LLPS-Mum-3130
Dcp1b

▼ OVERVIEW

Status: Unreviewed
Protein Name: mRNA-decapping enzyme 1B
Gene Name: Dcp1b
Ensembl Gene: ENSMUSG00000041477.14
Ensembl Protein: ENSMUSP00000073568.5
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: LLPS protein


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Droplet, P-body, Stress granule, Sponge body, OthersPredicted from orthologs(View)

▼ FUNCTION

May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAAAAGGLP  GKGHDISLAA  LRRHDPYISR  IVDVASQVAL  YTFGHRANEW  EKTGVEGTLF  60
61    VYTRSASPKH  GFTIMNRLSM  ENRTEPITKD  LDFQLQNPFL  LYRNGTLSIY  GIWFYDKEEC  120
121   QRIAKLMKNL  TQSEQLKACH  GAGSSPVTLS  SGEGQEVDIL  QMLTKAKDEY  TKCKTCSEPK  180
181   QMTNSSAICD  NPKLIKPVPV  RPSSSQRLQG  PAPSKTSDPE  PQHLSLTALF  GKQDKAPCQE  240
241   TVKPSRTFAH  HHHHHHQQQQ  ETRPVHHGVA  CSLSCEEPRK  LSLPVEKQLC  PAIQKLMLGS  300
301   PGLHPLPQHP  EQWSCKSGSP  SPAGGILPGP  VQLGSPWNGR  VAHCTQSTCR  GHKLLEQLQG  360
361   APGAVHKYNP  CAPTGPAVAT  QVAPGQSVAQ  SQLVYFSGPL  QPPAPGHQAL  RKEQGALPAQ  420
421   AVSLSGSQES  SPTVLPTQEL  LRKLQVVHQE  QQAAPRPALA  ARFPVSAQGS  GTEKPLEAWV  480
481   SKTASMEKQA  PLLQSTCAPL  RETDNGLMAL  GGQELPAASS  SLLLPLQNWE  SSTVASRPLT  540
541   RLQLQEALLN  LIQNDDNFLS  IIYEAYLFSV  TQAAMRTT  578
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGCCG  CGGCGGCAGG  TGGCCTGCCT  GGGAAGGGAC  ACGATATCAG  CCTGGCAGCC  60
61    CTGCGGCGCC  ACGACCCCTA  CATCAGTCGC  ATCGTGGACG  TGGCCAGCCA  GGTGGCTCTG  120
121   TACACTTTCG  GCCATCGGGC  CAACGAGTGG  GAGAAGACTG  GAGTGGAGGG  AACCTTGTTT  180
181   GTTTATACGA  GGTCTGCCTC  CCCAAAGCAC  GGATTCACCA  TTATGAATAG  GCTCAGCATG  240
241   GAAAACAGAA  CAGAACCCAT  TACTAAAGAC  CTGGACTTCC  AGCTCCAGAA  CCCTTTCCTT  300
301   CTCTACAGAA  ACGGCACACT  GTCCATTTAT  GGAATTTGGT  TTTATGATAA  GGAAGAGTGC  360
361   CAGAGAATTG  CAAAACTAAT  GAAAAACCTC  ACTCAGAGCG  AACAGTTGAA  AGCCTGTCAT  420
421   GGAGCCGGAT  CCTCCCCCGT  GACCTTGAGC  TCAGGAGAGG  GCCAAGAAGT  AGATATCCTG  480
481   CAGATGCTCA  CCAAGGCCAA  GGATGAGTAC  ACCAAGTGTA  AGACCTGTTC  CGAGCCAAAA  540
541   CAGATGACCA  ATTCCTCTGC  CATCTGTGAC  AACCCTAAAC  TTATCAAACC  TGTCCCCGTG  600
601   AGACCCAGCA  GCAGCCAGAG  GCTGCAAGGA  CCTGCGCCCA  GCAAGACCTC  GGACCCTGAG  660
661   CCTCAGCACT  TATCTTTAAC  AGCACTATTT  GGGAAACAAG  ACAAAGCTCC  CTGTCAGGAA  720
721   ACTGTAAAGC  CCTCCCGGAC  CTTTGCCCAC  CACCACCACC  ATCACCACCA  GCAGCAGCAA  780
781   GAGACGCGTC  CAGTTCATCA  CGGGGTCGCA  TGCTCCCTGT  CCTGTGAGGA  GCCCAGGAAG  840
841   CTCTCACTCC  CGGTGGAGAA  GCAGCTCTGC  CCGGCCATTC  AGAAACTCAT  GCTCGGGAGC  900
901   CCGGGGCTGC  ACCCCCTGCC  TCAGCACCCT  GAACAGTGGT  CCTGCAAAAG  TGGCAGCCCC  960
961   AGTCCTGCCG  GGGGAATTCT  CCCTGGTCCT  GTCCAGCTGG  GGTCCCCCTG  GAATGGCAGG  1020
1021  GTTGCACACT  GCACACAGAG  CACTTGCAGA  GGCCACAAGC  TATTAGAGCA  GCTTCAAGGT  1080
1081  GCCCCTGGGG  CAGTGCATAA  GTATAACCCC  TGTGCGCCTA  CCGGTCCAGC  TGTGGCCACT  1140
1141  CAGGTGGCTC  CGGGCCAGAG  TGTGGCCCAA  TCACAGCTGG  TGTATTTCAG  TGGCCCCCTT  1200
1201  CAACCTCCCG  CCCCAGGACA  CCAAGCTCTC  AGGAAGGAGC  AGGGTGCACT  GCCTGCACAA  1260
1261  GCGGTGTCCC  TCTCTGGCAG  CCAGGAGAGC  AGCCCCACCG  TGCTCCCTAC  GCAGGAGCTG  1320
1321  CTAAGGAAGC  TCCAGGTAGT  ACACCAGGAG  CAGCAGGCGG  CCCCCCGGCC  AGCCTTGGCA  1380
1381  GCCAGGTTCC  CTGTGTCAGC  CCAGGGATCA  GGGACAGAAA  AGCCCTTGGA  AGCCTGGGTC  1440
1441  AGCAAGACAG  CCAGCATGGA  GAAGCAGGCT  CCTCTTCTGC  AGAACTGGGA  GTCCTCCACC  1500
1501  GTGGCCAGCA  GGCCCCTCAC  CAGGCTGCAG  CTCCAGGAGG  CACTGCTGAA  CCTCATCCAG  1560
1561  AATGATGACA  ACTTCTTAAG  CATAATCTAT  GAAGCCTATC  TCTTCAGCGT  GACACAAGCA  1620
1621  GCCATGAGAA  CCACGTAA  1638

▼ KEYWORD

ID
Family
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Hydrolase
Nonsense-mediated mRNA decay
Nucleus
Phosphoprotein
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Intracellular membrane-bounded organelle
Cellular Component
Nucleus
Cellular Component
P-body
Molecular Function
Enzyme activator activity
Molecular Function
Hydrolase activity
Biological Process
Deadenylation-dependent decapping of nuclear-transcribed mRNA
Biological Process
Deadenylation-independent decapping of nuclear-transcribed mRNA
Biological Process
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-0927Rattus norvegicus92.290.0 977
LLPS-Mea-1671Mesocricetus auratus83.050.0 865
LLPS-Scm-0037Scophthalmus maximus78.465e-62 223
LLPS-Ora-0781Ornithorhynchus anatinus77.146e-65 215
LLPS-Ict-0622Ictidomys tridecemlineatus64.710.0 676
LLPS-Xim-2786Xiphophorus maculatus64.081e-80 272
LLPS-Leo-1564Lepisosteus oculatus64.024e-65 229
LLPS-Fec-0209Felis catus63.550.0 671
LLPS-Otg-0395Otolemur garnettii63.040.0 660
LLPS-Hos-0418Homo sapiens62.730.0 679
LLPS-Lac-0521Latimeria chalumnae62.582e-61 219
LLPS-Gog-0479Gorilla gorilla62.30.0 679
LLPS-Orc-0508Oryctolagus cuniculus62.150.0 600
LLPS-Caj-1863Callithrix jacchus62.140.0 660
LLPS-Cas-0730Carlito syrichta62.110.0 649
LLPS-Pap-2161Pan paniscus62.090.0 679
LLPS-Aim-2118Ailuropoda melanoleuca62.010.0 645
LLPS-Fud-0553Fukomys damarensis62.010.0 647
LLPS-Caf-1248Canis familiaris61.970.0 650
LLPS-Pat-1166Pan troglodytes61.930.0 675
LLPS-Mup-0446Mustela putorius furo61.740.0 640
LLPS-Nol-0216Nomascus leucogenys61.580.0 669
LLPS-Aon-0870Aotus nancymaae61.240.0 654
LLPS-Man-0317Macaca nemestrina61.080.0 657
LLPS-Mal-1778Mandrillus leucophaeus61.080.0 661
LLPS-Maf-0774Macaca fascicularis61.080.0 660
LLPS-Cea-0812Cercocebus atys61.080.0 657
LLPS-Chs-1256Chlorocebus sabaeus60.960.0 644
LLPS-Mam-0315Macaca mulatta60.920.0 656
LLPS-Orn-0227Oreochromis niloticus60.715e-63 222
LLPS-Paa-1186Papio anubis60.650.0 656
LLPS-Icp-1882Ictalurus punctatus59.882e-62 219
LLPS-Cap-0186Cavia porcellus59.570.0 606
LLPS-Myl-3571Myotis lucifugus59.540.0 548
LLPS-Ten-1371Tetraodon nigroviridis59.399e-60 214
LLPS-Tar-0617Takifugu rubripes59.173e-60 214
LLPS-Urm-1969Ursus maritimus58.933e-179 525
LLPS-Dar-1078Danio rerio58.438e-59 208
LLPS-Poa-3189Pongo abelii58.380.0 533
LLPS-Loa-1602Loxodonta africana58.282e-58 211
LLPS-Pof-1336Poecilia formosa57.995e-61 216
LLPS-Mod-0988Monodelphis domestica57.80.0 608
LLPS-Eqc-3517Equus caballus57.675e-58 209
LLPS-Rhb-0498Rhinopithecus bieti57.677e-58 209
LLPS-Bot-0487Bos taurus57.673e-58 210
LLPS-Ova-1054Ovis aries57.677e-58 209
LLPS-Sus-0473Sus scrofa57.678e-58 209
LLPS-Anc-2620Anolis carolinensis57.492e-55 202
LLPS-Pes-1928Pelodiscus sinensis57.41e-59 215
LLPS-Anp-0986Anas platyrhynchos55.610.0 580
LLPS-Scf-1170Scleropages formosus55.055e-100 320
LLPS-Sah-1636Sarcophilus harrisii55.03e-40 158
LLPS-Asm-1821Astyanax mexicanus55.05e-61 216
LLPS-Gaga-1389Gallus gallus54.970.0 578
LLPS-Tag-1070Taeniopygia guttata54.860.0 558
LLPS-Dio-1060Dipodomys ordii53.053e-49 185
LLPS-Gaa-3016Gasterosteus aculeatus52.66e-89 293
LLPS-Fia-1042Ficedula albicollis51.477e-143 431
LLPS-Meg-1653Meleagris gallopavo50.822e-173 512
LLPS-Xet-0079Xenopus tropicalis50.64e-151 453
LLPS-Orl-0485Oryzias latipes46.541e-83 281
LLPS-Drm-0170Drosophila melanogaster43.792e-36 144
LLPS-Sot-1686Solanum tuberosum42.866e-25 110
LLPS-Sol-2457Solanum lycopersicum42.864e-25 111
LLPS-Hea-0520Helianthus annuus42.611e-27 118
LLPS-Cii-0787Ciona intestinalis42.491e-48 176
LLPS-Prp-0785Prunus persica41.746e-27 116
LLPS-Dac-1101Daucus carota41.742e-27 118
LLPS-Tru-1401Triticum urartu41.512e-0963.2
LLPS-Tra-0122Triticum aestivum41.072e-26 115
LLPS-Hov-1342Hordeum vulgare41.073e-26 114
LLPS-Sob-0636Sorghum bicolor40.872e-25 112
LLPS-Orbr-0046Oryza brachyantha40.182e-25 112
LLPS-Nia-2265Nicotiana attenuata40.183e-24 108
LLPS-Art-0141Arabidopsis thaliana40.02e-26 115
LLPS-Met-2285Medicago truncatula40.03e-26 114
LLPS-Arl-0539Arabidopsis lyrata40.01e-26 115
LLPS-Brr-2476Brassica rapa39.666e-25 110
LLPS-Orm-0270Oryza meridionalis39.296e-25 110
LLPS-Orr-0122Oryza rufipogon39.295e-25 110
LLPS-Zem-0192Zea mays39.292e-25 112
LLPS-Org-1243Oryza glaberrima39.297e-25 110
LLPS-Ors-0526Oryza sativa39.291e-24 110
LLPS-Orgl-0815Oryza glumaepatula39.296e-25 110
LLPS-Lep-0005Leersia perrieri39.294e-25 111
LLPS-Brd-2263Brachypodium distachyon39.292e-24 110
LLPS-Sei-2435Setaria italica39.295e-25 110
LLPS-Ori-2099Oryza indica39.291e-24 110
LLPS-Orb-1447Oryza barthii39.295e-25 110
LLPS-Orni-2152Oryza nivara39.291e-24 110
LLPS-Coc-0279Corchorus capsularis39.133e-25 111
LLPS-Pot-1228Populus trichocarpa39.131e-26 115
LLPS-Mae-2325Manihot esculenta39.135e-26 114
LLPS-Via-0344Vigna angularis39.132e-25 112
LLPS-Cus-0050Cucumis sativus39.135e-26 114
LLPS-Abg-1002Absidia glauca38.895e-1891.7
LLPS-Spr-0106Sporisorium reilianum38.412e-24 109
LLPS-Gor-0826Gossypium raimondii38.266e-25 110
LLPS-Viv-2093Vitis vinifera38.268e-26 113
LLPS-Orp-1512Oryza punctata38.265e-26 114
LLPS-Phv-0926Phaseolus vulgaris38.264e-25 110
LLPS-Mua-1187Musa acuminata38.261e-25 112
LLPS-Php-0867Physcomitrella patens37.938e-25 110
LLPS-Bro-2624Brassica oleracea37.786e-26 116
LLPS-Sem-0430Selaginella moellendorffii37.612e-23 101
LLPS-Brn-2505Brassica napus37.55e-27 116
LLPS-Glm-1731Glycine max37.398e-25 110
LLPS-Osl-0011Ostreococcus lucimarinus36.451e-1682.0
LLPS-Thc-0100Theobroma cacao36.112e-25 112
LLPS-Put-0833Puccinia triticina36.01e-1894.4
LLPS-Pug-0263Puccinia graminis36.06e-1995.1
LLPS-Usm-0358Ustilago maydis35.867e-2199.0
LLPS-Miv-0094Microbotryum violaceum35.594e-1582.4
LLPS-Amt-1138Amborella trichopoda35.426e-25 110
LLPS-Vir-1386Vigna radiata33.095e-2199.4
LLPS-Scp-0003Schizosaccharomyces pombe32.748e-1473.9
LLPS-Lem-0310Leptosphaeria maculans31.825e-1167.8
LLPS-Chr-0077Chlamydomonas reinhardtii31.365e-1890.5
LLPS-Scc-0861Schizosaccharomyces cryophilus30.562e-1167.0
LLPS-Phn-0391Phaeosphaeria nodorum30.05e-1064.7
LLPS-Cae-0303Caenorhabditis elegans29.732e-1066.6
LLPS-Mao-0448Magnaporthe oryzae29.469e-1063.2
LLPS-Cym-0362Cyanidioschyzon merolae29.377e-0962.4
LLPS-Coo-0237Colletotrichum orbiculare28.474e-1064.3
LLPS-Mel-0545Melampsora laricipopulina27.815e-1789.0
LLPS-Pyt-0615Pyrenophora teres27.782e-1065.9
LLPS-Asf-1238Aspergillus flavus27.641e-0964.3
LLPS-Ast-1168Aspergillus terreus27.482e-0963.9
LLPS-Aso-0000Aspergillus oryzae27.24e-1064.7
LLPS-Asn-0382Aspergillus nidulans27.051e-1066.6
LLPS-Beb-0008Beauveria bassiana26.721e-0962.8
LLPS-Cogr-0023Colletotrichum graminicola26.715e-1063.9
LLPS-Pytr-0109Pyrenophora triticirepentis25.865e-1270.1
LLPS-Trv-0016Trichoderma virens25.66e-1063.5
LLPS-Fuo-0256Fusarium oxysporum25.02e-0858.9
LLPS-Trr-1367Trichoderma reesei24.02e-0858.9