LLPS-Mum-3345
Cnot10

▼ OVERVIEW

Status: Unreviewed
Protein Name: CCR4-NOT transcription complex subunit 10
Gene Name: Cnot10
Ensembl Gene: ENSMUSG00000056167.7
Ensembl Protein: ENSMUSP00000149867.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-body, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAADKPADQG  AEKHEGAGQS  SGVTDQEKEL  SASALQAFTS  GNYDACLQHL  ACLQDINKDD  60
61    YKIILNTAVA  EFFKNNQTTT  DNLRQTLNQL  KNQVHSAVEE  MDGLDDVENS  MLYYNQAVIL  120
121   YHLRQYTEAI  SVGEKLYQFI  EPFEEKFAQA  VCFLLVDLYI  LTHQAEKALH  LLAVLEKMIS  180
181   QGSGGKNGKN  ETGNNSSKDG  SNPKAESAAL  IEAAKSKIHQ  YKVRGYIQMK  SLKACKREIK  240
241   SVMNTAGNSA  PSLFLKSNFE  YLRGNYRKAV  KLLNSSNIAE  HPGFMKTGEC  LRCMFWNNLG  300
301   CIHFAMSKHN  LGIFYFKKAL  QENDNVCAQL  SAGGTDPGKK  FSGRPMCTLL  TNKRYELLYN  360
361   CGIQLLHVGR  PLAAFECLIE  AVQVYHANPR  LWLRLAECCI  AANKGTSEQE  TKGLPTKKGI  420
421   VQSIVGQGYH  RKIVLASQSI  QNTVYNDGQS  SAIPVASVEF  AAICLRNALL  LLPEEQQDPK  480
481   QENGSKSSSQ  LGGNTESSES  SETCSSKSHD  GDKFIPAPPS  SPLRKQELEN  LKCSILACSA  540
541   YVALALGDNL  MALNHADQLL  QQPKLSGSLK  FLGHLYAAEA  LISLDRISDA  ITHLNPENVT  600
601   DVSLGISSNE  QDQGSDKGEN  EAMESSGKRA  PQCYPSSVNS  ARTVMLFNLG  SAYCLRSEYD  660
661   KARKCLHQAA  SMIHPKEVPP  EAILLAVYLE  LQNGNTQLAL  QMIKRNQLLP  AVKAHSDVRK  720
721   KTVFQPVHPI  QPIQMPAFTT  VQRK  744
Nucleotide CDS Sequence (FASTA)
1     ATGGCTGCAG  ACAAGCCTGC  AGATCAGGGA  GCAGAGAAGC  ATGAAGGGGC  AGGCCAATCA  60
61    TCTGGGGTCA  CGGACCAGGA  GAAGGAGCTG  TCCGCCAGTG  CCCTCCAGGC  CTTCACGTCT  120
121   GGAAATTATG  ATGCCTGTCT  GCAACACCTT  GCCTGTCTCC  AAGATATAAA  CAAAGATGAT  180
181   TACAAAATTA  TTCTGAATAC  AGCAGTAGCT  GAATTTTTTA  AAAATAATCA  AACAACAACA  240
241   GATAATTTGA  GACAAACACT  TAACCAGCTG  AAGAATCAGG  TCCACTCGGC  TGTTGAAGAG  300
301   ATGGATGGGT  TAGACGATGT  TGAGAACAGC  ATGCTGTATT  ATAACCAGGC  TGTCATTCTC  360
361   TATCATCTGC  GCCAGTACAC  GGAGGCCATA  TCTGTCGGCG  AGAAGCTCTA  TCAGTTCATA  420
421   GAACCTTTCG  AAGAAAAATT  TGCCCAAGCG  GTGTGCTTTT  TGCTCGTAGA  CTTGTATATA  480
481   TTAACCCACC  AGGCTGAGAA  AGCTCTGCAT  CTTCTTGCCG  TCCTAGAAAA  AATGATTTCA  540
541   CAGGGTAGCG  GTGGCAAAAA  TGGGAAGAAC  GAGACTGGCA  ATAACAGCAG  CAAAGATGGA  600
601   TCCAACCCTA  AGGCTGAGAG  TGCAGCTCTA  ATAGAGGCTG  CCAAGTCCAA  GATACACCAG  660
661   TACAAAGTCA  GAGGGTACAT  CCAGATGAAG  TCCCTGAAGG  CTTGCAAAAG  GGAAATCAAG  720
721   TCTGTCATGA  ACACAGCTGG  AAATTCTGCA  CCTTCCCTGT  TTCTTAAAAG  CAACTTTGAG  780
781   TACTTAAGGG  GCAACTATCG  AAAAGCGGTG  AAGCTGTTGA  ATAGTTCAAA  CATTGCCGAG  840
841   CATCCAGGCT  TCATGAAGAC  AGGTGAATGC  TTGAGATGCA  TGTTCTGGAA  TAACCTTGGT  900
901   TGTATCCATT  TTGCCATGAG  CAAGCACAAT  TTGGGGATTT  TCTACTTCAA  GAAGGCTCTG  960
961   CAGGAAAATG  ACAACGTCTG  CGCCCAGCTC  AGTGCGGGTG  GCACTGATCC  AGGCAAAAAG  1020
1021  TTTTCTGGAA  GACCCATGTG  TACATTGCTG  ACCAACAAAA  GATATGAGCT  GCTCTACAAC  1080
1081  TGTGGGATCC  AGCTGCTGCA  CGTCGGGAGG  CCTCTCGCTG  CCTTCGAGTG  TCTGATTGAA  1140
1141  GCTGTTCAGG  TGTACCACGC  GAATCCTCGT  CTCTGGCTAC  GGCTGGCTGA  GTGCTGCATT  1200
1201  GCTGCCAATA  AAGGGACTTC  TGAGCAAGAA  ACTAAAGGTC  TTCCCACCAA  AAAAGGCATT  1260
1261  GTACAGTCTA  TTGTTGGTCA  GGGATATCAC  CGTAAAATAG  TTCTGGCATC  ACAGTCAATT  1320
1321  CAGAACACTG  TCTACAATGA  TGGTCAGTCT  TCAGCCATTC  CTGTAGCCAG  TGTGGAGTTT  1380
1381  GCAGCCATCT  GTCTCAGAAA  TGCCTTGTTG  CTGTTACCTG  AAGAACAGCA  AGATCCCAAG  1440
1441  CAGGAAAATG  GCTCCAAGAG  CAGCAGCCAG  CTTGGAGGGA  ACACGGAAAG  CAGCGAGAGC  1500
1501  AGCGAGACGT  GCAGCAGTAA  GAGCCATGAT  GGAGATAAGT  TCATTCCCGC  TCCACCGTCT  1560
1561  TCTCCGCTGA  GGAAACAGGA  GTTAGAAAAC  CTCAAGTGCT  CCATCCTTGC  TTGCAGTGCT  1620
1621  TATGTGGCTC  TGGCCTTAGG  TGATAACCTC  ATGGCTTTGA  ACCATGCAGA  TCAGCTCCTG  1680
1681  CAGCAGCCCA  AGCTGTCTGG  CTCTCTTAAA  TTTTTGGGCC  ATTTATATGC  CGCAGAAGCC  1740
1741  CTCATCTCCC  TCGACAGGAT  ATCTGATGCC  ATTACACACT  TGAACCCAGA  GAATGTCACT  1800
1801  GATGTCTCCT  TAGGGATCTC  TTCAAATGAG  CAGGACCAAG  GATCAGACAA  GGGTGAAAAT  1860
1861  GAAGCAATGG  AATCCTCTGG  CAAGCGCGCC  CCTCAGTGCT  ACCCCAGTTC  TGTGAACTCT  1920
1921  GCCCGGACTG  TGATGCTCTT  CAACCTGGGC  AGTGCCTACT  GCCTGAGGAG  CGAGTACGAC  1980
1981  AAGGCCCGAA  AGTGTCTGCA  TCAGGCGGCA  TCGATGATCC  ATCCTAAGGA  GGTGCCCCCT  2040
2041  GAAGCCATCC  TGCTGGCTGT  CTACCTTGAG  CTGCAGAATG  GTAATACACA  GCTGGCCTTG  2100
2101  CAGATGATCA  AGCGGAACCA  GCTGCTCCCC  GCAGTAAAGG  CGCACTCTGA  TGTGAGGAAG  2160
2161  AAGACAGTGT  TCCAGCCCGT  GCACCCCATC  CAGCCCATCC  AAATGCCAGC  GTTCACCACC  2220
2221  GTGCAGAGGA  AGTGA  2235

▼ KEYWORD

ID
Family
Acetylation
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Nucleus
Reference proteome
RNA-mediated gene silencing
Transcription
Transcription regulation
Translation regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
CCR4-NOT complex
Cellular Component
Cytoplasm
Cellular Component
Nucleus
Biological Process
Gene silencing by RNA
Biological Process
MRNA catabolic process
Biological Process
Negative regulation of translation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-2862Rattus norvegicus98.350.01087
LLPS-Mea-1212Mesocricetus auratus97.980.01451
LLPS-Chs-2334Chlorocebus sabaeus96.560.01281
LLPS-Mam-0251Macaca mulatta96.520.01320
LLPS-Man-0256Macaca nemestrina96.210.01418
LLPS-Hos-2467Homo sapiens96.210.01419
LLPS-Mal-3854Mandrillus leucophaeus96.210.01418
LLPS-Gog-3693Gorilla gorilla96.210.01419
LLPS-Cea-0964Cercocebus atys96.210.01418
LLPS-Maf-0823Macaca fascicularis96.210.01418
LLPS-Pap-1272Pan paniscus96.070.01417
LLPS-Pat-0248Pan troglodytes96.070.01417
LLPS-Paa-2037Papio anubis96.070.01416
LLPS-Caj-2609Callithrix jacchus96.070.01415
LLPS-Aon-1105Aotus nancymaae96.070.01418
LLPS-Ict-4180Ictidomys tridecemlineatus95.970.01430
LLPS-Poa-3483Pongo abelii95.970.01429
LLPS-Nol-2578Nomascus leucogenys95.930.01415
LLPS-Rhb-1354Rhinopithecus bieti95.510.0 777
LLPS-Fud-0286Fukomys damarensis95.30.01415
LLPS-Eqc-2740Equus caballus95.260.01397
LLPS-Cas-1280Carlito syrichta95.240.01057
LLPS-Dio-1037Dipodomys ordii95.160.01413
LLPS-Orc-4150Oryctolagus cuniculus94.990.01405
LLPS-Myl-1583Myotis lucifugus94.980.01391
LLPS-Cap-0683Cavia porcellus94.890.01407
LLPS-Urm-2511Ursus maritimus94.890.01411
LLPS-Sus-1381Sus scrofa94.890.01409
LLPS-Aim-0694Ailuropoda melanoleuca94.850.01396
LLPS-Bot-3560Bos taurus94.620.01405
LLPS-Caf-2606Canis familiaris94.580.01388
LLPS-Ova-0649Ovis aries94.580.01391
LLPS-Fec-2770Felis catus94.410.01389
LLPS-Loa-1147Loxodonta africana93.280.01383
LLPS-Ora-0404Ornithorhynchus anatinus92.260.01101
LLPS-Mup-0512Mustela putorius furo91.070.01322
LLPS-Mod-3502Monodelphis domestica90.50.01341
LLPS-Sah-2495Sarcophilus harrisii90.120.01340
LLPS-Anp-0687Anas platyrhynchos90.110.01349
LLPS-Tag-2476Taeniopygia guttata90.070.01363
LLPS-Gaga-2227Gallus gallus89.80.01357
LLPS-Fia-0376Ficedula albicollis89.580.01340
LLPS-Pes-1258Pelodiscus sinensis89.350.01348
LLPS-Anc-0700Anolis carolinensis88.440.01330
LLPS-Xet-0898Xenopus tropicalis81.560.01239
LLPS-Lac-1440Latimeria chalumnae81.070.01187
LLPS-Leo-0431Lepisosteus oculatus81.020.01186
LLPS-Icp-0212Ictalurus punctatus76.570.01148
LLPS-Scf-2256Scleropages formosus75.690.01111
LLPS-Dar-3143Danio rerio75.130.01127
LLPS-Orn-1066Oreochromis niloticus74.660.01072
LLPS-Asm-3909Astyanax mexicanus74.550.01115
LLPS-Scm-0298Scophthalmus maximus74.00.01092
LLPS-Gaa-0826Gasterosteus aculeatus73.480.01092
LLPS-Ten-0908Tetraodon nigroviridis72.740.01088
LLPS-Pof-0850Poecilia formosa72.550.01074
LLPS-Xim-2593Xiphophorus maculatus72.550.01057
LLPS-Tar-0545Takifugu rubripes72.470.01075
LLPS-Orl-1916Oryzias latipes71.450.01045
LLPS-Sob-1257Sorghum bicolor42.472e-1068.6
LLPS-Hov-1720Hordeum vulgare42.474e-1067.8
LLPS-Sei-1549Setaria italica42.476e-1067.0
LLPS-Org-0657Oryza glaberrima39.732e-0965.1
LLPS-Ori-0610Oryza indica39.732e-0965.1
LLPS-Via-1660Vigna angularis38.426e-29 127
LLPS-Orm-0645Oryza meridionalis37.041e-0759.3
LLPS-Cus-1075Cucumis sativus36.491e-0656.6
LLPS-Cii-0808Ciona intestinalis34.271e-112 365
LLPS-Cis-1104Ciona savignyi32.755e-53 196
LLPS-Vir-0277Vigna radiata32.041e-43 173
LLPS-Lep-0901Leersia perrieri31.972e-36 151
LLPS-Sol-1258Solanum lycopersicum31.971e-51 197
LLPS-Viv-1914Vitis vinifera31.821e-52 200
LLPS-Arl-0470Arabidopsis lyrata31.752e-44 175
LLPS-Amt-1436Amborella trichopoda31.633e-1584.0
LLPS-Prp-0983Prunus persica31.614e-46 180
LLPS-Mua-1753Musa acuminata31.552e-52 199
LLPS-Sot-1711Solanum tuberosum31.541e-50 194
LLPS-Brr-0216Brassica rapa31.451e-1482.4
LLPS-Tra-1515Triticum aestivum31.367e-46 179
LLPS-Brn-2183Brassica napus31.231e-47 184
LLPS-Tru-1181Triticum urartu31.175e-45 177
LLPS-Phv-0506Phaseolus vulgaris31.128e-47 182
LLPS-Bro-1668Brassica oleracea31.043e-47 183
LLPS-Php-1408Physcomitrella patens31.028e-54 203
LLPS-Mae-1629Manihot esculenta30.921e-44 176
LLPS-Zem-1462Zea mays30.833e-46 181
LLPS-Sem-1631Selaginella moellendorffii30.823e-1377.4
LLPS-Hea-0759Helianthus annuus30.811e-1688.2
LLPS-Dac-1623Daucus carota30.84e-52 198
LLPS-Glm-2780Glycine max30.73e-44 175
LLPS-Pot-1530Populus trichocarpa30.42e-42 169
LLPS-Art-1395Arabidopsis thaliana30.391e-41 167
LLPS-Nia-1197Nicotiana attenuata30.22e-46 181
LLPS-Thc-0989Theobroma cacao29.85e-1583.6
LLPS-Gor-1503Gossypium raimondii29.566e-43 171
LLPS-Coc-0738Corchorus capsularis29.262e-1068.9
LLPS-Brd-0511Brachypodium distachyon29.252e-38 157
LLPS-Orp-0766Oryza punctata28.943e-36 150
LLPS-Gas-1107Galdieria sulphuraria28.853e-34 144
LLPS-Orgl-0650Oryza glumaepatula28.848e-37 152
LLPS-Met-1696Medicago truncatula28.82e-39 160
LLPS-Orbr-0239Oryza brachyantha28.788e-40 161
LLPS-Orni-1914Oryza nivara28.351e-32 139
LLPS-Orr-0171Oryza rufipogon28.258e-37 152
LLPS-Orb-1619Oryza barthii28.258e-37 152
LLPS-Ors-1101Oryza sativa28.074e-36 150
LLPS-Drm-2072Drosophila melanogaster27.173e-33 140
LLPS-Chc-0592Chondrus crispus24.175e-2099.4