LLPS-Mum-2869
Snapc3
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | snRNA-activating protein complex subunit 3 |
| Gene Name: | Snapc3 |
| Ensembl Gene: | ENSMUSG00000028483.13 |
| Ensembl Protein: | ENSMUSP00000124468.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| OPT domain | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000137512.7 | ENSMUSP00000124468.1 |
| Ensembl | ENSMUST00000123262.7 | ENSMUSP00000124038.1 |
| Ensembl | ENSMUST00000124856.7 | ENSMUSP00000124181.1 |
| Ensembl | ENSMUST00000030206.9 | ENSMUSP00000030206.3 |
| Ensembl | ENSMUST00000143533.7 | ENSMUSP00000123793.1 |
| Ensembl | ENSMUST00000071544.10 | ENSMUSP00000102842.1 |
| UniProt | Q9D2C9, SNPC3_MOUSE, Q8C0A5 | |
| GeneBank | AK019863, BC048713, AK049933, AK031870 | AAH48713.1, BAB31890.2, BAC33990.1, BAC27585.1 |
| RefSeq | NM_029949.3, XM_006538369.3, XM_006538370.3, XM_006538372.3, XM_011250134.2, XM_017320455.1, XM_017320456.1 | NP_084225.1, XP_006538432.1, XP_006538433.1, XP_006538435.1, XP_011248436.1, XP_017175944.1, XP_017175945.1 |
| Entrez | 77634 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAEDLQGGGA GGPQHPVPSA SHSSFPEYEL PELHTRVFHV GSFGELWRGR LGAQDLSLSE 60 61 PQAAEQPTDG GASNDGFEDA AVASDLGCSL EAAAELRVVC GLDKLRCLGE DEDPEVIPEN 120 121 TDLVTLCVRK GLLDYREENI TIDRACRQEI FAYEMESHAL GKKPENPADM IEEGECILSV 180 181 NILYPVIFNK HKEHKPYQTM LVLGSQKLTE LRDSICCVSD LQIGGEFSNA PDQAPEHISK 240 241 DLYKSAFFYF EGTFYNDRRY PECRDLSRTI IEWSESHDRG YGKFQTARME DFTFNDLHIK 300 301 LGFPYLYCHQ GDCEHVVVIT DIRLVHHDDC LDRTLYPLLT KKHWLWTRKC FVCKMYTARW 360 361 VTNNDTFAPE DPCFFCDVCF RMLHYDSEGN KLGEFLAYPY VDPGTFN 407 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGAGG ACCTGCAGGG CGGCGGTGCG GGTGGCCCAC AGCACCCAGT CCCCAGTGCG 60 61 AGCCACAGCA GCTTTCCGGA ATACGAGCTT CCCGAGTTGC ACACGCGCGT GTTCCATGTG 120 121 GGCTCCTTTG GGGAGCTATG GCGTGGCCGG CTAGGGGCCC AGGATTTGTC GCTGAGCGAA 180 181 CCGCAGGCAG CCGAGCAGCC GACCGACGGA GGGGCATCCA ACGACGGCTT TGAGGATGCT 240 241 GCAGTAGCCA GCGATCTGGG CTGCAGTCTG GAGGCAGCAG CAGAGCTGAG GGTCGTGTGC 300 301 GGCCTTGATA AACTGAGATG CCTCGGGGAA GATGAAGACC CGGAAGTCAT CCCAGAGAAC 360 361 ACTGACCTAG TGACTTTATG TGTGAGGAAG GGGCTTTTGG ACTATCGGGA AGAAAACATC 420 421 ACAATAGATC GCGCCTGTAG ACAAGAAATA TTTGCTTATG AAATGGAATC TCATGCACTA 480 481 GGGAAGAAAC CTGAAAACCC AGCAGACATG ATTGAAGAAG GAGAGTGTAT CCTATCTGTG 540 541 AACATCTTAT ATCCTGTTAT ATTTAATAAG CACAAAGAAC ACAAACCATA CCAGACCATG 600 601 TTGGTACTGG GCAGTCAGAA GCTCACAGAA CTGAGAGATT CAATTTGCTG TGTCAGTGAC 660 661 CTCCAGATCG GTGGAGAATT CAGCAACGCG CCAGACCAAG CCCCTGAGCA CATCAGCAAA 720 721 GACCTCTACA AGTCGGCTTT TTTCTATTTT GAAGGAACAT TTTACAATGA CAGAAGATAC 780 781 CCAGAATGCA GAGACTTGAG CAGAACTATT ATAGAGTGGT CAGAGTCCCA TGATCGAGGA 840 841 TATGGAAAAT TTCAGACTGC TAGAATGGAA GATTTCACAT TTAATGACTT GCATATTAAA 900 901 CTTGGCTTTC CTTACTTATA CTGTCACCAG GGAGACTGTG AGCATGTTGT TGTCATCACA 960 961 GACATAAGGC TTGTGCACCA TGACGACTGC TTGGATAGAA CACTGTATCC CCTTCTTACC 1020 1021 AAGAAGCACT GGCTGTGGAC CAGAAAATGT TTTGTCTGTA AGATGTATAC AGCTAGATGG 1080 1081 GTGACGAACA ATGACACCTT TGCACCAGAG GACCCATGTT TCTTTTGTGA TGTTTGCTTC 1140 1141 AGAATGCTCC ACTATGATTC CGAAGGCAAC AAACTAGGGG AATTCCTTGC TTATCCTTAT 1200 1201 GTTGACCCAG GAACCTTTAA TTAG 1224 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nuclear body | |
Cellular Component | Nucleolus | |
Cellular Component | Nucleoplasm | |
Cellular Component | Nucleus | |
Molecular Function | DNA binding |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-3344 | Rattus norvegicus | 96.56 | 0.0 | 809 |
| LLPS-Mea-0865 | Mesocricetus auratus | 96.03 | 9e-83 | 258 |
| LLPS-Dio-0123 | Dipodomys ordii | 94.44 | 2e-81 | 253 |
| LLPS-Cas-0547 | Carlito syrichta | 90.32 | 7e-77 | 241 |
| LLPS-Fud-1475 | Fukomys damarensis | 89.9 | 0.0 | 591 |
| LLPS-Eqc-0797 | Equus caballus | 87.59 | 0.0 | 716 |
| LLPS-Tut-1113 | Tursiops truncatus | 86.58 | 0.0 | 711 |
| LLPS-Caf-1971 | Canis familiaris | 86.08 | 0.0 | 716 |
| LLPS-Fec-2868 | Felis catus | 85.19 | 0.0 | 721 |
| LLPS-Aon-1628 | Aotus nancymaae | 85.19 | 0.0 | 721 |
| LLPS-Hos-1090 | Homo sapiens | 84.95 | 0.0 | 713 |
| LLPS-Pap-0922 | Pan paniscus | 84.95 | 0.0 | 713 |
| LLPS-Pat-3284 | Pan troglodytes | 84.95 | 0.0 | 713 |
| LLPS-Ict-1686 | Ictidomys tridecemlineatus | 84.95 | 0.0 | 722 |
| LLPS-Sus-1417 | Sus scrofa | 84.95 | 0.0 | 718 |
| LLPS-Poa-2683 | Pongo abelii | 84.71 | 0.0 | 716 |
| LLPS-Nol-1427 | Nomascus leucogenys | 84.71 | 0.0 | 716 |
| LLPS-Gog-1863 | Gorilla gorilla | 84.71 | 0.0 | 715 |
| LLPS-Cea-3663 | Cercocebus atys | 84.47 | 0.0 | 711 |
| LLPS-Maf-1522 | Macaca fascicularis | 84.47 | 0.0 | 712 |
| LLPS-Paa-0472 | Papio anubis | 84.47 | 0.0 | 712 |
| LLPS-Mal-2331 | Mandrillus leucophaeus | 84.47 | 0.0 | 712 |
| LLPS-Mup-1394 | Mustela putorius furo | 84.47 | 0.0 | 718 |
| LLPS-Aim-2518 | Ailuropoda melanoleuca | 84.34 | 0.0 | 715 |
| LLPS-Rhb-1118 | Rhinopithecus bieti | 84.22 | 0.0 | 708 |
| LLPS-Cap-1421 | Cavia porcellus | 83.98 | 0.0 | 712 |
| LLPS-Chs-0306 | Chlorocebus sabaeus | 83.98 | 0.0 | 707 |
| LLPS-Urm-2645 | Ursus maritimus | 83.85 | 0.0 | 716 |
| LLPS-Otg-1522 | Otolemur garnettii | 83.33 | 0.0 | 700 |
| LLPS-Orc-3588 | Oryctolagus cuniculus | 82.77 | 0.0 | 706 |
| LLPS-Ova-0859 | Ovis aries | 82.65 | 0.0 | 700 |
| LLPS-Myl-2296 | Myotis lucifugus | 82.65 | 0.0 | 710 |
| LLPS-Loa-1769 | Loxodonta africana | 82.3 | 0.0 | 701 |
| LLPS-Bot-2690 | Bos taurus | 80.77 | 0.0 | 600 |
| LLPS-Mod-2091 | Monodelphis domestica | 79.69 | 0.0 | 646 |
| LLPS-Lac-2513 | Latimeria chalumnae | 78.54 | 4e-130 | 380 |
| LLPS-Anp-2927 | Anas platyrhynchos | 77.42 | 0.0 | 531 |
| LLPS-Fia-2583 | Ficedula albicollis | 77.24 | 6e-179 | 508 |
| LLPS-Caj-1953 | Callithrix jacchus | 76.46 | 0.0 | 622 |
| LLPS-Man-3109 | Macaca nemestrina | 75.49 | 0.0 | 625 |
| LLPS-Meg-1066 | Meleagris gallopavo | 75.0 | 0.0 | 519 |
| LLPS-Pes-2572 | Pelodiscus sinensis | 73.2 | 0.0 | 608 |
| LLPS-Ora-1931 | Ornithorhynchus anatinus | 71.81 | 0.0 | 607 |
| LLPS-Mam-3408 | Macaca mulatta | 71.73 | 0.0 | 523 |
| LLPS-Gaga-0691 | Gallus gallus | 68.5 | 0.0 | 553 |
| LLPS-Xet-3713 | Xenopus tropicalis | 67.1 | 2e-151 | 438 |
| LLPS-Anc-1321 | Anolis carolinensis | 66.32 | 0.0 | 566 |
| LLPS-Leo-1068 | Lepisosteus oculatus | 61.34 | 2e-166 | 480 |
| LLPS-Scf-0963 | Scleropages formosus | 54.17 | 7e-144 | 422 |
| LLPS-Dar-2285 | Danio rerio | 53.65 | 1e-145 | 427 |
| LLPS-Orn-2544 | Oreochromis niloticus | 53.47 | 5e-149 | 435 |
| LLPS-Ten-0755 | Tetraodon nigroviridis | 53.12 | 6e-139 | 409 |
| LLPS-Scm-1782 | Scophthalmus maximus | 52.42 | 1e-143 | 421 |
| LLPS-Icp-1625 | Ictalurus punctatus | 52.17 | 7e-146 | 427 |
| LLPS-Asm-1266 | Astyanax mexicanus | 52.05 | 5e-136 | 402 |
| LLPS-Tar-1712 | Takifugu rubripes | 51.28 | 4e-139 | 410 |
| LLPS-Pof-1324 | Poecilia formosa | 51.14 | 2e-134 | 397 |
| LLPS-Xim-3266 | Xiphophorus maculatus | 50.64 | 2e-132 | 393 |
| LLPS-Orl-3187 | Oryzias latipes | 50.0 | 1e-135 | 400 |
| LLPS-Gaa-1793 | Gasterosteus aculeatus | 49.1 | 2e-134 | 397 |
| LLPS-Dac-2063 | Daucus carota | 46.15 | 8e-29 | 120 |
| LLPS-Cis-1550 | Ciona savignyi | 44.05 | 9e-60 | 200 |
| LLPS-Sem-1873 | Selaginella moellendorffii | 42.6 | 1e-33 | 129 |
| LLPS-Cii-0271 | Ciona intestinalis | 39.46 | 4e-77 | 249 |
| LLPS-Osl-0765 | Ostreococcus lucimarinus | 37.19 | 6e-19 | 87.0 |
| LLPS-Nia-0713 | Nicotiana attenuata | 37.07 | 4e-38 | 148 |
| LLPS-Viv-1112 | Vitis vinifera | 37.04 | 8e-39 | 145 |
| LLPS-Prp-1472 | Prunus persica | 37.04 | 1e-34 | 138 |
| LLPS-Sol-1774 | Solanum lycopersicum | 35.89 | 9e-39 | 149 |
| LLPS-Sot-0546 | Solanum tuberosum | 35.89 | 2e-38 | 151 |
| LLPS-Coc-1644 | Corchorus capsularis | 35.1 | 3e-34 | 137 |
| LLPS-Glm-2071 | Glycine max | 34.51 | 9e-37 | 144 |
| LLPS-Ors-0099 | Oryza sativa | 34.48 | 6e-35 | 135 |
| LLPS-Orr-1003 | Oryza rufipogon | 34.48 | 3e-35 | 141 |
| LLPS-Hov-0622 | Hordeum vulgare | 34.2 | 9e-36 | 142 |
| LLPS-Mae-0030 | Manihot esculenta | 34.19 | 1e-35 | 141 |
| LLPS-Thc-2245 | Theobroma cacao | 34.16 | 1e-35 | 141 |
| LLPS-Orp-0515 | Oryza punctata | 34.05 | 2e-35 | 141 |
| LLPS-Orm-1860 | Oryza meridionalis | 34.05 | 2e-35 | 141 |
| LLPS-Org-0588 | Oryza glaberrima | 34.05 | 2e-35 | 141 |
| LLPS-Orb-1001 | Oryza barthii | 34.05 | 3e-35 | 141 |
| LLPS-Ori-0547 | Oryza indica | 34.05 | 2e-35 | 141 |
| LLPS-Orni-0239 | Oryza nivara | 34.05 | 2e-35 | 141 |
| LLPS-Orgl-1984 | Oryza glumaepatula | 34.05 | 3e-35 | 141 |
| LLPS-Brr-0703 | Brassica rapa | 34.0 | 1e-31 | 129 |
| LLPS-Hea-1705 | Helianthus annuus | 33.98 | 2e-38 | 150 |
| LLPS-Sei-1011 | Setaria italica | 33.96 | 2e-39 | 152 |
| LLPS-Tru-0521 | Triticum urartu | 33.77 | 5e-36 | 143 |
| LLPS-Tra-1485 | Triticum aestivum | 33.77 | 3e-36 | 144 |
| LLPS-Cus-0736 | Cucumis sativus | 33.73 | 3e-39 | 151 |
| LLPS-Phv-1865 | Phaseolus vulgaris | 33.59 | 6e-38 | 147 |
| LLPS-Abg-1516 | Absidia glauca | 33.48 | 2e-27 | 118 |
| LLPS-Via-1385 | Vigna angularis | 33.47 | 7e-38 | 147 |
| LLPS-Amt-1943 | Amborella trichopoda | 33.46 | 9e-33 | 132 |
| LLPS-Bro-2286 | Brassica oleracea | 33.46 | 2e-32 | 131 |
| LLPS-Brn-0276 | Brassica napus | 33.46 | 2e-32 | 131 |
| LLPS-Mua-2069 | Musa acuminata | 33.33 | 6e-34 | 134 |
| LLPS-Mel-0974 | Melampsora laricipopulina | 33.33 | 4e-17 | 83.2 |
| LLPS-Php-1025 | Physcomitrella patens | 33.22 | 2e-38 | 150 |
| LLPS-Arl-2464 | Arabidopsis lyrata | 33.21 | 2e-33 | 134 |
| LLPS-Brd-1622 | Brachypodium distachyon | 33.07 | 2e-37 | 147 |
| LLPS-Pot-2406 | Populus trichocarpa | 32.97 | 1e-37 | 147 |
| LLPS-Gor-2115 | Gossypium raimondii | 32.95 | 2e-36 | 143 |
| LLPS-Met-2029 | Medicago truncatula | 32.95 | 2e-36 | 143 |
| LLPS-Orbr-0230 | Oryza brachyantha | 32.51 | 9e-36 | 142 |
| LLPS-Zem-1457 | Zea mays | 32.13 | 1e-37 | 147 |
| LLPS-Lep-2386 | Leersia perrieri | 32.1 | 9e-36 | 142 |
| LLPS-Sob-1305 | Sorghum bicolor | 32.0 | 3e-36 | 143 |
| LLPS-Art-2445 | Arabidopsis thaliana | 31.72 | 7e-32 | 130 |
| LLPS-Drm-2106 | Drosophila melanogaster | 30.68 | 5e-26 | 112 |
| LLPS-Miv-1058 | Microbotryum violaceum | 29.3 | 6e-13 | 74.3 |
| LLPS-Cae-0716 | Caenorhabditis elegans | 29.06 | 5e-20 | 95.1 |