LLPS-Mum-3415
Aldh1a1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Retinal dehydrogenase 1 |
| Gene Name: | Aldh1a1, Ahd-2, Ahd2, Aldh1 |
| Ensembl Gene: | ENSMUSG00000053279.7 |
| Ensembl Protein: | ENSMUSP00000153011.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000225313.1 | ENSMUSP00000153011.1 |
| Ensembl | ENSMUST00000087638.3 | ENSMUSP00000084918.3 |
| Ensembl | ENSMUST00000225337.1 | ENSMUSP00000153410.1 |
| UniProt | P24549, AL1A1_MOUSE, Q7TQJ0, Q811J0 | |
| GeneBank | BC044729, M74571, BC054386, M74570, S77047, S75713 | AAH44729.1, AAH54386.1, AAA37202.1, AAA37203.1, AAB32754.2 |
| RefSeq | NM_013467.3 | NP_038495.2 |
| Entrez | 11668 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSSPAQPAVP APLADLKIQH TKIFINNEWH NSVSGKKFPV LNPATEEVIC HVEEGDKADV 60 61 DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLMERDR LLLATMEALN GGKVFANAYL 120 121 SDLGGCIKAL KYCAGWADKI HGQTIPSDGD IFTYTRREPI GVCGQIIPWN FPMLMFIWKI 180 181 GPALSCGNTV VVKPAEQTPL TALHLASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDVD 240 241 KVAFTGSTQV GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDIAVEF AHHGVFYHQG 300 301 QCCVAASRIF VEESVYDEFV KRSVERAKKY VLGNPLTPGI NQGPQIDKEQ HDKILDLIES 360 361 GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSVDDVIKR 420 421 ANNTTYGLAA GLFTKDLDKA ITVSSALQAG VVWVNCYMML SAQCPFGGFK MSGNGRELGE 480 481 HGLYEYTELK TVAMKISQKN S 501 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCTTCGC CTGCACAACC TGCAGTCCCT GCCCCACTGG CCGACTTGAA GATTCAACAT 60 61 ACCAAGATCT TCATAAACAA TGAATGGCAC AATTCAGTGA GCGGCAAGAA ATTTCCAGTT 120 121 CTTAACCCTG CAACTGAGGA GGTCATCTGC CACGTGGAAG AAGGGGACAA GGCTGATGTT 180 181 GACAAAGCTG TGAAGGCTGC AAGACAGGCT TTCCAGATTG GCTCTCCATG GCGCACCATG 240 241 GATGCTTCAG AGAGGGGCCG CCTGCTGAAC AAGCTGGCTG ACTTAATGGA GAGAGATCGT 300 301 CTGCTGCTGG CTACAATGGA GGCACTCAAT GGTGGGAAAG TCTTTGCCAA TGCATACTTG 360 361 TCGGATTTAG GAGGCTGCAT AAAAGCATTA AAGTACTGTG CAGGCTGGGC TGACAAGATT 420 421 CATGGTCAAA CAATACCAAG TGATGGAGAC ATTTTCACTT ATACAAGACG TGAACCTATT 480 481 GGAGTGTGTG GCCAAATCAT CCCCTGGAAT TTTCCAATGC TCATGTTCAT TTGGAAGATA 540 541 GGCCCTGCCC TTAGCTGTGG GAATACCGTG GTTGTCAAGC CAGCAGAGCA AACTCCTCTC 600 601 ACGGCTCTTC ACCTGGCATC TTTAATAAAA GAGGCAGGGT TTCCTCCTGG CGTGGTAAAC 660 661 ATTGTCCCTG GTTATGGGCC AACTGCAGGG GCAGCCATCT CCTCTCACAT GGATGTCGAC 720 721 AAGGTGGCCT TCACTGGATC AACACAGGTT GGCAAGTTAA TCAAGGAAGC TGCAGGGAAA 780 781 AGCAATCTGA AGAGAGTCAC CCTGGAGCTG GGGGGAAAGA GCCCTTGCAT TGTGTTTGCA 840 841 GATGCCGACT TGGACATTGC TGTTGAGTTT GCACACCATG GAGTGTTTTA TCATCAAGGC 900 901 CAATGTTGTG TCGCAGCATC CCGGATTTTT GTTGAGGAGT CAGTTTATGA TGAGTTTGTG 960 961 AAAAGGAGTG TTGAGCGAGC TAAGAAATAT GTTCTTGGAA ATCCTCTGAC CCCAGGAATA 1020 1021 AATCAAGGCC CTCAGATTGA CAAGGAACAA CATGATAAAA TACTCGATCT CATTGAGAGT 1080 1081 GGGAAGAAAG AAGGAGCCAA ACTGGAGTGT GGTGGAGGAC GCTGGGGGAA CAAAGGCTTC 1140 1141 TTTGTGCAGC CCACAGTGTT CTCCAACGTG ACTGATGAGA TGCGCATTGC CAAAGAGGAG 1200 1201 ATATTTGGAC CAGTGCAACA AATCATGAAG TTTAAGTCTG TAGATGATGT GATCAAGAGA 1260 1261 GCAAACAATA CTACCTATGG TTTAGCAGCA GGACTCTTCA CTAAAGACCT GGATAAGGCC 1320 1321 ATCACTGTGT CATCTGCTCT GCAGGCTGGG GTGGTGTGGG TTAACTGCTA TATGATGTTG 1380 1381 TCAGCCCAGT GCCCCTTCGG TGGATTCAAG ATGTCTGGAA ATGGAAGAGA ACTGGGTGAA 1440 1441 CATGGTCTTT ATGAATACAC TGAGCTCAAG ACAGTCGCAA TGAAGATATC TCAGAAGAAC 1500 1501 TCCTAA 1506 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Cytosol | |
Cellular Component | Nucleus | |
Molecular Function | 3-chloroallyl aldehyde dehydrogenase activity | |
Molecular Function | Aldehyde dehydrogenase (NAD) activity | |
Molecular Function | Benzaldehyde dehydrogenase (NAD+) activity | |
Molecular Function | Identical protein binding | |
Molecular Function | NAD binding | |
Molecular Function | Retinal dehydrogenase activity | |
Biological Process | 9-cis-retinoic acid biosynthetic process | |
Biological Process | 9-cis-retinoic acid metabolic process | |
Biological Process | Embryonic eye morphogenesis | |
Biological Process | Negative regulation of cold-induced thermogenesis | |
Biological Process | Optic cup morphogenesis involved in camera-type eye development | |
Biological Process | Oxidation-reduction process | |
Biological Process | Positive regulation of apoptotic process | |
Biological Process | Protein homotetramerization | |
Biological Process | Response to drug | |
Biological Process | Response to ethanol | |
Biological Process | Response to oxidative stress | |
Biological Process | Retinoic acid biosynthetic process | |
Biological Process | Retinoic acid metabolic process | |
Biological Process | Retinoid metabolic process | |
Biological Process | Retinol metabolic process |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CGDB | PIRSF | CellMarker | RaftProt | |
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-3096 | Rattus norvegicus | 97.01 | 0.0 | 989 |
| LLPS-Mea-3292 | Mesocricetus auratus | 90.64 | 0.0 | 927 |
| LLPS-Dio-3015 | Dipodomys ordii | 89.56 | 0.0 | 893 |
| LLPS-Ict-3987 | Ictidomys tridecemlineatus | 88.02 | 0.0 | 912 |
| LLPS-Myl-0599 | Myotis lucifugus | 88.02 | 0.0 | 916 |
| LLPS-Otg-3008 | Otolemur garnettii | 87.82 | 0.0 | 917 |
| LLPS-Sus-3793 | Sus scrofa | 87.23 | 0.0 | 914 |
| LLPS-Hos-2056 | Homo sapiens | 87.03 | 0.0 | 904 |
| LLPS-Pap-1399 | Pan paniscus | 87.03 | 0.0 | 905 |
| LLPS-Pat-2904 | Pan troglodytes | 87.03 | 0.0 | 905 |
| LLPS-Chs-4707 | Chlorocebus sabaeus | 87.03 | 0.0 | 904 |
| LLPS-Nol-1852 | Nomascus leucogenys | 86.83 | 0.0 | 902 |
| LLPS-Mal-2068 | Mandrillus leucophaeus | 86.83 | 0.0 | 902 |
| LLPS-Paa-4482 | Papio anubis | 86.83 | 0.0 | 904 |
| LLPS-Gog-3584 | Gorilla gorilla | 86.83 | 0.0 | 903 |
| LLPS-Cea-0122 | Cercocebus atys | 86.83 | 0.0 | 902 |
| LLPS-Cap-3799 | Cavia porcellus | 86.77 | 0.0 | 902 |
| LLPS-Poa-2030 | Pongo abelii | 86.46 | 0.0 | 892 |
| LLPS-Mam-1041 | Macaca mulatta | 86.43 | 0.0 | 898 |
| LLPS-Man-4649 | Macaca nemestrina | 86.43 | 0.0 | 898 |
| LLPS-Bot-1948 | Bos taurus | 86.43 | 0.0 | 903 |
| LLPS-Maf-3287 | Macaca fascicularis | 86.43 | 0.0 | 898 |
| LLPS-Caj-1294 | Callithrix jacchus | 86.23 | 0.0 | 899 |
| LLPS-Aon-1381 | Aotus nancymaae | 86.23 | 0.0 | 901 |
| LLPS-Rhb-4442 | Rhinopithecus bieti | 86.08 | 0.0 | 896 |
| LLPS-Loa-4342 | Loxodonta africana | 85.57 | 0.0 | 882 |
| LLPS-Fud-3524 | Fukomys damarensis | 85.43 | 0.0 | 879 |
| LLPS-Fec-2720 | Felis catus | 85.03 | 0.0 | 894 |
| LLPS-Mup-4256 | Mustela putorius furo | 85.03 | 0.0 | 891 |
| LLPS-Caf-2318 | Canis familiaris | 84.9 | 0.0 | 859 |
| LLPS-Sah-1778 | Sarcophilus harrisii | 83.13 | 0.0 | 860 |
| LLPS-Tag-3019 | Taeniopygia guttata | 82.29 | 0.0 | 828 |
| LLPS-Mod-1152 | Monodelphis domestica | 81.29 | 0.0 | 838 |
| LLPS-Gaga-2357 | Gallus gallus | 81.16 | 0.0 | 850 |
| LLPS-Fia-3849 | Ficedula albicollis | 81.16 | 0.0 | 851 |
| LLPS-Urm-2842 | Ursus maritimus | 80.99 | 0.0 | 806 |
| LLPS-Scf-3442 | Scleropages formosus | 76.78 | 0.0 | 697 |
| LLPS-Xet-3445 | Xenopus tropicalis | 76.44 | 0.0 | 802 |
| LLPS-Lac-2133 | Latimeria chalumnae | 75.0 | 0.0 | 776 |
| LLPS-Ere-0303 | Erinaceus europaeus | 73.19 | 0.0 | 687 |
| LLPS-Orc-1799 | Oryctolagus cuniculus | 72.73 | 0.0 | 740 |
| LLPS-Cas-4078 | Carlito syrichta | 72.62 | 0.0 | 752 |
| LLPS-Eqc-4326 | Equus caballus | 72.62 | 0.0 | 753 |
| LLPS-Aim-0345 | Ailuropoda melanoleuca | 72.62 | 0.0 | 754 |
| LLPS-Scm-1335 | Scophthalmus maximus | 72.46 | 0.0 | 762 |
| LLPS-Ova-3419 | Ovis aries | 72.41 | 0.0 | 752 |
| LLPS-Meg-2596 | Meleagris gallopavo | 72.22 | 0.0 | 734 |
| LLPS-Leo-0472 | Lepisosteus oculatus | 72.21 | 0.0 | 750 |
| LLPS-Pes-2060 | Pelodiscus sinensis | 71.6 | 0.0 | 739 |
| LLPS-Anp-1400 | Anas platyrhynchos | 71.6 | 0.0 | 742 |
| LLPS-Dar-4010 | Danio rerio | 71.2 | 0.0 | 721 |
| LLPS-Anc-3921 | Anolis carolinensis | 70.62 | 0.0 | 709 |
| LLPS-Asm-1923 | Astyanax mexicanus | 70.08 | 0.0 | 719 |
| LLPS-Gaa-1496 | Gasterosteus aculeatus | 69.84 | 0.0 | 713 |
| LLPS-Xim-0988 | Xiphophorus maculatus | 68.97 | 0.0 | 718 |
| LLPS-Orn-2704 | Oreochromis niloticus | 68.76 | 0.0 | 719 |
| LLPS-Orl-1885 | Oryzias latipes | 68.56 | 0.0 | 711 |
| LLPS-Tar-0755 | Takifugu rubripes | 68.15 | 0.0 | 702 |
| LLPS-Icp-3283 | Ictalurus punctatus | 67.75 | 0.0 | 706 |
| LLPS-Ten-2947 | Tetraodon nigroviridis | 67.71 | 0.0 | 687 |
| LLPS-Cii-0998 | Ciona intestinalis | 67.61 | 0.0 | 686 |
| LLPS-Cis-2091 | Ciona savignyi | 67.48 | 0.0 | 689 |
| LLPS-Ora-2775 | Ornithorhynchus anatinus | 66.6 | 0.0 | 669 |
| LLPS-Pof-1686 | Poecilia formosa | 65.18 | 0.0 | 676 |
| LLPS-Drm-1545 | Drosophila melanogaster | 63.43 | 0.0 | 649 |
| LLPS-Cae-1728 | Caenorhabditis elegans | 62.68 | 0.0 | 635 |
| LLPS-Asn-1584 | Aspergillus nidulans | 59.7 | 0.0 | 561 |
| LLPS-Thc-0999 | Theobroma cacao | 58.65 | 0.0 | 564 |
| LLPS-Art-1050 | Arabidopsis thaliana | 58.39 | 0.0 | 570 |
| LLPS-Zyt-1309 | Zymoseptoria tritici | 58.37 | 0.0 | 564 |
| LLPS-Phv-1195 | Phaseolus vulgaris | 58.32 | 0.0 | 565 |
| LLPS-Met-1672 | Medicago truncatula | 58.28 | 0.0 | 571 |
| LLPS-Nia-1008 | Nicotiana attenuata | 58.07 | 0.0 | 568 |
| LLPS-Glm-1808 | Glycine max | 58.0 | 0.0 | 572 |
| LLPS-Arl-1832 | Arabidopsis lyrata | 57.97 | 0.0 | 567 |
| LLPS-Coc-1204 | Corchorus capsularis | 57.65 | 0.0 | 564 |
| LLPS-Brr-0226 | Brassica rapa | 56.34 | 0.0 | 566 |
| LLPS-Brn-1709 | Brassica napus | 56.34 | 0.0 | 566 |
| LLPS-Bro-1894 | Brassica oleracea | 56.14 | 0.0 | 566 |