LLPS-Mum-3313
Mccc2
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial |
| Gene Name: | Mccc2 |
| Ensembl Gene: | ENSMUSG00000021646.9 |
| Ensembl Protein: | ENSMUSP00000152799.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
| Stress granule | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000221344.1 | ENSMUSP00000152799.1 |
| Ensembl | ENSMUST00000022148.6 | ENSMUSP00000022148.6 |
| Ensembl | ENSMUST00000222083.1 | ENSMUSP00000152781.1 |
| UniProt | Q3ULD5, MCCB_MOUSE, Q3UPS6 | |
| GeneBank | AK132265, AK146865, AK146844, AK145564, AK143233 | BAE27475.1, BAE25319.1, BAE21068.1, BAE27489.1, BAE26513.1 |
| RefSeq | NM_030026.2 | NP_084302.1 |
| Entrez | 78038 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MWGALRSALR PCCRAAVPPQ RAYHGDSVAR LGTQPDSASS TYQENYEQMK ALVSQLHERA 60 61 QYVRLGGSEK ARARHTSRGK LLPRDRIDNL IDPGSPFLEF SQFAGYQLYG DEEVPAGGII 120 121 TGIGRVSGVE CMIVANDATV KGGTYYPVTV KKHVRAQEIA LQNRLPCIYL VDSGGANLPR 180 181 QADTFPDRDH FGRIFYNQAI MSSKNITQIA VVMGSCTAGG AYVPAMADEN IIVQKQGTIF 240 241 LAGPPLVKAA TGEEVSAEDL GGADLHCRKS GVTDHYALDD HHALHLTRKV VRSLNYQKKM 300 301 DVTIEPSEEP LFPADELYGI VGANLKRSFD VREVIARIVD GSRFNEFKAL YGDTLVTGFA 360 361 RIFGYPVGII GNNGVLFSES AKKGAHFVQL CCQRNIPLLF LQNITGFMVG RDYEAEGIAK 420 421 DGAKMVAAVA CAKVPKITVI IGGSYGAGNY GMCGRAYSPR FLYMWPNARI SVMGGEQAAT 480 481 VLATVARDQK AREGKQFSSA EEAALKEPII KRFEEEGNPY YSSARLWDDG IIDPVDTRLV 540 541 LGLSLSAALN APIQRTDFGI FRM 563 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTGGGGCG CGCTGAGGTC AGCTCTGCGA CCGTGCTGTC GGGCTGCTGT ACCCCCGCAG 60 61 CGTGCCTATC ACGGGGACTC AGTGGCCCGA CTGGGCACCC AGCCTGACTC GGCCTCCTCC 120 121 ACCTACCAGG AGAACTATGA GCAGATGAAA GCTTTAGTGA GTCAACTTCA TGAGCGAGCC 180 181 CAGTATGTGA GACTAGGAGG GAGTGAGAAG GCCCGGGCGC GGCACACATC CAGAGGAAAA 240 241 CTGCTCCCCA GAGACAGAAT CGACAATCTC ATAGACCCAG GGTCTCCCTT TCTGGAATTC 300 301 TCCCAGTTTG CAGGTTACCA GTTATATGGC GACGAGGAAG TCCCCGCCGG TGGCATCATC 360 361 ACGGGCATTG GGCGAGTGTC GGGGGTAGAA TGCATGATTG TGGCTAACGA TGCCACCGTC 420 421 AAAGGAGGCA CCTACTACCC AGTGACTGTG AAAAAGCACG TGCGGGCACA AGAGATTGCG 480 481 CTGCAGAACC GACTCCCATG CATCTATCTG GTTGACTCAG GAGGGGCCAA CTTACCTCGG 540 541 CAAGCAGACA CCTTTCCAGA CCGGGACCAC TTTGGCCGCA TATTCTATAA TCAGGCAATT 600 601 ATGTCTTCTA AAAACATCAC ACAGATAGCT GTGGTCATGG GCTCCTGTAC GGCAGGAGGT 660 661 GCGTATGTGC CTGCAATGGC TGATGAAAAC ATCATTGTAC AGAAGCAGGG TACCATCTTC 720 721 TTGGCTGGAC CACCCTTGGT GAAGGCAGCT ACAGGTGAAG AGGTGTCCGC TGAGGATCTC 780 781 GGAGGTGCCG ACCTGCATTG CAGAAAGTCT GGGGTCACTG ACCACTATGC TTTGGACGAC 840 841 CACCACGCCC TCCACTTAAC AAGGAAGGTT GTGAGGAGTC TCAATTATCA GAAGAAAATG 900 901 GATGTTACCA TTGAGCCTTC TGAGGAGCCC TTGTTCCCTG CAGATGAGCT CTATGGAATA 960 961 GTTGGTGCAA ACCTGAAGAG GAGCTTTGAT GTCCGAGAGG TCATTGCTAG AATCGTGGAT 1020 1021 GGAAGCAGAT TCAATGAGTT CAAGGCCTTA TATGGAGACA CCCTAGTTAC AGGATTTGCT 1080 1081 CGAATATTTG GGTACCCCGT TGGCATCATT GGAAACAATG GAGTTTTGTT TTCTGAATCT 1140 1141 GCTAAGAAGG GTGCTCACTT CGTCCAGCTG TGCTGCCAGA GAAATATCCC TCTGCTGTTT 1200 1201 CTTCAGAATA TCACCGGATT CATGGTTGGC AGAGACTATG AAGCTGAAGG GATTGCCAAG 1260 1261 GATGGTGCCA AAATGGTAGC TGCAGTAGCC TGTGCCAAAG TGCCTAAGAT AACTGTCATA 1320 1321 ATTGGGGGAT CGTACGGGGC TGGAAACTAC GGAATGTGTG GCAGAGCATA CAGTCCAAGG 1380 1381 TTTCTCTACA TGTGGCCAAA TGCCCGCATC TCTGTGATGG GAGGAGAGCA GGCAGCCACG 1440 1441 GTGTTAGCCA CAGTGGCTAG AGACCAGAAA GCACGCGAGG GGAAGCAGTT CTCCAGTGCA 1500 1501 GAGGAGGCAG CTTTGAAAGA ACCCATCATT AAGAGGTTCG AAGAGGAAGG GAACCCTTAC 1560 1561 TACTCTAGTG CAAGGCTGTG GGACGATGGG ATTATTGACC CGGTGGACAC CAGGCTGGTC 1620 1621 CTGGGGCTCA GCCTCAGTGC AGCCCTCAAT GCGCCCATCC AGAGGACTGA CTTTGGCATC 1680 1681 TTCAGGATGT AA 1692 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Methylcrotonoyl-CoA carboxylase complex | |
Cellular Component | Mitochondrial matrix | |
Cellular Component | Mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | Methylcrotonoyl-CoA carboxylase activity | |
Biological Process | Coenzyme A metabolic process | |
Biological Process | Leucine catabolic process |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| RaftProt | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-1419 | Rattus norvegicus | 96.98 | 0.0 | 1071 |
| LLPS-Bot-2558 | Bos taurus | 92.97 | 0.0 | 917 |
| LLPS-Dio-1746 | Dipodomys ordii | 92.72 | 0.0 | 1019 |
| LLPS-Orc-3682 | Oryctolagus cuniculus | 91.65 | 0.0 | 1019 |
| LLPS-Ova-0551 | Ovis aries | 91.47 | 0.0 | 1005 |
| LLPS-Ict-0355 | Ictidomys tridecemlineatus | 91.47 | 0.0 | 1021 |
| LLPS-Cap-0177 | Cavia porcellus | 90.23 | 0.0 | 1006 |
| LLPS-Loa-0540 | Loxodonta africana | 90.05 | 0.0 | 981 |
| LLPS-Eqc-4361 | Equus caballus | 89.7 | 0.0 | 999 |
| LLPS-Otg-1121 | Otolemur garnettii | 89.7 | 0.0 | 996 |
| LLPS-Fec-0349 | Felis catus | 89.52 | 0.0 | 1006 |
| LLPS-Aim-4156 | Ailuropoda melanoleuca | 89.34 | 0.0 | 990 |
| LLPS-Urm-2885 | Ursus maritimus | 89.34 | 0.0 | 992 |
| LLPS-Mea-3224 | Mesocricetus auratus | 89.17 | 0.0 | 958 |
| LLPS-Fud-3784 | Fukomys damarensis | 89.17 | 0.0 | 981 |
| LLPS-Pat-3561 | Pan troglodytes | 88.99 | 0.0 | 971 |
| LLPS-Pap-2753 | Pan paniscus | 88.99 | 0.0 | 971 |
| LLPS-Sah-3782 | Sarcophilus harrisii | 88.89 | 0.0 | 922 |
| LLPS-Hos-2298 | Homo sapiens | 88.81 | 0.0 | 969 |
| LLPS-Gog-2176 | Gorilla gorilla | 88.45 | 0.0 | 967 |
| LLPS-Chs-2858 | Chlorocebus sabaeus | 88.28 | 0.0 | 984 |
| LLPS-Caf-3404 | Canis familiaris | 88.28 | 0.0 | 984 |
| LLPS-Pes-3648 | Pelodiscus sinensis | 88.16 | 0.0 | 895 |
| LLPS-Paa-4433 | Papio anubis | 88.1 | 0.0 | 961 |
| LLPS-Maf-2583 | Macaca fascicularis | 88.1 | 0.0 | 962 |
| LLPS-Cea-1655 | Cercocebus atys | 88.1 | 0.0 | 962 |
| LLPS-Man-4203 | Macaca nemestrina | 88.1 | 0.0 | 962 |
| LLPS-Rhb-4136 | Rhinopithecus bieti | 88.1 | 0.0 | 961 |
| LLPS-Fia-1689 | Ficedula albicollis | 88.08 | 0.0 | 906 |
| LLPS-Mal-1860 | Mandrillus leucophaeus | 87.92 | 0.0 | 961 |
| LLPS-Mam-1685 | Macaca mulatta | 87.92 | 0.0 | 961 |
| LLPS-Mup-4051 | Mustela putorius furo | 87.74 | 0.0 | 982 |
| LLPS-Sus-1439 | Sus scrofa | 87.74 | 0.0 | 979 |
| LLPS-Myl-0907 | Myotis lucifugus | 87.48 | 0.0 | 962 |
| LLPS-Caj-0933 | Callithrix jacchus | 87.39 | 0.0 | 972 |
| LLPS-Gaga-0270 | Gallus gallus | 86.54 | 0.0 | 889 |
| LLPS-Anp-3094 | Anas platyrhynchos | 86.23 | 0.0 | 860 |
| LLPS-Tag-3211 | Taeniopygia guttata | 86.0 | 0.0 | 925 |
| LLPS-Dar-3256 | Danio rerio | 84.9 | 0.0 | 920 |
| LLPS-Mod-3278 | Monodelphis domestica | 84.22 | 0.0 | 945 |
| LLPS-Nol-1603 | Nomascus leucogenys | 83.84 | 0.0 | 906 |
| LLPS-Orl-3065 | Oryzias latipes | 83.43 | 0.0 | 906 |
| LLPS-Icp-3835 | Ictalurus punctatus | 83.24 | 0.0 | 902 |
| LLPS-Poa-1963 | Pongo abelii | 83.19 | 0.0 | 902 |
| LLPS-Anc-3379 | Anolis carolinensis | 83.19 | 0.0 | 933 |
| LLPS-Ora-1287 | Ornithorhynchus anatinus | 82.74 | 0.0 | 612 |
| LLPS-Tar-3461 | Takifugu rubripes | 82.32 | 0.0 | 897 |
| LLPS-Scf-1580 | Scleropages formosus | 82.14 | 0.0 | 910 |
| LLPS-Orn-2314 | Oreochromis niloticus | 81.61 | 0.0 | 909 |
| LLPS-Xet-3436 | Xenopus tropicalis | 81.32 | 0.0 | 890 |
| LLPS-Xim-3828 | Xiphophorus maculatus | 81.17 | 0.0 | 910 |
| LLPS-Scm-1655 | Scophthalmus maximus | 81.04 | 0.0 | 900 |
| LLPS-Asm-1104 | Astyanax mexicanus | 80.96 | 0.0 | 900 |
| LLPS-Ten-2070 | Tetraodon nigroviridis | 80.9 | 0.0 | 895 |
| LLPS-Pof-1243 | Poecilia formosa | 80.82 | 0.0 | 912 |
| LLPS-Aon-3148 | Aotus nancymaae | 79.93 | 0.0 | 843 |
| LLPS-Gaa-3513 | Gasterosteus aculeatus | 79.78 | 0.0 | 853 |
| LLPS-Lac-0346 | Latimeria chalumnae | 79.5 | 4e-159 | 463 |
| LLPS-Leo-2894 | Lepisosteus oculatus | 78.38 | 0.0 | 851 |
| LLPS-Cis-1814 | Ciona savignyi | 73.42 | 0.0 | 793 |
| LLPS-Cii-2296 | Ciona intestinalis | 73.28 | 0.0 | 760 |
| LLPS-Drm-2090 | Drosophila melanogaster | 69.77 | 0.0 | 746 |
| LLPS-Abg-1471 | Absidia glauca | 68.95 | 0.0 | 749 |
| LLPS-Orbr-1109 | Oryza brachyantha | 67.82 | 0.0 | 574 |
| LLPS-Asf-1252 | Aspergillus flavus | 67.07 | 4e-115 | 356 |
| LLPS-Cae-1846 | Caenorhabditis elegans | 66.79 | 0.0 | 709 |
| LLPS-Php-0958 | Physcomitrella patens | 66.6 | 0.0 | 675 |
| LLPS-Tru-1233 | Triticum urartu | 65.88 | 0.0 | 592 |
| LLPS-Orb-0979 | Oryza barthii | 65.87 | 0.0 | 640 |
| LLPS-Sem-2448 | Selaginella moellendorffii | 65.1 | 0.0 | 668 |
| LLPS-Chr-0301 | Chlamydomonas reinhardtii | 65.01 | 0.0 | 643 |
| LLPS-Glm-1101 | Glycine max | 64.94 | 0.0 | 659 |
| LLPS-Sob-2043 | Sorghum bicolor | 64.85 | 0.0 | 658 |
| LLPS-Dac-2061 | Daucus carota | 64.42 | 0.0 | 643 |
| LLPS-Lep-1197 | Leersia perrieri | 64.29 | 0.0 | 649 |
| LLPS-Orgl-1923 | Oryza glumaepatula | 64.03 | 0.0 | 655 |
| LLPS-Orni-2122 | Oryza nivara | 64.03 | 0.0 | 656 |
| LLPS-Met-0194 | Medicago truncatula | 63.92 | 0.0 | 650 |
| LLPS-Tra-2440 | Triticum aestivum | 63.91 | 0.0 | 647 |
| LLPS-Brd-1525 | Brachypodium distachyon | 63.91 | 0.0 | 657 |
| LLPS-Sei-1034 | Setaria italica | 63.72 | 0.0 | 648 |
| LLPS-Phv-1968 | Phaseolus vulgaris | 63.72 | 0.0 | 646 |
| LLPS-Sot-0652 | Solanum tuberosum | 63.71 | 0.0 | 615 |
| LLPS-Mae-0130 | Manihot esculenta | 63.19 | 0.0 | 660 |
| LLPS-Via-1931 | Vigna angularis | 63.03 | 0.0 | 639 |
| LLPS-Orr-1892 | Oryza rufipogon | 62.98 | 0.0 | 651 |
| LLPS-Org-1218 | Oryza glaberrima | 62.98 | 0.0 | 652 |
| LLPS-Sol-1431 | Solanum lycopersicum | 62.71 | 0.0 | 619 |
| LLPS-Mua-0836 | Musa acuminata | 62.59 | 0.0 | 644 |
| LLPS-Prp-0442 | Prunus persica | 62.36 | 0.0 | 645 |
| LLPS-Ors-2407 | Oryza sativa | 62.26 | 1e-118 | 360 |
| LLPS-Aso-1152 | Aspergillus oryzae | 62.18 | 0.0 | 641 |
| LLPS-Vir-0572 | Vigna radiata | 62.17 | 0.0 | 634 |
| LLPS-Hea-1847 | Helianthus annuus | 62.17 | 0.0 | 655 |
| LLPS-Brr-2955 | Brassica rapa | 61.99 | 0.0 | 615 |
| LLPS-Viv-0630 | Vitis vinifera | 61.88 | 0.0 | 646 |
| LLPS-Gor-2381 | Gossypium raimondii | 61.81 | 0.0 | 652 |
| LLPS-Ori-0942 | Oryza indica | 61.78 | 0.0 | 647 |
| LLPS-Pyt-1647 | Pyrenophora teres | 61.75 | 0.0 | 627 |
| LLPS-Thc-1417 | Theobroma cacao | 61.61 | 0.0 | 656 |
| LLPS-Nia-1487 | Nicotiana attenuata | 61.55 | 0.0 | 627 |
| LLPS-Brn-3079 | Brassica napus | 61.44 | 0.0 | 636 |
| LLPS-Bro-1587 | Brassica oleracea | 61.44 | 0.0 | 637 |
| LLPS-Asfu-0411 | Aspergillus fumigatus | 61.43 | 0.0 | 632 |
| LLPS-Amt-0944 | Amborella trichopoda | 61.36 | 0.0 | 655 |
| LLPS-Cus-1109 | Cucumis sativus | 61.12 | 0.0 | 645 |
| LLPS-Coc-1355 | Corchorus capsularis | 61.03 | 0.0 | 657 |
| LLPS-Fus-0369 | Fusarium solani | 61.01 | 0.0 | 630 |
| LLPS-Cog-1250 | Colletotrichum gloeosporioides | 60.83 | 0.0 | 631 |
| LLPS-Phn-0905 | Phaeosphaeria nodorum | 60.79 | 0.0 | 630 |
| LLPS-Pytr-0836 | Pyrenophora triticirepentis | 60.72 | 0.0 | 633 |
| LLPS-Dos-1352 | Dothistroma septosporum | 60.66 | 0.0 | 624 |
| LLPS-Asn-0699 | Aspergillus nidulans | 60.53 | 0.0 | 637 |
| LLPS-Asni-0814 | Aspergillus niger | 60.47 | 0.0 | 625 |
| LLPS-Coo-1289 | Colletotrichum orbiculare | 60.47 | 0.0 | 630 |
| LLPS-Beb-0606 | Beauveria bassiana | 60.39 | 0.0 | 640 |
| LLPS-Ast-0978 | Aspergillus terreus | 60.28 | 0.0 | 620 |
| LLPS-Tum-1139 | Tuber melanosporum | 60.22 | 0.0 | 640 |
| LLPS-Nec-1152 | Neurospora crassa | 60.22 | 0.0 | 618 |
| LLPS-Nef-1109 | Neosartorya fischeri | 60.18 | 0.0 | 632 |
| LLPS-Pot-1239 | Populus trichocarpa | 60.03 | 0.0 | 660 |
| LLPS-Art-2520 | Arabidopsis thaliana | 60.0 | 0.0 | 617 |
| LLPS-Trr-1394 | Trichoderma reesei | 60.0 | 0.0 | 626 |
| LLPS-Asc-1442 | Aspergillus clavatus | 59.96 | 0.0 | 634 |
| LLPS-Zyt-0295 | Zymoseptoria tritici | 59.86 | 0.0 | 617 |
| LLPS-Lem-1559 | Leptosphaeria maculans | 59.82 | 0.0 | 625 |
| LLPS-Yal-0790 | Yarrowia lipolytica | 59.76 | 0.0 | 585 |
| LLPS-Fuo-0109 | Fusarium oxysporum | 59.75 | 0.0 | 625 |
| LLPS-Cogr-0574 | Colletotrichum graminicola | 59.75 | 0.0 | 624 |
| LLPS-Fuv-1397 | Fusarium verticillioides | 59.57 | 0.0 | 627 |
| LLPS-Gas-0631 | Galdieria sulphuraria | 59.49 | 0.0 | 613 |
| LLPS-Gag-1625 | Gaeumannomyces graminis | 59.44 | 0.0 | 626 |
| LLPS-Ved-1506 | Verticillium dahliae | 59.03 | 0.0 | 609 |
| LLPS-Spr-1493 | Sporisorium reilianum | 58.98 | 0.0 | 602 |
| LLPS-Pug-0604 | Puccinia graminis | 58.7 | 0.0 | 590 |
| LLPS-Mel-0242 | Melampsora laricipopulina | 58.63 | 0.0 | 568 |
| LLPS-Mao-1525 | Magnaporthe oryzae | 58.48 | 0.0 | 608 |
| LLPS-Zem-0928 | Zea mays | 58.48 | 0.0 | 613 |
| LLPS-Miv-1390 | Microbotryum violaceum | 58.02 | 0.0 | 584 |
| LLPS-Usm-0958 | Ustilago maydis | 57.89 | 0.0 | 592 |
| LLPS-Trv-1398 | Trichoderma virens | 57.86 | 0.0 | 622 |
| LLPS-Arl-1114 | Arabidopsis lyrata | 57.59 | 0.0 | 589 |
| LLPS-Blg-1386 | Blumeria graminis | 57.5 | 0.0 | 610 |
| LLPS-Put-0130 | Puccinia triticina | 56.18 | 2e-164 | 483 |
| LLPS-Cym-0852 | Cyanidioschyzon merolae | 53.68 | 2e-177 | 521 |
| LLPS-Crn-1339 | Cryptococcus neoformans | 51.79 | 1e-172 | 509 |
| LLPS-Map-0340 | Magnaporthe poae | 50.0 | 4e-21 | 97.8 |
| LLPS-Meg-1401 | Meleagris gallopavo | 49.41 | 7e-146 | 441 |