LLPS-Mum-3419
Lasp1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | LIM and SH3 domain protein 1 |
| Gene Name: | Lasp1, Mln50 |
| Ensembl Gene: | ENSMUSG00000038366.15 |
| Ensembl Protein: | ENSMUSP00000123050.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
| Stress granule, Others | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000148280.2 | ENSMUSP00000123050.1 |
| Ensembl | ENSMUST00000127033.8 | ENSMUSP00000127792.1 |
| Ensembl | ENSMUST00000138919.1 | ENSMUSP00000114407.1 |
| Ensembl | ENSMUST00000134428.1 | ENSMUSP00000119797.1 |
| Ensembl | ENSMUST00000136723.7 | ENSMUSP00000114306.1 |
| Ensembl | ENSMUST00000143571.1 | ENSMUSP00000116102.1 |
| Ensembl | ENSMUST00000129828.7 | ENSMUSP00000115308.1 |
| Ensembl | ENSMUST00000152962.7 | ENSMUSP00000120645.1 |
| Ensembl | ENSMUST00000155762.2 | ENSMUSP00000119538.1 |
| Ensembl | ENSMUST00000129558.7 | ENSMUSP00000123165.1 |
| Ensembl | ENSMUST00000043843.11 | ENSMUSP00000042123.5 |
| Ensembl | ENSMUST00000153520.2 | ENSMUSP00000120458.1 |
| Ensembl | ENSMUST00000146572.7 | ENSMUSP00000121907.1 |
| UniProt | Q61792, LASP1_MOUSE, Q62416 | |
| GeneBank | U58882, BC010840, AK078445, X96973 | AAH10840.1, CAA65659.1, AAC52639.1, BAC37278.1 |
| RefSeq | NM_010688.4, XM_006532341.1 | NP_034818.1, XP_006532404.1 |
| Entrez | 16796 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MNPNCARCGK IVYPTEKVNC LDKYWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ 60 61 SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRI KKTQDQISNI 120 121 KYHEEFEKSR MGPSGGEGVE PERREAQDSS SYRRPTEQQQ PQPHHIPTSA PVYQQPQQQQ 180 181 MTSSYGGYKE PAAPVSIQRS APGGGGKRYR AVYDYSAADE DEVSFQDGDT IVNVQQIDDG 240 241 WMYGTVERTG DTGMLPANYV EAI 263 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAACCCTA ACTGTGCCCG GTGCGGCAAG ATCGTGTACC CCACGGAGAA GGTGAACTGT 60 61 CTGGATAAGT ACTGGCATAA AGCATGCTTT CACTGCGAGA CCTGCAAGAT GACCCTGAAC 120 121 ATGAAGAACT ACAAGGGTTA TGAGAAGAAG CCTTACTGCA ATGCACACTA TCCCAAGCAG 180 181 TCCTTCACCA TGGTGGCCGA CACTCCGGAA AATCTCCGCC TCAAGCAACA GAGCGAGCTG 240 241 CAGAGTCAGG TGCGCTACAA GGAGGAATTT GAGAAGAATA AGGGCAAAGG TTTCAGCGTG 300 301 GTGGCAGACA CGCCTGAGCT GCAGAGAATC AAGAAGACCC AGGACCAGAT CAGCAATATC 360 361 AAATACCATG AGGAGTTTGA GAAGAGCCGC ATGGGGCCCA GTGGAGGAGA AGGGGTGGAA 420 421 CCAGAGCGCC GAGAAGCCCA GGACAGCAGC AGCTACCGGA GGCCCACAGA GCAGCAGCAG 480 481 CCGCAGCCTC ACCATATCCC GACCAGTGCC CCCGTGTACC AGCAGCCCCA GCAGCAGCAG 540 541 ATGACCTCGT CCTATGGTGG GTACAAGGAG CCAGCAGCCC CTGTCTCCAT ACAGCGCAGT 600 601 GCCCCAGGTG GCGGTGGGAA ACGGTACCGT GCAGTGTATG ACTACAGCGC TGCCGACGAG 660 661 GACGAGGTCT CCTTCCAGGA TGGGGACACC ATCGTCAATG TGCAGCAGAT CGATGACGGC 720 721 TGGATGTACG GGACCGTAGA GCGCACCGGT GACACGGGGA TGCTGCCAGC CAACTACGTG 780 781 GAGGCCATCT GA 792 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cortical actin cytoskeleton | |
Cellular Component | Cytoplasm | |
Cellular Component | Focal adhesion | |
Molecular Function | Actin filament binding | |
Molecular Function | Ion transmembrane transporter activity | |
Molecular Function | Metal ion binding | |
Biological Process | Ion transport |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-2383 | Rattus norvegicus | 98.48 | 1e-179 | 502 |
| LLPS-Ict-1458 | Ictidomys tridecemlineatus | 96.48 | 5e-143 | 408 |
| LLPS-Caf-3346 | Canis familiaris | 95.82 | 1e-167 | 472 |
| LLPS-Poa-2863 | Pongo abelii | 95.82 | 4e-169 | 476 |
| LLPS-Gog-3106 | Gorilla gorilla | 95.82 | 3e-169 | 476 |
| LLPS-Pap-0916 | Pan paniscus | 95.44 | 2e-168 | 474 |
| LLPS-Pat-1845 | Pan troglodytes | 95.44 | 2e-168 | 474 |
| LLPS-Hos-2211 | Homo sapiens | 95.44 | 2e-168 | 474 |
| LLPS-Aon-3887 | Aotus nancymaae | 95.44 | 6e-174 | 488 |
| LLPS-Sus-4710 | Sus scrofa | 95.44 | 4e-170 | 478 |
| LLPS-Dio-0798 | Dipodomys ordii | 95.44 | 1e-170 | 479 |
| LLPS-Man-1542 | Macaca nemestrina | 95.06 | 4e-168 | 473 |
| LLPS-Rhb-2118 | Rhinopithecus bieti | 95.06 | 4e-168 | 473 |
| LLPS-Mam-0764 | Macaca mulatta | 95.06 | 4e-168 | 473 |
| LLPS-Cea-1420 | Cercocebus atys | 95.06 | 4e-168 | 473 |
| LLPS-Chs-1411 | Chlorocebus sabaeus | 95.06 | 2e-172 | 484 |
| LLPS-Maf-3370 | Macaca fascicularis | 95.06 | 4e-168 | 473 |
| LLPS-Caj-2364 | Callithrix jacchus | 95.06 | 5e-173 | 485 |
| LLPS-Paa-3031 | Papio anubis | 95.06 | 4e-168 | 473 |
| LLPS-Otg-1756 | Otolemur garnettii | 94.68 | 1e-171 | 482 |
| LLPS-Fec-3520 | Felis catus | 94.3 | 5e-168 | 473 |
| LLPS-Myl-0387 | Myotis lucifugus | 94.3 | 4e-169 | 475 |
| LLPS-Ova-1636 | Ovis aries | 94.3 | 1e-167 | 471 |
| LLPS-Loa-3714 | Loxodonta africana | 93.54 | 2e-160 | 453 |
| LLPS-Mal-0463 | Mandrillus leucophaeus | 93.47 | 1e-148 | 423 |
| LLPS-Eqc-0643 | Equus caballus | 93.44 | 4e-150 | 431 |
| LLPS-Bot-3357 | Bos taurus | 93.16 | 2e-164 | 464 |
| LLPS-Orc-3577 | Oryctolagus cuniculus | 92.8 | 1e-161 | 456 |
| LLPS-Fud-2806 | Fukomys damarensis | 92.05 | 3e-165 | 466 |
| LLPS-Tut-1054 | Tursiops truncatus | 92.02 | 4e-159 | 450 |
| LLPS-Aim-0271 | Ailuropoda melanoleuca | 91.25 | 1e-154 | 438 |
| LLPS-Ora-2573 | Ornithorhynchus anatinus | 90.67 | 4e-36 | 130 |
| LLPS-Mod-4087 | Monodelphis domestica | 90.64 | 5e-162 | 457 |
| LLPS-Mup-1361 | Mustela putorius furo | 90.49 | 1e-153 | 437 |
| LLPS-Fia-2007 | Ficedula albicollis | 90.16 | 5e-34 | 123 |
| LLPS-Cap-1030 | Cavia porcellus | 90.04 | 2e-141 | 404 |
| LLPS-Gaga-1715 | Gallus gallus | 86.31 | 2e-153 | 435 |
| LLPS-Urm-0659 | Ursus maritimus | 85.5 | 1e-138 | 397 |
| LLPS-Anc-1280 | Anolis carolinensis | 85.34 | 6e-149 | 424 |
| LLPS-Meg-1126 | Meleagris gallopavo | 84.43 | 4e-134 | 386 |
| LLPS-Nol-1534 | Nomascus leucogenys | 83.65 | 4e-138 | 395 |
| LLPS-Sah-3042 | Sarcophilus harrisii | 82.96 | 5e-144 | 412 |
| LLPS-Pes-3026 | Pelodiscus sinensis | 81.33 | 7e-72 | 226 |
| LLPS-Xet-2838 | Xenopus tropicalis | 77.57 | 9e-135 | 388 |
| LLPS-Anp-2909 | Anas platyrhynchos | 73.8 | 3e-120 | 351 |
| LLPS-Tag-2941 | Taeniopygia guttata | 72.88 | 4e-71 | 223 |
| LLPS-Drm-2242 | Drosophila melanogaster | 71.7 | 7e-18 | 87.4 |
| LLPS-Leo-3646 | Lepisosteus oculatus | 68.42 | 1e-109 | 324 |
| LLPS-Scf-2122 | Scleropages formosus | 68.28 | 1e-107 | 318 |
| LLPS-Dar-0475 | Danio rerio | 66.92 | 2e-105 | 312 |
| LLPS-Orl-1162 | Oryzias latipes | 65.78 | 3e-104 | 310 |
| LLPS-Icp-2494 | Ictalurus punctatus | 65.41 | 8e-106 | 314 |
| LLPS-Asm-0146 | Astyanax mexicanus | 65.02 | 3e-103 | 306 |
| LLPS-Orn-2059 | Oreochromis niloticus | 64.36 | 8e-107 | 316 |
| LLPS-Xim-2716 | Xiphophorus maculatus | 63.98 | 6e-102 | 304 |
| LLPS-Scm-1166 | Scophthalmus maximus | 63.5 | 2e-100 | 300 |
| LLPS-Gaa-3689 | Gasterosteus aculeatus | 61.98 | 4e-99 | 297 |
| LLPS-Mea-2419 | Mesocricetus auratus | 61.45 | 8e-106 | 315 |
| LLPS-Cae-1412 | Caenorhabditis elegans | 61.29 | 3e-18 | 86.3 |
| LLPS-Ten-3395 | Tetraodon nigroviridis | 60.08 | 3e-94 | 284 |
| LLPS-Pof-2137 | Poecilia formosa | 57.09 | 3e-87 | 268 |
| LLPS-Cas-2710 | Carlito syrichta | 56.79 | 2e-24 | 108 |
| LLPS-Spr-1544 | Sporisorium reilianum | 55.77 | 4e-10 | 63.9 |
| LLPS-Tar-0742 | Takifugu rubripes | 55.51 | 1e-89 | 272 |
| LLPS-Lac-3716 | Latimeria chalumnae | 54.22 | 9e-25 | 109 |
| LLPS-Usm-1275 | Ustilago maydis | 53.85 | 4e-10 | 63.9 |
| LLPS-Miv-0904 | Microbotryum violaceum | 50.98 | 8e-09 | 60.1 |
| LLPS-Cis-1988 | Ciona savignyi | 50.0 | 2e-09 | 62.0 |
| LLPS-Cii-0216 | Ciona intestinalis | 50.0 | 4e-09 | 60.8 |
| LLPS-Scc-0314 | Schizosaccharomyces cryophilus | 45.9 | 2e-08 | 58.5 |
| LLPS-Nec-0049 | Neurospora crassa | 44.07 | 4e-10 | 63.5 |
| LLPS-Sac-0328 | Saccharomyces cerevisiae | 44.0 | 2e-09 | 61.6 |
| LLPS-Crn-1158 | Cryptococcus neoformans | 43.75 | 2e-10 | 64.7 |
| LLPS-Orbr-1953 | Oryza brachyantha | 43.4 | 7e-09 | 60.5 |
| LLPS-Sob-0284 | Sorghum bicolor | 43.4 | 4e-09 | 60.8 |
| LLPS-Zem-1114 | Zea mays | 43.4 | 1e-08 | 59.7 |
| LLPS-Lep-1979 | Leersia perrieri | 43.4 | 1e-08 | 59.3 |
| LLPS-Brd-1849 | Brachypodium distachyon | 43.4 | 6e-09 | 60.5 |
| LLPS-Sei-2115 | Setaria italica | 43.4 | 3e-09 | 61.2 |
| LLPS-Asg-0548 | Ashbya gossypii | 42.47 | 2e-12 | 70.5 |
| LLPS-Mao-1611 | Magnaporthe oryzae | 41.67 | 2e-08 | 58.9 |
| LLPS-Cogr-0532 | Colletotrichum graminicola | 40.68 | 1e-08 | 59.3 |