LLPS-Mum-3354
Cep63
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Centrosomal protein of 63 kDa |
| Gene Name: | Cep63, D9Mgc48e |
| Ensembl Gene: | ENSMUSG00000032534.18 |
| Ensembl Protein: | ENSMUSP00000150702.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and in delay mitotic progression. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000215253.1 | ENSMUSP00000150702.1 |
| Ensembl | ENSMUST00000162297.1 | ENSMUSP00000125705.1 |
| Ensembl | ENSMUST00000162655.8 | ENSMUSP00000125621.1 |
| Ensembl | ENSMUST00000213636.1 | ENSMUSP00000150899.1 |
| Ensembl | ENSMUST00000159100.1 | ENSMUSP00000124836.1 |
| Ensembl | ENSMUST00000161645.7 | ENSMUSP00000123954.1 |
| Ensembl | ENSMUST00000216281.1 | ENSMUSP00000149157.1 |
| Ensembl | ENSMUST00000093791.9 | ENSMUSP00000091306.3 |
| UniProt | Q3UPP8, CEP63_MOUSE, Q80ZM0 | |
| GeneBank | BC048718, AL450317, AK143341, CT573150 | BAE25347.1, AAH48718.1 |
| RefSeq | XM_006511745.3, XM_017313410.1, XM_017313414.1 | XP_006511808.1, XP_017168899.1, XP_017168903.1 |
| Entrez | 28135 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MPGCGCPVVA PLGSSSSLWD SGLAGQTTAM NWWPSNLQRW KSRSSRTQSC CQNKEDLEME 60 61 ALLEGIQNRG HSGGFLTSCE AELQELMKQI DIMVAHKKSE WEGQTHALET CLDIRDRELK 120 121 ALRSQLDMKH KEVGILHQQI EEHEKTKQEM AMEYKEELLK LQEELSRLKR SYEKLQKKQL 180 181 REFRGNTKSF REDRSEIERL TGKIEEFRQK SLDWEKQRLI YQQQVSSLEA QRKALAEQSE 240 241 IIQAQLANRK QKLESVELSS QSEIQHLNSK LERAKDTICA NELEIERLNI RVNDLMGTNM 300 301 TILQDHRQKE EKLRESEKLL EALQEEQKEL KASLQSQETF ILEAKMQEKL QTTLKAVGTQ 360 361 QSVERPLEDC QKERKYSSPG QGVLDNVLSQ LDFSHSSEEL LQAEVTRLEG SLESVSATCK 420 421 QLSQELMEKY EELKRMEGHN NEYRTEIKKL KEQILQADQT YSSALEGMKM EISQLTRELH 480 481 QRDITIASAK CSSSDMEKQL KAEMQKAEEK AVEHKEILSQ LESLKLENHR LSETVMKLEL 540 541 GLHEAKEISL ADLQENYIEA LNKLVSENQQ LQKDLMSTKS ELEHATNMCK KKDGEIFNPA 600 601 HSRAAGFKNA ELKPIHGQHR HDGIKTEQYK TGHHSPRGQT LDSIDPVARG PSPLSSHISP 660 661 GSSTVSLPSN FLFEAHSLPS VLDINDVNFS DSLSDCMNDQ EEFVSSGSLP TSPLGSIATR 720 721 FLEEEELRSH HILERLDAHI EELKRESEKT VRQFTALV 758 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCCGGGTT GCGGCTGCCC GGTCGTCGCG CCCCTGGGTT CCTCCTCCTC CCTATGGGAC 60 61 TCTGGGCTGG CCGGCCAGAC TACAGCAATG AATTGGTGGC CTAGCAACCT CCAAAGATGG 120 121 AAAAGCCGAA GTTCGAGGAC ACAGAGCTGT TGCCAAAACA AAGAGGATTT AGAGATGGAG 180 181 GCTTTGTTGG AAGGAATACA AAATCGGGGG CATAGTGGGG GATTTTTGAC ATCCTGTGAA 240 241 GCAGAACTGC AAGAGCTCAT GAAACAGATC GATATAATGG TGGCTCATAA GAAGTCGGAG 300 301 TGGGAGGGGC AGACGCACGC TCTGGAGACT TGCTTGGACA TCCGTGATCG GGAGCTGAAG 360 361 GCTCTGAGGA GTCAGCTGGA CATGAAGCAC AAAGAGGTTG GAATATTGCA TCAGCAGATA 420 421 GAAGAACATG AGAAAACCAA GCAAGAAATG GCCATGGAGT ACAAGGAGGA GTTACTGAAG 480 481 CTGCAGGAGG AATTAAGCAG ACTGAAGAGA AGCTATGAAA AGCTGCAGAA AAAGCAACTA 540 541 AGAGAATTTA GAGGAAATAC CAAAAGTTTT CGAGAGGATC GGTCTGAGAT TGAGAGGCTA 600 601 ACTGGAAAAA TAGAGGAATT CCGACAGAAG TCTCTGGACT GGGAGAAGCA GCGTCTGATT 660 661 TATCAGCAAC AGGTATCTTC TCTGGAAGCA CAGAGGAAGG CTCTGGCTGA ACAGTCGGAG 720 721 ATAATCCAGG CTCAGCTTGC CAACCGGAAA CAGAAATTAG AGTCCGTGGA ACTATCTAGC 780 781 CAGTCAGAAA TTCAACACCT GAACAGTAAG CTTGAGCGGG CTAAGGACAC CATCTGTGCC 840 841 AATGAGCTGG AAATAGAGCG CCTTAACATA AGGGTCAACG ACCTGATGGG AACCAATATG 900 901 ACTATCCTGC AGGACCATCG GCAGAAGGAG GAGAAACTAA GGGAATCTGA GAAGTTACTA 960 961 GAGGCTCTGC AGGAAGAACA GAAAGAGTTG AAGGCAAGTC TTCAATCTCA AGAAACCTTC 1020 1021 ATCCTTGAGG CAAAAATGCA GGAGAAACTG CAAACGACAT TAAAGGCAGT TGGCACTCAG 1080 1081 CAGTCCGTAG AAAGGCCTCT GGAGGACTGT CAGAAGGAAA GGAAGTACAG CTCTCCAGGG 1140 1141 CAAGGAGTCT TGGATAATGT GCTCTCCCAG CTGGACTTCA GCCACAGCAG TGAAGAACTC 1200 1201 CTGCAGGCAG AGGTGACGCG TCTTGAAGGC AGTTTAGAAT CTGTGAGTGC AACATGCAAA 1260 1261 CAGCTGAGCC AAGAACTAAT GGAAAAATAC GAAGAGCTGA AGAGGATGGA AGGGCATAAC 1320 1321 AATGAGTACC GGACAGAGAT AAAGAAGTTG AAGGAACAGA TTCTGCAGGC TGATCAGACC 1380 1381 TACAGTTCTG CCCTGGAAGG AATGAAGATG GAAATCTCCC AGCTAACTCG GGAGTTGCAC 1440 1441 CAGCGAGATA TCACTATTGC TTCTGCCAAG TGTTCCTCCT CAGACATGGA AAAGCAGCTG 1500 1501 AAGGCAGAGA TGCAGAAGGC AGAAGAAAAG GCTGTAGAGC ATAAGGAGAT TCTAAGTCAG 1560 1561 CTGGAATCTC TCAAATTAGA AAATCATCGT CTTTCTGAAA CAGTGATGAA GCTGGAACTG 1620 1621 GGCTTGCATG AGGCAAAAGA GATTTCACTA GCAGACCTTC AGGAGAATTA TATTGAGGCC 1680 1681 TTAAATAAAT TAGTGTCTGA AAATCAACAA CTGCAGAAAG ATTTGATGAG CACCAAATCT 1740 1741 GAGCTGGAGC ATGCTACTAA CATGTGCAAA AAAAAAGATG GCGAGATCTT TAACCCAGCA 1800 1801 CACAGCAGAG CTGCCGGGTT CAAGAATGCA GAGCTTAAGC CAATCCATGG CCAGCACAGA 1860 1861 CATGACGGAA TAAAGACCGA GCAGTACAAA ACAGGTCACC ACTCGCCTCG AGGACAAACG 1920 1921 TTGGATAGCA TAGACCCTGT GGCCAGGGGT CCCAGCCCCC TGAGTTCTCA CATCAGCCCC 1980 1981 GGCAGCTCCA CCGTCTCTCT GCCTTCCAAC TTTCTATTTG AGGCTCACTC TTTGCCTTCA 2040 2041 GTGCTAGATA TAAATGATGT CAACTTTTCT GACAGTCTGT CTGACTGTAT GAATGACCAA 2100 2101 GAAGAGTTTG TATCTTCGGG CTCGCTGCCC ACCTCTCCTC TGGGATCGAT AGCTACCAGG 2160 2161 TTTCTGGAAG AGGAGGAGCT GAGGTCTCAC CATATTCTAG AGCGCCTGGA CGCCCACATT 2220 2221 GAAGAACTGA AAAGAGAGAG TGAGAAGACG GTGAGGCAGT TCACAGCCCT CGTGTAG 2277 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Centriole | |
Cellular Component | Centrosome | |
Cellular Component | Spindle pole | |
Biological Process | Cell division | |
Biological Process | Centriole replication | |
Biological Process | Centrosome duplication | |
Biological Process | De novo centriole assembly involved in multi-ciliated epithelial cell differentiation | |
Biological Process | DNA damage checkpoint | |
Biological Process | Meiotic telomere clustering | |
Biological Process | Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator | |
Biological Process | Protein localization to centrosome | |
Biological Process | Reciprocal meiotic recombination | |
Biological Process | Signal transduction in response to DNA damage | |
Biological Process | Spindle assembly |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Poa-4354 | Pongo abelii | 100.0 | 2e-15 | 84.3 |
| LLPS-Chs-2294 | Chlorocebus sabaeus | 100.0 | 2e-15 | 84.0 |
| LLPS-Mup-3652 | Mustela putorius furo | 95.12 | 3e-14 | 80.5 |
| LLPS-Ran-2210 | Rattus norvegicus | 93.14 | 0.0 | 1165 |
| LLPS-Mea-3373 | Mesocricetus auratus | 88.19 | 0.0 | 1182 |
| LLPS-Fud-4067 | Fukomys damarensis | 82.02 | 0.0 | 1060 |
| LLPS-Pat-3060 | Pan troglodytes | 81.77 | 0.0 | 1008 |
| LLPS-Caf-3005 | Canis familiaris | 81.77 | 0.0 | 1013 |
| LLPS-Cap-4361 | Cavia porcellus | 81.65 | 0.0 | 1008 |
| LLPS-Ict-4029 | Ictidomys tridecemlineatus | 81.65 | 0.0 | 1005 |
| LLPS-Pap-0243 | Pan paniscus | 81.62 | 0.0 | 1006 |
| LLPS-Man-0768 | Macaca nemestrina | 81.62 | 0.0 | 1000 |
| LLPS-Cea-2994 | Cercocebus atys | 81.62 | 0.0 | 1001 |
| LLPS-Gog-2501 | Gorilla gorilla | 81.62 | 0.0 | 1009 |
| LLPS-Hos-2513 | Homo sapiens | 81.48 | 0.0 | 1001 |
| LLPS-Sus-4564 | Sus scrofa | 81.46 | 0.0 | 1008 |
| LLPS-Mam-4356 | Macaca mulatta | 81.34 | 0.0 | 997 |
| LLPS-Maf-3851 | Macaca fascicularis | 81.05 | 0.0 | 993 |
| LLPS-Paa-1708 | Papio anubis | 81.05 | 0.0 | 991 |
| LLPS-Dio-1755 | Dipodomys ordii | 80.94 | 0.0 | 984 |
| LLPS-Bot-1765 | Bos taurus | 80.82 | 0.0 | 1003 |
| LLPS-Nol-3550 | Nomascus leucogenys | 80.77 | 0.0 | 996 |
| LLPS-Caj-0545 | Callithrix jacchus | 80.63 | 0.0 | 986 |
| LLPS-Cas-3973 | Carlito syrichta | 80.48 | 0.0 | 988 |
| LLPS-Aon-3065 | Aotus nancymaae | 80.48 | 0.0 | 985 |
| LLPS-Urm-3661 | Ursus maritimus | 80.34 | 0.0 | 998 |
| LLPS-Aim-2806 | Ailuropoda melanoleuca | 80.34 | 0.0 | 993 |
| LLPS-Rhb-4081 | Rhinopithecus bieti | 80.06 | 0.0 | 993 |
| LLPS-Ova-2381 | Ovis aries | 79.97 | 0.0 | 1004 |
| LLPS-Myl-3613 | Myotis lucifugus | 79.06 | 0.0 | 962 |
| LLPS-Loa-4162 | Loxodonta africana | 78.9 | 0.0 | 982 |
| LLPS-Fec-4784 | Felis catus | 78.63 | 0.0 | 950 |
| LLPS-Mal-2261 | Mandrillus leucophaeus | 78.35 | 0.0 | 943 |
| LLPS-Orc-2773 | Oryctolagus cuniculus | 78.03 | 0.0 | 929 |
| LLPS-Eqc-3705 | Equus caballus | 77.98 | 0.0 | 1006 |
| LLPS-Otg-1367 | Otolemur garnettii | 77.1 | 0.0 | 928 |
| LLPS-Tag-3476 | Taeniopygia guttata | 71.05 | 8e-07 | 56.6 |
| LLPS-Mod-4212 | Monodelphis domestica | 56.1 | 0.0 | 591 |
| LLPS-Ora-1933 | Ornithorhynchus anatinus | 55.63 | 5e-76 | 253 |
| LLPS-Anp-2432 | Anas platyrhynchos | 55.43 | 0.0 | 585 |
| LLPS-Meg-1547 | Meleagris gallopavo | 54.69 | 0.0 | 570 |
| LLPS-Gaga-1683 | Gallus gallus | 54.6 | 0.0 | 573 |
| LLPS-Sah-0391 | Sarcophilus harrisii | 51.54 | 0.0 | 547 |
| LLPS-Fia-3494 | Ficedula albicollis | 51.31 | 2e-168 | 509 |
| LLPS-Pes-1170 | Pelodiscus sinensis | 50.35 | 5e-167 | 506 |
| LLPS-Anc-1365 | Anolis carolinensis | 43.46 | 4e-128 | 403 |
| LLPS-Lac-1512 | Latimeria chalumnae | 41.58 | 4e-92 | 308 |
| LLPS-Xet-3550 | Xenopus tropicalis | 40.22 | 1e-72 | 254 |
| LLPS-Pof-1721 | Poecilia formosa | 40.0 | 2e-28 | 125 |
| LLPS-Orl-0536 | Oryzias latipes | 40.0 | 1e-20 | 101 |
| LLPS-Icp-3859 | Ictalurus punctatus | 39.64 | 1e-81 | 281 |
| LLPS-Scf-1345 | Scleropages formosus | 39.58 | 3e-83 | 286 |
| LLPS-Leo-1012 | Lepisosteus oculatus | 39.46 | 2e-106 | 348 |
| LLPS-Asm-1759 | Astyanax mexicanus | 36.11 | 1e-86 | 295 |
| LLPS-Dar-1676 | Danio rerio | 36.07 | 2e-82 | 283 |
| LLPS-Gaa-3902 | Gasterosteus aculeatus | 33.4 | 1e-40 | 160 |
| LLPS-Scm-2003 | Scophthalmus maximus | 32.97 | 8e-61 | 224 |
| LLPS-Xim-2655 | Xiphophorus maculatus | 32.42 | 1e-47 | 183 |
| LLPS-Orn-1573 | Oreochromis niloticus | 31.53 | 2e-54 | 204 |