LLPS-Mum-3307
Add1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Alpha-adducin; Erythrocyte adducin subunit alpha |
| Gene Name: | Add1 |
| Ensembl Gene: | ENSMUSG00000029106.14 |
| Ensembl Protein: | ENSMUSP00000116075.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
| Stress granule | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
▼ CROSS REFERENCE
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MNGDTRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM 60 61 ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTA SVPNVYPAAP QGGMAALNMS 120 121 LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA AFYRLADLFG WSQLIYNHIT TRVNSEQEHF 180 181 LIVPFGLLYS EVTASSLVKV NLQGDIVDRG STNLGVNQAG FTLHSAVYAA RPDAKCIVHI 240 241 HTPAGAAVSA MKCGLLPISP EALSLGDVAY HDYHGILVDE EEKILIQKNL GPKSKVLILR 300 301 NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLDPGKYK AKSRSPGTPA 360 361 GEGSGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL RERSKKYSDV EVPASVTGHS 420 421 FASDGDSGTC SPLRHSFQKQ QREKTRWLHS GRGDDASEEG QNGSSPKSKT KWTKEDGHRT 480 481 STSAVPNLFV PLNTNPKEVQ EMRNKIREQN LQDIKTAGPQ SQVLCGVMMD RSLVQGELVT 540 541 ASKAIIEKEY QPHVIVSTTG PNPFNTLTDR ELEEYRREVE RKQKGSEENL DETREQKEKS 600 601 PPDQSAVPNT PPSTPVKLEE DLPQEPTSRD DSDATTFKPT PPDLSPDEPS EALAFPAVEE 660 661 EAHASPDPTQ PPAEADPEPA SAPTPGAEEV ASPATEEGSP MDPGSDGSPG KSPSKKKKKF 720 721 RTPSFLKKSK KKSDS 735 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAATGGTG ACACTCGGGC CGCAGTGGTG ACCTCACCAC CTCCAACCAC AGCCCCTCAC 60 61 AAGGAGAGGT ATTTTGACAG AGTCGATGAG AACAACCCAG AATATTTGCG GGAGAGGAAC 120 121 ATGGCACCAG ACCTTCGTCA GGACTTCAAT ATGATGGAGC AGAAGAAGAG GGTGTCTATG 180 181 ATTCTACAGA GTCCTGCCTT CTGTGAAGAG CTGGAGTCTA TGATACAGGA ACAGTTTAAG 240 241 AAGGGCAAGA ACCCCACAGG CCTGCTGGCA TTGCAGCAGA TTGCAGATTT CATGACTGCG 300 301 AGTGTACCAA ATGTCTACCC GGCAGCTCCT CAAGGAGGAA TGGCCGCCCT GAACATGAGT 360 361 CTTGGTATGG TCACTCCTGT GAATGACCTT AGAGGGTCGG ATTCTATCGC ATATGACAAA 420 421 GGGGAGAAGT TACTGCGGTG TAAACTGGCA GCATTTTACA GACTGGCAGA TCTCTTTGGC 480 481 TGGTCCCAGC TTATCTACAA TCATATCACA ACCAGAGTGA ACTCTGAGCA GGAACACTTC 540 541 CTCATCGTAC CTTTTGGACT TCTCTACAGT GAAGTGACTG CATCCAGCTT GGTTAAGGTC 600 601 AATCTACAAG GAGATATAGT AGACCGTGGA AGTACTAACC TAGGGGTGAA TCAGGCGGGC 660 661 TTCACTCTGC ACTCGGCAGT GTATGCTGCG CGACCAGATG CCAAGTGTAT TGTGCACATC 720 721 CACACCCCAG CGGGGGCAGC GGTCTCTGCG ATGAAGTGTG GACTCTTGCC TATCTCCCCG 780 781 GAGGCACTTT CCCTTGGAGA TGTTGCTTAT CATGACTATC ATGGCATTCT GGTTGATGAA 840 841 GAGGAAAAAA TTTTGATTCA GAAAAATCTG GGCCCTAAAA GCAAGGTCCT CATTCTGCGG 900 901 AATCACGGAC TCGTGTCAGT TGGAGAGAGC GTGGAGGAGG CCTTCTATTA CATCCATAAC 960 961 CTTGTGGTTG CATGTGAGAT CCAGGTTCGG ACTCTGGCAA GTGCTGGAGG ACCAGACAAC 1020 1021 TTAGTTCTGC TGGATCCTGG GAAGTACAAA GCCAAATCCC GTTCTCCAGG GACTCCAGCA 1080 1081 GGGGAAGGCT CTGGATCACC TCCCAAGTGG CAGATTGGGG AGCAGGAATT TGAAGCTCTT 1140 1141 ATGCGGATGC TCGATAATCT GGGCTACAGA ACTGGCTACC CTTATCGATA CCCTGCTCTG 1200 1201 AGAGAGAGAT CTAAAAAGTA CAGCGATGTG GAAGTCCCTG CCAGTGTCAC AGGCCACTCC 1260 1261 TTTGCTAGTG ATGGCGATTC GGGCACTTGC TCGCCGCTCA GGCACAGTTT TCAGAAGCAG 1320 1321 CAGCGAGAGA AGACAAGATG GCTGCACTCT GGCCGGGGTG ATGACGCTTC TGAGGAGGGG 1380 1381 CAGAACGGAA GCAGTCCCAA GTCGAAGACT AAGGTGTGGA CGAACATTAC ACACGATCAC 1440 1441 GTGAAACCCT TGCTGCAGTC TCTCTCGTCC GGTGTCTGCG TGCCAAGCTG TATTACCAAC 1500 1501 TGCTTGTGGA CTAAAGAGGA TGGACATAGA ACTTCCACCT CTGCTGTCCC TAACCTGTTT 1560 1561 GTTCCATTGA ACACTAACCC AAAAGAGGTC CAGGAGATGA GGAACAAGAT TCGAGAGCAG 1620 1621 AACTTACAGG ACATTAAGAC GGCAGGACCT CAGTCCCAGG TTTTGTGTGG TGTGATGATG 1680 1681 GACAGAAGCC TTGTTCAGGG GGAGCTGGTG ACGGCCTCCA AAGCCATCAT TGAGAAGGAA 1740 1741 TACCAGCCCC ATGTAATTGT GAGCACCACA GGTCCCAACC CCTTCAACAC GCTGACAGAC 1800 1801 CGTGAACTGG AAGAATACCG ACGAGAGGTG GAGCGGAAGC AGAAGGGCTC TGAAGAGAAC 1860 1861 CTGGATGAGA CAAGAGAGCA GAAAGAGAAG AGTCCTCCAG ACCAGTCAGC TGTCCCCAAC 1920 1921 ACTCCTCCCA GTACTCCTGT CAAGCTTGAA GAAGCAGGAG ACGGATGTGC TAAAGAGTAC 1980 1981 CTGTTACCCT AA 1992 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell-cell adherens junction | |
Cellular Component | Cytoplasm | |
Cellular Component | Cytoskeleton | |
Cellular Component | Dendrite | |
Cellular Component | Dendritic spine | |
Cellular Component | F-actin capping protein complex | |
Cellular Component | Membrane | |
Cellular Component | Nuclear body | |
Cellular Component | Nucleoplasm | |
Cellular Component | Nucleus | |
Cellular Component | Perinuclear region of cytoplasm | |
Cellular Component | Plasma membrane | |
Cellular Component | Plasma membrane raft | |
Cellular Component | Postsynaptic density | |
Cellular Component | Synapse | |
Molecular Function | Actin filament binding | |
Molecular Function | Calmodulin binding | |
Molecular Function | Protein heterodimerization activity | |
Molecular Function | Protein homodimerization activity | |
Molecular Function | Spectrin binding | |
Molecular Function | Structural molecule activity | |
Molecular Function | T cell receptor binding | |
Molecular Function | Transcription factor binding | |
Biological Process | Actin filament bundle assembly | |
Biological Process | Barbed-end actin filament capping | |
Biological Process | Cell morphogenesis | |
Biological Process | Cell volume homeostasis | |
Biological Process | Cellular response to calcium ion | |
Biological Process | Cellular response to retinoic acid | |
Biological Process | Erythrocyte differentiation | |
Biological Process | Hemoglobin metabolic process | |
Biological Process | Homeostasis of number of cells within a tissue | |
Biological Process | In utero embryonic development | |
Biological Process | Multicellular organism growth | |
Biological Process | Negative regulation of actin filament polymerization | |
Biological Process | Positive regulation of adherens junction organization | |
Biological Process | Positive regulation of angiogenesis | |
Biological Process | Positive regulation of endocytosis | |
Biological Process | Positive regulation of establishment of endothelial barrier | |
Biological Process | Positive regulation of protein binding |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CGDB | CellMarker | RaftProt | ||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-1732 | Rattus norvegicus | 98.1 | 0.0 | 1318 |
| LLPS-Gog-3976 | Gorilla gorilla | 97.66 | 3e-98 | 325 |
| LLPS-Poa-3328 | Pongo abelii | 95.81 | 0.0 | 1185 |
| LLPS-Chs-0596 | Chlorocebus sabaeus | 95.65 | 0.0 | 1184 |
| LLPS-Otg-3485 | Otolemur garnettii | 94.28 | 0.0 | 1246 |
| LLPS-Loa-1728 | Loxodonta africana | 92.32 | 0.0 | 1211 |
| LLPS-Sah-2858 | Sarcophilus harrisii | 92.06 | 0.0 | 1193 |
| LLPS-Fud-2528 | Fukomys damarensis | 91.98 | 0.0 | 1256 |
| LLPS-Myl-1070 | Myotis lucifugus | 91.68 | 0.0 | 1192 |
| LLPS-Ova-4046 | Ovis aries | 90.94 | 0.0 | 1105 |
| LLPS-Cas-1571 | Carlito syrichta | 90.94 | 0.0 | 1234 |
| LLPS-Cap-0313 | Cavia porcellus | 90.77 | 0.0 | 1239 |
| LLPS-Eqc-0246 | Equus caballus | 90.58 | 0.0 | 1224 |
| LLPS-Pap-3642 | Pan paniscus | 90.37 | 0.0 | 1231 |
| LLPS-Pat-2267 | Pan troglodytes | 90.37 | 0.0 | 1231 |
| LLPS-Sus-3021 | Sus scrofa | 90.3 | 0.0 | 1110 |
| LLPS-Fec-0395 | Felis catus | 90.17 | 0.0 | 1151 |
| LLPS-Bot-1986 | Bos taurus | 89.7 | 0.0 | 1216 |
| LLPS-Cea-4679 | Cercocebus atys | 89.64 | 0.0 | 1222 |
| LLPS-Mal-4192 | Mandrillus leucophaeus | 89.64 | 0.0 | 1222 |
| LLPS-Mam-4726 | Macaca mulatta | 89.64 | 0.0 | 1222 |
| LLPS-Maf-2644 | Macaca fascicularis | 89.5 | 0.0 | 1221 |
| LLPS-Man-3665 | Macaca nemestrina | 89.5 | 0.0 | 1221 |
| LLPS-Rhb-1884 | Rhinopithecus bieti | 89.5 | 0.0 | 1221 |
| LLPS-Paa-2546 | Papio anubis | 89.35 | 0.0 | 1219 |
| LLPS-Mea-3720 | Mesocricetus auratus | 89.28 | 0.0 | 1188 |
| LLPS-Meg-1863 | Meleagris gallopavo | 89.26 | 0.0 | 1177 |
| LLPS-Mup-3277 | Mustela putorius furo | 89.1 | 0.0 | 1235 |
| LLPS-Hos-1775 | Homo sapiens | 88.93 | 0.0 | 1241 |
| LLPS-Orc-2523 | Oryctolagus cuniculus | 88.75 | 0.0 | 1101 |
| LLPS-Nol-2944 | Nomascus leucogenys | 88.22 | 0.0 | 1193 |
| LLPS-Aon-2248 | Aotus nancymaae | 87.99 | 0.0 | 1239 |
| LLPS-Ict-4188 | Ictidomys tridecemlineatus | 87.99 | 0.0 | 1226 |
| LLPS-Caf-3020 | Canis familiaris | 87.68 | 0.0 | 1215 |
| LLPS-Ora-0542 | Ornithorhynchus anatinus | 87.42 | 0.0 | 842 |
| LLPS-Caj-3270 | Callithrix jacchus | 86.34 | 0.0 | 1166 |
| LLPS-Anp-2043 | Anas platyrhynchos | 86.3 | 0.0 | 1191 |
| LLPS-Aim-3744 | Ailuropoda melanoleuca | 86.01 | 0.0 | 1182 |
| LLPS-Tag-3196 | Taeniopygia guttata | 85.89 | 0.0 | 1175 |
| LLPS-Pes-2430 | Pelodiscus sinensis | 85.56 | 0.0 | 1193 |
| LLPS-Gaga-3812 | Gallus gallus | 85.35 | 0.0 | 1183 |
| LLPS-Mod-1793 | Monodelphis domestica | 84.68 | 0.0 | 1185 |
| LLPS-Leo-0085 | Lepisosteus oculatus | 84.16 | 0.0 | 990 |
| LLPS-Anc-3241 | Anolis carolinensis | 82.75 | 0.0 | 1130 |
| LLPS-Scf-1392 | Scleropages formosus | 80.64 | 0.0 | 1052 |
| LLPS-Pof-1903 | Poecilia formosa | 80.51 | 0.0 | 945 |
| LLPS-Fia-2747 | Ficedula albicollis | 80.15 | 0.0 | 1156 |
| LLPS-Orl-1093 | Oryzias latipes | 79.8 | 0.0 | 923 |
| LLPS-Xet-2100 | Xenopus tropicalis | 78.42 | 0.0 | 1096 |
| LLPS-Asm-2875 | Astyanax mexicanus | 78.03 | 0.0 | 899 |
| LLPS-Icp-0239 | Ictalurus punctatus | 77.9 | 0.0 | 949 |
| LLPS-Lac-2516 | Latimeria chalumnae | 77.43 | 0.0 | 1070 |
| LLPS-Dar-1077 | Danio rerio | 75.76 | 0.0 | 1015 |
| LLPS-Scm-3435 | Scophthalmus maximus | 75.2 | 0.0 | 922 |
| LLPS-Tar-3505 | Takifugu rubripes | 73.11 | 0.0 | 920 |
| LLPS-Orn-0950 | Oreochromis niloticus | 72.13 | 0.0 | 981 |
| LLPS-Ten-3231 | Tetraodon nigroviridis | 72.12 | 0.0 | 933 |
| LLPS-Xim-4011 | Xiphophorus maculatus | 70.89 | 0.0 | 925 |
| LLPS-Gaa-2692 | Gasterosteus aculeatus | 69.31 | 0.0 | 932 |
| LLPS-Cis-2081 | Ciona savignyi | 45.69 | 7e-20 | 92.4 |
| LLPS-Cii-0139 | Ciona intestinalis | 44.65 | 1e-145 | 446 |
| LLPS-Scp-1547 | Schizosaccharomyces pombe | 41.27 | 7e-47 | 174 |
| LLPS-Drm-1563 | Drosophila melanogaster | 38.58 | 5e-109 | 370 |
| LLPS-Cae-0912 | Caenorhabditis elegans | 36.9 | 5e-112 | 362 |
| LLPS-Coo-1089 | Colletotrichum orbiculare | 35.9 | 2e-27 | 118 |
| LLPS-Put-0535 | Puccinia triticina | 35.75 | 3e-25 | 111 |
| LLPS-Cog-0157 | Colletotrichum gloeosporioides | 35.68 | 2e-26 | 115 |
| LLPS-Cogr-1352 | Colletotrichum graminicola | 35.5 | 9e-25 | 110 |
| LLPS-Pug-1114 | Puccinia graminis | 35.23 | 3e-25 | 111 |
| LLPS-Miv-0722 | Microbotryum violaceum | 35.23 | 1e-17 | 88.6 |
| LLPS-Asc-0092 | Aspergillus clavatus | 35.11 | 2e-27 | 118 |
| LLPS-Asf-1498 | Aspergillus flavus | 34.48 | 9e-28 | 119 |
| LLPS-Dos-1521 | Dothistroma septosporum | 34.41 | 2e-26 | 115 |
| LLPS-Ast-0375 | Aspergillus terreus | 34.38 | 5e-28 | 119 |
| LLPS-Pytr-1595 | Pyrenophora triticirepentis | 34.22 | 5e-27 | 116 |
| LLPS-Mel-0389 | Melampsora laricipopulina | 34.2 | 7e-25 | 110 |
| LLPS-Asni-0203 | Aspergillus niger | 34.05 | 4e-27 | 117 |
| LLPS-Aso-1438 | Aspergillus oryzae | 34.05 | 1e-27 | 118 |
| LLPS-Pyt-1366 | Pyrenophora teres | 33.48 | 1e-25 | 113 |
| LLPS-Asn-1096 | Aspergillus nidulans | 33.16 | 7e-27 | 116 |
| LLPS-Spr-1520 | Sporisorium reilianum | 32.97 | 1e-23 | 106 |
| LLPS-Phn-0695 | Phaeosphaeria nodorum | 32.91 | 1e-33 | 135 |
| LLPS-Scs-1123 | Sclerotinia sclerotiorum | 32.82 | 6e-22 | 102 |
| LLPS-Yal-0269 | Yarrowia lipolytica | 32.8 | 3e-19 | 93.6 |
| LLPS-Zyt-1210 | Zymoseptoria tritici | 32.64 | 1e-26 | 116 |
| LLPS-Abg-1403 | Absidia glauca | 32.34 | 4e-29 | 123 |
| LLPS-Lem-1294 | Leptosphaeria maculans | 32.34 | 6e-27 | 116 |
| LLPS-Asfu-1377 | Aspergillus fumigatus | 32.34 | 4e-30 | 125 |
| LLPS-Fuv-1021 | Fusarium verticillioides | 32.28 | 1e-24 | 109 |
| LLPS-Nec-0299 | Neurospora crassa | 32.21 | 8e-20 | 95.5 |
| LLPS-Osl-1284 | Ostreococcus lucimarinus | 32.2 | 1e-20 | 96.3 |
| LLPS-Fus-1590 | Fusarium solani | 32.14 | 2e-25 | 112 |
| LLPS-Trv-1389 | Trichoderma virens | 32.11 | 8e-20 | 95.1 |
| LLPS-Nef-1199 | Neosartorya fischeri | 31.91 | 1e-29 | 124 |
| LLPS-Ved-1292 | Verticillium dahliae | 31.82 | 3e-21 | 100 |
| LLPS-Trr-0305 | Trichoderma reesei | 31.78 | 1e-19 | 95.1 |
| LLPS-Mao-1430 | Magnaporthe oryzae | 31.63 | 1e-24 | 109 |
| LLPS-Usm-1510 | Ustilago maydis | 31.5 | 4e-23 | 105 |
| LLPS-Tum-1184 | Tuber melanosporum | 31.47 | 3e-22 | 102 |
| LLPS-Fuo-0881 | Fusarium oxysporum | 31.16 | 8e-21 | 98.2 |
| LLPS-Map-0801 | Magnaporthe poae | 30.68 | 8e-15 | 80.1 |
| LLPS-Beb-1019 | Beauveria bassiana | 29.89 | 1e-12 | 72.8 |
| LLPS-Gag-0353 | Gaeumannomyces graminis | 29.7 | 3e-16 | 84.7 |