e-176 | 496 |
| LLPS-Loa-3483 | Loxodonta africana | 98.93 | 1e-175 | 494 |
| LLPS-Aon-1760 | Aotus nancymaae | 98.26 | 4e-178 | 500 |
| LLPS-Leo-0426 | Lepisosteus oculatus | 98.26 | 0.0 | 510 |
| LLPS-Anc-3481 | Anolis carolinensis | 97.92 | 2e-178 | 501 |
| LLPS-Otg-1769 | Otolemur garnettii | 97.57 | 3e-177 | 498 |
| LLPS-Chs-2316 | Chlorocebus sabaeus | 97.56 | 3e-176 | 496 |
| LLPS-Myl-2838 | Myotis lucifugus | 97.55 | 1e-176 | 496 |
| LLPS-Dar-3788 | Danio rerio | 97.22 | 3e-179 | 503 |
| LLPS-Gaa-1875 | Gasterosteus aculeatus | 96.95 | 9e-173 | 487 |
| LLPS-Scf-2754 | Scleropages formosus | 96.95 | 8e-172 | 484 |
| LLPS-Tar-1915 | Takifugu rubripes | 96.95 | 1e-172 | 486 |
| LLPS-Orn-0231 | Oreochromis niloticus | 96.8 | 3e-174 | 491 |
| LLPS-Orl-3260 | Oryzias latipes | 96.18 | 2e-171 | 484 |
| LLPS-Xim-3991 | Xiphophorus maculatus | 96.18 | 3e-178 | 500 |
| LLPS-Pof-2854 | Poecilia formosa | 96.18 | 3e-178 | 500 |
| LLPS-Ten-3701 | Tetraodon nigroviridis | 95.13 | 1e-169 | 479 |
| LLPS-Asm-0408 | Astyanax mexicanus | 94.44 | 1e-174 | 491 |
| LLPS-Icp-3437 | Ictalurus punctatus | 94.44 | 1e-174 | 491 |
| LLPS-Aim-2643 | Ailuropoda melanoleuca | 93.51 | 3e-162 | 460 |
| LLPS-Lac-3485 | Latimeria chalumnae | 93.13 | 2e-159 | 453 |
| LLPS-Ova-3577 | Ovis aries | 92.02 | 1e-156 | 446 |
| LLPS-Pat-1143 | Pan troglodytes | 87.85 | 3e-148 | 424 |
| LLPS-Anp-2971 | Anas platyrhynchos | 85.77 | 1e-142 | 410 |
| LLPS-Meg-1411 | Meleagris gallopavo | 85.77 | 1e-142 | 410 |
| LLPS-Fia-1281 | Ficedula albicollis | 85.77 | 9e-143 | 410 |
| LLPS-Urm-1092 | Ursus maritimus | 85.38 | 1e-141 | 407 |
| LLPS-Cas-0163 | Carlito syrichta | 84.03 | 3e-139 | 400 |
| LLPS-Gaga-0135 | Gallus gallus | 82.99 | 5e-144 | 418 |
| LLPS-Orc-3051 | Oryctolagus cuniculus | 82.64 | 1e-135 | 394 |
| LLPS-Mal-4719 | Mandrillus leucophaeus | 82.29 | 8e-145 | 416 |
| LLPS-Tut-2473 | Tursiops truncatus | 81.94 | 1e-143 | 413 |
| LLPS-Drm-0990 | Drosophila melanogaster | 73.84 | 2e-114 | 338 |
| LLPS-Ora-3312 | Ornithorhynchus anatinus | 71.92 | 5e-68 | 216 |
| LLPS-Scm-2073 | Scophthalmus maximus | 70.43 | 7e-106 | 316 |
| LLPS-Tag-1113 | Taeniopygia guttata | 67.58 | 2e-117 | 347 |
| LLPS-Cae-0788 | Caenorhabditis elegans | 65.82 | 2e-108 | 323 |
| LLPS-Cis-0121 | Ciona savignyi | 60.67 | 1e-98 | 298 |
| LLPS-Cii-0911 | Ciona intestinalis | 58.65 | 2e-82 | 255 |
| LLPS-Abg-1262 | Absidia glauca | 30.58 | 1e-29 | 120 |
| LLPS-Chr-1192 | Chlamydomonas reinhardtii | 29.8 | 3e-19 | 89.4 |
| LLPS-Dac-2213 | Daucus carota | 29.76 | 7e-20 | 91.3 |
| LLPS-Gas-1197 | Galdieria sulphuraria | 28.92 | 2e-21 | 96.7 |
| LLPS-Chc-0979 | Chondrus crispus | 28.34 | 1e-21 | 96.7 |
| LLPS-Sei-0604 | Setaria italica | 28.22 | 4e-21 | 94.7 |
| LLPS-Glm-2058 | Glycine max | 27.69 | 3e-21 | 95.5 |
| LLPS-Scc-0413 | Schizosaccharomyces cryophilus | 27.39 | 5e-17 | 82.8 |
| LLPS-Cog-1094 | Colletotrichum gloeosporioides | 27.31 | 1e-17 | 84.7 |
| LLPS-Via-2001 | Vigna angularis | 27.27 | 3e-21 | 95.1 |
| LLPS-Crn-0259 | Cryptococcus neoformans | 27.0 | 7e-17 | 83.2 |
| LLPS-Phv-2227 | Phaseolus vulgaris | 26.86 | 9e-21 | 94.0 |
| LLPS-Amt-2119 | Amborella trichopoda | 26.51 | 4e-19 | 89.0 |
| LLPS-Lep-1448 | Leersia perrieri | 25.94 | 7e-21 | 97.8 |