LLPS-Mum-3363
Mob1a
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | MOB kinase activator 1A; Mob1 homolog 1B; Mps one binder kinase activator-like 1B |
| Gene Name: | Mob1a, Mobk1b, Mobkl1b |
| Ensembl Gene: | ENSMUSG00000043131.14 |
| Ensembl Protein: | ENSMUSP00000144927.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000155580.3 | ENSMUSP00000144927.1 |
| Ensembl | ENSMUST00000038658.14 | ENSMUSP00000039115.8 |
| Ensembl | ENSMUST00000055261.10 | ENSMUSP00000054452.4 |
| Ensembl | ENSMUST00000101245.3 | ENSMUSP00000098802.2 |
| Ensembl | ENSMUST00000133045.6 | ENSMUSP00000144795.1 |
| UniProt | Q921Y0, MOB1A_MOUSE, Q3TJA6, Q8C194, Q8C1C7 | |
| GeneBank | BC009149, AK167515, BC033463, AK172205, AK028416, AK028695 | BAC26070.1, BAC25938.1, AAH09149.1, BAE39589.1, BAE42880.1, AAH33463.1 |
| RefSeq | NM_145571.2 | NP_663546.1 |
| Entrez | 232157 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSFLFSSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRQAVMLPEG EDLNEWIAVN 60 61 TVDFFNQINM LYGTITEFCT EASCPVMSAG PRYEYHWADG TNIKKPIKCS APKYIDYLMT 120 121 WVQDQLDDET LFPSKIGVPF PKNFMSVAKT ILKRLFRVYA HIYHQHFDSV MQLQEEAHLN 180 181 TSFKHFIFFV QEFNLIDRRE LAPLQELIEK LGSKDR 216 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGCTTCC TCTTCAGCAG CCGCTCTTCG AAAACATTCA AACCAAAGAA GAATATCCCT 60 61 GAAGGGTCCC ATCAGTATGA GCTCTTGAAG CATGCAGAGG CGACTCTCGG AAGTGGCAAT 120 121 CTGAGGCAAG CTGTTATGTT GCCTGAGGGA GAGGACCTCA ATGAATGGAT TGCTGTTAAT 180 181 AGTGTCCCTT TTCCCAAAAA CTTTATGTCT GTGGCAAAGA CTATTCTGAA GCGTCTCTTC 240 241 AGGGTTTATG CCCATATCTA CCACCAGCAC TTTGACTCCG TGATGCAGCT GCAGGAGGAG 300 301 GCTCACCTCA ACACCTCCTT TAAGCACTTT ATTTTCTTTG TTCAGGAGTT TAATCTGATT 360 361 GATAGGCGTG AGTTGGCACC ACTTCAGGAA TTAATTGAGA AGCTTGGATC TAAAGACAGA 420 421 TAA 423 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleolus | |
Cellular Component | Nucleus | |
Molecular Function | Metal ion binding | |
Biological Process | Hippo signaling |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Gog-2435 | Gorilla gorilla | 100.0 | 4e-159 | 446 |
| LLPS-Cea-2382 | Cercocebus atys | 100.0 | 6e-163 | 456 |
| LLPS-Aon-2066 | Aotus nancymaae | 100.0 | 6e-163 | 456 |
| LLPS-Sus-2018 | Sus scrofa | 100.0 | 6e-163 | 456 |
| LLPS-Mup-0818 | Mustela putorius furo | 100.0 | 6e-163 | 456 |
| LLPS-Ova-1096 | Ovis aries | 100.0 | 2e-162 | 455 |
| LLPS-Ran-3290 | Rattus norvegicus | 100.0 | 6e-163 | 456 |
| LLPS-Orc-1984 | Oryctolagus cuniculus | 100.0 | 6e-163 | 456 |
| LLPS-Pes-2520 | Pelodiscus sinensis | 100.0 | 1e-127 | 364 |
| LLPS-Otg-0799 | Otolemur garnettii | 100.0 | 3e-159 | 446 |
| LLPS-Man-0963 | Macaca nemestrina | 100.0 | 6e-163 | 456 |
| LLPS-Fec-1262 | Felis catus | 100.0 | 6e-163 | 456 |
| LLPS-Pat-0861 | Pan troglodytes | 100.0 | 3e-157 | 442 |
| LLPS-Urm-1314 | Ursus maritimus | 100.0 | 6e-163 | 456 |
| LLPS-Pap-0492 | Pan paniscus | 100.0 | 3e-158 | 446 |
| LLPS-Hos-0864 | Homo sapiens | 100.0 | 6e-163 | 456 |
| LLPS-Ict-3906 | Ictidomys tridecemlineatus | 100.0 | 6e-163 | 456 |
| LLPS-Nol-2639 | Nomascus leucogenys | 100.0 | 6e-163 | 456 |
| LLPS-Cas-1564 | Carlito syrichta | 100.0 | 2e-155 | 437 |
| LLPS-Eqc-1473 | Equus caballus | 100.0 | 6e-163 | 456 |
| LLPS-Cap-4273 | Cavia porcellus | 100.0 | 6e-163 | 456 |
| LLPS-Poa-2940 | Pongo abelii | 100.0 | 6e-163 | 456 |
| LLPS-Caf-0039 | Canis familiaris | 100.0 | 6e-163 | 456 |
| LLPS-Myl-0862 | Myotis lucifugus | 99.53 | 3e-160 | 449 |
| LLPS-Loa-2095 | Loxodonta africana | 99.53 | 4e-158 | 444 |
| LLPS-Ten-1248 | Tetraodon nigroviridis | 99.08 | 1e-160 | 450 |
| LLPS-Fud-2469 | Fukomys damarensis | 99.07 | 7e-160 | 448 |
| LLPS-Tar-1305 | Takifugu rubripes | 99.07 | 5e-161 | 451 |
| LLPS-Tut-1642 | Tursiops truncatus | 99.07 | 3e-160 | 449 |
| LLPS-Gaga-1044 | Gallus gallus | 99.07 | 2e-161 | 452 |
| LLPS-Paa-1969 | Papio anubis | 99.06 | 3e-158 | 444 |
| LLPS-Aim-1996 | Ailuropoda melanoleuca | 98.61 | 2e-160 | 449 |
| LLPS-Mam-4317 | Macaca mulatta | 98.61 | 3e-160 | 449 |
| LLPS-Mod-0202 | Monodelphis domestica | 98.58 | 1e-157 | 442 |
| LLPS-Bot-2949 | Bos taurus | 98.17 | 3e-160 | 449 |
| LLPS-Leo-2273 | Lepisosteus oculatus | 98.15 | 1e-159 | 447 |
| LLPS-Scf-1920 | Scleropages formosus | 98.15 | 4e-160 | 449 |
| LLPS-Xim-1647 | Xiphophorus maculatus | 98.15 | 3e-160 | 449 |
| LLPS-Xet-1327 | Xenopus tropicalis | 98.15 | 9e-161 | 450 |
| LLPS-Anp-0870 | Anas platyrhynchos | 98.14 | 5e-159 | 446 |
| LLPS-Orl-0155 | Oryzias latipes | 98.1 | 9e-156 | 439 |
| LLPS-Fia-0462 | Ficedula albicollis | 97.69 | 2e-159 | 447 |
| LLPS-Lac-0036 | Latimeria chalumnae | 97.69 | 8e-159 | 445 |
| LLPS-Meg-2401 | Meleagris gallopavo | 97.69 | 3e-159 | 447 |
| LLPS-Gaa-0731 | Gasterosteus aculeatus | 97.62 | 5e-154 | 434 |
| LLPS-Mea-2184 | Mesocricetus auratus | 96.88 | 1e-114 | 332 |
| LLPS-Scm-0399 | Scophthalmus maximus | 96.74 | 2e-156 | 442 |
| LLPS-Asm-0088 | Astyanax mexicanus | 96.3 | 4e-158 | 444 |
| LLPS-Dio-4310 | Dipodomys ordii | 96.26 | 3e-154 | 434 |
| LLPS-Caj-1379 | Callithrix jacchus | 95.96 | 4e-159 | 447 |
| LLPS-Maf-0442 | Macaca fascicularis | 95.96 | 6e-159 | 446 |
| LLPS-Dar-2097 | Danio rerio | 95.83 | 8e-157 | 440 |
| LLPS-Anc-0504 | Anolis carolinensis | 95.83 | 2e-156 | 439 |
| LLPS-Sah-0323 | Sarcophilus harrisii | 95.73 | 1e-152 | 430 |
| LLPS-Chs-0085 | Chlorocebus sabaeus | 95.73 | 9e-153 | 430 |
| LLPS-Mal-0101 | Mandrillus leucophaeus | 95.73 | 9e-153 | 430 |
| LLPS-Rhb-3269 | Rhinopithecus bieti | 95.73 | 9e-153 | 430 |
| LLPS-Pof-1797 | Poecilia formosa | 95.48 | 3e-157 | 441 |
| LLPS-Icp-0575 | Ictalurus punctatus | 95.33 | 3e-154 | 434 |
| LLPS-Tag-1979 | Taeniopygia guttata | 94.44 | 1e-154 | 435 |
| LLPS-Orn-0079 | Oreochromis niloticus | 93.98 | 1e-154 | 434 |
| LLPS-Ora-0953 | Ornithorhynchus anatinus | 92.13 | 3e-148 | 419 |
| LLPS-Drm-0084 | Drosophila melanogaster | 86.51 | 2e-141 | 402 |
| LLPS-Cis-0288 | Ciona savignyi | 82.41 | 2e-135 | 386 |
| LLPS-Cii-0030 | Ciona intestinalis | 81.94 | 4e-134 | 383 |
| LLPS-Tru-2036 | Triticum urartu | 70.27 | 9e-100 | 295 |
| LLPS-Php-0125 | Physcomitrella patens | 69.54 | 2e-79 | 242 |
| LLPS-Zem-1534 | Zea mays | 69.46 | 2e-108 | 318 |
| LLPS-Orni-1886 | Oryza nivara | 69.15 | 2e-107 | 318 |
| LLPS-Sob-0634 | Sorghum bicolor | 68.98 | 3e-97 | 290 |
| LLPS-Mae-0755 | Manihot esculenta | 68.9 | 4e-111 | 324 |
| LLPS-Brd-0872 | Brachypodium distachyon | 68.78 | 3e-108 | 319 |
| LLPS-Nia-1569 | Nicotiana attenuata | 68.42 | 5e-110 | 322 |
| LLPS-Orb-0067 | Oryza barthii | 68.4 | 5e-110 | 322 |
| LLPS-Orgl-0152 | Oryza glumaepatula | 68.4 | 5e-110 | 322 |
| LLPS-Orr-0297 | Oryza rufipogon | 68.4 | 5e-110 | 322 |
| LLPS-Vir-0551 | Vigna radiata | 68.11 | 8e-96 | 293 |
| LLPS-Via-1574 | Vigna angularis | 68.11 | 1e-98 | 291 |
| LLPS-Arl-1640 | Arabidopsis lyrata | 67.61 | 5e-110 | 322 |
| LLPS-Art-2021 | Arabidopsis thaliana | 67.61 | 5e-110 | 322 |
| LLPS-Spr-0222 | Sporisorium reilianum | 67.61 | 2e-107 | 315 |
| LLPS-Orm-0741 | Oryza meridionalis | 67.48 | 3e-107 | 314 |
| LLPS-Sot-0504 | Solanum tuberosum | 67.46 | 2e-109 | 320 |
| LLPS-Miv-0402 | Microbotryum violaceum | 67.32 | 8e-107 | 313 |
| LLPS-Gor-1462 | Gossypium raimondii | 67.31 | 1e-107 | 316 |
| LLPS-Thc-1375 | Theobroma cacao | 67.3 | 1e-108 | 318 |
| LLPS-Mua-0540 | Musa acuminata | 67.3 | 5e-109 | 319 |
| LLPS-Ori-0938 | Oryza indica | 67.3 | 3e-109 | 319 |
| LLPS-Glm-0802 | Glycine max | 67.3 | 1e-107 | 316 |
| LLPS-Tra-0608 | Triticum aestivum | 67.3 | 4e-109 | 319 |
| LLPS-Cus-1230 | Cucumis sativus | 67.3 | 6e-110 | 321 |
| LLPS-Met-1763 | Medicago truncatula | 67.3 | 4e-108 | 317 |
| LLPS-Hov-1385 | Hordeum vulgare | 67.3 | 3e-109 | 319 |
| LLPS-Lep-0146 | Leersia perrieri | 67.3 | 2e-109 | 320 |
| LLPS-Phv-1231 | Phaseolus vulgaris | 67.3 | 6e-108 | 316 |
| LLPS-Orbr-1259 | Oryza brachyantha | 67.3 | 2e-109 | 320 |
| LLPS-Orp-0517 | Oryza punctata | 67.3 | 2e-109 | 320 |
| LLPS-Ors-2019 | Oryza sativa | 67.3 | 2e-109 | 320 |
| LLPS-Org-0027 | Oryza glaberrima | 67.3 | 2e-109 | 320 |
| LLPS-Prp-0824 | Prunus persica | 67.3 | 8e-109 | 318 |
| LLPS-Coc-0338 | Corchorus capsularis | 67.3 | 4e-109 | 319 |
| LLPS-Amt-0529 | Amborella trichopoda | 67.16 | 3e-106 | 313 |
| LLPS-Sei-0674 | Setaria italica | 67.15 | 6e-106 | 311 |
| LLPS-Brn-1385 | Brassica napus | 67.14 | 2e-109 | 320 |
| LLPS-Brr-0428 | Brassica rapa | 67.14 | 2e-109 | 320 |
| LLPS-Viv-2393 | Vitis vinifera | 67.14 | 5e-107 | 314 |
| LLPS-Bro-1145 | Brassica oleracea | 67.14 | 2e-109 | 320 |
| LLPS-Dac-0661 | Daucus carota | 66.99 | 8e-109 | 318 |
| LLPS-Pot-1415 | Populus trichocarpa | 66.98 | 1e-107 | 316 |
| LLPS-Usm-0313 | Ustilago maydis | 66.67 | 6e-107 | 314 |
| LLPS-Sem-0540 | Selaginella moellendorffii | 66.35 | 3e-108 | 317 |
| LLPS-Sol-2196 | Solanum lycopersicum | 66.35 | 1e-108 | 318 |
| LLPS-Put-0733 | Puccinia triticina | 65.38 | 5e-88 | 265 |
| LLPS-Hea-0957 | Helianthus annuus | 65.07 | 4e-105 | 309 |
| LLPS-Pug-0058 | Puccinia graminis | 63.24 | 1e-95 | 286 |
| LLPS-Mel-0186 | Melampsora laricipopulina | 62.2 | 9e-96 | 285 |
| LLPS-Crn-1330 | Cryptococcus neoformans | 61.72 | 2e-93 | 280 |
| LLPS-Chr-0668 | Chlamydomonas reinhardtii | 60.66 | 4e-98 | 291 |
| LLPS-Scp-0060 | Schizosaccharomyces pombe | 57.42 | 3e-89 | 268 |
| LLPS-Scj-0962 | Schizosaccharomyces japonicus | 56.6 | 6e-87 | 263 |
| LLPS-Yal-0812 | Yarrowia lipolytica | 55.98 | 2e-81 | 249 |
| LLPS-Scc-0727 | Schizosaccharomyces cryophilus | 55.07 | 5e-84 | 255 |
| LLPS-Asc-0178 | Aspergillus clavatus | 54.03 | 2e-79 | 246 |
| LLPS-Nef-0878 | Neosartorya fischeri | 54.03 | 3e-79 | 246 |
| LLPS-Asfu-0012 | Aspergillus fumigatus | 54.03 | 2e-79 | 246 |
| LLPS-Ere-0165 | Erinaceus europaeus | 53.69 | 3e-82 | 251 |
| LLPS-Asf-1159 | Aspergillus flavus | 53.55 | 4e-81 | 248 |
| LLPS-Ast-0457 | Aspergillus terreus | 53.52 | 2e-80 | 248 |
| LLPS-Asni-1128 | Aspergillus niger | 53.08 | 6e-80 | 246 |
| LLPS-Pytr-0236 | Pyrenophora triticirepentis | 52.38 | 4e-77 | 238 |
| LLPS-Asn-0898 | Aspergillus nidulans | 52.13 | 3e-79 | 243 |
| LLPS-Pyt-1045 | Pyrenophora teres | 51.61 | 1e-76 | 243 |
| LLPS-Scs-0097 | Sclerotinia sclerotiorum | 51.18 | 2e-77 | 239 |
| LLPS-Trr-0602 | Trichoderma reesei | 50.93 | 1e-74 | 233 |
| LLPS-Blg-0227 | Blumeria graminis | 50.71 | 8e-78 | 239 |
| LLPS-Chc-0446 | Chondrus crispus | 50.49 | 2e-74 | 231 |
| LLPS-Mao-1101 | Magnaporthe oryzae | 50.24 | 1e-75 | 234 |
| LLPS-Gag-0422 | Gaeumannomyces graminis | 50.24 | 1e-76 | 236 |
| LLPS-Aso-0453 | Aspergillus oryzae | 50.0 | 1e-77 | 240 |
| LLPS-Map-0333 | Magnaporthe poae | 49.77 | 6e-76 | 235 |