LLPS-Mum-3148
Tars

▼ OVERVIEW


Status: Unreviewed
Protein Name: Threonine--tRNA ligase, cytoplasmic; Threonyl-tRNA synthetase; ThrRS
Gene Name: Tars
Ensembl Gene: ENSMUSG00000022241.6
Ensembl Protein: ENSMUSP00000022849.5
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-body, Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION


Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MSQEKASSPS  GKMDGEKPVD  ASEEKRKEGG  KKKSKDGGGD  GGRAELNPWP  EYINTRLDMY  60
61    NKLKAEHDSI  LAEKAAKDSK  PIKVTLPDGK  QVDAESWKTT  PYQIACGISQ  GLADNTVVAK  120
121   VNKVVWDLDR  PLETDCTLEL  LKFEDEEAQA  VYWHSSAHIM  GEAMERVYGG  CLCYGPPIEN  180
181   GFYYDMYLEE  GGVSSNDFSS  LETLCKKIIK  EKQTFERLEV  KKETLLEMFK  YNKFKCRILN  240
241   EKVNTPTTTV  YRCGPLIDLC  RGPHVRHTGK  IKTLKIHKNS  STYWEGKADM  ETLQRIYGIS  300
301   FPDPKLLKEW  EKFQEEAKNR  DHRKIGRDQE  LYFFHELSPG  SCFFLPKGAY  IYNTLMEFIR  360
361   SEYRKRGFQE  VVTPNIFNSR  LWMTSGHWQH  YSENMFSFEV  EKEQFALKPM  NCPGHCLMFD  420
421   HRPRSWRELP  LRLADFGVLH  RNELSGALTG  LTRVRRFQQD  DAHIFCAMEQ  IEDEIKGCLD  480
481   FLRTVYSVFG  FSFKLNLSTR  PEKFLGDIEI  WNQAEKQLEN  SLNEFGEKWE  LNPGDGAFYG  540
541   PKIDIQIKDA  IGRYHQCATI  QLDFQLPIRF  NLTYVSHDGD  DKKRPVIVHR  AILGSVERMI  600
601   AILTENYGGK  WPFWLSPRQV  MVVPVGPTCD  EYAQKVRQQF  HDAKFMADTD  LDPGCTLNKK  660
661   IRNAQLAQYN  FILVVGEKEK  ASGTVNIRTR  DNKVHGERTV  EETVRRLQQL  KQTRSKQAEE  720
721   EF  722
Nucleotide CDS Sequence (FASTA)
1     ATGTCGCAGG  AGAAGGCTAG  CAGCCCTTCG  GGGAAGATGG  ACGGCGAGAA  GCCGGTGGAT  60
61    GCCAGCGAGG  AGAAGCGGAA  AGAAGGAGGC  AAGAAGAAGA  GCAAAGATGG  AGGTGGAGAT  120
121   GGAGGTCGAG  CAGAGTTGAA  TCCCTGGCCT  GAATACATTA  ACACACGCCT  TGATATGTAC  180
181   AACAAACTCA  AAGCAGAACA  CGATTCTATC  CTGGCCGAAA  AGGCAGCAAA  AGATAGCAAG  240
241   CCGATTAAAG  TCACCCTGCC  TGACGGCAAG  CAGGTGGATG  CGGAGTCCTG  GAAAACCACG  300
301   CCGTATCAGA  TTGCTTGTGG  AATTAGTCAG  GGCCTGGCTG  ACAACACCGT  TGTTGCTAAG  360
361   GTGAACAAAG  TCGTTTGGGA  CCTGGACCGC  CCGCTGGAGA  CAGATTGCAC  GTTGGAGCTG  420
421   CTCAAGTTTG  AGGACGAGGA  AGCGCAGGCC  GTATACTGGC  ACTCCAGTGC  CCACATAATG  480
481   GGCGAGGCCA  TGGAGAGAGT  CTATGGCGGA  TGTCTATGTT  ACGGCCCACC  AATAGAAAAC  540
541   GGCTTCTATT  ATGATATGTA  CCTTGAAGAA  GGGGGCGTGT  CCAGCAATGA  CTTCTCTTCC  600
601   CTGGAAACTT  TGTGCAAGAA  AATCATTAAA  GAGAAACAAA  CTTTCGAAAG  ATTGGAAGTT  660
661   AAAAAGGAAA  CATTACTAGA  AATGTTTAAG  TACAACAAGT  TCAAGTGCCG  GATATTGAAT  720
721   GAGAAAGTGA  ATACTCCGAC  CACGACTGTC  TACAGATGTG  GCCCTCTGAT  AGATCTCTGC  780
781   CGGGGTCCTC  ATGTCCGACA  CACCGGCAAG  ATTAAGACTT  TGAAGATACA  CAAGAATTCT  840
841   TCCACGTACT  GGGAAGGCAA  AGCAGACATG  GAGACGCTCC  AGCGGATCTA  TGGCATTTCA  900
901   TTCCCTGACC  CCAAGCTACT  GAAAGAGTGG  GAGAAGTTCC  AAGAGGAAGC  CAAAAACCGA  960
961   GACCACAGGA  AAATCGGGAG  GGACCAAGAA  CTATATTTCT  TCCATGAACT  TAGCCCTGGA  1020
1021  AGTTGCTTTT  TCCTGCCCAA  AGGAGCCTAC  ATTTATAATA  CACTAATGGA  ATTTATCAGG  1080
1081  AGTGAATATA  GGAAAAGAGG  GTTCCAGGAG  GTCGTCACTC  CCAACATCTT  CAATAGCCGG  1140
1141  CTCTGGATGA  CCTCTGGCCA  CTGGCAGCAC  TACAGCGAGA  ACATGTTCTC  CTTTGAGGTG  1200
1201  GAGAAGGAGC  AGTTTGCACT  TAAGCCCATG  AACTGCCCGG  GACACTGCCT  GATGTTCGAT  1260
1261  CACCGGCCAC  GGTCCTGGCG  AGAGCTGCCC  CTGCGGCTAG  CTGACTTTGG  TGTGCTGCAT  1320
1321  AGGAATGAGC  TCTCGGGGGC  TCTCACCGGG  CTCACACGGG  TCCGAAGATT  CCAGCAGGAT  1380
1381  GACGCACACA  TCTTCTGTGC  CATGGAGCAG  ATTGAAGATG  AAATCAAAGG  TTGTTTGGAT  1440
1441  TTTCTTCGCA  CAGTATATAG  TGTCTTTGGA  TTTTCATTTA  AATTGAATCT  TTCTACTCGC  1500
1501  CCAGAAAAAT  TCCTTGGAGA  TATTGAAATA  TGGAACCAAG  CTGAGAAACA  ACTTGAAAAC  1560
1561  AGTTTGAATG  AGTTCGGTGA  GAAGTGGGAA  CTAAATCCTG  GAGATGGAGC  CTTCTATGGG  1620
1621  CCAAAGATTG  ACATACAGAT  AAAAGATGCC  ATCGGTCGCT  ACCACCAGTG  TGCAACCATC  1680
1681  CAGCTGGACT  TTCAGTTGCC  CATCAGGTTT  AACCTTACTT  ACGTCAGCCA  CGATGGCGAT  1740
1741  GATAAGAAAA  GGCCAGTGAT  TGTTCACAGA  GCCATCCTGG  GGTCGGTGGA  AAGAATGATT  1800
1801  GCCATCCTCA  CAGAAAACTA  TGGGGGCAAA  TGGCCTTTCT  GGCTCTCTCC  TCGCCAGGTG  1860
1861  ATGGTGGTCC  CAGTGGGACC  GACATGTGAT  GAATATGCCC  AAAAGGTACG  GCAACAATTC  1920
1921  CATGATGCTA  AATTCATGGC  GGACACTGAC  CTGGATCCAG  GCTGTACCTT  GAATAAGAAG  1980
1981  ATCAGAAACG  CACAGTTAGC  ACAGTATAAC  TTCATCCTTG  TTGTTGGTGA  AAAAGAGAAA  2040
2041  GCCAGTGGCA  CGGTGAACAT  CCGCACGAGA  GACAATAAGG  TCCACGGAGA  GCGGACAGTG  2100
2101  GAGGAGACGG  TGCGGCGGCT  GCAGCAGCTC  AAGCAGACGC  GCAGCAAGCA  GGCAGAGGAG  2160
2161  GAGTTCTAG  2169

▼ KEYWORD


ID
Family
Acetylation
Aminoacyl-tRNA synthetase
ATP-binding
Complete proteome
Cytoplasm
Ligase
Nucleotide-binding
Phosphoprotein
Protein biosynthesis
Reference proteome
Ubl conjugation

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Actin cytoskeleton
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Molecular Function
ATP binding
Molecular Function
Threonine-tRNA ligase activity
Biological Process
Threonyl-tRNA aminoacylation

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-0799Rattus norvegicus98.610.01437
LLPS-Ict-0075Ictidomys tridecemlineatus96.750.01391
LLPS-Poa-1533Pongo abelii95.930.01253
LLPS-Sus-0978Sus scrofa95.780.01350
LLPS-Dio-0541Dipodomys ordii95.710.01407
LLPS-Otg-0108Otolemur garnettii95.440.01398
LLPS-Fud-0870Fukomys damarensis95.240.01361
LLPS-Paa-0649Papio anubis94.880.01392
LLPS-Orc-0181Oryctolagus cuniculus94.880.01395
LLPS-Pap-0428Pan paniscus94.880.01391
LLPS-Mup-0320Mustela putorius furo94.740.01399
LLPS-Rhb-0370Rhinopithecus bieti94.610.01388
LLPS-Caf-1462Canis familiaris94.610.01394
LLPS-Chs-2988Chlorocebus sabaeus94.470.01390
LLPS-Urm-2026Ursus maritimus94.470.01389
LLPS-Caj-1323Callithrix jacchus94.330.01384
LLPS-Myl-1690Myotis lucifugus94.190.01398
LLPS-Bot-0785Bos taurus94.190.01397
LLPS-Eqc-0593Equus caballus94.040.01396
LLPS-Loa-2674Loxodonta africana93.770.01399
LLPS-Ova-0234Ovis aries93.640.01391
LLPS-Maf-3294Macaca fascicularis92.840.01385
LLPS-Man-1506Macaca nemestrina92.840.01385
LLPS-Mod-1801Monodelphis domestica92.250.01371
LLPS-Cap-0181Cavia porcellus92.120.01380
LLPS-Ora-2689Ornithorhynchus anatinus92.060.01357
LLPS-Fec-2664Felis catus92.030.01380
LLPS-Anp-0735Anas platyrhynchos92.020.01338
LLPS-Fia-1965Ficedula albicollis91.880.01339
LLPS-Cea-2152Cercocebus atys91.820.01367
LLPS-Tag-0925Taeniopygia guttata91.730.01336
LLPS-Gaga-2911Gallus gallus91.730.01331
LLPS-Pes-1646Pelodiscus sinensis91.140.01328
LLPS-Hos-1512Homo sapiens90.740.01373
LLPS-Gog-0778Gorilla gorilla90.610.01373
LLPS-Mam-3054Macaca mulatta90.610.01373
LLPS-Pat-2250Pan troglodytes90.480.01370
LLPS-Nol-2237Nomascus leucogenys90.480.01367
LLPS-Xet-0464Xenopus tropicalis90.250.01318
LLPS-Aon-2048Aotus nancymaae90.170.01369
LLPS-Mal-0271Mandrillus leucophaeus89.570.01294
LLPS-Aim-0522Ailuropoda melanoleuca89.510.01153
LLPS-Lac-1636Latimeria chalumnae89.510.01310
LLPS-Cas-1617Carlito syrichta89.140.01314
LLPS-Leo-0690Lepisosteus oculatus87.610.01268
LLPS-Asm-1333Astyanax mexicanus87.30.01280
LLPS-Dar-1307Danio rerio87.150.01276
LLPS-Scf-0437Scleropages formosus87.00.01263
LLPS-Orn-1428Oreochromis niloticus86.930.01273
LLPS-Xim-1004Xiphophorus maculatus86.870.01271
LLPS-Pof-1138Poecilia formosa86.870.01271
LLPS-Icp-2467Ictalurus punctatus86.710.01276
LLPS-Tar-2133Takifugu rubripes86.710.01274
LLPS-Scm-0508Scophthalmus maximus86.580.01266
LLPS-Gaa-0920Gasterosteus aculeatus86.430.01264
LLPS-Ten-1934Tetraodon nigroviridis86.390.01259
LLPS-Orl-0726Oryzias latipes86.140.01264
LLPS-Ere-0671Erinaceus europaeus78.070.01041
LLPS-Sah-0685Sarcophilus harrisii78.040.01148
LLPS-Meg-0688Meleagris gallopavo77.430.0 757
LLPS-Drm-0756Drosophila melanogaster75.980.01088
LLPS-Cii-1565Ciona intestinalis75.810.01004
LLPS-Mea-1126Mesocricetus auratus71.830.0 615
LLPS-Tut-0743Tursiops truncatus70.350.01046
LLPS-Cis-0462Ciona savignyi65.830.0 978
LLPS-Anc-1517Anolis carolinensis64.210.0 898
LLPS-Cae-0292Caenorhabditis elegans64.110.0 932
LLPS-Coc-0632Corchorus capsularis62.542e-151 451
LLPS-Kop-0055Komagataella pastoris60.920.0 852
LLPS-Mua-0361Musa acuminata60.820.0 670
LLPS-Cus-1248Cucumis sativus60.518e-138 416
LLPS-Zyt-1065Zymoseptoria tritici60.320.0 632
LLPS-Scp-1509Schizosaccharomyces pombe59.790.0 820
LLPS-Scj-0439Schizosaccharomyces japonicus59.590.0 838
LLPS-Spr-0444Sporisorium reilianum59.530.0 840
LLPS-Vir-0964Vigna radiata58.810.0 601
LLPS-Php-0836Physcomitrella patens58.640.0 816
LLPS-Miv-1000Microbotryum violaceum58.630.0 831
LLPS-Hov-0050Hordeum vulgare58.510.0 790
LLPS-Usm-1233Ustilago maydis58.390.0 826
LLPS-Tra-1094Triticum aestivum58.350.0 790
LLPS-Map-0260Magnaporthe poae58.230.0 647
LLPS-Ors-0391Oryza sativa58.230.0 803
LLPS-Org-0170Oryza glaberrima58.230.0 802
LLPS-Sol-1755Solanum lycopersicum58.070.0 782
LLPS-Scc-1066Schizosaccharomyces cryophilus58.060.0 811
LLPS-Brd-0591Brachypodium distachyon58.00.0 795
LLPS-Sot-0740Solanum tuberosum58.07e-168 496
LLPS-Yal-0973Yarrowia lipolytica57.870.0 850
LLPS-Beb-1046Beauveria bassiana57.660.0 809
LLPS-Asg-0121Ashbya gossypii57.640.0 791
LLPS-Gag-1044Gaeumannomyces graminis57.490.0 641
LLPS-Abg-1526Absidia glauca57.480.0 817
LLPS-Amt-0496Amborella trichopoda57.210.0 801
LLPS-Zem-1738Zea mays56.860.0 794
LLPS-Crn-0242Cryptococcus neoformans56.850.0 791
LLPS-Sob-0753Sorghum bicolor56.710.0 795
LLPS-Nia-0714Nicotiana attenuata56.570.0 785
LLPS-Mel-1074Melampsora laricipopulina56.560.0 808
LLPS-Orbr-0881Oryza brachyantha56.550.0 799
LLPS-Scs-0654Sclerotinia sclerotiorum56.530.0 804
LLPS-Sac-0312Saccharomyces cerevisiae56.520.0 810
LLPS-Gor-0923Gossypium raimondii56.510.0 760
LLPS-Thc-0939Theobroma cacao56.470.0 757
LLPS-Trr-0462Trichoderma reesei56.440.0 803
LLPS-Trv-0973Trichoderma virens56.30.0 793
LLPS-Pug-0815Puccinia graminis56.290.0 795
LLPS-Sei-0098Setaria italica56.230.0 786
LLPS-Fuv-0409Fusarium verticillioides56.210.0 799
LLPS-Fuo-0723Fusarium oxysporum56.210.0 800
LLPS-Put-1106Puccinia triticina55.890.0 745
LLPS-Bro-2715Brassica oleracea55.870.0 760
LLPS-Viv-1542Vitis vinifera55.610.0 767
LLPS-Ori-1857Oryza indica55.540.0 749
LLPS-Hea-0524Helianthus annuus55.390.0 784
LLPS-Fus-0083Fusarium solani55.170.0 788
LLPS-Chr-0139Chlamydomonas reinhardtii55.160.0 746
LLPS-Dac-1098Daucus carota54.930.0 775
LLPS-Pyt-0872Pyrenophora teres54.920.0 803
LLPS-Prp-1729Prunus persica54.90.0 757
LLPS-Sem-2308Selaginella moellendorffii54.880.0 741
LLPS-Glm-0916Glycine max54.860.0 765
LLPS-Met-1919Medicago truncatula54.860.0 767
LLPS-Osl-0338Ostreococcus lucimarinus54.810.0 752
LLPS-Lep-0669Leersia perrieri54.80.0 746
LLPS-Orb-0383Oryza barthii54.770.0 705
LLPS-Brr-0939Brassica rapa54.760.0 758
LLPS-Art-2093Arabidopsis thaliana54.710.0 771
LLPS-Pytr-0812Pyrenophora triticirepentis54.650.0 796
LLPS-Lem-0108Leptosphaeria maculans54.560.0 808
LLPS-Gas-0154Galdieria sulphuraria54.520.0 751
LLPS-Orni-0076Oryza nivara54.430.0 732
LLPS-Orr-0113Oryza rufipogon54.430.0 732
LLPS-Blg-0906Blumeria graminis54.380.0 780
LLPS-Tum-0843Tuber melanosporum54.360.0 706
LLPS-Arl-1047Arabidopsis lyrata54.260.0 764
LLPS-Phv-0187Phaseolus vulgaris54.260.0 763
LLPS-Pot-1744Populus trichocarpa54.20.0 761
LLPS-Orgl-0878Oryza glumaepatula53.990.0 732
LLPS-Orm-0832Oryza meridionalis53.990.0 729
LLPS-Phn-0812Phaeosphaeria nodorum53.860.0 792
LLPS-Brn-0289Brassica napus53.730.0 760
LLPS-Mae-0642Manihot esculenta53.340.0 753
LLPS-Cym-0941Cyanidioschyzon merolae53.10.0 780
LLPS-Cog-1323Colletotrichum gloeosporioides52.670.0 772
LLPS-Cogr-1411Colletotrichum graminicola52.540.0 769
LLPS-Dos-0659Dothistroma septosporum52.380.0 755
LLPS-Ved-0327Verticillium dahliae52.330.0 777
LLPS-Nec-0802Neurospora crassa52.210.0 751
LLPS-Via-1545Vigna angularis52.130.0 721
LLPS-Asf-0098Aspergillus flavus51.150.0 732
LLPS-Aso-0721Aspergillus oryzae51.150.0 732
LLPS-Mao-0741Magnaporthe oryzae50.870.0 728
LLPS-Coo-1074Colletotrichum orbiculare50.870.0 754
LLPS-Asni-0511Aspergillus niger50.870.0 721
LLPS-Chc-0466Chondrus crispus50.870.0 642
LLPS-Ast-0524Aspergillus terreus50.720.0 723
LLPS-Asn-0362Aspergillus nidulans50.220.0 720
LLPS-Tru-0163Triticum urartu50.080.0 649
LLPS-Asc-0770Aspergillus clavatus50.00.0 718
LLPS-Asfu-0431Aspergillus fumigatus50.00.0 716
LLPS-Nef-0588Neosartorya fischeri49.860.0 713
LLPS-Orp-0238Oryza punctata39.892e-134 419