LLPS-Mum-2885
Twistnb

▼ OVERVIEW

Status: Reviewed
Protein Name: DNA-directed RNA polymerase I subunit RPA43; Twist neighbor protein
Gene Name: Twistnb
Ensembl Gene: ENSMUSG00000020561.8
Ensembl Protein: ENSMUSP00000020877.7
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs

▼ FUNCTION

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAGSVESQR  SQAASERPVA  GQAGVLPCLE  LPSYAAACAL  VGSRYSCLVA  APHRRHIALS  60
61    PRYLSRKRTG  IREQLDAELL  RYSESLLGVP  IAYDNIRVVG  ELGDIYDDQG  HIHLNIEADF  120
121   VIFCPEPGQT  LMGTVNKVSS  SHIGCLVHGC  FNASIPKPEQ  MSYEEWQTLE  IHVGDELEFD  180
181   VFRLDSDSAG  VFCIRGKLST  TSLQLKHSAV  SEDVAETVVE  EVVEKTPKKK  KKKKDKDTDT  240
241   CGTVDSVTEV  ADVTDVTPQE  ETDIPCSDNV  NDFFEEEPKK  KKKKKKRHQE  DQDPIFQASD  300
301   SSGYQSDHNK  KKKKRKHSEE  ANFESPKKRQ  330
Nucleotide CDS Sequence (FASTA)
1     ATGGCTGCGG  GATCTGTGGA  GTCTCAGCGG  TCCCAGGCGG  CCTCCGAGAG  GCCCGTGGCG  60
61    GGTCAGGCCG  GGGTCCTGCC  TTGCCTGGAG  TTGCCGAGCT  ACGCGGCGGC  GTGCGCGCTG  120
121   GTGGGCAGCC  GCTATTCGTG  CTTGGTGGCT  GCCCCGCACC  GCAGGCACAT  CGCCCTGTCG  180
181   CCCCGCTACC  TGAGCAGGAA  GCGCACGGGC  ATCCGCGAGC  AGCTGGACGC  CGAGCTCCTG  240
241   CGCTACTCCG  AGAGCCTTTT  AGGTGTCCCT  ATTGCATATG  ATAACATCAG  AGTTGTGGGT  300
301   GAACTAGGAG  ATATTTATGA  TGATCAAGGA  CACATTCATC  TTAACATTGA  AGCAGATTTT  360
361   GTTATTTTCT  GCCCTGAGCC  TGGGCAGACG  TTAATGGGTA  CAGTTAATAA  AGTATCGTCT  420
421   AGCCATATTG  GCTGTCTAGT  CCATGGATGT  TTTAACGCCT  CTATCCCTAA  GCCTGAGCAG  480
481   ATGTCATATG  AGGAGTGGCA  AACATTGGAG  ATACATGTAG  GCGATGAACT  GGAATTTGAT  540
541   GTATTTCGCT  TAGATTCAGA  TTCTGCTGGA  GTGTTCTGCA  TTCGAGGAAA  ACTGAGTACC  600
601   ACCAGTTTGC  AACTTAAGCA  CTCTGCAGTT  TCTGAAGATG  TAGCAGAAAC  TGTCGTTGAA  660
661   GAGGTTGTTG  AAAAAACTCC  AAAGAAGAAA  AAGAAGAAGA  AAGACAAAGA  TACAGACACA  720
721   TGTGGAACAG  TTGATAGTGT  TACAGAGGTT  GCAGATGTTA  CAGATGTCAC  GCCACAGGAA  780
781   GAAACAGACA  TACCATGTAG  TGATAATGTG  AATGACTTCT  TTGAGGAAGA  GCCAAAGAAG  840
841   AAGAAAAAGA  AGAAGAAAAG  GCACCAGGAA  GATCAGGACC  CCATTTTCCA  AGCCAGTGAC  900
901   TCCAGTGGCT  ACCAGAGTGA  CCATAACAAG  AAAAAAAAGA  AAAGAAAGCA  CAGTGAAGAG  960
961   GCTAACTTTG  AGTCACCTAA  GAAGAGACAG  TAA  993

▼ KEYWORD

ID
Family
Complete proteome
DNA-directed RNA polymerase
Nucleus
Phosphoprotein
Reference proteome
Transcription

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
RNA polymerase I complex
Molecular Function
DNA-directed 5'-3' RNA polymerase activity
Biological Process
Cellular response to leukemia inhibitory factor
Biological Process
Transcription by RNA polymerase I

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-0518Rattus norvegicus87.276e-175 495
LLPS-Aim-0572Ailuropoda melanoleuca87.132e-125 372
LLPS-Mea-1576Mesocricetus auratus78.696e-106 317
LLPS-Eqc-0929Equus caballus76.565e-147 426
LLPS-Fec-1552Felis catus76.193e-148 428
LLPS-Urm-1088Ursus maritimus75.225e-147 425
LLPS-Ova-2051Ovis aries74.921e-139 406
LLPS-Otg-2863Otolemur garnettii74.772e-140 409
LLPS-Ict-0213Ictidomys tridecemlineatus74.75e-151 436
LLPS-Poa-0106Pongo abelii74.554e-149 431
LLPS-Gog-1008Gorilla gorilla74.244e-148 428
LLPS-Pat-2194Pan troglodytes74.244e-148 428
LLPS-Mup-2328Mustela putorius furo74.031e-145 422
LLPS-Hos-0686Homo sapiens73.941e-147 427
LLPS-Pap-1624Pan paniscus73.942e-146 424
LLPS-Fud-1558Fukomys damarensis73.855e-145 420
LLPS-Caj-0256Callithrix jacchus73.726e-147 425
LLPS-Sus-0012Sus scrofa73.351e-145 421
LLPS-Chs-1581Chlorocebus sabaeus73.331e-145 421
LLPS-Maf-0971Macaca fascicularis73.334e-146 423
LLPS-Aon-3221Aotus nancymaae73.338e-147 424
LLPS-Mal-1092Mandrillus leucophaeus73.332e-146 424
LLPS-Rhb-0942Rhinopithecus bieti73.339e-147 425
LLPS-Mam-3834Macaca mulatta73.334e-146 423
LLPS-Loa-2343Loxodonta africana73.292e-144 418
LLPS-Cap-3156Cavia porcellus73.291e-149 432
LLPS-Cea-1486Cercocebus atys73.037e-146 422
LLPS-Paa-0131Papio anubis73.038e-146 422
LLPS-Man-1504Macaca nemestrina72.731e-143 417
LLPS-Cas-1526Carlito syrichta72.497e-147 425
LLPS-Dio-3213Dipodomys ordii71.848e-137 399
LLPS-Bot-0073Bos taurus71.343e-140 407
LLPS-Tag-1211Taeniopygia guttata70.862e-76 238
LLPS-Orc-0450Oryctolagus cuniculus70.751e-89 276
LLPS-Caf-2101Canis familiaris69.945e-137 401
LLPS-Lac-2837Latimeria chalumnae69.786e-88 275
LLPS-Anp-0148Anas platyrhynchos68.991e-56 191
LLPS-Fia-0787Ficedula albicollis68.947e-77 244
LLPS-Myl-1183Myotis lucifugus67.521e-110 331
LLPS-Tut-0547Tursiops truncatus67.074e-88 271
LLPS-Anc-2324Anolis carolinensis63.915e-73 231
LLPS-Leo-0665Lepisosteus oculatus62.773e-79 252
LLPS-Scf-1786Scleropages formosus62.52e-66 218
LLPS-Xet-0885Xenopus tropicalis61.425e-86 274
LLPS-Ora-0861Ornithorhynchus anatinus60.171e-67 219
LLPS-Orl-0020Oryzias latipes60.112e-71 234
LLPS-Pof-0971Poecilia formosa59.773e-71 233
LLPS-Mod-0721Monodelphis domestica59.366e-98 304
LLPS-Xim-1578Xiphophorus maculatus58.515e-73 237
LLPS-Gaga-0357Gallus gallus58.392e-93 290
LLPS-Dar-1001Danio rerio58.062e-73 238
LLPS-Orn-0940Oreochromis niloticus57.226e-73 237
LLPS-Scm-0575Scophthalmus maximus56.94e-69 227
LLPS-Asm-0415Astyanax mexicanus55.911e-72 234
LLPS-Tar-2262Takifugu rubripes55.753e-62 209
LLPS-Gaa-2589Gasterosteus aculeatus55.752e-68 221
LLPS-Icp-1588Ictalurus punctatus51.242e-68 225
LLPS-Pes-0510Pelodiscus sinensis50.893e-55 188
LLPS-Ten-1760Tetraodon nigroviridis47.181e-55 191
LLPS-Chr-0382Chlamydomonas reinhardtii34.181e-1684.3
LLPS-Cii-0325Ciona intestinalis33.712e-25 106
LLPS-Scc-0201Schizosaccharomyces cryophilus32.283e-1576.6
LLPS-Scj-0187Schizosaccharomyces japonicus31.655e-1575.9
LLPS-Amt-0443Amborella trichopoda31.522e-0961.2
LLPS-Php-1013Physcomitrella patens31.07e-0857.0
LLPS-Sem-0322Selaginella moellendorffii30.892e-1063.9
LLPS-Asg-0452Ashbya gossypii30.585e-1063.5
LLPS-Cis-0549Ciona savignyi30.294e-1783.6
LLPS-Tum-1390Tuber melanosporum30.233e-1063.9
LLPS-Drm-1537Drosophila melanogaster29.925e-1063.2
LLPS-Abg-1305Absidia glauca29.662e-1271.2
LLPS-Scp-0479Schizosaccharomyces pombe29.191e-1474.7
LLPS-Kop-0316Komagataella pastoris29.061e-0756.6
LLPS-Yal-0066Yarrowia lipolytica28.574e-0857.8
LLPS-Crn-0861Cryptococcus neoformans28.167e-0754.3
LLPS-Sac-1054Saccharomyces cerevisiae27.424e-0858.2
LLPS-Usm-1019Ustilago maydis25.493e-0755.5